DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myo5a

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_038936774.1	Gene:	Myo5a / 25017	RGDID:	3143	Length:	1880	Species:	Rattus norvegicus

Alignment Length:	2256	Identity:	578/2256 - (25%)
Similarity:	904/2256 - (40%)	Gaps:	618/2256 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DGDEVWLA--------PERRIKAMHASS-----------------------VQGVEDMISLGDLH 75
            |.:|||.:        |..::..:|...                       :.|..|:.:|..||
  Rat    17 DPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYRLDPKTSELPHLRNPDILVGENDLTALSYLH 81

  Fly    76 EAGILRNLLIRYKEN-LIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNA 139
            |..:|.||.:|:.:: |||||.|.:|||:|||:.||||..|.|..|..:.:|::.|||||:.:.|
  Rat    82 EPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEA 146

  Fly   140 YAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW--IEQQILEANPILEAFGNAKT 202
            |..|.|..::|.|::|||||||||.|.|..::|.|.:||..|.  :|:::|.:|||:|:.|||||
  Rat   147 YKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKT 211

  Fly   203 IRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSR 267
            .||||||||||||:|.|.....|.||.:..|||||||:|.|...|||||:||.:.|.....|...
  Rat   212 TRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKM 276

  Fly   268 LDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYK 332
            |.||.|..:.|...|.|...||.|||.|.:..|.|..:|..|:.....|.::||.:||.||:.:.
  Rat   277 LRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFA 341

  Fly   333 ATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFV 397
            :.  |:...|..|:|..:.....|:|:..:.:...|..|.|....||.:..:|:.|:.:.|||..
  Rat   342 SR--DSDSCTIPPKHEPLIIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALA 404

  Fly   398 KGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQH 462
            |.||.::|..||..:|.|:.. .....:.||||||:|||.|:.|||||||||||||.|||.|..|
  Rat   405 KHIYAKLFNWIVGHVNQALHS-AVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMH 468

  Fly   463 IFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTH- 526
            :||||||||..|.|.|..|:|.|||..::||..| |.|:.|:|||.:.|||||.|...||:.||
  Rat   469 VFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESK-LGILDLLDEECKMPKGTDDTWAQKLYNTHL 532

  Fly   527 GSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDI 591
            .....:.||:.. |.:|.:.|||..|.|...|||:||:||...:.:.::..|..|.|.::|..|.
  Rat   533 NKCALFEKPRMS-NKAFIIKHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDE 596

  Fly   592 E----MGAETRKRTP----------------------TLSTQFRKSLDALMKTLSSCQPFFIRCI 630
            :    ..|.:..|||                      |:..|||.||..||:||::..|.::|||
  Rat   597 KAISPTSATSSGRTPLTRVPVKPTKGRPGQTAKEHKKTVGLQFRNSLHLLMETLNATTPHYVRCI 661

  Fly   631 KPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI--PGVPPAHRTD 693
            |||:.|.|..||.....:|||..|::|||||..||:|.|..::||..|||.|:  ..|....:..
  Rat   662 KPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLGDRKQT 726

  Fly   694 CQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLR 758
            ||....::   :|.|..||.|.||:|.:.....:||:.|...|....:.:|::||||:.|:|:|.
  Rat   727 CQNVLEKL---ILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKRYLC 788

  Fly   759 LRAAAITVQR-------------------------FWKGYAQRKRYRNMRVGYMRLQALIRSRVL 798
            ::.|||||||                         :|:.|..|::|:..|...:.||:.:|..:.
  Rat   789 MQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRMYVVRRKYKIRRAATIVLQSYLRGYLA 853

  Fly   799 SHRFRH-LRGH-IVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEV 861
            .:|:|. ||.| .|.:|...||:|.|..|...|.|:|.:|...|||:|.|..:||::|
  Rat   854 RNRYRKILREHKAVIIQKRVRGWLARTHYKRTMKAIIYLQCCFRRMMAKRELKKLKIE------- 911

  Fly   862 LQLRKLEEQELLHRGNKH-----AREIAEQH--YRDRLHELERRE--IQEQLENRRRVEVNMNII 917
              .|.:|..:.||.|.::     .|::.||:  |:..:.:|...|  ...:.|..|
  Rat   912 --ARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLR--------- 965

  Fly   918 NDAAR----KQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQD-DIIAP 977
            ||..|    ::|..|..|:::....:.                ..:..||...::..:. :..|.
  Rat   966 NDVERLQLSEEEAKVATGRVLSLQEEI----------------AKLRKDLEQTRSEKKSIEERAD 1014

  Fly   978 IHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKA------LKHPL------LPLHTQGDQLAAQ 1030
            .:..|.|:.:|..|.:.......:..:||...::|      ::..|      |.|....::|..|
  Rat  1015 KYKQETEQLVSNLKEENTLLKQEKETLNHLMVEQAKEMTETMERKLVEETKQLELDLNDERLRYQ 1079

  Fly  1031 ALWITILRFTG-------------DMPEPKYHTMDRMDTTSVMSKVTATLGRNFI-------RSK 1075
            .|.....|...             ::|:|.:   .|.|:|...::...|....|.       |::
  Rat  1080 NLLNEFSRLEERYDDLKEEMTLMLNVPKPGH---KRTDSTHSSNESEYTFSSEFAETEDIAPRTE 1141

  Fly  1076 EFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPT 1140
            |..|.: :.||...|||.:.|...       |:::.:|.:|...|.::....:.:.:   :.||.
  Rat  1142 EPTEKK-VPLDMSLFLKLQKRVTE-------LEQEKQLMQDELDRKEEQVLRSKAKE---EERPQ 1195

  Fly  1141 SNLEKLHFIIGHGILRAELRDEIYCQICKQLTN--NPLKSSHARGWILLSLCVGCFAPSEKFVNY 1203
            ....:|.:   ..:.|.||..|     .|:|.|  |.|:.                |.|||....
  Rat  1196 IRGAELEY---ESLKRQELESE-----NKKLKNELNELRK----------------ALSEKSAPE 1236

  Fly  1204 LRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADS 1268
            :.|   .|.|.|....|:....:.....|.:....|..|....|:.|. |..  |.||.|    .
  Rat  1237 VTA---PGAPAYRVLMEQLTAVSEELDVRKEEVLILRSQLVSQKEAIQ-PKD--DKNTMT----D 1291

  Fly  1269 ATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDH-----------VMDAISQCEQYA 1322
            :|...|...::.||..:.     ..||.|  |.::..|..|:           |.:.:.|..:..
  Rat  1292 STILLEDVQKMKDKGEIA-----QAYIGL--KETNRSSAMDYQELNEDGELWLVYEGLKQANRLL 1349

  Fly  1323 KEQ-GAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEED--LAMIA 1384
            :.| .:|:|                   :|:..|      :.:|    ||.:..|||:  ...:.
  Rat  1350 ESQLQSQKR-------------------SHENEA------EALR----GEIQSLKEENNRQQQLL 1385

  Fly  1385 AQQYFI--EYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKI 1447
            ||...:  |...:.|::...|.|.|                     ...|.:..|..|   |.|
  Rat  1386 AQNLQLPPEARIEASLQHEITRLTN---------------------ENLYFEELYADD---PKK- 1425

  Fly  1448 KEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVY--VVDDQEQVLLELSFPEIT 1510
                               |::||.|                 :|  ::|..||:
  Rat  1426 -------------------YQSYRIS-----------------LYKRMIDLMEQL---------- 1444

  Fly  1511 AVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDG 1575
                :|.:|         |||                       .|||:.|.
  Rat  1445 ----EKQDK---------TVR-----------------------KLKKQLKV------------- 1460

  Fly  1576 TSFLSFFK--GDLII--LEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDIL 1636
                 |.|  |:|.:  :|:.|.|:.:                 |.|...|.: |...|..|.:|
  Rat  1461 -----FAKKIGELEVGQMENISPGQII-----------------DEPIRPVNI-PRKEKDFQGML 1502

  Fly  1637 ALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLM----EYAL-------DHFRLPPKRTMSKTLTL 1690
            .....:|....:.|.:     .::||.....|:    .|.|       |:.....|.....|.|:
  Rat  1503 EYKREDEQKLVKNLIL-----ELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTI 1562

  Fly  1691 SSKRSEELWRYSRDPIKAPLLRK---LQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDH 1752
            :|             ||..|.::   .::...:....|.....:.:|.|:
  Rat  1563 NS-------------IKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGE--------------- 1599

  Fly  1753 IFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELL-------- 1809
              :|.:||...|...:|.....|.:.|..:|:        ||..::.....:|:.:|
  Rat  1600 --EGFMKHNTSRQNEHCLTNFDLAEYRQVLSD--------LAIQIYQQLVRVLENILQPMIVSGM 1654

  Fly  1810 --------------LFLRTRRHPISQDSMHRLQKTIRHGQRKYP---PHQVEVEAIQHKTTQIFH 1857
                          ..||.|...|:.:..:.|...:|.....:.   .|.::.|.|:....|:|:
  Rat  1655 LEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFY 1719

  Fly  1858 KVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSLFVKIADKVISVPEGDFFFDFVRHL 1922
            .|       .|..:::....||.| :.|:.:.:|.:                         |..|
  Rat  1720 IV-------GAITLNNLLLRKDMC-SWSKGMQIRYN-------------------------VSQL 1751

  Fly  1923 TDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREEA 1987
            .:|::....:..||.                                :.|..|::
  Rat  1752 EEWLRDKNLMNSGAK--------------------------------ETLEPLIQ---------- 1774

  Fly  1988 AKLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVA 2052
               ||.:.:|: .:...:.:||..|...|..:.|:|:       .::....|:    ..|...|:
  Rat  1775 ---AAQLLQVK-KKTDDDAEAICSMCNALTTAQIVKV-------LNLYTPVNE----FEERVSVS 1824

  Fly  2053 FLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVT 2098
            |::.:           :|:.....:.|::|:.|  ||    |.|||
  Rat  1825 FIRTI-----------QVRLRDRKDSPQLLMDA--KH----IFPVT 1853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	292/700 (42%)
		MYSc_Myo7	77..721	CDD:276832	284/675 (42%)
		MyTH4	<1138..1245	CDD:214535	24/108 (22%)
		B41	1251..1467	CDD:214604	40/231 (17%)
		FERM_B-lobe	1355..1439	CDD:271216	16/87 (18%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	15/99 (15%)
		SH3	1560..1624	CDD:302595	11/67 (16%)
		MyTH4	1701..1849	CDD:214535	26/175 (15%)
		B41	1856..2068	CDD:214604	28/211 (13%)
		FERM_M	1966..2068	CDD:278785	15/101 (15%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	10/35 (29%)
Myo5a	XP_038936774.1	COG5022	7..1275	CDD:227355	427/1340 (32%)
		MYSc_Myo5	83..751	CDD:276831	284/675 (42%)
		Smc	1157..>1484	CDD:224117	96/548 (18%)
		Myo5a_CBD	1506..1880	CDD:271262	78/498 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810