DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and unc-54

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_493596.1 Gene:unc-54 / 259839 WormBaseID:WBGene00006789 Length:1963 Species:Caenorhabditis elegans


Alignment Length:2159 Identity:521/2159 - (24%)
Similarity:870/2159 - (40%) Gaps:531/2159 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IWI-EPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGD 73
            :|| :|..|     .:...:.:.:|.::.:....|:||.|..| .::.|:....:..|||.:|..
 Worm    33 VWIPDPEEG-----YLAGEITATKGDQVTIVTARGNEVTLKKE-LVQEMNPPKFEKTEDMSNLSF 91

  Fly    74 LHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDN 138
            |::|.:|.||..||...|||||:|...|.:|||:.|||||....:::..::..|:|||:||:.|.
 Worm    92 LNDASVLHNLRSRYAAMLIYTYSGLFCVVINPYKRLPIYTDSCARMFMGKRKTEMPPHLFAVSDE 156

  Fly   139 AYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISG-------------KHSWIEQQILEA 190
            ||.:|.:..::|.::|:|||||||||:||.::.|.||:..             |...:|.||::.
 Worm   157 AYRNMLQDHENQSMLITGESGAGKTENTKKVICYFAAVGASQQEGGAEVDPNKKKVTLEDQIVQT 221

  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255
            ||:|||||||||:||:|||||||:|.|||:.:|.:....||.|||||||::.|...||.||:||.
 Worm   222 NPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGRLASCDIEHYLLEKSRVIRQAPGERCYHIFYQ 286

  Fly   256 ILAGLSADEKSRLDLGM-AADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKL 319
            |.:....:.|..|.|.: ..||.::.....| .:|.||..||.....|..:|.||..|..:..:|
 Worm   287 IYSDFRPELKKELLLDLPIKDYWFVAQAELI-IDGIDDVEEFQLTDEAFDILNFSAVEKQDCYRL 350

  Fly   320 LAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVV 381
            ::|.:|.||:|:|....:..   |.|:     ..|:.:.:.|:..:..:.|||:..:....|.|.
 Worm   351 MSAHMHMGNMKFKQRPREEQAEPDGTD-----EAEKASNMYGIGCEEFLKALTKPRVKVGTEWVS 410

  Fly   382 STLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN-AIGVLDIFGFENFDQNSFEQ 445
            ...:.:|......|..||:|.|:|..:|:|.|..: ..:|..|: .||||||.|||.||.|||||
 Worm   411 KGQNCEQVNWAVGAMAKGLYSRVFNWLVKKCNLTL-DQKGIDRDYFIGVLDIAGFEIFDFNSFEQ 474

  Fly   446 FCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEAR 509
            ..||:.||.|||||..|:|.||||||..|.|.|..|:| :|.|..::||. |.|.|::::|||..
 Worm   475 LWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWVFIDFGLDLQACIELIE-KPLGIISMLDEECI 538

  Fly   510 FPKGTDQTMLAKLHKTH-GSHKNYLKPK----SDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSP 569
            .||.||.|:.:||...| |.|.|:.|||    ......|.:.|:||.|.|:...:|:||:|..:.
 Worm   539 VPKATDLTLASKLVDQHLGKHPNFEKPKPPKGKQGEAHFAMRHYAGTVRYNCLNWLEKNKDPLND 603

  Fly   570 DLLHLVSQST-NKFLRQIF----------AQDIEMGAETRKRTP-----TLSTQFRKSLDALMKT 618
            .::..:.||. |..|.:|:          |:..|.|...:|:..     |:|..:|:||:.||..
 Worm   604 TVVSAMKQSKGNDLLVEIWQDYTTQEEAAAKAKEGGGGGKKKGKSGSFMTVSMLYRESLNNLMTM 668

  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683
            |:...|.|||||.|||.|:..|.|..|...||..:|::|.|||.|.|:|.|....:||:||..|.
 Worm   669 LNKTHPHFIRCIIPNEKKQSGMIDAALVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYAILA 733

  Fly   684 PGVPPAHRTDCQAATSRICAVV----LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQ 744
            .....:.....:.|.:.:..:|    |.:..:::|.||||.|......||..||..|...:...|
 Worm   734 AKEAKSDDDKKKCAEAIMSKLVNDGSLSEEMFRIGLTKVFFKAGVLAHLEDIRDEKLATILTGFQ 798

  Fly   745 RSIR---GWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLR 806
            ..||   |...|:|.:..||..:.|||..:.:...:.:...:: |.:::.::::...:.....:.
 Worm   799 SQIRWHLGLKDRKRRMEQRAGLLIVQRNVRSWCTLRTWEWFKL-YGKVKPMLKAGKEAEELEKIN 862

  Fly   807 GHIVGLQ-AHARGYLVRREYGHKMWAVIKIQSHV-------RRMIAMRRYRKLRLEHKQFAEVLQ 863
            ..:..|: :.|:...:|:|.......:::.::.:       :..::....|..:||.:|.....|
 Worm   863 DKVKALEDSLAKEEKLRKELEESSAKLVEEKTSLFTNLESTKTQLSDAEERLAKLEAQQKDASKQ 927

  Fly   864 LRKLEEQ---------ELLHRGNKHAREI----------------AEQHYRDRLHELERREIQEQ 903
            |.:|.:|         ::.....|...|:                ||...:.:.|::  |.:|::
 Worm   928 LSELNDQLADNEDRTADVQRAKKKIEAEVEALKKQIQDLEMSLRKAESEKQSKDHQI--RSLQDE 990

  Fly   904 L------------ENRRRVEVNMNIINDAARKQEEPVDDGKL---VEAMFDFLPDSSSDAPTPHG 953
            :            |.:.:.|:|..::.|...::::.....|:   :|...|.|.||..       
 Worm   991 MQQQDEAIAKLNKEKKHQEEINRKLMEDLQSEEDKGNHQNKVKAKLEQTLDDLEDSLE------- 1048

  Fly   954 GRETSVFNDLPHAQNVNQDDI-IAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPL 1017
             ||.....||...:...:.:: ||..:|.|                  .|...|. .:..||...
 Worm  1049 -REKRARADLDKQKRKVEGELKIAQENIDE------------------SGRQRHD-LENNLKKKE 1093

  Fly  1018 LPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQL 1082
            ..||:...:|.                          |..:::||:.        |..:..::::
 Worm  1094 SELHSVSSRLE--------------------------DEQALVSKLQ--------RQIKDGQSRI 1124

  Fly  1083 MGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKL- 1146
            ..|:.:...:::.||...:..|...:...:|||.:     |::..|.:.|..:..:..:.|.|| 
 Worm  1125 SELEEELENERQSRSKADRAKSDLQRELEELGEKL-----DEQGGATAAQVEVNKKREAELAKLR 1184

  Fly  1147 ----HFIIGH----GILR-------AELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAP 1196
                ...:.|    |.||       |||.|::     .||.....|....:            |.
 Worm  1185 RDLEEANMNHENQLGGLRKKHTDAVAELTDQL-----DQLNKAKAKVEKDK------------AQ 1232

  Fly  1197 SEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNT 1261
            :.:....|.|.:.:...|  ....|:|.:.|            |||.|:.:              
 Worm  1233 AVRDAEDLAAQLDQETSG--KLNNEKLAKQF------------ELQLTELQ-------------- 1269

  Fly  1262 KTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVM---DAISQCEQYAK 1323
                    :.|.|...||.|..|||.:..              ...||.|.   ||.||..|..:
 Worm  1270 --------SKADEQSRQLQDFTSLKGRLH--------------SENGDLVRQLEDAESQVNQLTR 1312

  Fly  1324 EQGAQERNAPWRLFFRKEIFAPWHEP--THDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQ 1386
                          .:.::.:...|.  |.|:.|..  .|.|....|  .|:.:.|:        
 Worm  1313 --------------LKSQLTSQLEEARRTADEEARE--RQTVAAQAK--NYQHEAEQ-------- 1351

  Fly  1387 QYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDI 1451
               ::.|.:..:|....:|..      ||..:..|::|         |:.:..:.:    :|.|.
 Worm  1352 ---LQESLEEEIEGKNEILRQ------LSKANADIQQW---------KARFEGEGL----LKADE 1394

  Fly  1452 VSYAKYKWPLLFSRFYEAY--RNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSS 1514
            :..||.:.....:...||.  .||     ||   .::..|...:|.|.:...:::......|.:.
 Worm  1395 LEDAKRRQAQKINELQEALDAANS-----KN---ASLEKTKSRLVGDLDDAQVDVERANGVASAL 1451

  Fly  1515 QKTNKVFTQTFSLSTVRGEEFT-----------------FQSPNA-EDIRDLVVYFLDGLKKRSK 1561
            :|..|.|.:.......:.::..                 |::.|| |::.::|    :||::.:|
 Worm  1452 EKKQKGFDKIIDEWRKKTDDLAAELDGAQRDLRNTSTDLFKAKNAQEELAEVV----EGLRRENK 1512

  Fly  1562 YVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLP 1626
            .:  .|:.:..:|                  ..||.        ||             :|:.: 
 Worm  1513 SL--SQEIKDLTD------------------QLGEG--------GR-------------SVHEM- 1535

  Fly  1627 TLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLS 1691
                  |.|:....||:..                       :::|||......:...||.|...
 Worm  1536 ------QKIIRRLEIEKEE-----------------------LQHALDEAEAALEAEESKVLRAQ 1571

  Fly  1692 SKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDG 1756
            .:.|:         |::.:.:::|.|||..|......|..|:      |.:..:..|...     
 Worm  1572 VEVSQ---------IRSEIEKRIQEKEEEFENTRKNHARALE------SMQASLETEAKG----- 1616

  Fly  1757 PLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPISQ 1821
              |.|:||      :.|:|..:.|.:                        |:.|....:.:..:|
 Worm  1617 --KAELLR------IKKKLEGDINEL------------------------EIALDHANKANADAQ 1649

  Fly  1822 DSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQ 1886
            .::.|.|:.:|.       .|::||..|....          ||.|.|            .|..:
 Worm  1650 KNLKRYQEQVRE-------LQLQVEEEQRNGA----------DTREQF------------FNAEK 1685

  Fly  1887 RLSLRTSEGFSLFV--KIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKK 1949
            |.:|..||...|.|  :.|::.....|               .:|...||.|| :...||     
 Worm  1686 RATLLQSEKEELLVANEAAERARKQAE---------------YEAADARDQAN-EANAQV----- 1729

  Fly  1950 LWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIPQ--- 2011
              ::....|.:....|...|.:|.:.|..| |.:.|.:.|  |:....|..|..::.|...|   
 Worm  1730 --SSLTSAKRKLEGEIQAIHADLDETLNEY-KAAEERSKK--AIADATRLAEELRQEQEHSQHVD 1789

  Fly  2012 MLRELIPSDIMKIQ 2025
            .||:.:...:.:||
 Worm  1790 RLRKGLEQQLKEIQ 1803

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 271/712 (38%)
MYSc_Myo7 77..721 CDD:276832 263/687 (38%)
MyTH4 <1138..1245 CDD:214535 24/122 (20%)
B41 1251..1467 CDD:214604 37/220 (17%)
FERM_B-lobe 1355..1439 CDD:271216 14/83 (17%)
FERM_C1_MyoVII 1461..1559 CDD:270019 20/117 (17%)
SH3 1560..1624 CDD:302595 8/63 (13%)
MyTH4 1701..1849 CDD:214535 26/147 (18%)
B41 1856..2068 CDD:214604 38/175 (22%)
FERM_M 1966..2068 CDD:278785 16/63 (25%)
FERM_C2_MyoVII 2064..2159 CDD:270020
unc-54NP_493596.1 Myosin_N 31..68 CDD:280832 8/39 (21%)
Myosin_head 83..775 CDD:278492 268/699 (38%)
MYSc_class_II 95..775 CDD:276951 263/687 (38%)
Myosin_tail_1 855..1932 CDD:279860 224/1322 (17%)
Prefoldin 903..>969 CDD:298833 10/65 (15%)
YlqD 946..>1020 CDD:287979 11/75 (15%)
GluZincin 1649..>1784 CDD:301352 41/189 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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