Protein Alignment ck and Myo1g

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_006514763.1
• Gene: Myo1g / 246177
• MGIID: 1927091
• Length: 1039
• Species: Mus musculus
• Alignment Length: 1086
• Identity: 349/1086 - (32%)
• Similarity: 533/1086 - (49%)
• Gaps: 158/1086 - (14%)

  Fly    57 MHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYK 121
            :|.:  :|....:||..:...|      :::::..||||.|.:||:|||||.||:|..:.|..|:
Mouse    32 LHCA--EGCSGWLSLLRMAPRG------LKFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIAKYQ 88

  Fly   122 ERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQ 186
            .|::.|.|||::|:.:.||..|||..:|.||||||||||||||::|.|:||:||::......|.:
Mouse    89 GRELYERPPHLYAVANAAYKAMKRRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVE 153

  Fly   187 -----ILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHS 246
                 :|::..:|||||||:|.||.||||||||:||:|...|...|..|..|||||||::.|:..
Mouse   154 RVKNVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVG 218

  Fly   247 ERNYHVFYCILAGLSADEKSRLDLGM-AADYKYLTGGNSITCEGRD----DAAEFSDIRSAMKVL 306
            |||:|.||.:|.|....|...|.|.. .|.|.:...|..:.....:    |......:..||:::
Mouse   219 ERNFHAFYQLLRGSEDQELQGLHLERNPAVYNFTRQGAGLNMGVHNALDSDEKSHQGVMEAMRII 283

  Fly   307 LFSDQEIWEIIKLLAALLHCGNIKYKATVVD--NLDATEIPEHINVERVAGLLGLPIQPLIDALT 369
            .||..|:..|.::|||:||.|||::..|..:  .....|:.:...|..||.|...|...::..|.
Mouse   284 GFSPDEVESIHRILAAILHLGNIEFVETEENGPQKGGLEVADEALVGYVAKLTATPRDLVLRTLL 348

  Fly   370 RRTLFAHGETVVS---TLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGT------SRN 425
            .||:.:.|..|:.   |::  ::...|||..|.:|.|:|..:|.||| :|.:||..      ...
Mouse   349 ARTVASGGREVIEKSHTVA--EASYARDACAKAMYQRLFEWVVNKIN-SIMEPRNRDPRCDGKDT 410

  Fly   426 AIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDAL 490
            .||||||:|||.|..||||||||||.||.|||.|:|.|.|.|||||..|.|.||.||:.:|...:
Mouse   411 VIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGIAWQTIEYFNNATIV 475

  Fly   491 DLIAIKQLNIMALIDEEARFPKG--TDQTMLAKLHKTHGSHKNY----LKPKSDINTSFG----L 545
            :|:......|:|::| ||....|  ||:..|..|...|..|.:|    |.| :|....||    :
Mouse   476 ELVEQPHRGILAVLD-EACSTAGPITDRIFLQTLDTHHRHHPHYSSRQLCP-TDKTMEFGRDFQI 538

  Fly   546 NHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIF---AQDIEMGAETRKRTPTLSTQ 607
            .|:||.|.|...||:|||||:...|...|:..|.:..||.::   .|||   .|..||..|..|.
Mouse   539 KHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYNSVDPTLRAMWPDGQQDI---TEVTKRPLTAGTL 600

  Fly   608 FRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGF 672
            |:.|:.||::.|:|.:||::|||||||.|.....|...|..|:.|.|::|.:|:||||:..|..:
Mouse   601 FKNSMVALVENLASKEPFYVRCIKPNEDKVAGRLDEAHCRHQVEYLGLLENVRVRRAGFASRQPY 665

  Fly   673 REFVERYRFLIPGVPPAH--RTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLF-LEQERDR 734
            ..|:.||:.......|.|  .:|..|.::.:....| :.|...||:|:|::....|. |||.|.|
Mouse   666 PRFLLRYKMTCEYTWPNHLLGSDRDAVSALLEQHGL-QGDVAFGHSKLFIRSPRTLVTLEQSRAR 729

  Fly   735 VLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQR-------KRYRNMRVGYMRLQAL 792
            ::...:|:||::.||.:.|....||| |..|:.|:::.:..|       :|::..|...:..:.|
Mouse   730 LIPIIVLLLQKAWRGTLARWHCRRLR-AIYTIMRWFRRHKVRAHLIELQRRFQAARQPPLYGRDL 793

  Fly   793 I-------------RSRVLSHRFRHLR-------GHIVGLQAH--ARGYL--VRREYG-HKMWAV 832
            :             ..|||..|:|..:       ..::.::|.  |.|.|  :|:::| .:.||.
Mouse   794 VWPTPPAVLQPFQDTCRVLFSRWRARQLVKNIPPSDMIQIKAKVAAMGALQGLRQDWGCQRAWAR 858

  Fly   833 IKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRG------NKHAREIAEQHYRDR 891
            ..:.|......|..          .|||  ||:.|.|::    |      :.|.|::      :|
Mouse   859 DYLSSDTDNPTASH----------LFAE--QLKALREKD----GFGSVLFSSHVRKV------NR 901

  Fly   892 LHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRE 956
            ..:...|.:               ::.|....:.||....:::.|    :|..:....:...||:
Mouse   902 FRKSRDRAL---------------LLTDRYLYKLEPGRQYRVMRA----VPLEAVTGLSVTSGRD 947

  Fly   957 TSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLH 1021
            ..|   :.|||  ..||::..:|.|:...|....:.....|.:.||.......:.:   ..:||.
Mouse   948 QLV---VLHAQ--GYDDLVVCLHRSQPPLDNRIGELVGMLAAHCQGEGRTLEVRVS---DCIPLS 1004

  Fly  1022 TQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATL 1067
            .:|      |..:..:....:.|||.:.:          |:.|.||
Mouse  1005 QRG------ARRLISVEPRPEQPEPDFQS----------SRSTFTL 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	266/679 (39%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo1g	XP_006514763.1	MYSc_Myo1	52..715	CDD:276829	265/671 (39%)
		Myosin_TH1	836..1007	CDD:461801	42/219 (19%)