DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myo9b

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_038950134.1	Gene:	Myo9b / 25486	RGDID:	3146	Length:	2156	Species:	Rattus norvegicus

Alignment Length:	2265	Identity:	538/2265 - (23%)
Similarity:	837/2265 - (36%)	Gaps:	786/2265 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IQVRDDDGDEVWLAPERRIKAMHASSVQGVE------------DMISLGDLHEAGILRNLLIRYK 88
            :|.|:.||...:|  ..::.|...::.:.||            |:.:|.:|:||.:|::|.:|:.
  Rat   109 LQERNADGSIQYL--HVQLLAQPTAACRLVERGLLPRPQADFDDLCNLPELNEANLLQSLKLRFV 171

  Fly    89 ENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIV 153
            :..||||.||||||:||::.||||....:|:|:.:::|:|.||:||:.|.||..|.|...:||||
  Rat   172 QQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKHVNQCIV 236

  Fly   154 ISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYID 216
            ||||||:|||:||..::..|.|:|  |..|.:|:.||.|.|:|||||||||..|:|||||||:|.
  Rat   237 ISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQ 301

  Fly   217 IHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTG 281
            :::..:|::.||.:|:|||||||:|||...||||||||.:|.|:|.:|:....|....||.||..
  Rat   302 VNYLESGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERQEFQLKQPQDYFYLNQ 366

  Fly   282 GNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPE 346
            .|....:|.|...:|..::.||:::.|......:|..:|:|:|:.||:.||.......:..|:..
  Rat   367 HNLNIEDGEDLKHDFERLQQAMEMVGFLPATKKQIFSVLSAILYLGNVTYKKRATGRDEGLEVGP 431

  Fly   347 HINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRK 411
            ...::.::.||.:..:.|::.||:|......:.::...|..:::..||:..|.:|..:|..||.:
  Rat   432 PEVLDTLSQLLKVKRETLVEVLTKRKTITVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLR 496

  Fly   412 INTAIFKPR----GTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYN 472
            ||.|:...:    ..|..:||||||||||:|::|||||||||||||.||.:|.|||||||||||.
  Rat   497 INHALLNKKDMEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFTQHIFKLEQEEYQ 561

  Fly   473 HEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKS 537
            .|.|:|.:|::.||...:.||:.|...:..|:|||:.||..|..|:|||..:.|..:|.:|....
  Rat   562 GEGISWHNIDYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSHTLLAKFKQQHEDNKYFLGTPV 626

  Fly   538 DINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQD------------ 590
             :..:|.:.||||.|.|..:.|.:||.|...||::.|:..|.:.::||:...|
  Rat   627 -LEPAFIIQHFAGRVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRA 690

  Fly   591 -------------------------------------IEMGAET--------------------- 597
                                                 :..||.|
  Rat   691 AIRAMAVLREAGRLRAERAEKAEAGVSSPVTRSHVEELPRGANTPSEKLYRCAGLDFSFERSEEL 755

  Fly   598 ----------------------------------------------------------------- 597

  Rat   756 DVNAFEDIMAFYESRKVRERSDLHNQIIKSLKGLPWQGEDPRRLLQSLSRLQKPRTFFLKSKGIK 820

  Fly   598 ------------------------------------RKRTPTLSTQFRKSLDALMKTLSSCQPFF 626
                                                :|:.|::|.||:.||:.|::.|...:|||
  Rat   821 QKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFF 885

  Fly   627 IRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHR 691
            ||||:.|..||.:.||..|..:||||:||:||:||||:||..::.|::|.|:::.|:|
  Rat   886 IRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLP------- 943

  Fly   692 TDCQAATSRICAVV----LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVY 752
            .|.|.....|.|::    :.:.:||:|.||||||:.....|::.....:.|:||:||...|..:.
  Rat   944 KDVQPCREAIAALLEKLQVDRQNYQIGKTKVFLKETERQALQERLHGEVLRRILLLQSWFRMVLE 1008

  Fly   753 RRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHAR 817
            ||.|::::.||:|:|..|:.|..|:.....|..                        |.|||..|
  Rat  1009 RRHFVQMKHAALTIQACWRSYRVRRTLERTRAA------------------------VYLQAAWR 1049

  Fly   818 GYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRK---------------- 866
            |||.|:.|.|:..::|::||..|..:..|.:.::.|| ||.||  |.|:
  Rat  1050 GYLQRQAYHHQRHSIIRLQSLCRGHLQRRSFSQMMLE-KQKAE--QARETAGAEMSEGEPSPVAA 1111

  Fly   867 --------LEEQELL------------HRGNKHAREI--------AEQHYRDRLHE-----LERR 898
                    :|:.|.|            ..|....:||        |::......||     .|:|
  Rat  1112 GEQPSEHPVEDPESLGVETETWMNSKSPNGLSPKKEIPSPEMETPAQKTVPAESHEKVPSSREKR 1176

  Fly   899 EIQEQ--LENRRRVEVNM-------NIINDAARK------------QEEPVDDG----------- 931
            |.:.|  ||:..|...::       :.:.:.:||            .:||.:||
  Rat  1177 ESRRQRGLEHVERQNKHIQSCREENSTLREPSRKASLETGESFPEDTKEPREDGLETWTETAAPS 1241

  Fly   932 --KLVEAMFD----------------------FLPDSSSDAPTPHG-GRETSVFNDLPHA----- 966
              |.|..:.|                      .||.||.::|.... |..::...|.|.:
  Rat  1242 CPKQVPIVGDPPRSPSPLQRPASLDLDSRVSPVLPSSSLESPQDEDKGENSTKVQDKPESPSGST 1306

  Fly   967 -----QNVNQDDIIAPIHI---------------------------------------SEDEEDL 987
                 |:.:.:.:...:.|                                       :.|...|
  Rat  1307 QIQRYQHPDTERLATAVEIWRGKKLASAMLSQSLDLSEKPRTAGAALTPTEERRISFSTSDVSKL 1371

  Fly   988 SEFKFQKFAATYFQGNVNHQYAKKALKHPL------------LPLHTQGDQLAA----------- 1029
            |..|.|  .:|...|:::   |||...|..            ||..:|||..:|
  Rat  1372 SPVKVQ--TSTEVDGDLS---AKKPAGHKKKSEDPSAGPDAGLPTGSQGDSKSAFKRLFLHKAKD 1431

  Fly  1030 ----------------QALWITILRFTGDMPEPKYH----------------------TMDRMDT 1056
                            ||......|.|.|:|..:.|                      |:.....
  Rat  1432 KKPSLEGVEETEGSGGQAAQEAPARKTLDVPSSQQHRHTTGEKPLKGKKNRNRKVGQITVSEKWR 1496

  Fly  1057 TSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHK---LVSLTLKRKNKLGEDVR 1118
            .||..|:|......|:               |.||..|...:|.:   :.||.::...:...:::
  Rat  1497 ESVFRKITNANELKFL---------------DEFLLNKVNDLRSQKTPIESLFIEATERFRSNIK 1546

  Fly  1119 -------------------------------RRLQDDEYTADSYQSWL----------------Q 1136
                                           |..:|.....:.:||.|                |
  Rat  1547 TMYSVPNGKIHVGYKDLMENYQIVVSNLAAERGEKDTNLVLNVFQSLLDEFTRSYNKTDFEPVKQ 1611

  Fly  1137 SRPTSNLEKLHFII----GHGILRAELRDEIYCQICKQLTNNPLKSSHARGW-----ILLSLC-- 1190
            .:......|....:    ||.....::.....|:.|....           |     :|.|:|
  Rat  1612 GKAQKKKRKQERAVQEHNGHVFASYQVNIPQSCEQCLSYI-----------WLMDKALLCSVCKM 1665

  Fly  1191 ---VGCFAPSEKFVNYL--RAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPI 1250
               ..|....:.:.:|.  |.......||:...|.:                  .|.:.|:..||
  Rat  1666 TCHKKCVHKIQSYCSYTGRRKSELGAEPGHFGVCVD------------------SLTSDKASVPI 1712

  Fly  1251 MLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAI 1315
            :|                        .:|.:.:.:...:...||
  Rat  1713 VL------------------------EKLLEHVEMHGLYTEGLY--------------------- 1732

  Fly  1316 SQCEQYAKEQGAQERNAPWRLFFRKE----------------IFAPWHEPTHDQVATNLIYQQVV 1364
                   ::.||..|....|...:.:                :...|.....:.:.|...|...:
  Rat  1733 -------RKSGAANRTRELRQALQTDPATVKLEDFPIHAITGVLKQWLRELPEPLMTFAQYGDFL 1790

  Fly  1365 RGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLF------TLLPN------------FIPD 1411
            |.|:..|    |:|.||.|.|....:..:...|:|||.      .||.:            |.|.
  Rat  1791 RAVELPE----KQEQLAAIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPC 1851

  Fly  1412 F--CLSGVDK--------AIERWAALVLQAYKKSYYVK-DKIAPLKIKEDI----VSYAKYK--W 1459
            .  |....|.        .|.....::::...:.|.|| ::|..|:..|.|    :|..:..  |
  Rat  1852 LLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKVKMEEINHLEAAESIAFRRLSLLRQNAPW 1916

  Fly  1460 PLL--FSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFT 1522
            ||.  ||..||..|...|..|              ||.|.|::   .:.||..|...:...|...
  Rat  1917 PLKLGFSSPYEGVRTKSPRTP--------------VVQDLEEL---GALPEEAAGGDEDREKEIL 1964

  Fly  1523 QTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLI 1587
            .. .:.:::.|:        |||    .|.|..|..|.            ||..:..|
  Rat  1965 ME-RIQSIKEEK--------EDI----TYRLPELDPRG------------SDEENLDS------- 1997

  Fly  1588 ILEDESCGESVLNNGWCIGRCDRSQERGDFPA--------ETVYVLPTLSKPPQDILALFNIEEA 1644
              |..:..||:|..     |..|....|. ||        .|...||..:.||:
  Rat  1998 --ETSASTESLLEE-----RAVRGAAEGP-PAPALPCPISPTPNPLPAATAPPR----------- 2043

  Fly  1645 HHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAP 1709
              ||..|..: .....||..|  :|..|  :.:|||    ...|.|:|      |        ||
  Rat  2044 --GRPTSFVT-VRVKTPRRTP--IMPMA--NIKLPP----GLPLHLTS------W--------AP 2083

  Fly  1710 LLRK----LQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKH 1760
            .|::    ::.:|..|.......:..:....||||:...           |||.|
  Rat  2084 ALQEAAVPVKRREPPARRQDQVHSVYIAPGADLPSQGTL-----------GPLDH 2127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	284/861 (33%)
		MYSc_Myo7	77..721	CDD:276832	275/824 (33%)
		MyTH4	<1138..1245	CDD:214535	16/122 (13%)
		B41	1251..1467	CDD:214604	44/268 (16%)
		FERM_B-lobe	1355..1439	CDD:271216	23/111 (21%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	23/99 (23%)
		SH3	1560..1624	CDD:302595	13/71 (18%)
		MyTH4	1701..1849	CDD:214535	13/64 (20%)
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo9b	XP_038950134.1	Ubiquitin_like_fold	16..112	CDD:421700	1/2 (50%)
		MYSc_Myo9	160..977	CDD:276836	275/824 (33%)
		IQ	1014..1033	CDD:197470	6/18 (33%)
		IQ	1036..1058	CDD:197470	10/45 (22%)
		PTZ00449	<1145..1493	CDD:185628	56/352 (16%)
		C1_Myosin-IXb	1626..1683	CDD:410434	10/67 (15%)
		RhoGAP	1696..1881	CDD:413382	36/258 (14%)
		MCP_Sipho	1941..>2064	CDD:411416	37/181 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900