DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and MYH3

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_002461.2 Gene:MYH3 / 4621 HGNCID:7573 Length:1940 Species:Homo sapiens


Alignment Length:2234 Identity:547/2234 - (24%)
Similarity:900/2234 - (40%) Gaps:560/2234 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 RVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENL 91
            ::.|::..::.|..:|...:.:.|| .:.||:......:|||..|..|:|..:|.||..||...:
Human    51 KIKSSQDGKVTVETEDNRTLVVKPE-DVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWM 114

  Fly    92 IYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISG 156
            ||||:|...|.||||:.||:|..:.::.|:.:|..|.|||||:|.||||..|...|::|.|:|:|
Human   115 IYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179

  Fly   157 ESGAGKTESTKLILQYLAAI-----------SGKHSWIEQQILEANPILEAFGNAKTIRNDNSSR 210
            |||||||.:||.::||.|.|           |.....:|.||:.|||:|||||||||:|||||||
Human   180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSR 244

  Fly   211 FGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAA- 274
            |||:|.|||...|.:..|.||.|||||||:..|..:||:||:||.|   ||..:...::|.:.. 
Human   245 FGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQI---LSNKKPELIELLLITT 306

  Fly   275 ---DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVV 336
               ||.:::.| .|.....|||.|.....||:.:|.|:.:|...:.||..|::|.||:|:|....
Human   307 NPYDYPFISQG-EILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQR 370

  Fly   337 DNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVK 398
            :..   |.||:     .::.|.|:||....|:.||....:....|.|....:.||.....:|..|
Human   371 EEQAEPDGTEV-----ADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSK 430

  Fly   399 GIYGRMFVHIVRKINTAIFK--PRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQ 461
            .:|.::|:.:|.:||..:..  ||   ::.||||||.|||.|:.||.||.|||:.||.|||||..
Human   431 SVYEKLFLWMVTRINQQLDTKLPR---QHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNH 492

  Fly   462 HIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKT 525
            |:|.||||||..|.|.|..|:| :|....::||. |.:.|.::::||..|||.||.:...||:..
Human   493 HMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQ 556

  Fly   526 H-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQI 586
            | |...|:.||   |......|.|.|:||.|.|...|:|:||:|..:..::.|..:|:|:.|..:
Human   557 HLGKSNNFQKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHL 621

  Fly   587 FAQDIEMGAETRKRT---------PTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFD 642
            :|......|::.|:.         .|:|..||::|:.||..|.:..|.|:|||.|||.|.|...:
Human   622 YATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAME 686

  Fly   643 RGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFL-IPGVPPAHRTDCQAATSRICAVV- 705
            ..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.| ...:|.....|.:.|..::.|.: 
Human   687 HSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASID 751

  Fly   706 LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRL---RAAAITVQ 767
            :..:.|:.||||||.|......||:.||..|.:.|...|...||::.|..|.::   |.:...:|
Human   752 IDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQ 816

  Fly   768 RFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHRFRHLRGHIVGLQAHARGYLVRREY 825
            ...:.:...|.:..|:: :.:::.|::|       ..:...|:..:..:      |:....|:|.
Human   817 YNIRSFMNVKHWPWMKL-FFKIKPLLKSAETEKEMATMKEEFQKTKDEL------AKSEAKRKEL 874

  Fly   826 GHKMWAVI--------KIQSHVRRMI-AMRR-----YRKLRLEHK-----QFAE---------VL 862
            ..|:..::        ::|:....:: |..|     ..|.:||.|     :.||         ..
Human   875 EEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTA 939

  Fly   863 QLRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRLHEL---------ERREIQE-- 902
            :.||||::  ||..            ...|||.|...::..:.|..|         |::.:||  
Human   940 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH 1004

  Fly   903 --QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPH 965
              .|::.:..|..:|.:|....|.|:.|:|   :|:..:               :|..:..||..
Human  1005 QQALDDLQAEEDKVNSLNKTKSKLEQQVED---LESSLE---------------QEKKLRVDLER 1051

  Fly   966 AQNVNQDDI-IAP---IHISEDEEDLSE-FKFQKFAATYFQGNVNH------QYAKKALKHPLLP 1019
            .:...:.|: :|.   :.:..|::.|.| .|.:.|.....|..|..      |:.||     :..
Human  1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKK-----IKE 1111

  Fly  1020 LHTQGDQL-----AAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQE 1079
            |..:.::|     |.:|......:...|.........:|::....::.....|.:.       :|
Human  1112 LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKK-------RE 1169

  Fly  1080 AQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGED------VRRRLQDD----EYTAD 1129
            |:.:.|..|.    :..:::|:.:...|::|:     :|||.      |:::|:.:    :...|
Human  1170 AEFLKLRRDL----EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 1230

  Fly  1130 SYQSWLQ--SRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVG 1192
            ...|.::  |:..:||||                     ||:.|.:   :.|.|||         
Human  1231 DLSSSMESVSKSKANLEK---------------------ICRTLED---QLSEARG--------- 1262

  Fly  1193 CFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFM 1257
                                      ..|.::|:.:           ||...||:          
Human  1263 --------------------------KNEEIQRSLS-----------ELTTQKSR---------- 1280

  Fly  1258 DGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYA 1322
                      ..|.|.||..||.:|.|:..|...|                   ..|.:|..:..
Human  1281 ----------LQTEAGELSRQLEEKESIVSQLSRS-------------------KQAFTQQTEEL 1316

  Fly  1323 KEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQ 1387
            |.|..:|..|.                           ..:...::...:.||       :..:|
Human  1317 KRQLEEENKAK---------------------------NALAHALQSSRHDCD-------LLREQ 1347

  Fly  1388 YFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIV 1452
            |..|......::|            .||..:..:.:|         ::.|..|.|...:..|:  
Human  1348 YEEEQEGKAELQR------------ALSKANSEVAQW---------RTKYETDAIQRTEELEE-- 1389

  Fly  1453 SYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVN-------WTGVYVVDDQEQVLLELSFPEIT 1510
              ||.|   |..|..::          .:.:.|||       .|...:..:.|.:::::......
Human  1390 --AKKK---LAQRLQDS----------EEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 1439

  Fly  1511 AVSSQKTNKVFTQTFSLSTVRGEEFTFQ-SPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSD 1574
            |.:..|..:.|.:..:....:.||...: ..:.::.|.|..   :..|.::.|..||..      
Human  1440 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLST---ELFKLKNAYEEALDQ------ 1495

  Fly  1575 GTSFLSFFKGDLIILEDE--SCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDI-L 1636
                |...|.:...||.|  ...|.:..||..|...::|:::             :.....|| |
Human  1496 ----LETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ-------------IELEKADIQL 1543

  Fly  1637 ALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRY 1701
            ||   |||                         |.||:|       ..:|.|.:..:.::     
Human  1544 AL---EEA-------------------------EAALEH-------EEAKILRIQLELTQ----- 1568

  Fly  1702 SRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRD- 1765
                :|:.:.||:..|:|..|:....:...::.|........|..||..      .||.::..| 
Human  1569 ----VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAI------RLKKKMEGDL 1623

  Fly  1766 -EIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLR---------------- 1813
             ||..||     .:.||.:.|....|..:        ||.||:..|.|.                
Human  1624 NEIEIQL-----SHANRQAAETLKHLRSV--------QGQLKDTQLHLDDALRGQEDLKEQLAIV 1675

  Fly  1814 TRRHPISQDSMHRLQKTIRHGQRKYPPHQVE-------VEAIQHKTTQIFH--KVYFPDDTDEAF 1869
            .||..:.|..:..|:.|:...:|.....:.|       |:.:..:.|.:.|  |....|......
Human  1676 ERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 1740

  Fly  1870 EVDSSTRAKDFCNNISQRLSLRTSEGFSLFVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRD 1934
            ||:.::|            ..|.:|      :.|.|.|               ||....|..:: 
Human  1741 EVEDASR------------DARNAE------EKAKKAI---------------TDAAMMAEELK- 1771

  Fly  1935 GANPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKL-LRGYHKCSREEAAKLAALVFRVR 1998
             .....:..:..|||....||  ||     :.|...|..:| |:|..|..::...::..|.|.:.
Human  1772 -KEQDTSAHLERMKKNLEQTV--KD-----LQHRLDEAEQLALKGGKKQIQKLETRIRELEFELE 1828

  Fly  1999 FGENKQELQAI------PQMLRELI------PSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKV 2051
             ||.|:..:::      .:.::||.      ..:::::|...:..:..|.||.:......|.|..
Human  1829 -GEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANA 1892

  Fly  2052 AFLKIVYRWPTFGSAFFEVKQTTE 2075
            ...|       |..|..|:::..|
Human  1893 HLTK-------FRKAQHELEEAEE 1909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 278/704 (39%)
MYSc_Myo7 77..721 CDD:276832 269/679 (40%)
MyTH4 <1138..1245 CDD:214535 15/106 (14%)
B41 1251..1467 CDD:214604 34/215 (16%)
FERM_B-lobe 1355..1439 CDD:271216 10/83 (12%)
FERM_C1_MyoVII 1461..1559 CDD:270019 15/105 (14%)
SH3 1560..1624 CDD:302595 13/65 (20%)
MyTH4 1701..1849 CDD:214535 35/172 (20%)
B41 1856..2068 CDD:214604 43/226 (19%)
FERM_M 1966..2068 CDD:278785 22/114 (19%)
FERM_C2_MyoVII 2064..2159 CDD:270020 3/12 (25%)
MYH3NP_002461.2 Myosin_N 36..73 CDD:280832 3/21 (14%)
Myosin_head 88..767 CDD:278492 275/691 (40%)
MYSc_Myh3 100..767 CDD:276878 269/679 (40%)
Actin-binding 656..678 10/21 (48%)
Actin-binding 758..772 7/13 (54%)
GrpE 843..>962 CDD:295646 21/124 (17%)
Myosin_tail_1 847..1924 CDD:279860 247/1423 (17%)
BAR <956..1063 CDD:299863 22/124 (18%)
MIT_CorA-like <1296..>1408 CDD:294313 27/202 (13%)
COG6 1373..>1506 CDD:303003 27/162 (17%)
TMPIT 1739..>1850 CDD:285135 29/153 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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