DRSC/TRiP Functional Genomics Resources

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Protein Alignment ck and Mhc

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:2109 Identity:555/2109 - (26%)
Similarity:886/2109 - (42%) Gaps:460/2109 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 EPASGREFDVAIGARVVSAEGRRIQVRD--DDGDEVWLAPER------RIKAMHASSV----QG- 64
            :|.:.:|.:.......||.|.|||....  |.....|:..|:      .|||.....|    || 
  Fly     3 KPVANQEDEDPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGG 67

  Fly    65 --------------------VEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQIL 109
                                :|||..:..|:...:|.||..||...|||||:|...||:|||:..
  Fly    68 EVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRY 132

  Fly   110 PIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLA 174
            |:||....|:|:.::..|:|||||||.|.||..|.....:|.::|:|||||||||:||.::.|.|
  Fly   133 PVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFA 197

  Fly   175 AISGKHSW---------IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKI 230
            .:......         :|.|:::.||:|||||||||:||||||||||:|.|||...|.:.||.|
  Fly   198 TVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADI 262

  Fly   231 EQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAAD--YKY-LTGGNSITCEGRDD 292
            |.|||||:|::||...||:||:||.|::|.....|   |:.:..|  |.| :.....:|....||
  Fly   263 ETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVK---DICLLTDNIYDYHIVSQGKVTVASIDD 324

  Fly   293 AAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVE---RVA 354
            |.|||....|..:|.|:.||..::.::.||::|.|.:|:|     .....|..|....|   ||:
  Fly   325 AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFK-----QRGREEQAEQDGEEEGGRVS 384

  Fly   355 GLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKP 419
            .|.|.....|...|.:..:....|.|....:..|..:...|..||::.|:|..:|:|.|..: ..
  Fly   385 KLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL-DT 448

  Fly   420 RGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF- 483
            :...::.||||||.|||.|:.|.|||.|||:.||.|||||..|:|.||||||..|.|:|..|:| 
  Fly   449 QQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFG 513

  Fly   484 VDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKPK----SDINTSF 543
            :|....:|||. |.:.|:::::||:.|||.||||...||..|| |....:.|||    ......|
  Fly   514 MDLLACIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHF 577

  Fly   544 GLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEM--GAETRK------- 599
            .:.|:||.|.|:..|:|:||:|..:..::....:|.||.|.:|||.....  |.|..|       
  Fly   578 AIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKG 642

  Fly   600 -RTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRR 663
             ...|:|:.:::.|::||.||.|.||.|:|||.|||:|:|.:.|..|...||..:|::|.|||.|
  Fly   643 GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICR 707

  Fly   664 AGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFL 728
            .|:|.|..:.:|..||:.:.|.:......|.:|....|..:.|.:..|:||:||||.:......:
  Fly   708 KGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQM 772

  Fly   729 EQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALI 793
            |:.||..|.:        |..|               :|.:.:||..||       |:.:||   
  Fly   773 EEFRDERLGK--------IMSW---------------MQAWARGYLSRK-------GFKKLQ--- 804

  Fly   794 RSRVLSHRFRHLRGHIVGLQAHARGYLVRREY-GHKMWAVIKIQSHVRRM---IAMRRYRKLRLE 854
            ..||.          :..:|.:.|.||..|.: .:|:|..:|...:|.|:   ||....:..:.|
  Fly   805 EQRVA----------LKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAE 859

  Fly   855 HKQFAEVLQLRKLEEQELLHRGNKHAREIAE---------------QHYRDR-------LHELER 897
            ....||| ::||  |.|.|     :|:.:||               |.|::|       .::||.
  Fly   860 ELHAAEV-KVRK--ELEAL-----NAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLEN 916

  Fly   898 --REIQEQLENRRRVEVNMNIINDAARKQEEPVDD-GKLVEAMFDFLPDSSSDAPT-PHGGRETS 958
              |:|||:|...   |...|.:....:|.::.:.. .|.:|.:...:..:..|..| .|..|.  
  Fly   917 QLRDIQERLTQE---EDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRN-- 976

  Fly   959 VFNDLPHAQNVNQDDIIAPIHISED-EEDLSEFKFQKFAATYFQGNVNHQYAKKA-LKHPLLPLH 1021
             .||    :..:||::|..::..:. :.:.::...::..|.  :..:||....|| |:..|..|.
  Fly   977 -LND----EIAHQDELINKLNKEKKMQGETNQKTGEELQAA--EDKINHLNKVKAKLEQTLDELE 1034

  Fly  1022 -------------------TQGD-QLAAQALWITILRFTGDMPEPK---YHTMDRMDTTSVMSKV 1063
                               .:|| :|..:|:        .|:...|   ..|:.|.|  ..:|.:
  Fly  1035 DSLEREKKVRGDVEKSKRKVEGDLKLTQEAV--------ADLERNKKELEQTIQRKD--KELSSI 1089

  Fly  1064 TATLGRNFI-------RSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRL 1121
            ||.|....:       :.||.| |::..|:.:...:::.|:...|..:...:...:|||    ||
  Fly  1090 TAKLEDEQVVVLKHQRQIKELQ-ARIEELEEEVEAERQARAKAEKQRADLARELEELGE----RL 1149

  Fly  1122 QDDEYTADSYQSWLQSRPTSNLEKL-----HFIIGHGILRAELR---DEIYCQICKQLTN-NPLK 1177
             ::...|.|.|..|..:..:.|.||     ...|.|....|.||   ::...::.:|:.. |.||
  Fly  1150 -EEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLK 1213

  Fly  1178 SSHARGWILLSLCVGCFAPSEK-----FVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPS 1237
            :.               |..||     .:|.|||.:.......|  .:|::.:...: |.|:..|
  Fly  1214 AK---------------AEKEKNEYYGQLNDLRAGVDHITNEKA--AQEKIAKQLQH-TLNEVQS 1260

  Fly  1238 WLELQATKSKKPIMLPITFMDGNTKTLLADSATTAREL------CNQLSD-KISLKDQFGFSLYI 1295
            .|: :..::       :...|.:.|.|..:::...|:|      .:|||. ||||..|...:..:
  Fly  1261 KLD-ETNRT-------LNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRL 1317

  Fly  1296 A---------LFDKVSSLGSGGDHVMDAI-SQCEQYAKEQGAQER-----NAP---WRLFFRKEI 1342
            |         |..|..:|    :|.:|.: .|.|:.|:.:...:|     ||.   ||..:..  
  Fly  1318 ADEESRERATLLGKFRNL----EHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES-- 1376

  Fly  1343 FAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTD--MSMERLFTLL 1405
                     |.||.:...::..|.::            |.:|..:..||....  :.:|:....|
  Fly  1377 ---------DGVARSEELEEAKRKLQ------------ARLAEAEETIESLNQKCIGLEKTKQRL 1420

  Fly  1406 PNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFY--- 1467
            ...:.|..|.     ::|..|:...|.||.......|...|:|.|.:: |:........|.|   
  Fly  1421 STEVEDLQLE-----VDRANAIANAAEKKQKAFDKIIGEWKLKVDDLA-AELDASQKECRNYSTE 1479

  Fly  1468 ---------------EAYRNSGPNLPK--NDVIIAVNWTG--VYVVD------DQEQVLLELSFP 1507
                           ||.|....||..  .|::..:...|  ::.::      :.|:..|:.:..
  Fly  1480 LFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALE 1544

  Fly  1508 EITAVSSQKTNKVFTQTFSLSTVR----------GEEFTFQSPNAEDIRDLVVYFLDG------- 1555
            |..|...|:.|||......||.||          .|||.....|.:...|.:...|:.       
  Fly  1545 EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAE 1609

  Fly  1556 ---LKKR-----SKYVIALQDY--RAPSDGTSFLSFFKGDL----IILEDESCGESVLNNGWCIG 1606
               :||:     ::..||| |:  :|.::....:..::..|    ..||:|....          
  Fly  1610 ALRMKKKLEADINELEIAL-DHANKANAEAQKNIKRYQQQLKDIQTALEEEQRAR---------- 1663

  Fly  1607 RCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEY 1671
              |.::|:..........|....:..:.:|     |:|..|||.:      ..|..|....|.|.
  Fly  1664 --DDAREQLGISERRANALQNELEESRTLL-----EQADRGRRQA------EQELADAHEQLNEV 1715

  Fly  1672 ALDHFRL-PPKRTMSKTL-TLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKY 1734
            :..:..: ..||.:...| ||.|...|             ||.:.::.||.|::|....|     
  Fly  1716 SAQNASISAAKRKLESELQTLHSDLDE-------------LLNEAKNSEEKAKKAMVDAA----- 1762

  Fly  1735 MGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFA 1799
                     |:.:|:.     ....|...::::...|.:|:.:.:.|:.|..       |..|..
  Fly  1763 ---------RLADELR-----AEQDHAQTQEKLRKALEQQIKELQVRLDEAE-------ANALKG 1806

  Fly  1800 CSQGLLK--------ELLLFLRTRRHPISQDSMHRLQKTIR-------HGQRKYPPHQVEVEAIQ 1849
            ..:.:.|        |..|....|||..:|.::.:.::.::       ..::.:...|..|:.:|
  Fly  1807 GKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQ 1871

  Fly  1850 HKTTQIFHKVYFPDDTDEAFEVDSSTRAK 1878
            .|.     |.| ....:||.|:.:...||
  Fly  1872 QKI-----KTY-KRQIEEAEEIAALNLAK 1894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 273/720 (38%)
MYSc_Myo7 77..721 CDD:276832 267/674 (40%)
MyTH4 <1138..1245 CDD:214535 25/120 (21%)
B41 1251..1467 CDD:214604 50/242 (21%)
FERM_B-lobe 1355..1439 CDD:271216 15/85 (18%)
FERM_C1_MyoVII 1461..1559 CDD:270019 28/145 (19%)
SH3 1560..1624 CDD:302595 11/69 (16%)
MyTH4 1701..1849 CDD:214535 25/162 (15%)
B41 1856..2068 CDD:214604 7/23 (30%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 8/36 (22%)
MYSc 81..777 CDD:214580 272/705 (39%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 267/674 (40%)
Myosin_tail_1 842..1897 CDD:279860 242/1217 (20%)
V_Alix_like 1557..1877 CDD:187408 70/387 (18%)
ATP-synt_B <1671..1771 CDD:304375 27/142 (19%)
TMPIT 1739..>1825 CDD:285135 19/124 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466282
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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