DRSC/TRiP Functional Genomics Resources

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Protein Alignment ck and MYH4

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_060003.2 Gene:MYH4 / 4622 HGNCID:7574 Length:1939 Species:Homo sapiens


Alignment Length:2244 Identity:553/2244 - (24%)
Similarity:898/2244 - (40%) Gaps:574/2244 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67
            |..:.||..            :.|.|.|.||.::..:.:.|..| ...|.::.:|:......:||
Human    27 AQNKPFDAKTSVFVVDPKESYVKAIVQSREGGKVTAKTEAGATV-TVKEDQVFSMNPPKYDKIED 90

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132
            |..:..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
Human    91 MAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHI 155

  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI------------SGK-HSWIE 184
            |:|.||||..|...|::|.|:|:||||||||.:||.::||.|.|            ||| ...:|
Human   156 FSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEPASGKMQGTLE 220

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            .||:.|||:|||||||||:||||||||||:|.|||.|.|.:..|.||.|||||||:..|..:||:
Human   221 DQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLKAERS 285

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAA------DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308
            ||:||.||    :::|..| :.|..      |:.:::.| .||....||..|.....||:.:|.|
Human   286 YHIFYQIL----SNKKPEL-IEMLLITTNPYDFAFVSQG-EITVPSIDDQEELMATDSAVDILGF 344

  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTR 370
            :..|...|.||..|::|.||:|:|....:..   |.||:     .::.|.|..|....|:.:|..
Human   345 TADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-----ADKAAYLTSLNSADLLKSLCY 404

  Fly   371 RTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIF 433
            ..:....|.|....:..|..:...|..|.||.:||:.:|.:||..:  .:||   :..||||||.
Human   405 PRVKVGNEFVTKGQTVQQVYNAVGALAKAIYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIA 466

  Fly   434 GFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQ 497
            |||.||.||.||.|||:.||.|||||..|:|.||||||..|.|.|:.|:| :|....::||. |.
Human   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIE-KP 530

  Fly   498 LNIMALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRG 558
            :.|.::::||..|||.||.:...||::.| |...|:.||   |......|.|.|:||.|.|:..|
Human   531 MGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKPEAHFSLVHYAGTVDYNIAG 595

  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIF--AQDIEM--------GAETRKRTPTLSTQFRKSLD 613
            :||||:|..:..::.|..:|..|.|..:|  ||..|.        |.:......|:|..||::|:
Human   596 WLDKNKDPLNETVVGLYQKSAMKTLAFLFSGAQTAEAEGGGGKKGGKKKGSSFQTVSALFRENLN 660

  Fly   614 ALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVER 678
            .||..|.|..|.|:|||.|||.|.|...:..|...|||.:|::|.|||.|.|:|.|..:.:|.:|
Human   661 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQR 725

  Fly   679 YRFL-IPGVPPAHRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKIL 741
            |:.| ...:|.....|.:.|:.::. ::.:..:.|:.||||||.|......||:.||..|.:.|.
Human   726 YKVLNASAIPEGQFIDSKKASEKLLGSIEIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLIT 790

  Fly   742 ILQRSIRGWVYR---RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRV------ 797
            ..|...||::.|   |:.:..|.:...:|...:.:...|.:..|:: |.:::.|::|..      
Human   791 RTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNVKHWPWMKL-YFKIKPLLKSAETEKEMA 854

  Fly   798 -LSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMI---------AMRR----- 847
             :...|...:..:...:|.      |:|...||..:::.::.::..:         |..|     
Human   855 NMKEEFEKTKEELAKTEAK------RKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLI 913

  Fly   848 YRKLRLEHK-----QFAE---------VLQLRKLEEQ--ELLH------------RGNKHAREIA 884
            ..|::||.|     :.||         ..:.||||::  ||..            ...|||.|..
Human   914 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 978

  Fly   885 EQHYRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEA 936
            .::..:.:..|         |::.:||    .|::.:..|..:|.:..|..|.|:.|||   :|.
Human   979 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDD---LEG 1040

  Fly   937 MFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDI----IAPIHISEDEEDLSE-FKFQKFA 996
            ..:               :|..:..||..|:...:.|:    .:.:....|::.|:| .|.::|.
Human  1041 SLE---------------QEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFE 1090

  Fly   997 ATYFQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMD 1055
            .:..||.:..:.|     :|.:|.....:....:::.|: |......:...|:........:|::
Human  1091 MSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE 1155

  Fly  1056 TTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGE 1115
            ...  ...:|.:..|..|..|||:   |..|    |::.  :::|:..:..|::|:     :|||
Human  1156 EAG--GATSAQIEMNKKREAEFQK---MRRD----LEES--TLQHEATAAALRKKHADSVAELGE 1209

  Fly  1116 DVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSH 1180
            .:           ||.|     |....|||         .::||:.||     ..|.:|....|.
Human  1210 QI-----------DSLQ-----RVKQKLEK---------EKSELKMEI-----NDLASNMETVSK 1244

  Fly  1181 ARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATK 1245
            |:            |..||....|...:.|     ....||..:|..|           ||.|.|
Human  1245 AK------------ANFEKMCRTLEDQLSE-----IKTKEEEQQRLIN-----------ELSAQK 1281

  Fly  1246 SKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQF-----GFSLYI-----ALFDK 1300
            ::                    ..|.:.|...||.:|.::..|.     .|:..|     .|.::
Human  1282 AR--------------------LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE 1326

  Fly  1301 VSSLGSGGDHVMDAISQC----EQYAKEQ--------GAQERN---APWRLFFRKEIFAPWHEPT 1350
            ..:..:....:..|...|    |||.:||        |..:.|   |.||..:..:......|  
Human  1327 TKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEE-- 1389

  Fly  1351 HDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLS 1415
                     .::..:  |..:...|.||.:..:        .|...|:|:....|.|.:.|..:.
Human  1390 ---------LEEAKK--KLAQRLQDAEEHVEAV--------NSKCASLEKTKQRLQNEVEDLMID 1435

  Fly  1416 GVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKN 1480
                 :||..|..:...||.                                   ||.       
Human  1436 -----VERSNAACIALDKKQ-----------------------------------RNF------- 1453

  Fly  1481 DVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQ--KTNKVFTQTFS-LSTVRGEEFTFQSPNA 1542
            |.::| .|...|   ::.|..||.|..|..::|::  |....:.::.. |.|::.|....|    
Human  1454 DKVLA-EWKQKY---EETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQ---- 1510

  Fly  1543 EDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGR 1607
            ::|.||.....:|    .|::..|:..:...|                                 
Human  1511 QEISDLTEQIAEG----GKHIHELEKVKKQLD--------------------------------- 1538

  Fly  1608 CDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYA 1672
                .|:.:...                    ::|||                         |.:
Human  1539 ----HEKSELQT--------------------SLEEA-------------------------EAS 1554

  Fly  1673 LDH-------FRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAA 1730
            |:|       .:|...:..|:.....:::.|||     |.:|...||.::|.:...:       |
Human  1555 LEHEEGKILRIQLELNQVKSEIDRKIAEKDEEL-----DQLKRNHLRVVESMQSTLD-------A 1607

  Fly  1731 ILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLAT 1795
            .::...|....:.:|..::.:        .||..:....|..:.|.:.||               
Human  1608 EIRSRNDALRIKKKMEGDLNE--------MEIQLNHANRQAAEALRNLRN--------------- 1649

  Fly  1796 GLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVY 1860
                 :||:||:..|.|.....  .||.   |::.:...:|:....|.|||.::           
Human  1650 -----TQGILKDTQLHLDDAIR--GQDD---LKEQLAMVERRANLMQAEVEELR----------- 1693

  Fly  1861 FPDDTDEAFEVDSSTRAKDFCN----NISQRLSLRTSEGFSLF--VKIADKVISVPEGDFFFDFV 1919
                    ..::.:.|.:....    :.|:|:.|..::..||.  .|..:..||..:|:      
Human  1694 --------ASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE------ 1744

  Fly  1920 RHLTDWIKKARPIRDGANPQFTYQVFF----------------MKKLWTNTVPGKDRNADLIFHY 1968
              :.|.:::||...:.|....|.....                |||....||      .||....
Human  1745 --MEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV------KDLQLRL 1801

  Fly  1969 HQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAI------PQMLRELI------PSDI 2021
            .:.....|:|..|..::..|::..|...|. .|.|..::|:      .:.::||.      ..:|
Human  1802 DEAEQLALKGGKKQIQKLEARVRELESEVE-SEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNI 1865

  Fly  2022 MKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFLK 2055
            :::|...:..::.|.:|.:......|.:.|...|
Human  1866 LRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAK 1899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 284/709 (40%)
MYSc_Myo7 77..721 CDD:276832 275/684 (40%)
MyTH4 <1138..1245 CDD:214535 24/106 (23%)
B41 1251..1467 CDD:214604 37/240 (15%)
FERM_B-lobe 1355..1439 CDD:271216 15/83 (18%)
FERM_C1_MyoVII 1461..1559 CDD:270019 21/100 (21%)
SH3 1560..1624 CDD:302595 4/63 (6%)
MyTH4 1701..1849 CDD:214535 28/147 (19%)
B41 1856..2068 CDD:214604 40/234 (17%)
FERM_M 1966..2068 CDD:278785 18/102 (18%)
FERM_C2_MyoVII 2064..2159 CDD:270020
MYH4NP_060003.2 Myosin_N 36..73 CDD:280832 7/37 (19%)
Myosin_head 88..770 CDD:278492 281/696 (40%)
MYSc_Myh4 100..770 CDD:276879 275/684 (40%)
Actin-binding. /evidence=ECO:0000250 659..681 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 761..775 7/13 (54%)
Myosin_tail_1 850..1927 CDD:279860 241/1404 (17%)
RILP-like 965..1098 CDD:304877 30/150 (20%)
MIT_CorA-like <1299..>1411 CDD:294313 21/124 (17%)
COG6 1376..>1511 CDD:303003 34/210 (16%)
DUF342 <1670..1767 CDD:302792 21/126 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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