Protein Alignment ck and Myo5b

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_008770307.1
• Gene: Myo5b / 25132
• RGDID: 621347
• Length: 1854
• Species: Rattus norvegicus
• Alignment Length: 2219
• Identity: 564/2219 - (25%)
• Similarity: 876/2219 - (39%)
• Gaps: 641/2219 - (28%)

  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKE-NLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGE 127
            |..|:.:|..|||..:|.||.:|:.| |.||||.|.:|||:|||:.||||..|.|..|..:.:|:
  Rat    78 GENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGD 142

  Fly   128 LPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHS--WIEQQILEA 190
            :.|||||:.:.||..|.|..::|.|::|||||||||.|.|..::|.|.:.|..|  .||:::|.:
  Rat   143 MDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLAS 207

  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255
            :||:||.|||||.||||||||||||:|.|.....|.||.:..|||||||:|.|...|||||:||.
  Rat   208 SPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQ 272

  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320
            :.|..|..|...|.|..|.|:.|...|.:.|.||.|||.:|...|.|:.:|...:.....|.|::
  Rat   273 LCAAASLPEFKELALTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISIFKII 337

  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385
            |::||.|:::.:|. .|....:..|:..::.....|||:....:...|..|.|....||.|.|:|
  Rat   338 ASILHLGSVEIQAE-RDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLCHRKLVTTSETYVKTMS 401

  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTS---RNAIGVLDIFGFENFDQNSFEQFC 447
            ..|.|:.|:|..|.||.::|..||..||.|:    .||   .:.||||||:|||.|:.|||||||
  Rat   402 LQQVVNARNALAKHIYAQLFSWIVEHINKAL----QTSLKQHSFIGVLDIYGFETFEINSFEQFC 462

  Fly   448 INYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPK 512
            ||||||.|||.|..|:||||||||..|.|.|..|:|.|||..:|||..| |.|:.|:|||.:.||
  Rat   463 INYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAK-LGILDLLDEECKVPK 526

  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQ 577
            ||||....||::.|.:.:::.||:.. ||:|.:.|||..|.|.:.|||:|||||...:.::::..
  Rat   527 GTDQNWAQKLYERHSNSQHFQKPRMS-NTAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKA 590

  Fly   578 STNKFLRQIFAQDIE------------------------MGAETRKRTPTLSTQFRKSLDALMKT 618
            |....:..:|..|.:                        |.|..::...::..|||.||:.||:|
  Rat   591 SKFPLVADLFRDDKDSVPATNTAKSRSSSKINVRSSRPLMKAPNKEHKKSVGYQFRTSLNLLMET 655

  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683
            |::..|.::||||||:.|.|..||.....:|||..|::|||||..||||.|..:.:|..|||.|:
  Rat   656 LNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLM 720

  Fly   684 PGVPPAHRTDCQAATSRICAVVL-----GKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILIL 743
            .....|:.||    ...||..||     ....:|.|.||:|.:.....:||:.|........:::
  Rat   721 KKRELANTTD----KKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMI 781

  Fly   744 QRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGH 808
            |:::|||:.|.::.|||||.:|:|||.:||..|:...::|    |.:|.|   |...::|.|:
  Rat   782 QKTVRGWLQRVKYRRLRAATLTLQRFCRGYLARRLTEHLR----RTRAAI---VFQKQYRMLK-- 837

  Fly   809 IVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELL 873
                        .||.|.....|.:.|||:.|.|...|.||::..|||  |.::|
  Rat   838 ------------ARRAYCRVRRAAVIIQSYTRAMCVRRSYRQVLTEHK--ATIIQ---------- 878

  Fly   874 HRGNKHARE-IAEQHY---RD-------RLHELERREIQEQL-------ENRRRVEVNMNIINDA 920
                |:||. :|.:|:   ||       ....|:.|:..:.|       |:.:|:.|.|.  |..
  Rat   879 ----KYARGWMARRHFQRQRDAAIVIQCAFRRLKARQALKALKIEARSAEHLKRLNVGME--NKV 937

  Fly   921 ARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEE 985
            .:.|.: :||                                    ||
  Rat   938 VQLQRK-IDD------------------------------------QN----------------- 948

  Fly   986 DLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHT 1050
              .|||                              |..:||:|
  Rat   949 --KEFK------------------------------TLSEQLSA--------------------- 960

  Fly  1051 MDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRK----- 1110
                 .||..:.....|.:...|.::.|||     ||...|:::.:|:|.:|.....:|:
  Rat   961 -----VTSTHAMEVEKLKKELARYQQNQEA-----DPSLQLQEEVQSLRTELQKAHSERRVLEDT 1015

  Fly  1111 -NKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNN 1174
             |:...::|:|:.|.|:.                            .|.|:||     .:.|.|.
  Rat  1016 HNRENGELRKRVADLEHE----------------------------NALLKDE-----KEHLNNQ 1047

  Fly  1175 PLKSSHARGWILLSLCVGCFAPSEKFVN---YLRAFIREGPPGYAPYCEE--RLKRTFNN----- 1229
            .|:.|.|..             |:..|.   .::..:.|....|....:|  :|::.:.|
  Rat  1048 ILRQSKAES-------------SQSSVEENLLIKKELEEERSRYQNLVKEYSQLEQRYENLRDEQ 1099

  Fly  1230 ---GTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGF 1291
               |.|..|.:...|::              |.|..::.........:...|:.:....|.....
  Rat  1100 QTPGHRKNPSNQSSLES--------------DSNYPSISTSEIGDTEDALQQVEEIGIEKAAMDM 1150

  Fly  1292 SLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVAT 1356
            ::::.|..:|..|......:...:.:.:|.:|:...:::|....:               ||.|
  Rat  1151 TVFLKLQKRVRELEQERKKLQVQLEKEQQDSKKVQVEQQNNGLDV---------------DQDA- 1199

  Fly  1357 NLIYQQVVRGVKFGEYRCDKEE--DLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDK 1419
            ::.|..:.|.....|.:..|.:  :|....|.|...:.||..|.:. ::||.|.:.   |:..:.
  Rat  1200 DIAYNSLKRQELESENKKLKNDLNELRKAVADQAMQDNSTHSSPDS-YSLLLNQLK---LANEEL 1260

  Fly  1420 AIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVII 1484
            .:.:...|:|:....:...: :::...::.:|  .|:..||           ||..::.:.|.|.
  Rat  1261 EVRKEEVLILRTQIMNADQR-RLSGKNMEPNI--NARTSWP-----------NSEKHVDQEDAIE 1311

  Fly  1485 AVNWTGV-----------YVVDDQE---------QV--LLELSF--------PEITAVSSQ---- 1515
            |  :.||           |:.:|.|         ||  |||...        .|:..:.:|
  Rat  1312 A--YHGVCQTNSQTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQNLKHEEEVEHLKAQVEAM 1374

  Fly  1516 -----KTNKVFTQTFSLSTVRGEEFTFQSPNAE------DIRDLVVYFLDGLKKRSK----YVIA 1565
                 |..:.|.||..||.....||..|...:.      |.::||.......||..|    |:..
  Rat  1375 KEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNEKKLKKQLKIYMKK 1439

  Fly  1566 LQD-----------------------YRAPSDGTSFLSFFKGD--LII------LEDESCGESVL 1599
            :||                       .|...|....|.:.|.|  |:|      |:.:....:|.
  Rat  1440 VQDLEAAQALAQSDRRHHELTRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVP 1504

  Fly  1600 NNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDR 1664
                |:            ||..:|:....:....|.|.:.::        ||...||
  Rat  1505 ----CL------------PAYILYMCIRHADYTNDDLKVHSL--------LSSTING-------- 1537

  Fly  1665 PHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFA 1729
                               :.|.|   .|.:|:                .:....:....|....
  Rat  1538 -------------------IKKVL---KKHNED----------------FEMTSFWLSNTCRLLH 1564

  Fly  1730 AILKYMGD--LPSKRPRMGNEITDHIFDGPLKHEILRD---EIYCQLMKQLTDNRNRMSEERGWE 1789
            .:.:|.||  ..::.....||.....||.....::|.|   :||.||:|
  Rat  1565 CLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIK---------------- 1613

  Fly  1790 LMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVE------VEAI 1848
                      .::|||:.:::...     :..:|:..|......|.||.....|:      :|||
  Rat  1614 ----------IAEGLLQPMIVSAM-----LENESIQGLSGVRPTGYRKRSSSMVDGENSYCLEAI 1663

  Fly  1849 QHKTTQIFHKVYFPDDTD---------------EAFEVDSSTRAKDFCNNISQRLSLRTSEGFSL 1898
             .:....||.|......|               .|..:::....||.|:         .|.|..|
  Rat  1664 -IRQMNFFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACS---------WSTGMQL 1718

  Fly  1899 FVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNAD 1963
            ...|:                 .|.:|::       |.|.|.:..|..|:.|
  Rat  1719 RYNIS-----------------QLEEWLR-------GKNLQQSGAVQTMEPL------------- 1746

  Fly  1964 LIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKIQSTS 2028
                                 .:||:|..|.     .:.:::.:||..:...|....|:||
  Rat  1747 ---------------------IQAAQLLQLK-----KKTQEDAEAICSLCTSLSTQQIVKI---- 1781

  Fly  2029 EWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSL 2093
               .::....|:    ..|...|:|::.:.            .|..|.:.|:.||:. :||...:
  Rat  1782 ---LNLYTPLNE----FEERVTVSFIRTIQ------------AQLQERSDPQQLLLD-SKHMFPV 1826

  Fly  2094 IHPVTKDIL 2102
            :.|.....|
  Rat  1827 LFPFNPSAL 1835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	287/678 (42%)
		MyTH4	<1138..1245	CDD:214535	20/119 (17%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	10/97 (10%)
		B41	1251..1467	CDD:214604	33/217 (15%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	30/142 (21%)
		SH3	1560..1624	CDD:473055	16/98 (16%)
		MyTH4	1701..1849	CDD:214535	26/158 (16%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	19/111 (17%)
		B41	1856..2068	CDD:214604	34/226 (15%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	9/39 (23%)
Myo5b	XP_008770307.1	MYSc_Myo5	91..759	CDD:276831	287/678 (42%)
		IQ	773..795	CDD:197470	5/21 (24%)
		IQ	821..842	CDD:197470	9/41 (22%)
		IQ	871..891	CDD:197470	10/35 (29%)
		SMC_prok_B	906..>1268	CDD:274008	86/560 (15%)
		Myo5b_CBD	1480..1851	CDD:271261	90/554 (16%)