Protein Alignment ck and Plekhh3

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_666142.1
• Gene: Plekhh3 / 217198
• MGIID: 2384950
• Length: 796
• Species: Mus musculus
• Alignment Length: 666
• Identity: 124/666 - (18%)
• Similarity: 216/666 - (32%)
• Gaps: 246/666 - (36%)

  Fly  1680 PKRTMSKTLTLS---------SKRSEELWRY---------SRDPIKAP---LLRKLQ-------- 1715
            ||.|...::|:|         |.|..|..|:         |:.|::.|   |||.:|
Mouse   160 PKETGLWSVTVSGRKHSIRLCSPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEA 224

  Fly  1716 --------------SKEEFA--------------------EEACFAFAAILKYMGDLPSKRPRMG 1746
                          |...:|                    |||...|.|:....|   ::||
Mouse   225 VALIYRRNPILRHTSSALYAPLLPLPYEVSAPGPGYAPLREEAVRLFLALQALEG---ARRP--- 283

  Fly  1747 NEITDHIFDGPLKHEI---------LRDEIYCQLMKQ-----------LTDNRNRMSEERGWELM 1791
                     |||...:         |:||::.||.||           .|.:...:   |.|:|:
Mouse   284 ---------GPLMQGVLQTCRDLPALQDELFLQLAKQTSGPAGPPGLPATQDPATL---RYWQLL 336

  Fly  1792 WLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHG-----QRKYPPHQVEVEAIQHK 1851
            ...:..|.....:...||..|......:....:....:.||..     .|:..|...|:.|:..:
Mouse   337 TCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSRR 401

  Fly  1852 TTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSL-RTSEGFSLFVKIADKVISVPEGDFF 1915
             .::...|:.|........:||.|.|.:....:..||.| |:...|:|:.:...:..::..|...
Mouse   402 -QELLCTVHCPGAGACPVSIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLV 465

  Fly  1916 FDFV---RHLTD------------W---IKKARPIR-DGANPQFTYQVFFMKKLWTNTVPGKDRN 1961
            .|.:   .:||.            |   ::...|:. :|.:|:                     .
Mouse   466 ADVLTRFENLTSEEAGLEDSPDCGWRLCLRLHGPLHPEGLSPE---------------------G 509

  Fly  1962 ADLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIPQ---------MLRELI 2017
            .:|.|.:.|....||||......:....||||           .||::.:         :|..|:
Mouse   510 HELPFLFEQAHALLLRGRPPPPEDTLRALAAL-----------RLQSLHRDFSPRGPLPLLDRLL 563

  Fly  2018 PSDI----------------MKIQSTSEW-----KR----------------------------- 2032
            |..|                ..:.:.:.|     ||
Mouse   564 PPPIPPREQPPCPTRRPPPSAALLAGALWSPGLAKRRAERARRGGTGRSTGSTAQVGGGGASTTA 628

  Fly  2033 SIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQ-TTEP--NYPEMLLIAINKHGVSLI 2094
            :::..:.:..||...:|..|:|.:..:.|.||:|.::|.: :|||  ..|:.|.:.:....:||.
Mouse   629 AVLGGWKRLRGMGQAEAMAAYLALAAQCPGFGAARYDVLELSTEPGGGAPQKLCLGLGAKAMSLS 693

  Fly  2095 HPVTKDILVTHPFTRISNWSSGNTYFHM---------TIGNLVRGSKLLCETSLGYKMDDLLTSY 2150
            .|..     |.|...:|       |.|:         |:...|..|:||.::....::.:|:.:|
Mouse   694 RPGE-----TEPIHSVS-------YGHVAACQLIGPHTLALRVGDSQLLLQSPQVEEIMELVNAY 746

  Fly  2151 ISLMLTNMNKNRTIRA 2166
                |.|.:..|..|:
Mouse   747 ----LANPSPERPCRS 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535	41/226 (18%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	20/116 (17%)
		B41	1856..2068	CDD:214604	49/290 (17%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	25/106 (24%)
Plekhh3	NP_666142.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..71
		PH-like	84..208	CDD:473070	11/47 (23%)
		MyTH4	288..397	CDD:459939	20/111 (18%)
		Ubl1_cv_Nsp3_N-like	401..500	CDD:475130	17/99 (17%)
		FERM_M	514..>552	CDD:459788	12/48 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	557..584		4/26 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..625		2/26 (8%)
		PH-like	660..747	CDD:473070	23/102 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	750..796		2/9 (22%)