DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ck and Myo1a

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_001074688.1	Gene:	Myo1a / 432516	MGIID:	107732	Length:	1043	Species:	Mus musculus

Alignment Length:	886	Identity:	322/886 - (36%)
Similarity:	490/886 - (55%)	Gaps:	91/886 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGEL 128
            ||||:|.|..|.|..:::||.:||:...||||.|::::::|||:.||||..:.|..|::....||
Mouse     9 GVEDLILLEPLDEESLIKNLQLRYENKEIYTYIGNVVISMNPYEQLPIYGPEFIAKYRDYTFYEL 73

  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH---SWIEQQILEA 190
            .|||:|:.:.||..:|...:||||:|:|||||||||::||::.|:||:.||.   :.:::|:|::
Mouse    74 KPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQS 138

  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255
            ||:||||||||||||:||||||||:||.|...|...|..|..|||||||:|.|...|||:|:||.
Mouse   139 NPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNFHIFYQ 203

  Fly   256 ILAGLSADEKSRLDLGMAAD---YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEII 317
            :|||  ||.:....|.:..|   |.||.|..| ...|.|||:.|..::.||.|:.||::||.:::
Mouse   204 LLAG--ADAQLLKALKLEEDTSVYGYLNGEVS-KVNGMDDASNFRAVQHAMSVIGFSEEEIRQVL 265

  Fly   318 KLLAALLHCGNIKYKATVVDNLDATEIP-----EHINVERVAGLLGLPIQPLIDALTRRTLFAHG 377
            ::.|.:|..||:|    :.|...|..||     :...::.:..::||....|..||..||:....
Mouse   266 EVTALVLKLGNVK----LTDEFQANGIPASGICDGKGIQEIGEMMGLNSTELERALCSRTMETGK 326

  Fly   378 ETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNS 442
            |.||:.|:..|:...|||..|.||.|:|..||::||.:|....|..:..:|||||:|||..:.||
Mouse   327 EKVVTVLNVTQAQYARDALAKNIYSRLFDWIVKRINESIKVGTGEKKKVMGVLDIYGFEILEDNS 391

  Fly   443 FEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEE 507
            ||||.|||.||.|||.|::...|.|||||..|.|.|..:|:.||....:||...|..|:|::|||
Mouse   392 FEQFVINYCNERLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICNLIEHSQRGILAMLDEE 456

  Fly   508 ARFPKG--TDQTMLAKLHKTHGSHKNYLKPKSDIN-----------TSFGLNHFAGVVFYDTRGF 559
            ...| |  :|.|.||||::....|.:| :.|...|           :.|.::|:||.|.|:..||
Mouse   457 CLRP-GVVSDSTFLAKLNQLFSKHSHY-ESKVSQNAQRQYDRTMGLSCFRISHYAGKVTYNVTGF 519

  Fly   560 LDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQP 624
            :|||.|....||...:.::.:..|:.:|.:.....| :.||.||..|||:.|:..|||.|.|..|
Mouse   520 IDKNNDLLFRDLSQTMWKAQHPLLKSLFPEGNPKEA-SLKRPPTAGTQFKNSVAVLMKNLYSKNP 583

  Fly   625 FFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPA 689
            .:|||||||:.::...|...:...|.||.|::|.:|:|||||..|.|::.|:||||.|.....|.
Mouse   584 NYIRCIKPNDQQQKGRFTSEMVMVQARYLGLLENVRVRRAGYAFRQGYKPFLERYRLLSRSTWPR 648

  Fly   690 HRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLF-LEQERDRVLTRKILILQRSIRGWVY 752
            ...|.:....::. ::.|...:...|.||:|::....|| ||::|...|.:...::|:..|||..
Mouse   649 WNGDDREGVEKVLGSLTLSSEELAYGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKVYRGWRC 713

  Fly   753 RRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHAR 817
            |..:.::|.:.|.:..:::|..|:|.|           ..|||.||.            :||..|
Mouse   714 RTHYQQMRKSQILISAWFRGNKQKKHY-----------GKIRSSVLL------------IQAFVR 755

  Fly   818 GYLVRREYG--HKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRK-LEEQELL------ 873
            |:..|:.|.  .:..|.:.:.:.:.:.:|.:             .:|.|:| |...::|
Mouse   756 GWRARKNYRKYFRSGAALTLANFIYQSMAQK-------------FLLNLKKNLPSTKVLDNTWPA 807

  Fly   874 ------HRGNKHAREIAEQ----HYRDRLHELERREIQEQL 904
                  :..|:..:.:..|    .:||:|...:.:.::|:|
Mouse   808 APYRCFNTANQELQRLFYQWKCKKFRDQLSPKQVQTLREKL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	284/694 (41%)
		MYSc_Myo7	77..721	CDD:276832	272/668 (41%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo1a	NP_001074688.1	MYSc_Myo1	22..681	CDD:276829	272/668 (41%)
		Actin-binding. /evidence=ECO:0000255	571..593		12/21 (57%)
		IQ	742..764	CDD:197470	10/33 (30%)
		Myosin_TH1	847..1042	CDD:368706	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910