DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myo5c

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_006510998.1	Gene:	Myo5c / 208943	MGIID:	2442485	Length:	1749	Species:	Mus musculus

Alignment Length:	1698	Identity:	490/1698 - (28%)
Similarity:	741/1698 - (43%)	Gaps:	395/1698 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKEN- 90
            |::..:|..::...|.|.   |.|.|     :...:.|..|:.:|..|||..:|.||.||:.|:
Mouse    39 RLLLEDGMELEYPVDPGS---LPPLR-----NPDILVGENDLTALSYLHEPAVLHNLRIRFAESK 95

  Fly    91 LIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVIS 155
            |||||:|.||||:|||:.||||....|..|..:.:|::.|||||:.:.||..|.|..::|.|::|
Mouse    96 LIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPHIFAVAEEAYKQMARNNRNQSIIVS 160

  Fly   156 GESGAGKTESTKLILQYLAAI--SGKHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIH 218
            ||||||||.|.:..::|.|.:  |..::.:|.::|.:|||.||.|||||.|||||||||||.:|.
Mouse   161 GESGAGKTVSARYAMRYFATVSKSSSNAHVEDKVLASNPITEAVGNAKTTRNDNSSRFGKYTEIS 225

  Fly   219 FSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGN 283
            |.....|.||.:..|||||||:|.|:.:|||||:||.:.|.....|...|.||.|.::.|...|.
Mouse   226 FDERNQIIGANMRTYLLEKSRVVFQSENERNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMGG 290

  Fly   284 SITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHI 348
            :...||.:|.|:..:.:....:|.|......::.|:|||:||.||::......:....:|...|:
Mouse   291 NTVIEGVNDRADMVETQKTFTLLGFKKDFQMDVFKILAAILHLGNVQVTTVGNERSSVSEDDSHL 355

  Fly   349 NVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKIN 413
            .|  ...||||....:...|..|.:....||||..::|.|:::.|||..|.||..:|..||.:||
Mouse   356 KV--FCELLGLETSKVAQWLCNRKIVTSSETVVKPMTRPQAINARDALAKKIYAHLFDFIVEQIN 418

  Fly   414 TAI-FKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAIN 477
            .|: |.  |.....||||||:|||.||.|||||||||||||.|||.|..|:||||||||..|.|.
Mouse   419 QALHFS--GKQHTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIP 481

  Fly   478 WQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYL--KPKSDIN 540
            |..|:|.|||..:|||..| :.|:.|:|||...|.|||:..|.||:... .:||.|  ||:.. |
Mouse   482 WTLIDFYDNQPVIDLIEAK-MGILELLDEECLLPHGTDENWLQKLYNNF-VNKNSLFEKPRMS-N 543

  Fly   541 TSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKF-LRQIFAQDIEM-----GA---- 595
            :||.:.|||..|.|...|||:|||||....|:.::..|  || |...|.|:..:     ||
Mouse   544 SSFIIQHFADKVEYQCEGFLEKNRDTVYDMLVEILRAS--KFHLCAAFFQESPVPSSPFGAMITV 606

  Fly   596 ---------ETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLR 651
                     .|:....|:..:||.||..||:||::..|.::||||||:.|.|..||.....:|||
Mouse   607 KSAKQVIKPNTKHFRTTVGNKFRSSLYLLMETLNATTPHYVRCIKPNDEKMPFEFDSKRIVQQLR 671

  Fly   652 YSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATS---RICAVVLGK----- 708
            ..|::|||||....||.|..:.||..||..|:        |..:.:.|   .:|.|||.:
Mouse   672 ACGVLETIRISAQSYPSRWTYLEFYSRYGILM--------TQQELSLSDKKEVCKVVLHRLIQDS 728

  Fly   709 SDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGY 773
            :.||.|.||:|.:.....:||:.|...|.:..:::|:.:|||:.||:|||.|.||:|:||:::|
Mouse   729 NQYQFGRTKIFFRAGQVAYLEKLRLDKLRQDCIMIQKHVRGWLQRRKFLRERQAALTIQRYFRG- 792

  Fly   774 AQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSH 838
                            |..:|..:.:...:.....|: ||.:.||||||..|.....|.|.||:|
Mouse   793 ----------------QQTVRKAITATALKEAWAAII-LQKYCRGYLVRNLYQLIRVATITIQAH 840

  Fly   839 VRRMIAMRRYRKLRLEHK---------------------QFAEVLQL--------RKLEEQELLH 874
            .|..:|.||||||..|||                     :|...:||        :|||:|...:
Mouse   841 TRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRRFVLNIQLTYRVQRLQKKLEDQNREN 905

  Fly   875 RG-------------------------------NKHAREIAEQHYRD----RLHELERREIQEQL 904
            .|                               ::|:.|...:.|||    ||.:|::...:.:|
Mouse   906 HGLVEKLTSLAALRVGDLEKVQKLEAELEKAATHRHSYEEKGRRYRDTVEERLSKLQKHNAELEL 970

  Fly   905 ENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRE------------- 956
            : |.|.|   .::.:.:.:.:|.:|  ||...:||.:............|.|
Mouse   971 Q-RERAE---QMLQEKSEELKEKMD--KLTRQLFDDVQKEEQQRLVLEKGFELKTQAYEKQIESL 1029

  Fly   957 -----------TSVFNDLPHAQNVNQDDIIAPI-HISEDEEDLSEFK------------------ 991
                       :.:.:.|...| |..|.:...: .:|:..:.:|||:
Mouse  1030 REEIKALKDERSQLHHQLEEGQ-VTSDRLKGEVARLSKQAKTISEFEKEIELLQAQKIDVEKHVQ 1093

  Fly   992 -------------FQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDM 1043
                         .::...:|...:|..:.:.:.|:|    |:..|:      ||..   :.|
Mouse  1094 SQKREMRERMSEVTKQLLESYDIEDVRSRLSVEDLEH----LNEDGE------LWFA---YEG-- 1143

  Fly  1044 PEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLD-PDAFLKQK------------- 1094
                            :.|.|..|..:|...|:..|.::.||: ....|.|:
Mouse  1144 ----------------LKKATRVLESHFQSQKDCYEKEIEGLNFKVVHLSQEINHLQKLFREETD 1192

  Fly  1095 -PRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSR----------PTSNL----- 1143
             ..||||::..||  .:|.:..|.::::.:.|......:|.|:.:          |.|:|
Mouse  1193 INESIRHEVTRLT--SENMMIPDFKQQISELERQKQDLESRLKEQAEKIEGKLEEPFSHLNRIRE 1255

  Fly  1144 -EKLHFIIGHGILRA-ELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRA 1206
             |::.....|..||| |.:.|::.:..::|                   ||......:.:.:
Mouse  1256 EERMQGRAPHPFLRAVEAQSEMHPEGKERL-------------------VGAIHEPHEAIKF--- 1298

  Fly  1207 FIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLP---ITFMDGNTKTLLADS 1268
                  |...|..||.::...     .|..|.|.|:....::.:.:.   |..:....|||   :
Mouse  1299 ------PKKQPEAEEEVESIL-----QQEASRLSLEKRDLEEELDMKDRMIRRLQDQVKTL---T 1349

  Fly  1269 ATT-----------ARELCNQLSDK------------ISLKDQF-------GFSLYIALFDKVSS 1303
            .||           :||....|..|            :.||.:.       |...:| ||..|..
Mouse  1350 KTTEKANHVHLPSGSREYLGMLEYKKEDEGKLIQNLILDLKPRGVVVNMIPGLPAHI-LFMCVRY 1413

  Fly  1304 LGSGGDHVM------DAISQCEQYAKEQGAQ-ERNAPW-----------RLFFRKEIFAPWHEPT 1350
            ..|..|..|      .||:..:...||.... |..:.|           :.:..:|.|..::.|.
Mouse  1414 ADSLNDANMLKSLMNSAINGIKHVVKEHFEDLEMLSFWLSNTCHFLNCLKQYSGEEEFMKYNSPQ 1478

  Fly  1351 HDQVATNLI----YQQVVRGVK---FGEYRCDKEEDLAMIAAQQYFIEY---------------- 1392
            .::...|..    |:|::..|.   :.::....|.:|..|.... .:||
Mouse  1479 QNKNCLNNFDLTEYRQILSDVAIRIYHQFIIVMENNLQPIIVPG-MLEYESLQGISGLKPTGFRK 1542

  Fly  1393 ------STD-MSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIA--PLKIK 1448
                  .|| .:|..:...|..|....|.:|:|..|.|      ||.|:.:|:...:.  .|.::
Mouse  1543 RSSSIDDTDAYTMTSILQQLSYFYSTMCQNGLDPEIVR------QAVKQLFYLVGAVTLNSLLLR 1601

  Fly  1449 EDIVSYAK 1456
            :|:.|..|
Mouse  1602 KDMCSCRK 1609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	294/701 (42%)
		MYSc_Myo7	77..721	CDD:276832	286/676 (42%)
		MyTH4	<1138..1245	CDD:214535	21/123 (17%)
		B41	1251..1467	CDD:214604	56/289 (19%)
		FERM_B-lobe	1355..1439	CDD:271216	23/113 (20%)
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo5c	XP_006510998.1	MYSc_Myo5	81..741	CDD:276831	286/676 (42%)
		DUF3584	<767..>1043	CDD:378817	71/299 (24%)
		SMC_prok_A	<922..1276	CDD:274009	67/393 (17%)
		ERM	1220..>1354	CDD:366293	30/169 (18%)
		Myo5c_CBD	1376..1743	CDD:271260	46/242 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810