DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and myo7aa

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_021323248.1	Gene:	myo7aa / 252846	ZFINID:	ZDB-GENE-020709-1	Length:	2185	Species:	Danio rerio

Alignment Length:	2192	Identity:	1363/2192 - (62%)
Similarity:	1705/2192 - (77%)	Gaps:	39/2192 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVIVTRGDYIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPER--RIKAMHASSVQ 63
            |||:.:|||:|::..:|.||:|.|||.|...:..:|||.||:|:|.|::|:.  .||.||.:|:.
Zfish     1 MVILQQGDYVWLDLKTGHEFEVPIGAVVKLCDSGQIQVLDDEGNEHWISPQNATNIKPMHPTSIH 65

  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIY------TYTGSILVAVNPYQILPIYTGDQIKLYKE 122
            ||||||.||||:||||||||||||:|:|||      ||||||||||||||:|||||.|||:||..
Zfish    66 GVEDMIRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAVNPYQLLPIYTADQIRLYTN 130

  Fly   123 RKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQI 187
            :||||:|||||||.||.|.:|:|..:|||.:||||||||||||||||||:||||||:|||||||:
Zfish   131 KKIGEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQV 195

  Fly   188 LEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHV 252
            ||||||||||||||||||||||||||||||||:..|.|||||||||||||||:..|...|||||:
Zfish   196 LEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQARDERNYHI 260

  Fly   253 FYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEII 317
            |||:|.|::.|:|.:|.|..|.||.|||.||...|:||||..|:|:||||||||:|:|:|.|||.
Zfish   261 FYCMLKGMTPDQKKQLGLSKATDYTYLTIGNCTVCDGRDDQKEYSNIRSAMKVLMFTDKENWEIS 325

  Fly   318 KLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVS 382
            |||||:||.||::|:|...|||||.|:.....:...|.||.:.::.|::.||.||:...||||.:
Zfish   326 KLLAAILHMGNLRYEARTYDNLDACEVVRCSALTTAAVLLEVDLKDLMNCLTSRTIITRGETVST 390

  Fly   383 TLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTS----RNAIGVLDIFGFENFDQNSF 443
            .||.:|::|||||||||||||:||.||.|||.||:||....    |.:||:|||||||||..|||
Zfish   391 PLSIEQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRRSIGLLDIFGFENFMVNSF 455

  Fly   444 EQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEA 508
            ||.|||:||||||||||:|:|||||||||.|.||||||||.|||||||:||||.:||::|||||:
Zfish   456 EQLCINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEES 520

  Fly   509 RFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLH 573
            :||||||.|||.||:..|..:.||:.||:...|.||:.||||||:|:|||||:|||||...|::.
Zfish   521 KFPKGTDTTMLNKLNSQHKLNTNYIPPKNTYETQFGIQHFAGVVYYETRGFLEKNRDTLHGDIIQ 585

  Fly   574 LVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKP 638
            ||..|.|||::|||..|:.||||||||:||||:||::||:.||:|||.|||||:|||||||.|||
Zfish   586 LVHSSKNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNEYKKP 650

  Fly   639 MMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHR-TDCQAATSRIC 702
            |:|||.||.||||||||||||||||||||||:.|.|||:|||.|:|||.||:: .|.:....||.
Zfish   651 MLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQEDLRGTCQRIA 715

  Fly   703 AVVLGK-SDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITV 766
            ..|||: .|:|:|.||:||||.||:.||.|||:.:|.|::::|:.:||:..|..||:::.:|:.:
Zfish   716 EAVLGRDDDWQMGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKDRSNFLKMKKSAMLI 780

  Fly   767 QRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWA 831
            |:.|:||..||.|..||.|:.|||||.|||.|...:...|..|:..|...||:||||.:.|::||
Zfish   781 QKTWRGYYCRKNYGAMRGGFSRLQALYRSRKLYQTYHVARQRIMLFQGRCRGFLVRRAFRHRLWA 845

  Fly   832 VIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHR-GNKHAREIAEQHYRDRLHEL 895
            ||.||::.|.|||.|.|::|:.|:::..|..:||..|||:|.:: ..:.|:|.||:.:::||.:|
Zfish   846 VITIQAYTRGMIARRLYKRLKGEYRRRLEAEKLRLAEEQKLRNQMSARKAKEEAEKMHQERLAQL 910

  Fly   896 ERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSS----DAPTPHGGRE 956
            .|.:.:.:.:.|:.....|.:::...:.::|||:|..:|:.||.||..::|    :...|.|
Zfish   911 AREDAEREKKERQEARRKMEMLDQMEKARQEPVNDSDMVDKMFGFLGTTNSFPGQEGQAPAG--- 972

  Fly   957 TSVFNDLPHA-QNVNQDDIIAPIHISEDE-EDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLP 1019
               |.||... :.:..:|:...:.:.||: |||||:||.||:||||||...|.|.::.||.|||.
Zfish   973 ---FEDLERTHRELEVEDLDESLPLPEDDLEDLSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLF 1034

  Fly  1020 LHTQGDQLAAQALWITILRFTGDMPEPKYHT--MDRMDTTSVMSKVTATLGRNFIRSKEFQEAQL 1082
            ...:||||||.|:|||:|||.||:|||||||  .|..:...||:|:..|||:...: :|.|..|.
Zfish  1035 HEDEGDQLAALAVWITVLRFMGDLPEPKYHTAISDGSEKIPVMTKIYETLGKKTYK-RELQALQG 1098

  Fly  1083 MGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLH 1147
            .|.:.: ....|..|:||||||||||:|:|:.|:|.:||.|.|||... .|.|:.||||||||||
Zfish  1099 EGENTN-IESHKKSSVRHKLVSLTLKKKSKITEEVTKRLNDGEYTVHG-NSMLEDRPTSNLEKLH 1161

  Fly  1148 FIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGP 1212
            ||||:||||..|||||||||||||..||.||||||||||:||||||||||||||.|||.||.|||
Zfish  1162 FIIGNGILRPGLRDEIYCQICKQLNQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFISEGP 1226

  Fly  1213 PGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCN 1277
            |||||||||||:|||.||||.||||||||||||||||||||:|||||.|||||.||||||:||||
Zfish  1227 PGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCN 1291

  Fly  1278 QLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEI 1342
            .|||||||:|:|||||||||||||||||||.||||||:|||||||||||||||||||||||||||
Zfish  1292 ALSDKISLQDRFGFSLYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFFRKEI 1356

  Fly  1343 FAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPN 1407
            |.|||:|..|.|||||||||:||||||||||||: ||||.:|:|||:::|.:::.:|||.:|:|:
Zfish  1357 FTPWHDPAEDAVATNLIYQQIVRGVKFGEYRCDR-EDLAELASQQYYVDYGSEILVERLLSLIPS 1420

  Fly  1408 FIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRN 1472
            :|||..:|.. |.:||||..::.|:||..|.:.::.|.|:||::|.:|:|||||||||||||::.
Zfish  1421 YIPDREISSA-KTVERWAQFIMAAHKKGVYTQKRVDPQKVKEEVVDFARYKWPLLFSRFYEAFKF 1484

  Fly  1473 SGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTF 1537
            |||:|||||||:||||||||.||:||||||||||||||||||.|..|:..|:|:|:|::.:||||
Zfish  1485 SGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEITAVSSSKGGKLQAQSFTLATIKADEFTF 1549

  Fly  1538 QSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAP-SDGTSFLSFFKGDLIILEDESCGESVLNN 1601
            .|.||||||||||.||:||:||||:|:||||..:| :|.::||||.|||||:| |:..||.|:.:
Zfish  1550 TSNNAEDIRDLVVTFLEGLRKRSKFVVALQDNPSPAADDSTFLSFLKGDLIVL-DQDTGEQVMTS 1613

  Fly  1602 GWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNI--EEAHHGRRLSMASNGGAVEPRDR 1664
            ||..|..||:::||||||:.||||||:.:||.|::|...:  ::.....|:|........|.|.:
Zfish  1614 GWAHGTNDRTKQRGDFPADCVYVLPTVVRPPHDVVAFVTMTPDQRQESLRISHVPALTETEERVK 1678

  Fly  1665 PHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFA 1729
            |:||.|::.|:||.|||.|:|:.:...::..::||..:|:|||..||:|....||.::|||.||.
Zfish  1679 PYTLEEFSYDYFRPPPKHTLSRVMITKNRGKDKLWCCTREPIKQALLKKCGGHEELSQEACMAFI 1743

  Fly  1730 AILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLA 1794
            |::|||||.||||.|..||:||.||:|.||.|.|:||||||::||||:|..:.|||:||||:||.
Zfish  1744 AVMKYMGDYPSKRTRSVNELTDQIFEGALKAEPLKDEIYCQILKQLTENHIKYSEEKGWELLWLC 1808

  Fly  1795 TGLFACSQGLLKELLLFLRTRR-HPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHK 1858
            .|||..|..||..:..||:::: ||::.|.|.||||.:|:|.||||||.||||||||||||||||
Zfish  1809 VGLFPPSNVLLPHVQRFLQSKKHHPLALDCMQRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHK 1873

  Fly  1859 VYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSLFVKIADKVISVPEGDFFFDFVRHLT 1923
            |||||||||||||:|||:|||||.|||.||.|:|.|||||||||:||||||||||||||||||||
Zfish  1874 VYFPDDTDEAFEVESSTKAKDFCLNISSRLLLKTPEGFSLFVKISDKVISVPEGDFFFDFVRHLT 1938

  Fly  1924 DWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREEAA 1988
            ||||||||.:||..|..||||||||||||.||||||..||.||||:|||||.|||||||||||..
Zfish  1939 DWIKKARPAKDGIVPSLTYQVFFMKKLWTTTVPGKDSFADSIFHYYQELPKYLRGYHKCSREEVF 2003

  Fly  1989 KLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVAF 2053
            :|.||::||:|.::|....:||:||:|:||.|:::..|..:|||||||.:|:..|.:.|:||:.|
Zfish  2004 QLGALIYRVKFEDDKSHFPSIPKMLKEMIPQDLIRQLSPDDWKRSIVAYFNRHAGKSREEAKLMF 2068

  Fly  2054 LKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNWSSGNT 2118
            |||:::|||||||||||||||||::||:|||||||:|||||.|..||||.|:|||:|||||||||
Zfish  2069 LKIIFKWPTFGSAFFEVKQTTEPHFPEILLIAINKYGVSLIDPKNKDILTTYPFTKISNWSSGNT 2133

  Fly  2119 YFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLMLTNMNKNRTIR 2165
            |||:||||||:|||||||||||||||||||||||.|||.|:|.|..|
Zfish  2134 YFHITIGNLVQGSKLLCETSLGYKMDDLLTSYISQMLTTMSKQRNSR 2180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	459/680 (68%)
		MYSc_Myo7	77..721	CDD:276832	440/655 (67%)
		MyTH4	<1138..1245	CDD:214535	93/106 (88%)
		B41	1251..1467	CDD:214604	152/215 (71%)
		FERM_B-lobe	1355..1439	CDD:271216	47/83 (57%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	72/97 (74%)
		SH3	1560..1624	CDD:302595	35/64 (55%)
		MyTH4	1701..1849	CDD:214535	85/148 (57%)
		B41	1856..2068	CDD:214604	150/211 (71%)
		FERM_M	1966..2068	CDD:278785	58/101 (57%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	80/94 (85%)
myo7aa	XP_021323248.1	MYSc_Myo7	79..735	CDD:276832	440/655 (67%)
		IQ	772..793	CDD:197470	7/20 (35%)
		MAP7	<863..941	CDD:310345	19/77 (25%)
		UFD1	893..>1160	CDD:332114	114/275 (41%)
		MyTH4	1023..1259	CDD:214535	156/238 (66%)
		B41	1265..1479	CDD:214604	152/215 (71%)
		FERM_C1_MyoVII	1473..1571	CDD:270019	72/97 (74%)
		SH3	1572..1636	CDD:327375	35/64 (55%)
		MyTH4	1716..1864	CDD:214535	85/147 (58%)
		B41	1871..2083	CDD:214604	150/211 (71%)
		FERM_C2_MyoVII	2079..2174	CDD:270020	80/94 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581977
Domainoid	1	1.000	918	1.000	Domainoid score	I45
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H219
Inparanoid	1	1.050	2730	1.000	Inparanoid score	I25
OMA	1	1.010	-	-		QHG52371
OrthoDB	1	1.010	-	-		D21221at33208
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	1	1.000	-	-		otm25519
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1286
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910