Protein Alignment ck and Myo5a

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_001423326.1
• Gene: Myo5a / 25017
• RGDID: 3143
• Length: 1877
• Species: Rattus norvegicus
• Alignment Length: 2257
• Identity: 577/2257 - (25%)
• Similarity: 903/2257 - (40%)
• Gaps: 623/2257 - (27%)

  Fly    42 DGDEVWLA--------PERRIKAMHASS-----------------------VQGVEDMISLGDLH 75
            |.:|||.:        |..::..:|...                       :.|..|:.:|..||
  Rat    17 DPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYRLDPKTSELPHLRNPDILVGENDLTALSYLH 81

  Fly    76 EAGILRNLLIRYKEN-LIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNA 139
            |..:|.||.:|:.:: |||||.|.:|||:|||:.||||..|.|..|..:.:|::.|||||:.:.|
  Rat    82 EPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEA 146

  Fly   140 YAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW--IEQQILEANPILEAFGNAKT 202
            |..|.|..::|.|::|||||||||.|.|..::|.|.:||..|.  :|:::|.:|||:|:.|||||
  Rat   147 YKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKT 211

  Fly   203 IRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSR 267
            .||||||||||||:|.|.....|.||.:..|||||||:|.|...|||||:||.:.|.....|...
  Rat   212 TRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKM 276

  Fly   268 LDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYK 332
            |.||.|..:.|...|.|...||.|||.|.:..|.|..:|..|:.....|.::||.:||.||:.:.
  Rat   277 LRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFA 341

  Fly   333 ATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFV 397
            :.  |:...|..|:|..:.....|:|:..:.:...|..|.|....||.:..:|:.|:.:.|||..
  Rat   342 SR--DSDSCTIPPKHEPLIIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALA 404

  Fly   398 KGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQH 462
            |.||.::|..||..:|.|:.. .....:.||||||:|||.|:.|||||||||||||.|||.|..|
  Rat   405 KHIYAKLFNWIVGHVNQALHS-AVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMH 468

  Fly   463 IFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTH- 526
            :||||||||..|.|.|..|:|.|||..::||..| |.|:.|:|||.:.|||||.|...||:.||
  Rat   469 VFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESK-LGILDLLDEECKMPKGTDDTWAQKLYNTHL 532

  Fly   527 GSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDI 591
            .....:.||:.. |.:|.:.|||..|.|...|||:||:||...:.:.::..|..|.|.::|..|.
  Rat   533 NKCALFEKPRMS-NKAFIIKHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDE 596

  Fly   592 E----MGAETRKRTP----------------------TLSTQFRKSLDALMKTLSSCQPFFIRCI 630
            :    ..|.:..|||                      |:..|||.||..||:||::..|.::|||
  Rat   597 KAISPTSATSSGRTPLTRVPVKPTKGRPGQTAKEHKKTVGLQFRNSLHLLMETLNATTPHYVRCI 661

  Fly   631 KPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI--PGVPPAHRTD 693
            |||:.|.|..||.....:|||..|::|||||..||:|.|..::||..|||.|:  ..|....:..
  Rat   662 KPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLGDRKQT 726

  Fly   694 CQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLR 758
            ||....::   :|.|..||.|.||:|.:.....:||:.|...|....:.:|::||||:.|:|:|.
  Rat   727 CQNVLEKL---ILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKRYLC 788

  Fly   759 LRAAAITVQR-------------------------FWKGYAQRKRYRNMRVGYMRLQALIRSRVL 798
            ::.|||||||                         :|:.|..|::|:..|...:.||:.:|..:.
  Rat   789 MQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRMYVVRRKYKIRRAATIVLQSYLRGYLA 853

  Fly   799 SHRFRH-LRGH-IVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEV 861
            .:|:|. ||.| .|.:|...||:|.|..|...|.|:|.:|...|||:|.|..:||::|
  Rat   854 RNRYRKILREHKAVIIQKRVRGWLARTHYKRTMKAIIYLQCCFRRMMAKRELKKLKIE------- 911

  Fly   862 LQLRKLEEQELLHRGNKH-----AREIAEQH--YRDRLHELERRE--IQEQLENRRRVEVNMNII 917
              .|.:|..:.||.|.::     .|::.||:  |:..:.:|...|  ...:.|..|
  Rat   912 --ARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLR--------- 965

  Fly   918 NDAAR----KQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQD-DIIAP 977
            ||..|    ::|..|..|:::....:.                ..:..||...::..:. :..|.
  Rat   966 NDVERLQLSEEEAKVATGRVLSLQEEI----------------AKLRKDLEQTRSEKKSIEERAD 1014

  Fly   978 IHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKA------LKHPL------LPLHTQGDQLAAQ 1030
            .:..|.|:.:|..|.:.......:..:||...::|      ::..|      |.|....::|..|
  Rat  1015 KYKQETEQLVSNLKEENTLLKQEKETLNHLMVEQAKEMTETMERKLVEETKQLELDLNDERLRYQ 1079

  Fly  1031 ALWITILRFTG-------------DMPEPKYHTMDRMDTTSVMSKVTATLGRNFI-------RSK 1075
            .|.....|...             ::|:|.:   .|.|:|...::...|....|.       |::
  Rat  1080 NLLNEFSRLEERYDDLKEEMTLMLNVPKPGH---KRTDSTHSSNESEYTFSSEFAETEDIAPRTE 1141

  Fly  1076 EFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPT 1140
            |..|.: :.||...|||.:.|...       |:::.:|.:|...|.::....:.:.:   :.||.
  Rat  1142 EPTEKK-VPLDMSLFLKLQKRVTE-------LEQEKQLMQDELDRKEEQVLRSKAKE---EERPQ 1195

  Fly  1141 SNLEKLHFIIGHGILRAELRDEIYCQICKQLTN--NPLKSSHARGWILLSLCVGCFAPSEKFVNY 1203
            ....:|.:   ..:.|.||..|     .|:|.|  |.|:.                |.|||....
  Rat  1196 IRGAELEY---ESLKRQELESE-----NKKLKNELNELRK----------------ALSEKSAPE 1236

  Fly  1204 LRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADS 1268
            :.|   .|.|.|....|:....:.....|.:....|..|....|:.|....|..|   .|:|
  Rat  1237 VTA---PGAPAYRVLMEQLTAVSEELDVRKEEVLILRSQLVSQKEAIQPKNTMTD---STIL--- 1292

  Fly  1269 ATTARELCNQLSDKISLKDQFGFS-LYIALFDKVSSLGSGGDH-----------VMDAISQCEQY 1321
                      |.|...:||:...: .||.|  |.::..|..|:           |.:.:.|..:.
  Rat  1293 ----------LEDVQKMKDKGEIAQAYIGL--KETNRSSAMDYQELNEDGELWLVYEGLKQANRL 1345

  Fly  1322 AKEQ-GAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEED--LAMI 1383
            .:.| .:|:|                   :|:..|      :.:|    ||.:..|||:  ...:
  Rat  1346 LESQLQSQKR-------------------SHENEA------EALR----GEIQSLKEENNRQQQL 1381

  Fly  1384 AAQQYFI--EYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLK 1446
            .||...:  |...:.|::...|.|.|                     ...|.:..|..|   |.|
  Rat  1382 LAQNLQLPPEARIEASLQHEITRLTN---------------------ENLYFEELYADD---PKK 1422

  Fly  1447 IKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVY--VVDDQEQVLLELSFPEI 1509
                                |::||.|                 :|  ::|..||:
  Rat  1423 --------------------YQSYRIS-----------------LYKRMIDLMEQL--------- 1441

  Fly  1510 TAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSD 1574
                 :|.:|         |||                       .|||:.|.
  Rat  1442 -----EKQDK---------TVR-----------------------KLKKQLKV------------ 1457

  Fly  1575 GTSFLSFFK--GDLII--LEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDI 1635
                  |.|  |:|.:  :|:.|.|:.:                 |.|...|.: |...|..|.:
  Rat  1458 ------FAKKIGELEVGQMENISPGQII-----------------DEPIRPVNI-PRKEKDFQGM 1498

  Fly  1636 LALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLM----EYAL-------DHFRLPPKRTMSKTLT 1689
            |.....:|....:.|.:     .::||.....|:    .|.|       |:.....|.....|.|
  Rat  1499 LEYKREDEQKLVKNLIL-----ELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTST 1558

  Fly  1690 LSSKRSEELWRYSRDPIKAPLLRK---LQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITD 1751
            ::|             ||..|.::   .::...:....|.....:.:|.|:
  Rat  1559 INS-------------IKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGE-------------- 1596

  Fly  1752 HIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELL------- 1809
               :|.:||...|...:|.....|.:.|..:|:        ||..::.....:|:.:|
  Rat  1597 ---EGFMKHNTSRQNEHCLTNFDLAEYRQVLSD--------LAIQIYQQLVRVLENILQPMIVSG 1650

  Fly  1810 ---------------LFLRTRRHPISQDSMHRLQKTIRHGQRKYP---PHQVEVEAIQHKTTQIF 1856
                           ..||.|...|:.:..:.|...:|.....:.   .|.::.|.|:....|:|
  Rat  1651 MLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMF 1715

  Fly  1857 HKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSLFVKIADKVISVPEGDFFFDFVRH 1921
            :.|       .|..:::....||.| :.|:.:.:|.:                         |..
  Rat  1716 YIV-------GAITLNNLLLRKDMC-SWSKGMQIRYN-------------------------VSQ 1747

  Fly  1922 LTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREE 1986
            |.:|::....:..||.                                :.|..|::
  Rat  1748 LEEWLRDKNLMNSGAK--------------------------------ETLEPLIQ--------- 1771

  Fly  1987 AAKLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKV 2051
                ||.:.:|: .:...:.:||..|...|..:.|:|:       .::....|:    ..|...|
  Rat  1772 ----AAQLLQVK-KKTDDDAEAICSMCNALTTAQIVKV-------LNLYTPVNE----FEERVSV 1820

  Fly  2052 AFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVT 2098
            :|::.:           :|:.....:.|::|:.|  ||    |.|||
  Rat  1821 SFIRTI-----------QVRLRDRKDSPQLLMDA--KH----IFPVT 1850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	284/675 (42%)
		MyTH4	<1138..1245	CDD:214535	24/108 (22%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	20/110 (18%)
		B41	1251..1467	CDD:214604	39/232 (17%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	15/99 (15%)
		SH3	1560..1624	CDD:473055	11/67 (16%)
		MyTH4	1701..1849	CDD:214535	26/175 (15%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	14/96 (15%)
		B41	1856..2068	CDD:214604	28/211 (13%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	10/35 (29%)
Myo5a	NP_001423326.1	COG5022	7..1445	CDD:227355	477/1632 (29%)
		MYSc_Myo5	83..751	CDD:276831	284/675 (42%)
		Myo5a_CBD	1503..1877	CDD:271262	78/498 (16%)