DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and MYH7

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_000248.2	Gene:	MYH7 / 4625	HGNCID:	7577	Length:	1935	Species:	Homo sapiens

Alignment Length:	2080	Identity:	549/2080 - (26%)
Similarity:	882/2080 - (42%)	Gaps:	411/2080 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAG 78
            |...:||   :.|::||.||.::....:.|..| ...|.::...:......:|||..|..|||..
Human    40 PDDKQEF---VKAKIVSREGGKVTAETEYGKTV-TVKEDQVMQQNPPKFDKIEDMAMLTFLHEPA 100

  Fly    79 ILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHM 143
            :|.||..||...:||||:|...|.||||:.||:||.:.:..|:.:|..|.|||||:|.||||.:|
Human   101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYM 165

  Fly   144 KRYRQDQCIVISGESGAGKTESTKLILQYLAAIS------------GKHSWIEQQILEANPILEA 196
            ...|::|.|:|:||||||||.:||.::||.|.|:            ||.: :|.||::|||.|||
Human   166 LTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGT-LEDQIIQANPALEA 229

  Fly   197 FGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLS 261
            ||||||:||||||||||:|.|||.|.|.:..|.||.|||||||::.|..:||:||:||.|   ||
Human   230 FGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQI---LS 291

  Fly   262 ADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAA 322
            ..:...||:.:..    ||.:::.|.: |....|||.|.....:|..||.|:.:|...:.||..|
Human   292 NKKPELLDMLLITNNPYDYAFISQGET-TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGA 355

  Fly   323 LLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTL 384
            ::|.||:|:|....:..   |.||     ..::.|.|:||....|:..|....:....|.|....
Human   356 IMHFGNMKFKLKQREEQAEPDGTE-----EADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415

  Fly   385 SRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCIN 449
            :..|.:....|..|.:|.|||..:|.:|| |..:.:...:..||||||.|||.||.|||||.|||
Human   416 NVQQVIYATGALAKAVYERMFNWMVTRIN-ATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCIN 479

  Fly   450 YANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEARFPKG 513
            :.||.|||||..|:|.||||||..|.|.|..|:| :|.|..:|||. |.:.||::::||..|||.
Human   480 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIE-KPMGIMSILEEECMFPKA 543

  Fly   514 TDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHL 574
            ||.|..|||...| |...|:.||   |......|.|.|:||:|.|:..|:|.||:|..:..::.|
Human   544 TDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGL 608

  Fly   575 VSQSTNKFLRQIFAQ------DIEMGAETRKR---TPTLSTQFRKSLDALMKTLSSCQPFFIRCI 630
            ..:|:.|.|..:||.      .||.|....|:   ..|:|...|::|:.||..|.|..|.|:|||
Human   609 YQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCI 673

  Fly   631 KPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDC 694
            .|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.| .:|.....|.
Human   674 IPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738

  Fly   695 QAATSRICAVV-LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYR---RR 755
            :....::.:.: :..:.|:.||||||.|......||:.||..|:|.|..:|...||.:.|   ::
Human   739 RKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKK 803

  Fly   756 FLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGL-QAHARGY 819
            .|..|.:.:.:|...:.:...|.:..|:: |.:::.|::|.........::.....| :|..:..
Human   804 LLERRDSLLVIQWNIRAFMGVKNWPWMKL-YFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSE 867

  Fly   820 LVRREYGHKMWAVIKIQSHVRRMIAMRR--------------YRKLRLEH--KQFAEVLQ----- 863
            ..|:|...||.::::.::.::..:...:              ..|::||.  |:..|.|:
Human   868 ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM 932

  Fly   864 -------LRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRLHEL---------ERR 898
                   .||||::  ||..            ...|||.|...::..:.:..|         |::
Human   933 NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997

  Fly   899 EIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSV 959
            .:||    .|::.:..|..:|.:..|..|.|:.|||   :|...:               :|..|
Human   998 ALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD---LEGSLE---------------QEKKV 1044

  Fly   960 FNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFAATYFQGNVNHQYA-----KK 1011
            ..||..|:       .:.|:.|   :.:..|::.|.| .|.:.|........:..:.|     :|
Human  1045 RMDLERAKRKLEGDLKLTQESI---MDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK 1106

  Fly  1012 ALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSK 1075
            .||.....:....::|.|: .....:.:...|:........:|::.....:.|...:.:.  |..
Human  1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK--REA 1169

  Fly  1076 EFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGEDV---RRRLQDDEYTADSYQ 1132
            |||:   |..|      .:..:::|:..:..|::|:     :|||.:   :|..|..|.....::
Human  1170 EFQK---MRRD------LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225

  Fly  1133 SWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICK-QLTNNPLKSSHARGWILLSLCVGCFAP 1196
            ..|.. .|||:|:        |::|:...|..|:..: |:..:..|:..
Human  1226 LELDD-VTSNMEQ--------IIKAKANLEKMCRTLEDQMNEHRSKAEE---------------- 1265

  Fly  1197 SEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLEL---QATKSKKPIMLPITFMD 1258
            :::.||.|.:              :|.|....||..::.....|.   |.|:.|      :|:
Human  1266 TQRSVNDLTS--------------QRAKLQTENGELSRQLDEKEALISQLTRGK------LTY-- 1308

  Fly  1259 GNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQC----E 1319
              |:.|        .:|..||.:::..|:....:|..|..|                  |    |
Human  1309 --TQQL--------EDLKRQLEEEVKAKNALAHALQSARHD------------------CDLLRE 1345

  Fly  1320 QYAKE-----------QGAQERNAPWRLFFRKEIFAPWH--EPTHDQVATNLIYQQVVRGVKFGE 1371
            ||.:|           ..|....|.||..:..:......  |....::|..|  |:....|:...
Human  1346 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QEAEEAVEAVN 1408

  Fly  1372 YRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSY 1436
            .:|.                     |:|:....|.|.|.|..   ||......||..|...::::
Human  1409 AKCS---------------------SLEKTKHRLQNEIEDLM---VDVERSNAAAAALDKKQRNF 1449

  Fly  1437 YVKDKI-APLKIK-----EDIVSYAKYKWPLLFSRF------------YEAYRNSGPNLPK--ND 1481
               ||| |..|.|     .::.|..|....|....|            .|.::....||.:  :|
Human  1450 ---DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISD 1511

  Fly  1482 VIIAVNWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQ 1538
            :...:..:|..:.:        :.|::.|:.:..|..|....:..|:.......:.::.|   .:
Human  1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE---IE 1573

  Fly  1539 SPNAEDIRDLVVYFLDGLKKRSKYVIALQ-----DYRAPSDGTSFLSFFKGDLIILEDESCGESV 1598
            ...||...::.    ...:...:.|.:||     :.|:.::........:|||..:|.:
Human  1574 RKLAEKDEEME----QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ------ 1628

  Fly  1599 LNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRD 1663
                  :...:|......   :.|..|.:|.|..|     ..:::|..... .:..|...||
Human  1629 ------LSHANRMAAEAQ---KQVKSLQSLLKDTQ-----IQLDDAVRAND-DLKENIAIVE--- 1675

  Fly  1664 RPHTLMEYALDHFRLPPKRT------MSKTLTLSSKRSEELWRYSRDPIKAPL-----LRKLQSK 1717
            |.:.|::..|:..|...::|      ..:.|..:|:|.:.|...:...|....     |.:||::
Human  1676 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE 1740

  Fly  1718 EEFAEEAC--------------FAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIY 1768
            .|.|.:.|              ...|..||...|..:...||...:...|.|  |:|.:...|..
Human  1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD--LQHRLDEAEQI 1803

  Fly  1769 C------QLMK-----QLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPI--S 1820
            .      ||.|     :..:|.....::|..|.:   .|: ..|:..:|||.......|..:  .
Human  1804 ALKGGKKQLQKLEARVRELENELEAEQKRNAESV---KGM-RKSERRIKELTYQTEEDRKNLLRL 1864

  Fly  1821 QDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQI--FHKVYFP-DDTDEAFEVDSS----TRAK 1878
            ||.:.:||..::..:|     |.| ||.:...|.:  |.||... |:.:|..::..|    .|||
Human  1865 QDLVDKLQLKVKAYKR-----QAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923

Fly 1879 1878
Human 1924 1923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	292/703 (42%)
		MYSc_Myo7	77..721	CDD:276832	282/678 (42%)
		MyTH4	<1138..1245	CDD:214535	19/110 (17%)
		B41	1251..1467	CDD:214604	46/250 (18%)
		FERM_B-lobe	1355..1439	CDD:271216	16/83 (19%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	15/119 (13%)
		SH3	1560..1624	CDD:302595	10/68 (15%)
		MyTH4	1701..1849	CDD:214535	39/179 (22%)
		B41	1856..2068	CDD:214604	9/28 (32%)
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	446/1541 (29%)
		MYSc_Myh7	99..766	CDD:276881	282/678 (42%)
		Actin-binding	655..677		11/21 (52%)
		Actin-binding	757..771		7/13 (54%)
		SMC_prok_B	1173..1930	CDD:274008	168/907 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1907..1935		5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910