Protein Alignment ck and Myo16

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_006508841.1
• Gene: Myo16 / 244281
• MGIID: 2685951
• Length: 1941
• Species: Mus musculus
• Alignment Length: 1147
• Identity: 283/1147 - (24%)
• Similarity: 478/1147 - (41%)
• Gaps: 291/1147 - (25%)

  Fly    66 EDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKE---RKIGE 127
            :|:.:|.:|:::.:|..:..|:..:.|:|:.|.|.:.|||::.||||:....::|..   ::...
Mouse   425 DDLATLSELNDSSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTMVSQMYLSPTGQRSPS 489

  Fly   128 LPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAA-ISGKHSWIEQQILEAN 191
            ||||:|:..:.|:..:.:.|:.|.|::|||.|:|||:::|.|::||.: .|...:..:.::..|.
Mouse   490 LPPHLFSCAERAFHRLFQERKPQNIILSGERGSGKTQASKQIMKYLTSRASSSCTMFDSRLRHAI 554

  Fly   192 PILEAFGNAKTIRNDNSSRFGKYIDI-------HFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            .|:||||:|||..|:.||...:|.::       |      |.||:|..|:|||||:|:|...:..
Mouse   555 YIVEAFGHAKTTLNNVSSCLIQYWELQCCQRRKH------ITGARISTYMLEKSRVVAQPPGQGT 613

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGG---NSITCEGRDDAAEFSDIRSAMKVLLFSDQ 311
            :.:|..::.|||::||..|.|.....::|::.|   :..|.|...:....:.::.|:.|:.||..
Mouse   614 FLIFSWLMDGLSSEEKCGLHLNNFCAHRYVSQGMREDVSTAEHSLNKERLAALKHALNVIGFSTL 678

  Fly   312 EIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAH 376
            |:..:..:|:|:||.|:|::  |.:...|:..:.:...:|:|||:|.:....|..|||....:..
Mouse   679 EVENLFVILSAILHIGDIQF--TALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFK 741

  Fly   377 GETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI-----FKPRGTSRNAIGVLDIFGFE 436
            |:.::...:...:...||...|.:|.|:|..::..:|..:     :|...|.  .||:|||||||
Mouse   742 GDVIIRRHTIQMAAFYRDLLAKSLYSRLFGFLINTVNCCLQNQDEYKSLQTL--DIGILDIFGFE 804

  Fly   437 NFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQ-DALDLIAIKQLNI 500
            .|.:|.|||.|:|..||.:..:..:.:|..||.|...|.:..:......|| ..||....|....
Mouse   805 EFQKNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQAGVLDFFFQKPSGF 869

  Fly   501 MALIDEEARFPKGTDQTMLAKLH-KTHGSHKNYL-KPKSDIN---------TSFGLNHFAGVVFY 554
            .:|:|||::.....:..:..||. ....|:.|.: .|..|.|         .:|.:.|:||.|.|
Mouse   870 FSLLDEESQVIWSGEPNLPRKLQGLLESSNTNAVYSPVKDGNGNVAFKGQGAAFTVMHYAGRVMY 934

  Fly   555 DTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDI---------------------------- 591
            :..|.:::|:|:.|.:||.::..|.|..:..:|...:
Mouse   935 EMGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSQTGSLISSYPSFKFGGHKSTLLSKRTA 999

  Fly   592 ------------------EMGAET------RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKP 632
                              :.|..|      |....|.::|..|||..:...|....|.||.||||
Mouse  1000 SSMVGVNKNYLELSKLLKKKGTSTFLQRLERGEPATAASQLTKSLADITAKLQRGSPHFILCIKP 1064

  Fly   633 NELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAH----RTD 693
            |..:.|.:||......||:|.|::..:|:.|:|||:|..|.:|:.||.      |.|.    .|.
Mouse  1065 NTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRSGYPVRPSFEDFLSRYE------PLASVLLGETK 1123

  Fly   694 CQAATSRICAVVLGK---SDYQLGHTKVFLKDAH-----DLFLEQERDRVLTRKILILQRSIRGW 750
            .|||..| |.:||.:   ..:|:|..|||||..|     ||:|:      |.|||:..|:.|||:
Mouse  1124 GQAAEER-CRLVLQRCKLQGWQIGVHKVFLKYWHVDQLSDLWLQ------LQRKIVTCQKVIRGF 1181

  Fly   751 VYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAH 815
            :
Mouse  1182 L---------------------------------------------------------------- 1182

  Fly   816 ARGYLVRREYGHKMWAVIKIQSHVRRM--IAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNK 878
            ||.:|::| ...|...|..|:|.::..  :|::.|..|         |:|
Mouse  1183 ARQHLLQR-MSIKQQEVTSIKSFLQSTEDMALKTYDAL---------VIQ--------------- 1222

  Fly   879 HAREIAEQH--YRDRLHELERREIQEQLENRRRVE-------VNMN------IINDAARKQEEPV 928
            :|.:||.:|  .|..:|....|..||  |..:|.|       |:.|      :::..|:....|.
Mouse  1223 NASDIAREHDRLRKEVHTAYHRNRQE--EGTKRAEDQGGCRHVHSNSVPVPMVVDSLAQALTGPS 1285

  Fly   929 DDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISED---------- 983
            .....:.::|..  |.|:..|:|..........|.....:.:.:.:.|.:..::|
Mouse  1286 TRPPSLHSVFSM--DDSTGLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAKDAAGEALTRPR 1348

  Fly   984 --EEDLSEFK-----------FQKFAATYFQ--------------------GNVNHQYAKK---A 1012
              .:|.|..|           ..|.:.:|.:                    |.::.|:|:.   .
Mouse  1349 PHSDDYSTMKKIPPRKPKRSPHTKLSGSYEEIWGPPRPSGTMGQGGRHQAPGTLSVQWARPDSVP 1413

  Fly  1013 LKHPLLPLH---TQGDQLAAQALWITILRFTGDMPEPKYHTM 1051
            ...|.||||   .|||.              .|..||.|..|
Mouse  1414 QCTPQLPLHLPLPQGDY--------------DDDAEPVYIEM 1441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	208/733 (28%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo16	XP_006508841.1	ANKYR	81..336	CDD:440430
		ANK repeat	114..145	CDD:293786
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786
		ANK repeat	243..274	CDD:293786
		ANK repeat	276..307	CDD:293786
		MYSc_Myo16	436..1153	CDD:276844	208/733 (28%)
		NYAP_N	1235..1605	CDD:464717	41/225 (18%)