DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myo5b

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_008770307.1 Gene:Myo5b / 25132 RGDID:621347 Length:1854 Species:Rattus norvegicus


Alignment Length:2219 Identity:564/2219 - (25%)
Similarity:876/2219 - (39%) Gaps:641/2219 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKE-NLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGE 127
            |..|:.:|..|||..:|.||.:|:.| |.||||.|.:|||:|||:.||||..|.|..|..:.:|:
  Rat    78 GENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGD 142

  Fly   128 LPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHS--WIEQQILEA 190
            :.|||||:.:.||..|.|..::|.|::|||||||||.|.|..::|.|.:.|..|  .||:::|.:
  Rat   143 MDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLAS 207

  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255
            :||:||.|||||.||||||||||||:|.|.....|.||.:..|||||||:|.|...|||||:||.
  Rat   208 SPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQ 272

  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320
            :.|..|..|...|.|..|.|:.|...|.:.|.||.|||.:|...|.|:.:|...:.....|.|::
  Rat   273 LCAAASLPEFKELALTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISIFKII 337

  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385
            |::||.|:::.:|. .|....:..|:..::.....|||:....:...|..|.|....||.|.|:|
  Rat   338 ASILHLGSVEIQAE-RDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLCHRKLVTTSETYVKTMS 401

  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTS---RNAIGVLDIFGFENFDQNSFEQFC 447
            ..|.|:.|:|..|.||.::|..||..||.|:    .||   .:.||||||:|||.|:.|||||||
  Rat   402 LQQVVNARNALAKHIYAQLFSWIVEHINKAL----QTSLKQHSFIGVLDIYGFETFEINSFEQFC 462

  Fly   448 INYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPK 512
            ||||||.|||.|..|:||||||||..|.|.|..|:|.|||..:|||..| |.|:.|:|||.:.||
  Rat   463 INYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAK-LGILDLLDEECKVPK 526

  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQ 577
            ||||....||::.|.:.:::.||:.. ||:|.:.|||..|.|.:.|||:|||||...:.::::..
  Rat   527 GTDQNWAQKLYERHSNSQHFQKPRMS-NTAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKA 590

  Fly   578 STNKFLRQIFAQDIE------------------------MGAETRKRTPTLSTQFRKSLDALMKT 618
            |....:..:|..|.:                        |.|..::...::..|||.||:.||:|
  Rat   591 SKFPLVADLFRDDKDSVPATNTAKSRSSSKINVRSSRPLMKAPNKEHKKSVGYQFRTSLNLLMET 655

  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683
            |::..|.::||||||:.|.|..||.....:|||..|::|||||..||||.|..:.:|..|||.|:
  Rat   656 LNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLM 720

  Fly   684 PGVPPAHRTDCQAATSRICAVVL-----GKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILIL 743
            .....|:.||    ...||..||     ....:|.|.||:|.:.....:||:.|........:::
  Rat   721 KKRELANTTD----KKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMI 781

  Fly   744 QRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGH 808
            |:::|||:.|.::.|||||.:|:|||.:||..|:...::|    |.:|.|   |...::|.|:  
  Rat   782 QKTVRGWLQRVKYRRLRAATLTLQRFCRGYLARRLTEHLR----RTRAAI---VFQKQYRMLK-- 837

  Fly   809 IVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELL 873
                        .||.|.....|.:.|||:.|.|...|.||::..|||  |.::|          
  Rat   838 ------------ARRAYCRVRRAAVIIQSYTRAMCVRRSYRQVLTEHK--ATIIQ---------- 878

  Fly   874 HRGNKHARE-IAEQHY---RD-------RLHELERREIQEQL-------ENRRRVEVNMNIINDA 920
                |:||. :|.:|:   ||       ....|:.|:..:.|       |:.:|:.|.|.  |..
  Rat   879 ----KYARGWMARRHFQRQRDAAIVIQCAFRRLKARQALKALKIEARSAEHLKRLNVGME--NKV 937

  Fly   921 ARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEE 985
            .:.|.: :||                                    ||                 
  Rat   938 VQLQRK-IDD------------------------------------QN----------------- 948

  Fly   986 DLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHT 1050
              .|||                              |..:||:|                     
  Rat   949 --KEFK------------------------------TLSEQLSA--------------------- 960

  Fly  1051 MDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRK----- 1110
                 .||..:.....|.:...|.::.|||     ||...|:::.:|:|.:|.....:|:     
  Rat   961 -----VTSTHAMEVEKLKKELARYQQNQEA-----DPSLQLQEEVQSLRTELQKAHSERRVLEDT 1015

  Fly  1111 -NKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNN 1174
             |:...::|:|:.|.|:.                            .|.|:||     .:.|.|.
  Rat  1016 HNRENGELRKRVADLEHE----------------------------NALLKDE-----KEHLNNQ 1047

  Fly  1175 PLKSSHARGWILLSLCVGCFAPSEKFVN---YLRAFIREGPPGYAPYCEE--RLKRTFNN----- 1229
            .|:.|.|..             |:..|.   .::..:.|....|....:|  :|::.:.|     
  Rat  1048 ILRQSKAES-------------SQSSVEENLLIKKELEEERSRYQNLVKEYSQLEQRYENLRDEQ 1099

  Fly  1230 ---GTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGF 1291
               |.|..|.:...|::              |.|..::.........:...|:.:....|.....
  Rat  1100 QTPGHRKNPSNQSSLES--------------DSNYPSISTSEIGDTEDALQQVEEIGIEKAAMDM 1150

  Fly  1292 SLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVAT 1356
            ::::.|..:|..|......:...:.:.:|.:|:...:::|....:               ||.| 
  Rat  1151 TVFLKLQKRVRELEQERKKLQVQLEKEQQDSKKVQVEQQNNGLDV---------------DQDA- 1199

  Fly  1357 NLIYQQVVRGVKFGEYRCDKEE--DLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDK 1419
            ::.|..:.|.....|.:..|.:  :|....|.|...:.||..|.:. ::||.|.:.   |:..:.
  Rat  1200 DIAYNSLKRQELESENKKLKNDLNELRKAVADQAMQDNSTHSSPDS-YSLLLNQLK---LANEEL 1260

  Fly  1420 AIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVII 1484
            .:.:...|:|:....:...: :::...::.:|  .|:..||           ||..::.:.|.|.
  Rat  1261 EVRKEEVLILRTQIMNADQR-RLSGKNMEPNI--NARTSWP-----------NSEKHVDQEDAIE 1311

  Fly  1485 AVNWTGV-----------YVVDDQE---------QV--LLELSF--------PEITAVSSQ---- 1515
            |  :.||           |:.:|.|         ||  |||...        .|:..:.:|    
  Rat  1312 A--YHGVCQTNSQTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQNLKHEEEVEHLKAQVEAM 1374

  Fly  1516 -----KTNKVFTQTFSLSTVRGEEFTFQSPNAE------DIRDLVVYFLDGLKKRSK----YVIA 1565
                 |..:.|.||..||.....||..|...:.      |.::||.......||..|    |:..
  Rat  1375 KEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNEKKLKKQLKIYMKK 1439

  Fly  1566 LQD-----------------------YRAPSDGTSFLSFFKGD--LII------LEDESCGESVL 1599
            :||                       .|...|....|.:.|.|  |:|      |:.:....:|.
  Rat  1440 VQDLEAAQALAQSDRRHHELTRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVP 1504

  Fly  1600 NNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDR 1664
                |:            ||..:|:....:....|.|.:.::        ||...||        
  Rat  1505 ----CL------------PAYILYMCIRHADYTNDDLKVHSL--------LSSTING-------- 1537

  Fly  1665 PHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFA 1729
                               :.|.|   .|.:|:                .:....:....|....
  Rat  1538 -------------------IKKVL---KKHNED----------------FEMTSFWLSNTCRLLH 1564

  Fly  1730 AILKYMGD--LPSKRPRMGNEITDHIFDGPLKHEILRD---EIYCQLMKQLTDNRNRMSEERGWE 1789
            .:.:|.||  ..::.....||.....||.....::|.|   :||.||:|                
  Rat  1565 CLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIK---------------- 1613

  Fly  1790 LMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVE------VEAI 1848
                      .::|||:.:::...     :..:|:..|......|.||.....|:      :|||
  Rat  1614 ----------IAEGLLQPMIVSAM-----LENESIQGLSGVRPTGYRKRSSSMVDGENSYCLEAI 1663

  Fly  1849 QHKTTQIFHKVYFPDDTD---------------EAFEVDSSTRAKDFCNNISQRLSLRTSEGFSL 1898
             .:....||.|......|               .|..:::....||.|:         .|.|..|
  Rat  1664 -IRQMNFFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACS---------WSTGMQL 1718

  Fly  1899 FVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNAD 1963
            ...|:                 .|.:|::       |.|.|.:..|..|:.|             
  Rat  1719 RYNIS-----------------QLEEWLR-------GKNLQQSGAVQTMEPL------------- 1746

  Fly  1964 LIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKIQSTS 2028
                                 .:||:|..|.     .:.:::.:||..:...|....|:||    
  Rat  1747 ---------------------IQAAQLLQLK-----KKTQEDAEAICSLCTSLSTQQIVKI---- 1781

  Fly  2029 EWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSL 2093
               .::....|:    ..|...|:|::.:.            .|..|.:.|:.||:. :||...:
  Rat  1782 ---LNLYTPLNE----FEERVTVSFIRTIQ------------AQLQERSDPQQLLLD-SKHMFPV 1826

  Fly  2094 IHPVTKDIL 2102
            :.|.....|
  Rat  1827 LFPFNPSAL 1835

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 295/703 (42%)
MYSc_Myo7 77..721 CDD:276832 287/678 (42%)
MyTH4 <1138..1245 CDD:214535 20/119 (17%)
B41 1251..1467 CDD:214604 33/217 (15%)
FERM_B-lobe 1355..1439 CDD:271216 17/85 (20%)
FERM_C1_MyoVII 1461..1559 CDD:270019 30/142 (21%)
SH3 1560..1624 CDD:302595 16/98 (16%)
MyTH4 1701..1849 CDD:214535 26/158 (16%)
B41 1856..2068 CDD:214604 34/226 (15%)
FERM_M 1966..2068 CDD:278785 14/101 (14%)
FERM_C2_MyoVII 2064..2159 CDD:270020 9/39 (23%)
Myo5bXP_008770307.1 MYSc 72..770 CDD:214580 295/702 (42%)
MYSc_Myo5 91..759 CDD:276831 287/678 (42%)
IQ 871..891 CDD:197470 10/35 (29%)
DUF1690 910..1002 CDD:285231 31/210 (15%)
Rab5-bind 919..1179 CDD:286404 63/438 (14%)
RILP-like <979..1069 CDD:304877 26/140 (19%)
Uso1_p115_C 1155..1267 CDD:282695 23/131 (18%)
GBP_C <1340..1416 CDD:303769 17/75 (23%)
coiled coil 1385..1396 CDD:293879 5/10 (50%)
coiled coil 1405..1416 CDD:293879 1/10 (10%)
Myo5b_CBD 1480..1851 CDD:271261 90/554 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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