Protein Alignment ck and MYH7

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_000248.2
• Gene: MYH7 / 4625
• HGNCID: 7577
• Length: 1935
• Species: Homo sapiens
• Alignment Length: 2076
• Identity: 549/2076 - (26%)
• Similarity: 883/2076 - (42%)
• Gaps: 403/2076 - (19%)

  Fly    14 PASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAG 78
            |...:||   :.|::||.||.::....:.|..| ...|.::...:......:|||..|..|||..
Human    40 PDDKQEF---VKAKIVSREGGKVTAETEYGKTV-TVKEDQVMQQNPPKFDKIEDMAMLTFLHEPA 100

  Fly    79 ILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHM 143
            :|.||..||...:||||:|...|.||||:.||:||.:.:..|:.:|..|.|||||:|.||||.:|
Human   101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYM 165

  Fly   144 KRYRQDQCIVISGESGAGKTESTKLILQYLAAIS------------GKHSWIEQQILEANPILEA 196
            ...|::|.|:|:||||||||.:||.::||.|.|:            ||.: :|.||::|||.|||
Human   166 LTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGT-LEDQIIQANPALEA 229

  Fly   197 FGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLS 261
            ||||||:||||||||||:|.|||.|.|.:..|.||.|||||||::.|..:||:||:||.|   ||
Human   230 FGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQI---LS 291

  Fly   262 ADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAA 322
            ..:...||:.:..    ||.:::.|.: |....|||.|.....:|..||.|:.:|...:.||..|
Human   292 NKKPELLDMLLITNNPYDYAFISQGET-TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGA 355

  Fly   323 LLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTL 384
            ::|.||:|:|....:..   |.||     ..::.|.|:||....|:..|....:....|.|....
Human   356 IMHFGNMKFKLKQREEQAEPDGTE-----EADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415

  Fly   385 SRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCIN 449
            :..|.:....|..|.:|.|||..:|.:|| |..:.:...:..||||||.|||.||.|||||.|||
Human   416 NVQQVIYATGALAKAVYERMFNWMVTRIN-ATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCIN 479

  Fly   450 YANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEARFPKG 513
            :.||.|||||..|:|.||||||..|.|.|..|:| :|.|..:|||. |.:.||::::||..|||.
Human   480 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIE-KPMGIMSILEEECMFPKA 543

  Fly   514 TDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHL 574
            ||.|..|||...| |...|:.||   |......|.|.|:||:|.|:..|:|.||:|..:..::.|
Human   544 TDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGL 608

  Fly   575 VSQSTNKFLRQIFAQ------DIEMGAETRKR---TPTLSTQFRKSLDALMKTLSSCQPFFIRCI 630
            ..:|:.|.|..:||.      .||.|....|:   ..|:|...|::|:.||..|.|..|.|:|||
Human   609 YQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCI 673

  Fly   631 KPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDC 694
            .|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.| .:|.....|.
Human   674 IPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738

  Fly   695 QAATSRICAVV-LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYR---RR 755
            :....::.:.: :..:.|:.||||||.|......||:.||..|:|.|..:|...||.:.|   ::
Human   739 RKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKK 803

  Fly   756 FLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGL-QAHARGY 819
            .|..|.:.:.:|...:.:...|.:..|:: |.:::.|::|.........::.....| :|..:..
Human   804 LLERRDSLLVIQWNIRAFMGVKNWPWMKL-YFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSE 867

  Fly   820 LVRREYGHKMWAVIKIQSHVRRMIAMRR--------------YRKLRLEH--KQFAEVLQ----- 863
            ..|:|...||.::::.::.::..:...:              ..|::||.  |:..|.|:
Human   868 ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM 932

  Fly   864 -------LRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRLHEL---------ERR 898
                   .||||::  ||..            ...|||.|...::..:.:..|         |::
Human   933 NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997

  Fly   899 EIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSV 959
            .:||    .|::.:..|..:|.:..|..|.|:.|||   :|...:               :|..|
Human   998 ALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD---LEGSLE---------------QEKKV 1044

  Fly   960 FNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFAATYFQGNVNHQYA-----KK 1011
            ..||..|:       .:.|:.|   :.:..|::.|.| .|.:.|........:..:.|     :|
Human  1045 RMDLERAKRKLEGDLKLTQESI---MDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK 1106

  Fly  1012 ALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSK 1075
            .||.....:....::|.|: .....:.:...|:........:|::.....:.|...:.:.  |..
Human  1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK--REA 1169

  Fly  1076 EFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGEDV---RRRLQDDEYTADSYQ 1132
            |||:   |..|      .:..:::|:..:..|::|:     :|||.:   :|..|..|.....::
Human  1170 EFQK---MRRD------LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225

  Fly  1133 SWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICK-QLTNNPLKSSHARGWILLSLCVGCFAP 1196
            ..|.. .|||:|:        |::|:...|..|:..: |:..:..|:..
Human  1226 LELDD-VTSNMEQ--------IIKAKANLEKMCRTLEDQMNEHRSKAEE---------------- 1265

  Fly  1197 SEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLEL---QATKSKKPIMLPITFMD 1258
            :::.||.|.:              :|.|....||..::.....|.   |.|:.|      :|:
Human  1266 TQRSVNDLTS--------------QRAKLQTENGELSRQLDEKEALISQLTRGK------LTY-- 1308

  Fly  1259 GNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAK 1323
              |:.|        .:|..||.:::..|:....:|..|            .|..|.:.  |||.:
Human  1309 --TQQL--------EDLKRQLEEEVKAKNALAHALQSA------------RHDCDLLR--EQYEE 1349

  Fly  1324 E-----------QGAQERNAPWRLFFRKEIFAPWH--EPTHDQVATNLIYQQVVRGVKFGEYRCD 1375
            |           ..|....|.||..:..:......  |....::|..|  |:....|:....:|.
Human  1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QEAEEAVEAVNAKCS 1412

  Fly  1376 KEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKD 1440
                                 |:|:....|.|.|.|..   ||......||..|...::::   |
Human  1413 ---------------------SLEKTKHRLQNEIEDLM---VDVERSNAAAAALDKKQRNF---D 1450

  Fly  1441 KI-APLKIK-----EDIVSYAKYKWPLLFSRF------------YEAYRNSGPNLPK--NDVIIA 1485
            || |..|.|     .::.|..|....|....|            .|.::....||.:  :|:...
Human  1451 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1515

  Fly  1486 VNWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNA 1542
            :..:|..:.:        :.|::.|:.:..|..|....:..|:.......:.::.|   .:...|
Human  1516 LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE---IERKLA 1577

  Fly  1543 EDIRDLVVYFLDGLKKRSKYVIALQ-----DYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNG 1602
            |...::.    ...:...:.|.:||     :.|:.::........:|||..:|.:
Human  1578 EKDEEME----QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ---------- 1628

  Fly  1603 WCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHT 1667
              :...:|......   :.|..|.:|.|..|     ..:::|..... .:..|...||   |.:.
Human  1629 --LSHANRMAAEAQ---KQVKSLQSLLKDTQ-----IQLDDAVRAND-DLKENIAIVE---RRNN 1679

  Fly  1668 LMEYALDHFRLPPKRT------MSKTLTLSSKRSEELWRYSRDPIKAPL-----LRKLQSKEEFA 1721
            |::..|:..|...::|      ..:.|..:|:|.:.|...:...|....     |.:||::.|.|
Human  1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEA 1744

  Fly  1722 EEAC--------------FAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYC--- 1769
            .:.|              ...|..||...|..:...||...:...|.|  |:|.:...|...
Human  1745 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD--LQHRLDEAEQIALKG 1807

  Fly  1770 ---QLMK-----QLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPI--SQDSM 1824
               ||.|     :..:|.....::|..|.:   .|: ..|:..:|||.......|..:  .||.:
Human  1808 GKKQLQKLEARVRELENELEAEQKRNAESV---KGM-RKSERRIKELTYQTEEDRKNLLRLQDLV 1868

  Fly  1825 HRLQKTIRHGQRKYPPHQVEVEAIQHKTTQI--FHKVYFP-DDTDEAFEVDSS----TRAK 1878
            .:||..::..:|     |.| ||.:...|.:  |.||... |:.:|..::..|    .|||
Human  1869 DKLQLKVKAYKR-----QAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	282/678 (42%)
		MyTH4	<1138..1245	CDD:214535	19/110 (17%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	19/108 (18%)
		B41	1251..1467	CDD:214604	46/246 (19%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	15/119 (13%)
		SH3	1560..1624	CDD:473055	10/68 (15%)
		MyTH4	1701..1849	CDD:214535	39/179 (22%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	9/32 (28%)
		B41	1856..2068	CDD:214604	9/28 (32%)
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	446/1537 (29%)
		MYSc_Myh7	99..766	CDD:276881	282/678 (42%)
		Actin-binding	655..677		11/21 (52%)
		Actin-binding	757..771		7/13 (54%)
		SMC_prok_B	1173..1930	CDD:274008	168/903 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1907..1935		5/17 (29%)