Protein Alignment ck and Myo1e

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_775124.1
• Gene: Myo1e / 25484
• RGDID: 3144
• Length: 1107
• Species: Rattus norvegicus
• Alignment Length: 1059
• Identity: 337/1059 - (31%)
• Similarity: 546/1059 - (51%)
• Gaps: 121/1059 - (11%)

  Fly    58 HASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKE 122
            |.....||:||:.|..:.|:.|:.||..||.::.|:||.||:|::|||::.:|.:...:|::|:.
  Rat    14 HNVKHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQG 78

  Fly   123 RKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISG---KHSWIE 184
            ....|.||||:|:.|:.|.:|...|::||::||||||||||.:.|.|:.|::.:||   |...::
  Rat    79 AAQYENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQHVK 143

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            ..||::||:|||||||||:||:||||||||.:|.||..|..:|.||..:||||||:|.:|..||:
  Rat   144 DIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERS 208

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVL-LFSDQEI 313
            :|:||.::.|.|.::|..|.:.....|.||:...|...:..||..:|.:...||.|: :||:::.
  Rat   209 FHIFYQLIEGASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFSEEQT 273

  Fly   314 WEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA--- 375
            . :::::|.:||.|||.:|.  |.|..|.|..|.:...  |.|||:....|.:.||.|.:.:
  Rat   274 L-VLQIVAGILHLGNINFKE--VGNYAAVESEEFLAFP--AYLLGINQDRLKEKLTSRQMDSKWG 333

  Fly   376 -HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFD 439
             ..|::..||:.:|:...|||..|.::.|:|..:|..||.|:.|..  ....||||||:|||.|.
  Rat   334 GKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDH--EEYNIGVLDIYGFEIFQ 396

  Fly   440 QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLN---IM 501
            :|.|||||||:.||.|||.|::...|.|||||..|.|.|..||:.:|:...|||..| :|   ||
  Rat   397 KNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIESK-VNPPGIM 460

  Fly   502 ALIDEEA----RFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDK 562
            :::|:..    ...:|.|||:|.||....|||:::    :..|..|.::|:||.|.||..||.::
  Rat   461 SILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHF----NSWNQGFIIHHYAGKVSYDMDGFCER 521

  Fly   563 NRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFI 627
            |||....||:.|:..|...|::.:|.::::  |:.:.|..|..::.:|..:.|:.||..|.|.:|
  Rat   522 NRDVLFMDLIELMQSSELPFIKSLFPENLQ--ADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYI 584

  Fly   628 RCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRT 692
            |||||||.|||..::......|:.|.|:.|.||:|||||..|..|::|::||..|.....|..|.
  Rat   585 RCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPVWRG 649

  Fly   693 D-CQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRF 756
            | .|.....:.:|.:....:|||.:|||:|....|||.:|          :.:|...|:
  Rat   650 DEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEE----------MRERKYDGY------ 698

  Fly   757 LRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAH--ARGY 819
                  |..:|:.|:.:..||:|..||.....|....:.|..:...|:..|..:|::.|  .:.:
  Rat   699 ------ARVIQKTWRKFVARKKYVQMREDASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQF 757

  Fly   820 LVRREYGHKMWAVIKIQSHVRRMIAMRR---------YRKLRLEHKQ------FAEVLQLRKLEE 869
            :.:||   |:.....:..:.||...::|         |...|.:.||      ..|||: ||:|.
  Rat   758 VGKRE---KIDFADIVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLK-RKIEV 818

  Fly   870 QELLHRGNKHARE----IAEQHYRDRLHELERRE----IQEQLENRRRVEVNMNIINDAARKQEE 926
            :.:|.......::    :.||.|...|..:.:.|    :.::.|.:.:.::.:...|....|.::
  Rat   819 ERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLTKRYEEKTQKQLPLKFSNTLELKLKK 883

  Fly   927 PVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSV---FNDLPHAQNVNQDDIIAPIHISED-EEDL 987
            .           ::.|.|:.      |.|:...   |.||...:..|:   :..:.|... .::.
  Rat   884 E-----------NWGPWSAG------GSRQVQFYQGFGDLAILKPSNK---VLQVSIGPGLPKNA 928

  Fly   988 SEFKFQKFAATYFQGNVNHQYAKKALKHP-------------LLPLHTQGDQLAAQ-ALWITILR 1038
            ...:....::..:.|..|:.|..:|...|             :.|....|:|.:.| :|:.::.|
  Rat   929 RPTRRNTVSSRGYSGGTNNNYPMRAAPAPPGCHRNGLTRNQFVHPPRASGNQRSNQKSLYTSMAR 993

  Fly  1039 FTGDMPEPKYHTMDRMDTT 1057
              ..:|..:....||:..|
  Rat   994 --PPLPRQQSTGSDRLSQT 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	260/659 (39%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo1e	NP_775124.1	MYSc_Myo1	33..679	CDD:276829	260/659 (39%)
		Actin-binding. /evidence=ECO:0000255	581..591		7/9 (78%)
		Myosin_TH1	719..920	CDD:461801	40/224 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	920..1052		16/93 (17%)
		SH3_MyoIe_If_like	1055..1106	CDD:212761