DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myh6

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_058935.2 Gene:Myh6 / 29556 RGDID:62029 Length:1939 Species:Rattus norvegicus


Alignment Length:2113 Identity:547/2113 - (25%)
Similarity:879/2113 - (41%) Gaps:462/2113 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67
            |..|.||:.            :.|::||.||.::....::|..| ...|.::...:......:||
  Rat    26 AQTRPFDIRTECFVPDDKEEYVKAKIVSREGGKVTAETENGKTV-TVKEDQVMQQNPPKFDKIED 89

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132
            |..|..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
  Rat    90 MAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHI 154

  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHS----------WIEQ 185
            |:|.||||.:|...|::|.|:|:||||||||.:||.::||.|:|:  |..|          .:|.
  Rat   155 FSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKDNPNANKGTLED 219

  Fly   186 QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNY 250
            ||::|||.|||||||||:||||||||||:|.|||.|.|.:..|.||.|||||||::.|..:||||
  Rat   220 QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNY 284

  Fly   251 HVFYCILAGLSADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQ 311
            |:||.|   ||..:...||:.:..    ||.:::.| .::....||:.|.....||..||.|:.:
  Rat   285 HIFYQI---LSNKKPELLDMLLVTNNPYDYAFVSQG-EVSVASIDDSEELLATDSAFDVLGFTAE 345

  Fly   312 EIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373
            |...:.||..|::|.||:|:|....:..   |.||     :.::.|.|:||....|:..|....:
  Rat   346 EKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTE-----DADKSAYLMGLNSADLLKGLCHPRV 405

  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENF 438
            ....|.|....|..|......|..|.:|.:||..:|.:|| |..:.:...:..||||||.|||.|
  Rat   406 KVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRIN-ATLETKQPRQYFIGVLDIAGFEIF 469

  Fly   439 DQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMA 502
            |.|||||.|||:.||.|||||..|:|.||||||..|.|.|:.|:| :|.|..:|||. |.:.||:
  Rat   470 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIE-KPMGIMS 533

  Fly   503 LIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKN 563
            :::||..|||.||.|..|||:..| |...|:.||   |......|.|.|:||.|.|:..|:|:||
  Rat   534 ILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGTVDYNILGWLEKN 598

  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQ-------DIEMGAETRKR---TPTLSTQFRKSLDALMKT 618
            :|..:..::.|..:|:.|.:..:|:.       |...|...:|:   ..|:|...|::|:.||..
  Rat   599 KDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENLNKLMTN 663

  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683
            |.:..|.|:|||.|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.
  Rat   664 LRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 728

  Fly   684 P-GVPPAHRTDCQAATSRICAVVLGKSD-----YQLGHTKVFLKDAHDLFLEQERDRVLTRKILI 742
            | .:|.....|.:....::    ||..|     |:.||||||.|......||:.||..|:|.|..
  Rat   729 PAAIPEGQFIDSRKGAEKL----LGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITR 789

  Fly   743 LQRSIRGWVYRRRFLRL---RAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRH 804
            :|...||.:.|..|.::   |.|.:.:|...:.:...|.:..|:: |.:::.|::|........:
  Rat   790 IQAQARGQLMRIEFKKMVERRDALLVIQWNIRAFMGVKNWPWMKL-YFKIKPLLKSAETEKEMAN 853

  Fly   805 LR---GHIVGL--QAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRR--------------YRK 850
            ::   |.:...  ::.||    |:|...||.::::.::.::..:...:              ..|
  Rat   854 MKEEFGRVKDALEKSEAR----RKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNK 914

  Fly   851 LRLEH--KQFAEVLQ------------LRKLEEQ--ELLH------------RGNKHAREIAEQH 887
            ::||.  |:..|.|:            .||||::  ||..            ...|||.|...::
  Rat   915 IQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 979

  Fly   888 YRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFD 939
            ..:.:..|         |::.:||    .|::.:..|..:|.:..:..|.|:.|||   :|...:
  Rat   980 LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLIKSKVKLEQQVDD---LEGSLE 1041

  Fly   940 FLPDSSSDAPTPHGGRETSVFNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFA 996
                           :|..|..||..|:       .:.|:.|   :.:..|:..|.| .|.::|.
  Rat  1042 ---------------QEKKVRMDLERAKRKLEGDLKLTQESI---MDLENDKLQLEEKLKKKEFD 1088

  Fly   997 ATYFQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMD 1055
            .:.....:..:.|     :|.||.....:....::|.|: .....:.:...|:........:|::
  Rat  1089 ISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLTRELEEISERLE 1153

  Fly  1056 TTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGE 1115
            .....:.|...:.:.  |..|||:   |..|      .:..:::|:..:..|::|:     :|||
  Rat  1154 EAGGATSVQIEMNKK--REAEFQK---MRRD------LEEATLQHEATAAALRKKHADSVAELGE 1207

  Fly  1116 DV---RRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLK 1177
            .:   :|..|..|.....::..|.. .|||:|:        |::|:...|   ::.:.|      
  Rat  1208 QIDNLQRVKQKLEKEKSEFKLELDD-VTSNMEQ--------IIKAKANLE---KVSRTL------ 1254

  Fly  1178 SSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNG---TRNQPPSWL 1239
                                |...|..|..:.|.......:..:|.|....||   .:.:....|
  Rat  1255 --------------------EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299

  Fly  1240 ELQATKSKKPIMLPITFM------DGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALF 1298
            ..|.|:.|......:..:      :|..|..||.:..:||..|:      .|::|:         
  Rat  1300 ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCD------LLREQY--------- 1349

  Fly  1299 DKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQV 1363
                      :..|:|.::.::...:  |....|.||..:..:......|           .::.
  Rat  1350 ----------EEEMEAKAELQRVLSK--ANSEVAQWRTKYETDAIQRTEE-----------LEEA 1391

  Fly  1364 VRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALV 1428
            .:  |..:...|.||.:..:.|:        ..|:|:....|.|.|.|..   ||......||..
  Rat  1392 KK--KLAQRLQDAEEAVEAVNAK--------CSSLEKTKHRLQNEIEDLM---VDVERSNAAAAA 1443

  Fly  1429 LQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYV 1493
            |...::::   ||                                          |...|...| 
  Rat  1444 LDKKQRNF---DK------------------------------------------ILAEWKQKY- 1462

  Fly  1494 VDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEF----TFQSPN---AEDIRDLV-- 1549
              ::.|..||.|..|..::|        |:.|.|.....|..    ||:..|   .|:|.||.  
  Rat  1463 --EESQSELESSQKEARSLS--------TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517

  Fly  1550 -------VYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILE----------------- 1590
                   |:.|:.::|:.: |..|:...|..:..:.|...:|.::..:                 
  Rat  1518 LGEGGKNVHELEKIRKQLE-VEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1581

  Fly  1591 DESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASN 1655
            ||...::..|:   :...|..|...|....:......:.|..:..|....|:.:...|..|.|..
  Rat  1582 DEEMEQAKRNH---LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQK 1643

  Fly  1656 ----------------GGAVEPRD----------RPHTLMEYALDHFRLPPKRT------MSKTL 1688
                            ..||...|          |.:||::..|:..|...::|      ..:.|
  Rat  1644 HLKNAQAHLKDTQLQLDDAVRANDDLKENIAIVERRNTLLQAELEELRAVVEQTERSRKLAEQEL 1708

  Fly  1689 TLSSKRSEELWRYSRDPIKAPL-----LRKLQSKEEFAEEAC--------------FAFAAILKY 1734
            ..:|:|.:.|...:...|....     |.:||::.|.|.:.|              ...|..||.
  Rat  1709 IETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK 1773

  Fly  1735 MGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYC------QLMK-----QLTDNRNRMSEERGW 1788
            ..|..:...||...:...|.|  |:|.:...|...      ||.|     :..:|.....::|..
  Rat  1774 EQDTSAHLERMKKNMEQTIKD--LQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1836

  Fly  1789 ELMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEV-EAIQHKT 1852
            |.:   .|: ..|:..:|||     |.:....:.::.|||..:...|.|...::.:. ||.:...
  Rat  1837 ESV---KGM-RKSERRIKEL-----TYQTEEDKKNLVRLQDLVDKLQLKVKAYKRQAEEAEEQAN 1892

  Fly  1853 TQI--FHKVYFP-DDTDEAFEVDSS----TRAK 1878
            |.:  |.||... |:.:|..::..|    .|||
  Rat  1893 TNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 290/708 (41%)
MYSc_Myo7 77..721 CDD:276832 280/683 (41%)
MyTH4 <1138..1245 CDD:214535 18/109 (17%)
B41 1251..1467 CDD:214604 34/221 (15%)
FERM_B-lobe 1355..1439 CDD:271216 16/83 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 22/113 (19%)
SH3 1560..1624 CDD:302595 11/80 (14%)
MyTH4 1701..1849 CDD:214535 37/178 (21%)
B41 1856..2068 CDD:214604 9/28 (32%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Myh6NP_058935.2 Myosin_N 34..72 CDD:397036 7/38 (18%)
MYSc_class_II 99..768 CDD:276951 280/683 (41%)
Actin-binding 657..679 10/21 (48%)
Actin-binding 759..773 7/13 (54%)
Calmodulin-binding. /evidence=ECO:0000250 790..807 5/16 (31%)
Calmodulin-binding. /evidence=ECO:0000250 816..833 2/16 (13%)
Myosin_tail_1 848..1925 CDD:396244 225/1272 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1908..1939 5/18 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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