DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myo31DF

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	840	Identity:	305/840 - (36%)
Similarity:	459/840 - (54%)	Gaps:	94/840 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGEL 128
            ||:|.:.|..:.....:.||..|::...||||.|.:.|::|||:.:.||..:.|:.||.|::.|.
  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFEN 72

  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW-----IEQQIL 188
            .||:|||.|:||..:|:.:||.||:|||||||||||::|:|::|:||::.....     ::..::
  Fly    73 APHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLI 137

  Fly   189 EANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVF 253
            ::|.|||.||||||.|||||||||||:||.|.......|..|..|||||||:|.|...|||:|.|
  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202

  Fly   254 YCILAGLSADEKSRLDLGM-AADYKYLTGGNSITCEGRDDAAEFSDIR---SAMKVLLFSDQEIW 314
            |.:|.|.:.:|..:.:|.. ...|.||..|:      .|...|.||.:   :|.|.|.||..|:.
  Fly   203 YQLLRGANDNELRQYELQKETGKYHYLNQGS------MDILTEKSDYKGTCNAFKTLGFSTDEVQ 261

  Fly   315 EIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            .|.:.:||:||.||:::: |:.|.|   .|....:::..|.||.:....|..|||:|.:.|.|..
  Fly   262 TIWRTIAAVLHLGNVEFQ-TIEDEL---VISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNV 322

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIF----KPRGTSRNAIGVLDIFGFENFDQ 440
            :....:..|:...:||..|.||.|:|..|:.:||.||.    |.:....:.||||||:|||.||.
  Fly   323 MQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDS 387

  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALID 505
            ||||||||||.||.|||.|::.:.|.|||||..|.|.|.:||:.:|:...||:......|:|::|
  Fly   388 NSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMD 452

  Fly   506 EEA-RFPKGTDQTMLAKLHKTHGSHKNY-----------LKPKSDINTSFGLNHFAGVVFYDTRG 558
            |.. ...|.||.|:|..:.|....|.:|           ||.:.|    |.:.|:||.|.|:..|
  Fly   453 EACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHRED----FRITHYAGDVIYNING 513

  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIF---AQDIEMGAETRKRTPTLSTQFRKSLDALMKTLS 620
            |::||:||...|...|:..|.:..|.:::   ||||:   :|.||..|..|.|::|:..|:.||.
  Fly   514 FIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIK---KTTKRPLTAGTLFQRSMADLVVTLL 575

  Fly   621 SCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPG 685
            ..:||::||||||:||...:||......|:||.|::|.:|:||||:..|..:.:|:.||:.:...
  Fly   576 KKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQY 640

  Fly   686 VPPAHRTDCQAATSRICAVVLGK-----SDYQLGHTKVFLKDAHDLF-LEQERDRVLTRKILILQ 744
            ..|..|    |.:.|....||.:     .|.:.||||:|::....|| ||.:|:.::...:.:||
  Fly   641 TWPNFR----AGSDRDGVRVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQ 701

  Fly   745 RSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRH----- 804
            :.:|||:.||.|.::: ||||:.|.:|.|              :|::.::.  |::|.|.
  Fly   702 KRVRGWIVRRNFKKMK-AAITIVRAYKAY--------------KLRSYVQE--LANRLRKAKQMR 749

  Fly   805 ------------LRGHIVGLQAHA-----RGYLVRREYGHKMWAVIKIQSHVRRMIAMRR 847
                        |.|..|..:.|.     |..::..:|....|..:::|......:|.||
  Fly   750 DYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRR 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	274/702 (39%)
		MYSc_Myo7	77..721	CDD:276832	266/676 (39%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	274/702 (39%)
		MYSc_Myo1	21..677	CDD:276829	266/676 (39%)
		Myosin_TH1	801..983	CDD:283635	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940