DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and hum-4

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_001359540.1 Gene:hum-4 / 181335 WormBaseID:WBGene00002037 Length:2577 Species:Caenorhabditis elegans


Alignment Length:2750 Identity:559/2750 - (20%)
Similarity:982/2750 - (35%) Gaps:867/2750 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 VEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELP 129
            ::::|.|.|..||||.:||..|:|:.:.||...::||.||.:....  :.||:........|   
 Worm     1 MDNLIELPDQSEAGIAQNLHERFKKGVTYTKASNVLVFVNDFNDKD--SEDQLSWETSSTSG--- 60

  Fly   130 PHIFAIGDNAYAHMKRYRQD-QCIVISGESGAGKTESTKLILQYLAA-----ISGKHSWIEQQIL 188
              :.|:..||...:.....: :.||..||||:||:.:.....:||.:     :|.|||    ..:
 Worm    61 --VNAVAKNALNKIFNMSSNAESIVFGGESGSGKSYNVFKAFKYLTSQPKSKVSTKHS----SSI 119

  Fly   189 EANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYL-LEKSRIVSQNHSERNYHV 252
            |.  :.::||.|||::||.::|||..||:.:..| |:.|..::..: ||..|::||...|||:::
 Worm   120 EF--VFKSFGCAKTLKNDEATRFGCSIDLLYKRN-VLTGLNLKYTVPLEVPRVISQKPGERNFNI 181

  Fly   253 FYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEG-RDDAAEFSDIRSAMKVLLFSDQEIWEI 316
            ||.:..|||.:.|::..:.....:.|:..|||  .|. :.|...|..:.||:.||.|||.....|
 Worm   182 FYEVYHGLSDEMKAKFGIKGLQKFFYINQGNS--SENIQHDVNRFKHLESALHVLGFSDDHCMSI 244

  Fly   317 IKLLAALLHCGNIKYKATVVDNL--DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            .|:::.:||.|||.::.....|:  |..||.....::.:|.||.:....|:     :.|....|.
 Worm   245 YKIISTILHIGNIYFRTKRNPNVEQDVVEIGNLAELKWIAFLLEVDFDQLV-----KFLLPTSED 304

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFE 444
             .||:..:.::|.||:|...||..:|..::.:|...:.....|  ..|.:||.:|||.::.|..|
 Worm   305 -GSTIELNAALDNRDSFAMMIYEELFKWVLNRIGLQLKCSLHT--GVISILDHYGFEKYNNNGVE 366

  Fly   445 QFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-----VDNQDALDLIAIKQLNIMALI 504
            :|.||..||.::..||:|.|..:..:|..:.|:   :::     ::|...::|:..|...:::|:
 Worm   367 EFLINSVNERIENLFVKHCFHDQLIDYAKDGIS---VDYKVPNSIENGKTVELLFKKPYGLLSLL 428

  Fly   505 DEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSP 569
            .:|.:|||||.:|.|...:..|.....|.|.::.....||:.|..|..:|:...|..:|:...|.
 Worm   429 TDECKFPKGTHETYLEHCNLNHTDRSAYGKARNKERLEFGVRHCIGTTWYNVTDFFARNKRIISL 493

  Fly   570 DLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNE 634
            ..:.|:..|.|..:..:|.   ..|..|.....:.:....:....:...::.....|:||||.|.
 Worm   494 SAVQLMRNSKNPIIGLLFE---SYGGNTSDIIVSQAQFVLRGAQDIADKINVSHVHFVRCIKSNN 555

  Fly   635 LKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATS 699
            .::...||..|..||::...:.|.:..|..|||::.....|..:||.|:||    ....||....
 Worm   556 ERQSTKFDIPLVNRQIKNLLLAELLSFRVKGYPVKISKTTFARQYRCLLPG----DIAQCQNEKE 616

  Fly   700 RICAVVLG-----KSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKI-----LILQRSIRGWVYRR 754
            .|..::.|     :.|:::|...|||::.     ..||...|..||     :|:|::::.:|.::
 Worm   617 IIQDILQGQGVKYEDDFKIGTEYVFLRER-----LAERYDGLQNKICGDAAIIIQKNMKSFVAQK 676

  Fly   755 RFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRL--QALIRSRVLSHRFRHLRGHIVG-LQAHA 816
            .:.|:|||.|.:|...:|:..|:.|...|....:.  :.:.|::.|....:.|.....| ||...
 Worm   677 VYKRMRAAIIKLQSGLRGWKARRDYIIKREEMFKAIGRTMKRNKRLDAYHQALGTENSGQLQQTL 741

  Fly   817 RGYLVRREYGHKM----------------WAVIKIQSHVRRMIAMRRYRKLRLEHKQFAE----- 860
            .||:...|...|.                :..:.:::.:..|      ..:.||  ||||     
 Worm   742 VGYIDINEDAKKFLERPTSDSDATETLTHYLTVPMKNFLSNM------NSITLE--QFAEENFKG 798

  Fly   861 -VLQLRKLE-EQELLHRGNKHAREIAEQHY-------------RDRLHELERREIQEQLENR-RR 909
             :|:.|:.. ....||:.:.:...::.:.:             :.:..:|.|..:|:.:.|. :|
 Worm   799 HLLEPRREPIMTPFLHKESDYDFRLSVEIFKLILKYMNDIKLTKKQREDLGRYIVQQGISNPCQR 863

  Fly   910 VEVNMNIINDAARKQEEPVDDG--KLVEAMFDFLPDSSSDAPTPHG--GRE-------------- 956
            .|:.:..||...:.|::...|.  |||.......|.:.:..|...|  .:|              
 Worm   864 DEILVQTINQINKNQDKTASDNGWKLVHMAISVFPPTENIIPMLIGFFNKESVPMKEQLFATLQR 928

  Fly   957 ------TSVFNDLPHAQ--------------NVN-QDDIIAPIHIS--EDEEDLSEFKFQK---- 994
                  :.:..:||.:.              .:| .|.:...:|:|  ....:::|...::    
 Worm   929 RLKIYDSEIARELPPSNLELIATPNIPNTVAEINCYDGLCCDVHLSPWSTTSEIAERILKQRGVG 993

  Fly   995 ---------------FAAT--YF-----------------QGNV--NHQYAKKALKHPLLPLH-T 1022
                           ||.|  :|                 |.|:  |....|...|.|::|.. .
 Worm   994 IALGWTVEVETPNRVFAPTGNHFIHDVFSQIEGANMDSENQQNIFFNFPPEKLVKKPPVVPKEVV 1058

  Fly  1023 QGDQLAAQALWITILRFTGDMPEPK------------------YHTMDRMDTTSVMSKVTATLGR 1069
            |..::.:|....||.:.....|.|:                  :...|.....|::.:.....|.
 Worm  1059 QEQEIVSQNTNGTIPKAARTYPTPEEWINQPPQRTESRNTPRDHQKPDEESDESLVREYNEEAGY 1123

  Fly  1070 NF------------IRSKEFQEAQLMGLDPDAFLKQKPRSIR---------------HKLVSLTL 1107
            .:            :...|..|::  ..|.||..:....::|               |.|.|..|
 Worm  1124 AYTLPRKNKPAPQAVEDNETSESE--EDDEDAANRVGYETVRPEENMKMMETIQDHSHILKSPVL 1186

  Fly  1108 KRKNKLGEDVRRRLQDDEYTADSYQ-----SWLQSRP---------TSN---------------- 1142
            .||.     ..|..|.:|||..::.     ::.|..|         ||:                
 Worm  1187 PRKT-----YSRNEQHEEYTPMNFAPPPTFTYPQQMPMMQYVPVMMTSSMMTPSMMTPSMMPGQQ 1246

  Fly  1143 --------LEKLHFII------------------------------------GHGILRA------ 1157
                    :.:.||..                                    |||..|:      
 Worm  1247 IAMVPQQMMMQPHFSYVPQYPQIPQYCPPEPILSPQSVRSEVPPMMAPVMHDGHGSTRSRDYRIM 1311

  Fly  1158 -------------------------ELRDEIYCQI------------CKQLTN------------ 1173
                                     :..|.::.|:            ..||.|            
 Worm  1312 KRGEVPSQYSTIRNMPVPEHGKDVDQFLDAVFDQVLSKDEQRAAHFNSNQLANTIKGGKLRPEGY 1376

  Fly  1174 -----------------------NPLKS-------------------SHARG------------- 1183
                                   :||:|                   .|:|.             
 Worm  1377 YEPPVQTYSPVPPRYPTLRRVDDSPLRSRAKSLPRIISPRHEHFVRRPHSRNSYSNESTSSDDQM 1441

  Fly  1184 ----------------------------------------WILLSLCVG---------------- 1192
                                                    .||||....                
 Worm  1442 NYRTRSRERSLPRFHSNNGYNYDPSQPVYMMPVQMNGHGEMILLSPVASEHKAQSRHRTHDRSHR 1506

  Fly  1193 CFAPS--EKFV-------------------------NYLRAFIREGPPGYA-------------- 1216
            ...||  |:::                         .|:|..:.:.|.|..              
 Worm  1507 HHVPSGVERYMAKRSPSVDILKPPMSRRTPDAMVEQTYVRPHLAQSPVGRQTSRFEEFSALPRGD 1571

  Fly  1217 ---------PYCEERLKRT--FNNGTRNQPP-------------------------SWLE--LQA 1243
                     |....::.|.  :.||....||                         |:.|  ::.
 Worm  1572 SRARERMENPLLARQIPRAYPYQNGNVVPPPPSSYRAPSPAPTSGDRRGLNRLPQESYTEPAVKN 1636

  Fly  1244 TKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKI------------------------- 1283
            ||:....:.|..|.....|.::.....||:...|.|||::                         
 Worm  1637 TKNNSEYLSPHRFNLDEQKAVIRHEKETAKNAINMLSDRLRKLPPPVDNVRLIRPITPAQPPITQ 1701

  Fly  1284 --------------------------SLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCE--- 1319
                                      .:::::      .:.|.|.         .|.::|..   
 Worm  1702 SPVPSEPVVVRTPSPVPQPTPPPPPPPVREEW------VIRDSVE---------RDPVTQGRIRG 1751

  Fly  1320 ---------------QYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKF 1369
                           ..|::...:...|||:|..|||:|.| .|..:|....:.::.|:|...|.
 Worm  1752 SFRKEPLVPQPPRPPVVAEKPAVKFVKAPWKLTIRKEMFYP-GEVLNDIQIIDQVFAQIVEDCKK 1815

  Fly  1370 G-EYRCDKEEDLAMI--AAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQA 1431
            . .||. :|:|...:  ..:||.|..| |::.:      .|..||                    
 Worm  1816 SYPYRI-REQDRKQVETVLRQYEIPPS-DLNNQ------SNIHPD-------------------- 1852

  Fly  1432 YKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDV--IIAVNWTGVYVV 1494
                           :|..::..|:. |||.|::.||.....    |...|  |.|::..|:.::
 Worm  1853 ---------------VKVAVIELARL-WPLYFNQVYEVVEKR----PDESVSTIFAISEHGIRLI 1897

  Fly  1495 -----DDQEQVLLELSFP-EITAVSSQKTNKVFT-------QTFSLSTVRGEEFTFQSPNAEDIR 1546
                 |.:..:.::..|| |..|..|.:.|.:.:       :..:.|.||.:  |.|:|..:...
 Worm  1898 VHTPHDLENPLKIQDFFPFETIADVSLEANDILSVHVRHEDEENAYSAVRIK--TNQAPQIKKTL 1960

  Fly  1547 DLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDR- 1610
            |..:  ..|:..:.|:|.||:||  .:...:.|||.:||:|.|..|..||:.....|..|:.:. 
 Worm  1961 DRCL--SGGVVPKRKFVRALEDY--VTSEVNHLSFKQGDVIELLQEPEGETPPVGNWLYGKIENR 2021

  Fly  1611 ----------SQERGDFPA---ETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPR 1662
                      |.:..:.|.   ||       |:...:.:..|:.|......|             
 Worm  2022 FGFLLAQYVDSTDGDNVPPIRHET-------SEDRDERVRFFDDEVPFSSER------------- 2066

  Fly  1663 DRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELW---------RYSRDPIKAPLLRKLQSKE 1718
               :|::::|..:||.|           ..|:.:|.|         |:|..||...||..|.::|
 Worm  2067 ---YTMIDFATKYFRKP-----------KDKKKQETWAWEDISQIVRFSEKPISQSLLADLGNEE 2117

  Fly  1719 -EFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPL---KHEILRDEIYCQLMKQLTDNR 1779
             ::|.|   .|.||:|:|||.|.|:   ...:||.:|...|   :...||||:||||:||.|.|.
 Worm  2118 SKYAVE---TFHAIMKFMGDEPLKK---SESMTDVVFKVLLICHRQPTLRDEVYCQLIKQTTSNI 2176

  Fly  1780 NRM--SEERGWELMWLATGLFACSQGLLKELLLFLRTRR-------HPISQDSMHRLQKTIRHGQ 1835
            ::.  |..|.|.|:.:.|..|..|..|...:|.:|....       |..::.....:.:|.::|.
 Worm  2177 SQKPNSALRAWRLLTIITAYFPSSLTLKPYVLQYLGDNADEWQRPFHGTARICQTNMIQTFKYGG 2241

  Fly  1836 RKYPPHQVEVEAI---------------QHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNIS 1885
            ||...:.:||:.|               .|..:|....:...::           ..::.||.::
 Worm  2242 RKVLLNALEVQQITDGCQLRRQAFYISKDHNVSQTLRPITVAEE-----------MIQELCNLLN 2295

  Fly  1886 QRLSLRTSEGFSLFVKIA-DKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKK 1949
            .| ||...:.|||...:. ||.::..:.|      .:|.|.|.::.      :.:..:|.:..:.
 Worm  2296 VR-SLHEQQEFSLCYTVGKDKHLNYCKND------NYLMDIITESE------HKKLPFQFYLKRT 2347

  Fly  1950 LWTNTVPGKDRNADLI-FHYHQELPKLLRG----------YHKCSREEAAKLAALVFRVRFGENK 2003
            :|.:  |.:..||..| ..:.|.:...|||          ....:.||..||||.:| :...:|.
 Worm  2348 VWVH--PLRYDNAAYIDSMFDQVIDDYLRGSLISTNSLGQLTAATTEEIIKLAAYLF-LLLPDNP 2409

  Fly  2004 QELQAIPQMLRELIPSDIM--KIQSTSEWKRSIVASYNQDGG-MTSEDAKVAFLKIVYRWPTFGS 2065
            :.|.|  :.|.:::|..::  |.:...|....|.......|| |...:||..||:::..|||||.
 Worm  2410 KGLNA--KTLPQIVPKSVIEPKHRHQEEMVTRISRQLKMFGGRMRPAEAKSHFLELLSTWPTFGV 2472

  Fly  2066 AFFEVKQTTEPNY--PEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNWSSGNTYFHMTIGNLV 2128
            ..:.:|...|..:  ||::| .|||.|:.|:.|.:|::.....:.:|.:..|    ...|...:|
 Worm  2473 LHYRLKSVVENGHQLPEVIL-TINKSGIQLLQPKSKEVFKERNYDQIVSVES----IRKTAYKIV 2532

  Fly  2129 RGSKLLCETSLGYKMDDLLT 2148
            |   |:..|..|.:..|:.|
 Worm  2533 R---LVINTMQGEETLDIKT 2549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 189/687 (28%)
MYSc_Myo7 77..721 CDD:276832 183/663 (28%)
MyTH4 <1138..1245 CDD:214535 38/420 (9%)
B41 1251..1467 CDD:214604 46/287 (16%)
FERM_B-lobe 1355..1439 CDD:271216 15/86 (17%)
FERM_C1_MyoVII 1461..1559 CDD:270019 24/112 (21%)
SH3 1560..1624 CDD:302595 22/77 (29%)
MyTH4 1701..1849 CDD:214535 52/175 (30%)
B41 1856..2068 CDD:214604 51/226 (23%)
FERM_M 1966..2068 CDD:278785 31/114 (27%)
FERM_C2_MyoVII 2064..2159 CDD:270020 22/86 (26%)
hum-4NP_001359540.1 MYSc_Myo12 13..643 CDD:276841 183/663 (28%)
IQ 680..701 CDD:197470 8/20 (40%)
MyTH4 803..952 CDD:214535 22/148 (15%)
PRK10263 <1162..>1357 CDD:236669 24/199 (12%)
SH3 1974..2030 CDD:388381 17/57 (30%)
MyTH4 2100..2255 CDD:214535 51/160 (32%)
B41 2262..2475 CDD:214604 53/241 (22%)
PH-like 2489..2563 CDD:388408 18/68 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.