DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myo1h

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_001158045.1	Gene:	Myo1h / 231646	MGIID:	1914674	Length:	1022	Species:	Mus musculus

Alignment Length:	908	Identity:	326/908 - (35%)
Similarity:	500/908 - (55%)	Gaps:	71/908 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AMHASSVQGVEDMISLGDLH--EAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIK 118
            |:.|....||:|.:.| |.:  |:..|.||..|::|||||||.|::||:|||||.|.|||..|::
Mouse     4 ALTARDKVGVQDFVLL-DAYTSESAFLENLRKRFRENLIYTYIGTLLVSVNPYQELGIYTASQME 67

  Fly   119 LYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWI 183
            ||:.....|||||::||.||||..|.....:..|:|||||||||||::|.||||.|........:
Mouse    68 LYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTESL 132

  Fly   184 E---QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNH 245
            :   .::|.:.|:|||||||||:|||||||||||:||.|...||..|..|..||:||||:|.|||
Mouse   133 QIARDRLLLSIPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFQGVPVGGHIISYLIEKSRVVYQNH 197

  Fly   246 SERNYHVFYCILAGLSADEKSRLDLGMAAD---YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLL 307
            .|||:|:||.:|||..::..:  .||:..|   ||||:.|:........|..::..:..|..|:.
Mouse   198 GERNFHIFYQLLAGGGSERLA--SLGLERDPQLYKYLSQGHCARESPISDKNDWETVCGAFSVIG 260

  Fly   308 FSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRT 372
            |::.::..:..::|::||.||:.:|.   |......:|:...::.:|.|||:....|::|||.|.
Mouse   261 FTEADLENLFGIIASVLHLGNVCFKG---DKQGCASVPDTHEIKWIAKLLGVCPAVLLEALTHRK 322

  Fly   373 LFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFEN 437
            :.|..|.|:..|:.:.||..|||..|.:|||.|..:|.:||:::.....|.:..||:|||:|||.
Mouse   323 IEAKTEEVICPLTVELSVYARDAMAKAVYGRTFTWLVNRINSSLVNKDFTQKTVIGLLDIYGFEV 387

  Fly   438 FDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMA 502
            ||:|.||||||||.||.|||..::...|.||.||..|.|.|:.:::.:|:...||:..:...|::
Mouse   388 FDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYESEGIEWETVQYFNNKIICDLVEERHRGIIS 452

  Fly   503 LIDEEARFP-KGTDQTMLAKLHKTHGSHKNYL-------KPKSDIN-TSFGLNHFAGVVFYDTRG 558
            ::|||...| ..||.:.|.||.:..|.|.::.       |.:..|. ..|.|.|:||.|.|.|:|
Mouse   453 ILDEECIRPGPATDLSFLEKLEEKVGKHAHFQTRKLAGPKGRKRIGWLEFCLLHYAGEVTYCTKG 517

  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQ 623
            ||:||.|.....|..::..|.|..||:.|   :....|.|:|.||:.|||:.||.:|::.|.|.:
Mouse   518 FLEKNNDLLYRHLKEVLCSSKNSILRECF---LVAELENRRRPPTVGTQFKNSLSSLLEILISKE 579

  Fly   624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGV-P 687
            |.:||||||||.|:|..||..|...|::|.|:||.:|:||||:..|..:..|::||:.|.|.. |
Mouse   580 PSYIRCIKPNERKEPSKFDDFLISHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWP 644

  Fly   688 PAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLF-----LEQERDRVLTRKILILQRSI 747
            ..|....:.....|..:.....||:||.||:|::....||     .|..:.::::|    :|.:.
Mouse   645 HWHGPPGEGVERLIKYIGYQPQDYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVSR----IQATY 705

  Fly   748 RGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHL------- 805
            :|.:.||.:::.|.||..::..|:|...||..:..|.....::..::..:  :|.:.|
Mouse   706 KGCLGRREYMKKRQAATKLEAHWRGVLARKEIKRRRWAVQIIRRFVKGFI--NRDKPLCPDNEEF 768

  Fly   806 -----RGHIVGLQAHARGYLVRREYGHKMW----AVIKIQSH-VRRMIA---MRRY-RKLRLEHK 856
                 :.:|:.|:.|     |.:....|.|    .:::..|: :|||..   :|:| |.:..|.|
Mouse   769 VVLVRKNYILNLRYH-----VPKNVLDKSWLRPPGILENASNLLRRMCTRNLVRKYCRGISAERK 828

  Fly   857 QFAEVLQLRKLEEQELLHRGNK--HAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNII 917
                .:..:|:...|:. ||.|  :|..:.:.....||.|........||....:::..:.:|
Mouse   829 ----AMMQQKVVTSEIF-RGKKEGYAESLNQLFAGSRLDESNINPKVLQLLGSEKIQYGVPVI 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	282/691 (41%)
		MYSc_Myo7	77..721	CDD:276832	273/659 (41%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo1h	NP_001158045.1	MYSc	8..689	CDD:214580	281/689 (41%)
		MYSc_Myo1	26..678	CDD:276829	273/659 (41%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	568..590		11/21 (52%)
		Myosin_TH1	834..1001	CDD:283635	12/54 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910