Protein Alignment ck and Myo1d

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_037115.2
• Gene: Myo1d / 25485
• RGDID: 621321
• Length: 1006
• Species: Rattus norvegicus
• Alignment Length: 1095
• Identity: 359/1095 - (32%)
• Similarity: 539/1095 - (49%)
• Gaps: 191/1095 - (17%)

  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGEL 128
            |..|.:.:..:.....:.||.:|:::..|||:.|.::|:||||::|.||..|.|:.||.|::.|.
  Rat    10 GKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKVLNIYGRDTIEQYKGRELYER 74

  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQ---QIL 188
            |||:|||.|.||..|||..:|.||:|||||||||||::|.|:||:|||:  .:.:.||:   .:|
  Rat    75 PPHLFAIADAAYKAMKRRSKDTCIMISGESGAGKTEASKYIMQYIAAITNPSQRAEIERVKNMLL 139

  Fly   189 EANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVF 253
            ::|.:|||||||||.|||||||||||:||:|...|...|..|..|||||||::.|...||::|.|
  Rat   140 KSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSF 204

  Fly   254 YCILAGLSADEKSRLDLGMA-ADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEII 317
            |.:|.|.|......|.|..: :.|.|:..|..:. ...:|||||..:..||||:.|..:||..:.
  Rat   205 YQLLQGGSEQMLHSLHLQKSLSSYNYIRVGAQLK-SSINDAAEFKVVADAMKVIGFKPEEIQTVY 268

  Fly   318 KLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVS 382
            |:|||:||.||:|:   :||. |...|.....|..:|.||......:..||..||: |.|..::.
  Rat   269 KILAAILHLGNLKF---IVDG-DTPLIENGKVVSVIAELLSTKADMVEKALLYRTV-ATGRDIID 328

  Fly   383 TLSRDQSVDV-RDAFVKGIYGRMFVHIVRKINTAI-FKPRGTS----RNAIGVLDIFGFENFDQN 441
            ....:|.... ||||.|.||.|:|..||.:||..| .|...|:    ...||||||:|||.||.|
  Rat   329 KQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTVHGKNTVIGVLDIYGFEIFDNN 393

  Fly   442 SFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDE 506
            |||||||||.||.|||.|:|.:.|.|||||..|.|.|:||::.:||..:||:..:...|:|::|:
  Rat   394 SFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDD 458

  Fly   507 EA-RFPKGTDQTMLAKLHKTHGSHKNYLKPKS-------DINTSFGLNHFAGVVFYDTRGFLDKN 563
            .. ...|.||...|..|:...|.|.::...|:       :.:..|.:.|:||.|.|...||:|||
  Rat   459 ACMNVGKVTDGMFLEALNSKLGKHGHFSSRKTCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKN 523

  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIR 628
            :||...|...|:..|:|..|:.::.:......|..||..|.:|.|:.|:.||:..|:|.:|:::|
  Rat   524 KDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVR 588

  Fly   629 CIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAH--R 691
            |||||:.|.|.:||...|..|:.|.|::|.:|:||||:..|..:.:|:.||:.:.....|.|  .
  Rat   589 CIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLP 653

  Fly   692 TDCQAATSRI--CAVVLGKSDYQLGHTKVFLKDAHDLF-LEQERDRVLTRKILILQRSIRGWVYR 753
            :|.:|....|  |..   :.|...|.||:|::....|| ||:.|.::|.|.:|.||:..||.:.|
  Rat   654 SDKEAVKKLIERCGF---QDDVAYGKTKIFIRTPRTLFTLEELRAQMLVRVVLFLQKVWRGTLAR 715

  Fly   754 RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARG 818
            .|:.|.: ||:|:.|::      :||:            ::|.:          |.|..:.|  |
  Rat   716 MRYKRTK-AALTIIRYY------RRYK------------VKSYI----------HEVARRFH--G 749

  Fly   819 YLVRREYG-HKMWAV-IKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEE--QELLHRGNKH 879
            ....|:|| |..|.. .|:                            ||:.||  |.:.:|.  .
  Rat   750 VKNMRDYGKHVKWPTPPKV----------------------------LRRFEEALQSIFNRW--R 784

  Fly   880 AREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNII---NDAARKQEEPVDDGKLVEAMFDFL 941
            |.::.:......|.::..:....::...:|.::.:...   |..|.|.:.|...|       .|:
  Rat   785 ASQLIKTIPASDLPQVRAKVAAMEMLKGQRADLGLQRAWEGNYLASKPDTPQTSG-------TFV 842

  Fly   942 PDSSSDAPTPHGGRETSVFNDLP------------HAQNVNQDDIIAPIHISEDEEDLSEFKFQK 994
            |                |.|:|.            |.:.||:...:         ||.:.|...:
  Rat   843 P----------------VANELKRKDKYMNVLFSCHVRKVNRFSKV---------EDRAIFVTDR 882

  Fly   995 FAATYFQGNVNHQYAKKALKHPLLPLH-------TQG-DQLAAQALWITILRFTGDMPEPKYHTM 1051
            .   .::.:...||  |.:|  .:||:       :.| |||..                  :||.
  Rat   883 H---LYKMDPTKQY--KVMK--TIPLYNLTGLSVSNGKDQLVV------------------FHTK 922

  Fly  1052 DRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLT 1106
            |..|....:.....|        .|.:..:|:|:..:.|..:|    ||..|::|
  Rat   923 DNKDLIVCLFSKQPT--------HESRIGELVGVLVNHFKSEK----RHLQVNVT 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	276/667 (41%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo1d	NP_037115.2	MYSc_Myo1	24..682	CDD:276829	276/666 (41%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		10/21 (48%)
		Interaction with calmodulin. /evidence=ECO:0000269|PubMed:8034741	776..896		24/158 (15%)
		Myosin_TH1	803..996	CDD:461801	41/232 (18%)