DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myo7a

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_006229804.1	Gene:	Myo7a / 266714	RGDID:	628830	Length:	2276	Species:	Rattus norvegicus

Alignment Length:	2225	Identity:	1364/2225 - (61%)
Similarity:	1705/2225 - (76%)	Gaps:	81/2225 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RGDYIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPER--RIKAMHASSVQGVEDM 68
            :|||:|::..||:||||.|||.|...|..:|||.||:|:|.|::|:.  .||.||.:||.|||||
  Rat    67 KGDYVWMDLKSGQEFDVPIGAMVKLCESGQIQVVDDEGNEHWISPQNATHIKPMHPTSVHGVEDM 131

  Fly    69 ISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIF 133
            |.||||:||||||||||||:::|||||||||||||||||:|.||:.:.|:.|..:||||:|||||
  Rat   132 IRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSSEHIRQYTNKKIGEMPPHIF 196

  Fly   134 AIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEANPILEAFG 198
            ||.||.|.:|||..:|||.:||||||||||||||||||:||||||:|||||||:|||.|||||||
  Rat   197 AIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPILEAFG 261

  Fly   199 NAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSAD 263
            |||||||||||||||||||||:..|.|||||||||||||||:..|...|||||||||:|.|::.:
  Rat   262 NAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDERNYHVFYCMLEGMNEE 326

  Fly   264 EKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGN 328
            ||.:|.||.||||.||..||.||||||.|:.|:::||||||||:|:|.|.|||:|||||:||.||
  Rat   327 EKKKLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEILKLLAAILHMGN 391

  Fly   329 IKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVR 393
            ::|:|...:||||.|:....::...|..|.:....|:..||.|||...||||.:.|||:|::|||
  Rat   392 LQYEARTFENLDACEVLFSPSLATAASHLEVNPPDLMSCLTSRTLITRGETVSTPLSREQALDVR 456

  Fly   394 DAFVKGIYGRMFVHIVRKINTAIFKPRG----TSRNAIGVLDIFGFENFDQNSFEQFCINYANEN 454
            ||||||||||:||.||.|||.||:||..    .||.:||:|||||||||..|||||.|||:|||:
  Rat   457 DAFVKGIYGRLFVWIVEKINAAIYKPPSQEVTNSRRSIGLLDIFGFENFTVNSFEQLCINFANEH 521

  Fly   455 LQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTML 519
            ||||||:|:||||||||:.|:|:|.||||.|||:|||:||.:.:|:::|||||::||||||.|||
  Rat   522 LQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMNVISLIDEESKFPKGTDATML 586

  Fly   520 AKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLR 584
            .||:..|..:.||:.||:...|.||:|||||:|:|:::|||:|||||...|::.||..|.|||::
  Rat   587 HKLNSQHRLNANYVPPKNSHETQFGINHFAGIVYYESQGFLEKNRDTLHGDIIQLVHSSRNKFVK 651

  Fly   585 QIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQ 649
            |||..|:.||||||||:||||:||::||:.||:||.:|||||:|||||||.||||:|||.||.||
  Rat   652 QIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQ 716

  Fly   650 LRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHR-TDCQAATSRICAVVLG-KSDYQ 712
            |||||||||||||.||||||:.|.|||||||.|:|||.||:: .|.|....|:...||| ..|:|
  Rat   717 LRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQDDLQGTCQRMAEAVLGTHDDWQ 781

  Fly   713 LGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRK 777
            :|.||:||||.||:.||.|||:.:|.::::||:.|||:..|..||||::||..:||.|:|:..||
  Rat   782 IGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWRGHHCRK 846

  Fly   778 RYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRM 842
            .|..:|:|::|||||.|||.|..::|..|..|:..||..|.|||||.:.|::||||.:|::.|.|
  Rat   847 NYELIRLGFLRLQALHRSRKLHKQYRLARQRIIKFQARCRAYLVRRAFRHRLWAVITVQAYARGM 911

  Fly   843 IAMRRYRKLRLEHKQFAEVLQLRKLEEQEL-LHRGNKHAREIAEQHYRDRLHELER----REIQE 902
            ||.|.:|:||:|:.:..|..::|..||::| .....|.|:|.||:.:::||.:|.|    ||::|
  Rat   912 IARRLHRRLRVEYWRRLEAERMRLAEEEKLRKEMSAKKAKEEAERKHQERLAQLAREDAERELKE 976

  Fly   903 QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHA- 966
            :.|.||:.|    ::....|.:.||::...:|:.||.|| .:||..|... |:..|.|.||...
  Rat   977 KEEARRKKE----LLQQMERARHEPINHSDMVDKMFGFL-GTSSGLPGQE-GQAPSGFEDLERGR 1035

  Fly   967 QNVNQDDIIAPIHI-SEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQ 1030
            :.:.::|:.|.:.: .||||||||:||.|||||||||...|.|.::.||.|||....:||||||.
  Rat  1036 REMVEEDVDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAAL 1100

  Fly  1031 ALWITILRFTGDMPEPKYHT--MDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLK- 1092
            |:|||||||.||:|||||||  .|..:...||:|:..|||:...: :|.|..|..|   :|.|.
  Rat  1101 AVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYK-RELQALQGEG---EAQLSE 1161

  Fly  1093 -QKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILR 1156
             ||..|::||||.||||:|:||.|:|.:||.|.|..... .|.|:.||||||||||||||:||||
  Rat  1162 GQKKTSVKHKLVHLTLKKKSKLTEEVTKRLHDGESMVQG-NSMLEDRPTSNLEKLHFIIGNGILR 1225

  Fly  1157 AELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEE 1221
            ..|||||||||.||||:||.|||:||||||:||||||||||||||.|||.||..|||||||||||
  Rat  1226 PALRDEIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPGYAPYCEE 1290

  Fly  1222 RLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLK 1286
            ||:|||.||||.||||||||||||||||||||:|||||.||||||||||||:||||.|:||||||
  Rat  1291 RLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLADSATTAKELCNALADKISLK 1355

  Fly  1287 DQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTH 1351
            |:|||||||||||||||||||.|||||||||||||||||||||||||||||||||:|.|||.|:.
  Rat  1356 DRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHNPSE 1420

  Fly  1352 DQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSG 1416
            |.|||||||||||||||||||||:||:|||.:|:||||::|.::|.:|||.:|:|.:|||..::.
  Rat  1421 DNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLSLVPTYIPDREITP 1485

  Fly  1417 VDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKND 1481
            : |.:|:||.|.:.|:||..|.:.:....|:|:|:|:||::|||||||||||||:.|||.|||:|
  Rat  1486 L-KNLEKWAQLAIAAHKKGIYAQRRTDAQKVKQDVVNYARFKWPLLFSRFYEAYKFSGPPLPKSD 1549

  Fly  1482 VIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKT----------------------------- 1517
            ||:||||||||.||:|||||||||||||.||||.:.
  Rat  1550 VIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRECRVLLSLGCSDLGCASCHSGRAGLTPAGP 1614

  Fly  1518 ---------NKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPS 1573
                     .|:...:|:|:|::|:|:||.|.||||||||||.||:||:||||||:||||...|:
  Rat  1615 CSPCWSCRGAKLMAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPA 1679

  Fly  1574 -DGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILA 1637
             :.:.||||.||||||| |...||.|:|:||..|..:|:::|||||.:.|||:||::.||::|:|
  Rat  1680 GEESGFLSFAKGDLIIL-DHDTGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTLPPREIVA 1743

  Fly  1638 LFNI---EEAHHGRRLSMASNGGAVEP--RDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEE 1697
            |..:   :.....|.|.:.:    .||  |.:|:||.|::.|:||.|||.|:|:.:...::..:.
  Rat  1744 LVTMTPDQRQDVVRLLQLRT----AEPEVRTKPYTLEEFSYDYFRSPPKHTLSRVMVSKARGKDR 1804

  Fly  1698 LWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEI 1762
            ||.::|:|:|..||:|:...||.::|||.:|.|:||||||.||||.|..||:||.||:..:|.|.
  Rat  1805 LWSHTREPLKQALLKKIVGSEELSQEACMSFIAVLKYMGDYPSKRTRSVNELTDQIFEWAVKAEP 1869

  Fly  1763 LRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRH-PISQDSMHR 1826
            |:||.|.|::||||||..|.|||:||||:||.||||..|..||..:..||::|:| |::.|.:.|
  Rat  1870 LKDEAYVQILKQLTDNHIRYSEEKGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQR 1934

  Fly  1827 LQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLR 1891
            |||.:|:|.||||||.|||||||||||||||||||||||||||||:|||:|||||.||:.||.|:
  Rat  1935 LQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNIASRLLLK 1999

  Fly  1892 TSEGFSLFVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVP 1956
            :|||||||||||||||||||.||||||||||||||||||||:||..|..||||||||||||.|||
  Rat  2000 SSEGFSLFVKIADKVISVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVFFMKKLWTTTVP 2064

  Fly  1957 GKDRNADLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIPQMLRELIPSDI 2021
            |||..||.||||:|||||.|||||||:|||..:|.||::||:|.|:|....:||::||||:|.|:
  Rat  2065 GKDPMADSIFHYYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPSIPKLLRELVPQDL 2129

  Fly  2022 MKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAI 2086
            ::..|..:|||||||.:|:..|.:.|:||:||||::::||||||||||||||||||:||:|||||
  Rat  2130 IRQVSPDDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTTEPNFPEILLIAI 2194

  Fly  2087 NKHGVSLIHPVTKDILVTHPFTRISNWSSGNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYI 2151
            ||:|:|||.|.|||||.|||||:||||||||||||:|||||||||||||||||||||||||||||
  Rat  2195 NKYGISLIDPRTKDILTTHPFTKISNWSSGNTYFHITIGNLVRGSKLLCETSLGYKMDDLLTSYI 2259

  Fly  2152 SLMLTNMNKNRTIRA 2166
            |.|||.|:|.|..|:
  Rat  2260 SQMLTAMSKQRNSRS 2274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	446/674 (66%)
		MYSc_Myo7	77..721	CDD:276832	427/649 (66%)
		MyTH4	<1138..1245	CDD:214535	91/106 (86%)
		B41	1251..1467	CDD:214604	154/215 (72%)
		FERM_B-lobe	1355..1439	CDD:271216	49/83 (59%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	69/135 (51%)
		SH3	1560..1624	CDD:302595	35/64 (55%)
		MyTH4	1701..1849	CDD:214535	83/148 (56%)
		B41	1856..2068	CDD:214604	150/211 (71%)
		FERM_M	1966..2068	CDD:278785	58/101 (57%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	83/94 (88%)
Myo7a	XP_006229804.1	MYSc	121..802	CDD:214580	449/680 (66%)
		MYSc_Myo7	140..790	CDD:276832	427/649 (66%)
		IQ	827..848	CDD:197470	10/20 (50%)
		MAP7	<918..996	CDD:283355	26/81 (32%)
		eIF3_subunit	936..>991	CDD:285763	19/58 (33%)
		MyTH4	1078..1314	CDD:214535	155/240 (65%)
		B41	1320..1535	CDD:214604	154/215 (72%)
		FERM_N	1323..>1362	CDD:286467	32/38 (84%)
		FERM_B-lobe	1424..1524	CDD:271216	54/100 (54%)
		FERM_C1_MyoVII	1529..1665	CDD:270019	69/135 (51%)
		SH3_MYO7A	1666..1730	CDD:212814	35/64 (55%)
		MyTH4	1808..1957	CDD:214535	83/148 (56%)
		B41	1964..2176	CDD:214604	150/211 (71%)
		FERM_M	2074..2176	CDD:278785	58/101 (57%)
		FERM_C2_MyoVII	2172..2267	CDD:270020	83/94 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341931
Domainoid	1	1.000	889	1.000	Domainoid score	I49
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H219
Inparanoid	1	1.050	2714	1.000	Inparanoid score	I25
OMA	1	1.010	-	-		QHG52371
OrthoDB	1	1.010	-	-		D21221at33208
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	1	1.000	-	-		oto97162
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1286
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770