DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myo10A

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster


Alignment Length:3130 Identity:715/3130 - (22%)
Similarity:1112/3130 - (35%) Gaps:1144/3130 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 ERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGD 115
            |..::|.......|||||..|.|||||.:|.||.:||.:.||||:.||||:|||||::.|...|.
  Fly   143 EGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGL 207

  Fly   116 QI-KLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI--- 176
            :: |.|..|.:|.||||:||||..|:|.:.   ..|.:|||||||:||||||||::|||||:   
  Fly   208 EVAKQYAGRPLGSLPPHLFAIGAAAHAALP---SPQVVVISGESGSGKTESTKLVMQYLAAVVPG 269

  Fly   177 -SGKHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRI 240
             ....:.|.:|||||.|:|||||||:|.|||||||||||::::|. :|.|.||||.|||||||||
  Fly   270 GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRI 333

  Fly   241 VSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKV 305
            |:|...||||||||.:|.|||..|:|:..|..|..|.||..|.:....||.|   :..::.||:|
  Fly   334 VTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQV 395

  Fly   306 LLFSDQEIWEIIKLLAALLHCGNIKY-KATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALT 369
            |..|:.|...|:::|||:||.||:.: :..:....:..|:.....::..|.||.:....|..|||
  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALT 460

  Fly   370 RRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFG 434
            .||..|..|.:.:.|..||::|.||||.|.:|..:|..:|.:||:.:.|......:.|.:|||||
  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFG 525

  Fly   435 FENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLN 499
            ||:..:|||||.||||||||||.:|.:|:|||||.||..|.:.|..:.:.||...:.|:|.|.:.
  Fly   526 FEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVG 590

  Fly   500 IMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNR 564
            |..|:|:|:.||:.||.:.|.|.|..|...:.|.:|:.... .||:.|:||.|:|...|||||||
  Fly   591 ICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQ-EFGVTHYAGQVWYCVDGFLDKNR 654

  Fly   565 DTFSPDLLHLVSQS----TNKFLRQIFAQ-----DIEMGAETR-----KRTPTLSTQFRKSLDAL 615
            |....|:|.|::.|    ..:..:|:.||     .:..|:..|     .||||::.:|..||..|
  Fly   655 DALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQL 719

  Fly   616 MKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYR 680
            ::::..|.|:|:||||||:.|..:..|.....:||||.||::||:||:.|||:|..|:.||||||
  Fly   720 LQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYR 784

  Fly   681 FLIP-----GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKI 740
            .|:|     |.|  :|..|:|....:....:...|||||.|:|||::|....||..|...|.|..
  Fly   785 HLLPSPLARGTP--YRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAA 847

  Fly   741 LILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHL 805
            :.:||.:||.:.||:..|.:|||..:|..|:|...::||..:|.|.:..|.|.|.|....|.:.|
  Fly   848 VSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQL 912

  Fly   806 RGHIVGLQAHARGYLVR------REYGHKMWAVI-------------------KIQS-------- 837
            |..      |.|....|      ||......||:                   |:|.        
  Fly   913 RSD------HRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDR 971

  Fly   838 HVRRMI--------------------AMRRYRK-----LRLEHKQ-----------------FAE 860
            |:.:::                    :..::..     |||:.::                 |.:
  Fly   972 HLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQD 1036

  Fly   861 VLQLRKL------------EEQELL----------HRG--------------------------- 876
            .|.:.||            .:::||          .||                           
  Fly  1037 ALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLW 1101

  Fly   877 ----------------NKHAREIAEQHYRDRLHELERREIQEQ---------------------- 903
                            :|:.....:....:.|..|..|::..|                      
  Fly  1102 QLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAW 1166

  Fly   904 LENRRRV-------------EVNMNIINDAARKQEEP------------------VDDGK----- 932
            ||.|...             |.:..:..|:....||.                  :|||:     
  Fly  1167 LEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDS 1231

  Fly   933 -------------------------LVEAMFDF----LPDS------SSDAPTPHGGRE------ 956
                                     |:.:...|    |||:      ...||....|:|      
  Fly  1232 CGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRER 1296

  Fly   957 ---------TSVFND------------------LPHAQNVNQDDIIA--------------PIH- 979
                     :|..|:                  ...:::.:.||::|              |:| 
  Fly  1297 RSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHT 1361

  Fly   980 --ISEDE--------EDLSEF------KFQK--------FAATYFQGNVNHQYAKKA-------- 1012
              :||..        |.|:..      ::||        .||::  |:.:.:||.||        
  Fly  1362 LGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASH--GSHSSKYADKAEYATRSSA 1424

  Fly  1013 ----LKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMD-RMDTTSVMSKVTATLGRNFI 1072
                .:.|.|..|.:..::.:||  ..:.:|..|:..|   .:| .:|..|....:.|::.....
  Fly  1425 MSDTSEAPSLASHVRRVRVPSQA--SDVDQFLDDLFSP---VLDGSLDELSDARSLAASIRGGSY 1484

  Fly  1073 RSKEFQEAQLMGLDP---DAFLKQKPRSIRHKLVSLTLKRKNKLG--------------EDVRRR 1120
            ..:...|:::..||.   |.|   :|..:...|..||  .|::|.              .|....
  Fly  1485 EQENEAESEIDDLDDYINDIF---QPIPLVQNLEKLT--SKDQLAAIIKGGGVASKPEERDEESE 1544

  Fly  1121 LQD-DEY-------------------------------TADS----------------------- 1130
            ::| |:|                               :.||                       
  Fly  1545 IEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPAL 1609

  Fly  1131 YQ-----SWLQSRPTSNLE-KLHFIIGHGILRAELRDEIYCQICKQLTNNP-------------- 1175
            ||     ::|||....||: :...:..:..|:..|..:.........|:.|              
  Fly  1610 YQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPP 1674

  Fly  1176 -------LKSSHARGWILLSL-------------CVGCFAPSE--KFVN-YLRA-FIREG----- 1211
                   :|::.:...::.||             .:.|..|||  .|:: |.|| .:|.|     
  Fly  1675 PPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWP 1739

  Fly  1212 PPGYAPYCE---------------------ERLKRTFNNGTRNQPP----------SWLELQATK 1245
            ||...|..:                     :..:.|.|.|.....|          .|.|.:...
  Fly  1740 PPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIES 1804

  Fly  1246 SKKPIM---LPITFMDGNTKTLLADSATTARELCNQLSD-------------------------- 1281
            ...|.|   |..:.:...|.|....||...|:...:..|                          
  Fly  1805 PTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPP 1869

  Fly  1282 ----------------------------------------------KISLKDQFGFSLYIALFDK 1300
                                                          |:.|:.|.|     .||..
  Fly  1870 PGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLG-----GLFAS 1929

  Fly  1301 VSSLGSGGDHVMD---------------------------------------------------- 1313
            ||...||...|:|                                                    
  Fly  1930 VSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP 1994

  Fly  1314 ----------------------------------------------------------------- 1313
                                                                             
  Fly  1995 PAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDH 2059

  Fly  1314 ------AISQCEQ-----------------YA-------------------KEQGAQER------ 1330
                  |::..||                 |:                   ||:..:||      
  Fly  2060 SASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLY 2124

  Fly  1331 ----------------------------------------------------------------- 1330
                                                                             
  Fly  2125 EIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASS 2189

  Fly  1331 -------------------------------------------------------NAPWRLFFRK 1340
                                                                   ..||:|..||
  Fly  2190 GMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRK 2254

  Fly  1341 EIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRC------DKEEDLAMIAAQQYFIEYSTDMSME 1399
            |:|.| |||....||.:|::.||: |..||...|      :|...|.|:        :...:|::
  Fly  2255 EVFQP-HEPIGPPVALDLLFAQVL-GDVFGVTPCLRITPQEKSSALNML--------HGHGVSVD 2309

  Fly  1400 RLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFS 1464
            .|.....:........|..:|:                         :|..:|..|: .|||.|:
  Fly  2310 TLSNRNGSGAGGGGNGGQVRAL-------------------------VKRHLVDMAR-DWPLYFA 2348

  Fly  1465 RFYEAYRNSGPNLPKNDV-IIAVNWTGVYVV---DDQEQVLLELSFPEI-TAVSSQKTNKVFTQT 1524
            |.:..  ...|..|  || |:.|:.:|:|:.   .|...|:..:||.|| :||:..:     ...
  Fly  2349 RLFAV--QGAPLYP--DVSIMGVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPR-----PAA 2404

  Fly  1525 FSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKK-RSKYVIALQDYRAPS--------------- 1573
            ..|:...|:.....:..|..|:.:|..|:...:| :||........||.:               
  Fly  2405 LQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQA 2469

  Fly  1574 ---------DGTSFLSFFKGDLIILEDESCGESVLNN---------------------------- 1601
                     ||.|           .::|...:|.|::                            
  Fly  2470 HAQRNEHGVDGGS-----------RQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAM 2523

  Fly  1602 -------------GWCIGRCDRSQERGDFPAETVYV-LPTLSKPPQDILALFNIEEAHHGRR--- 1649
                         ...:|:....|:|  |..:..|: ....|...|...:|.| .:.||..:   
  Fly  2524 EEQHMATDHQQQQQQQLGQQQGQQQR--FLKQQSYLHSARKSNAGQQPSSLTN-GQVHHQEQMLQ 2585

  Fly  1650 ------------------LSMASNGGAVEPRDRPHTLMEYALDHFR----LPPKRTMSKTLTLSS 1692
                              |...|||| ..|....::|:::|:.|||    ....|...:..:.::
  Fly  2586 QQQQQSQSLPHHDLDANYLQDESNGG-TPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAAN 2649

  Fly  1693 KRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITD------ 1751
            :...||.::....|:.||||   ...:.|..|...|..||:|.||:|     :..::|:      
  Fly  2650 RSYAELVKWQGHAIRLPLLR---LPNDLAPLALECFDCILRYCGDIP-----LDPDLTEVKCVYT 2706

  Fly  1752 ---HIFDGPLKHEILRDEIYCQLMKQLTDNRNRM--SEERGWELMWLATGLFACSQGLLKELLLF 1811
               |..    |:..||||:|||||||.|.||:..  |.:|.|.|:.:....|.||..|...|:..
  Fly  2707 VLMHCH----KYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEH 2767

  Fly  1812 LRT-----RR--HPISQDSMHRLQKTIRHGQRKYPPHQVEVEAI---QHKTTQIFHKVYFPDDTD 1866
            |.:     ||  |..:...:..|:||.|.|.||..|...||.|:   :....||:.   .|...:
  Fly  2768 LTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYR---LPGGAE 2829

  Fly  1867 EAFEVDSSTRAKDFCNNISQRLSLRT---SEGFSLFVKIADKVISVP--EGDFFFDFVRHLTDWI 1926
            .......||...|....:...|.:.:   .:.|||:..:.....::|  ..::..|..   |:.:
  Fly  2830 RVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVT---TELL 2891

  Fly  1927 KKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFH--YHQELPKLLRG----------- 1978
            |..:|          :.:.|.:.:|...:..:.....|...  ::|..|..|.|           
  Fly  2892 KSGQP----------FYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAPDYLEGLLLELPGNGVP 2946

  Fly  1979 YHKCSREEAAKLAALVFRVRFGENKQELQAIPQM--LRELIPSDIMKIQS--TSEWKRSIVASYN 2039
            ..:..| :.|::|||:.|.      .:|..:|.|  ::.|:|...:.|:.  .::|...:.:::.
  Fly  2947 VPEMVR-DMARIAALLHRA------ADLSHVPAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWP 3004

  Fly  2040 QDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQT-------TEPNYPEM---LLIAINKHGVSLI 2094
            |...::....|..||.::..||.|||:||.||:.       .|.|:..|   |::|:|:.||..:
  Fly  3005 QVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFL 3069

  Fly  2095 HPVTKDILVTHPF-----TRISNWSSGNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLM 2154
            .|.|.:.|....|     ||......|..:..|.:|||::...:..:|...:::..|:..||::.
  Fly  3070 DPNTHETLQHWSFMEVISTRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITMA 3134

  Fly  2155 LTNMNKNRTI 2164
            ..:....|.:
  Fly  3135 QISQRDKREL 3144

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 310/693 (45%)
MYSc_Myo7 77..721 CDD:276832 296/668 (44%)
MyTH4 <1138..1245 CDD:214535 28/181 (15%)
B41 1251..1467 CDD:214604 63/581 (11%)
FERM_B-lobe 1355..1439 CDD:271216 15/89 (17%)
FERM_C1_MyoVII 1461..1559 CDD:270019 26/103 (25%)
SH3 1560..1624 CDD:302595 14/128 (11%)
MyTH4 1701..1849 CDD:214535 55/168 (33%)
B41 1856..2068 CDD:214604 42/233 (18%)
FERM_M 1966..2068 CDD:278785 26/118 (22%)
FERM_C2_MyoVII 2064..2159 CDD:270020 29/109 (27%)
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 308/689 (45%)
MYSc_Myo15 169..828 CDD:276838 296/668 (44%)
MyTH4 1014..1171 CDD:295320 15/156 (10%)
MyTH4 2704..2810 CDD:279165 39/109 (36%)
B41 2823..3033 CDD:214604 42/232 (18%)
FERM_B-lobe 2920..3025 CDD:271216 21/111 (19%)
FERM_C_MyoXV 3029..3138 CDD:270022 29/108 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466288
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1389at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - P PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
65.750

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