DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myo5a

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_006510890.1	Gene:	Myo5a / 17918	MGIID:	105976	Length:	1880	Species:	Mus musculus

Alignment Length:	1704	Identity:	491/1704 - (28%)
Similarity:	758/1704 - (44%)	Gaps:	354/1704 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DGDEVWLA--------PERRIKAMHASS-----------------------VQGVEDMISLGDLH 75
            |.:|||.:        |..::..:|...                       :.|..|:.:|..||
Mouse    17 DPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYRLDPKTGELPHLRNPDILVGENDLTALSYLH 81

  Fly    76 EAGILRNLLIRYKEN-LIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNA 139
            |..:|.||.:|:.:: |||||.|.:|||:|||:.||||..|.|..|..:.:|::.|||||:.:.|
Mouse    82 EPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEA 146

  Fly   140 YAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW--IEQQILEANPILEAFGNAKT 202
            |..|.|..::|.|::|||||||||.|.|..::|.|.:||..|.  :|:::|.:|||:|:.|||||
Mouse   147 YKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKT 211

  Fly   203 IRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSR 267
            .||||||||||||:|.|.....|.||.:..|||||||:|.|...|||||:||.:.|.....|...
Mouse   212 TRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKM 276

  Fly   268 LDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYK 332
            |.||.|..:.|...|.|...||.|||.|.:..|.|..:|..|:.....|.::||.:||.||:.:.
Mouse   277 LRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFA 341

  Fly   333 ATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFV 397
            :.  |:...|..|:|..:.....|:|:..:.:...|..|.|....||.:..:|:.|:.:.|||..
Mouse   342 SR--DSDSCTIPPKHEPLTIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALA 404

  Fly   398 KGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQH 462
            |.||.::|..||..:|.|:.. .....:.||||||:|||.|:.|||||||||||||.|||.|..|
Mouse   405 KHIYAKLFNWIVDHVNQALHS-AVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMH 468

  Fly   463 IFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTH- 526
            :||||||||..|.|.|..|:|.|||..::||..| |.|:.|:|||.:.|||||.|...||:.||
Mouse   469 VFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESK-LGILDLLDEECKMPKGTDDTWAQKLYNTHL 532

  Fly   527 GSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDI 591
            .....:.||:.. |.:|.:.|||..|.|...|||:||:||...:.:.::..|..|.|.::|..|.
Mouse   533 NKCALFEKPRMS-NKAFIIKHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDE 596

  Fly   592 E----MGAETRKRTP----------------------TLSTQFRKSLDALMKTLSSCQPFFIRCI 630
            :    ..|.:..|||                      |:..|||.||..||:||::..|.::|||
Mouse   597 KAISPTSATSSGRTPLTRVPVKPTKGRPGQTAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCI 661

  Fly   631 KPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI--PGVPPAHRTD 693
            |||:.|.|..||.....:|||..|::|||||..||:|.|..::||..|||.|:  ..|....:..
Mouse   662 KPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLGDRKQT 726

  Fly   694 CQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLR 758
            |:....::   :|.|..||.|.||:|.:.....:||:.|...|....:.:|::||||:.|:|:|.
Mouse   727 CKNVLEKL---ILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKRYLC 788

  Fly   759 LRAAAITVQR-------------------------FWKGYAQRKRYRNMRVGYMRLQALIRSRVL 798
            ::.|||||||                         :|:.|..|:||:..|...:.:|:.:|..:.
Mouse   789 MQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRMYVVRRRYKIRRAATIVIQSYLRGYLT 853

  Fly   799 SHRFRH-LRGH-IVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEV 861
            .:|:|. ||.: .|.:|...||:|.|..|...|.|::.:|...|||:|.|..:||::|
Mouse   854 RNRYRKILREYKAVIIQKRVRGWLARTHYKRTMKAIVYLQCCFRRMMAKRELKKLKIE------- 911

  Fly   862 LQLRKLEEQELLHRGNKH-----AREIAEQH--YRDRLHELERRE--IQEQLENRRRVEVNMNII 917
              .|.:|..:.||.|.::     .|::.||:  |:..:.:|...|  ...:.|..|
Mouse   912 --ARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLR--------- 965

  Fly   918 NDAAR----KQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQD-DIIAP 977
            ||..|    ::|..|..|:::....:.                ..:..||...::..:. :..|.
Mouse   966 NDVERLQLSEEEAKVATGRVLSLQEEI----------------AKLRKDLEQTRSEKKSIEERAD 1014

  Fly   978 IHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKA------LKHPL------LPLHTQGDQLAAQ 1030
            .:..|.::.:|..|.:.......:..:||:..::|      ::..|      |.|....::|..|
Mouse  1015 KYKQETDQLVSNLKEENTLLKQEKETLNHRIVEQAKEMTETMERKLVEETKQLELDLNDERLRYQ 1079

  Fly  1031 ALWITILRFTG-------------DMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQE--- 1079
            .|.....|...             ::|:|.:   .|.|:|...::...|....|..:::...
Mouse  1080 NLLNEFSRLEERYDDLKEEMTLMLNVPKPGH---KRTDSTHSSNESEYTFSSEFAETEDIAPRTE 1141

  Fly  1080 ---AQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTS 1141
               .:.:.||...|||.:.|...       |:::.:|.:|...|.::..:.:.:.:   :.||..
Mouse  1142 EPIEKKVPLDMSLFLKLQKRVTE-------LEQEKQLMQDELDRKEEQVFRSKAKE---EERPQI 1196

  Fly  1142 NLEKLHFIIGHGILRAELRDEIYCQICKQLTN--NPLKSSHARGWILLSLCVGCFAPSEKFVNYL 1204
            ...:|.:   ..:.|.||..|     .|:|.|  |.|:.                |.|||....:
Mouse  1197 RGAELEY---ESLKRQELESE-----NKKLKNELNELRK----------------ALSEKSAPEV 1237

  Fly  1205 RAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSA 1269
            .|   .|.|.|....|:....:.....|.:....|..|....|:.|. |..  |.||.|    .:
Mouse  1238 TA---PGAPAYRVLMEQLTSVSEELDVRKEEVLILRSQLVSQKEAIQ-PKD--DKNTMT----DS 1292

  Fly  1270 TTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDH-----------VMDAISQCEQYAK 1323
            |...|...::.||..:.     ..||.|  |.::..|..|:           |.:.:.|..:..:
Mouse  1293 TILLEDVQKMKDKGEIA-----QAYIGL--KETNRSSTMDYQELNEDGELWMVYEGLKQANRLLE 1350

  Fly  1324 EQ-GAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEED--LAMIAA 1385
            .| .:|:|                   :|:..|      :.:|    ||.:..|||:  ...:.|
Mouse  1351 SQLQSQKR-------------------SHENEA------EALR----GEIQSLKEENNRQQQLLA 1386

  Fly  1386 QQYFI--EYSTDMSMERLFTLLPN---FIPDFCLSGVDKAIERWAALVLQAYKKSYYVK------ 1439
            |...:  |...:.|::...|.|.|   :..:.......|         .|:|:.|.|.:
Mouse  1387 QNLQLPPEARIEASLQHEITRLTNENLYFEELYADDPKK---------YQSYRISLYKRMIDLME 1442

  Fly  1440 -----DKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGP-----------NLPKNDVIIAVNW 1488
                 ||.. .|:|:.:..:||....|...:.    .|..|           |:|:.:    .::
Mouse  1443 QLEKQDKTV-RKLKKQLKVFAKKIGELEVGQM----ENISPGQIIDEPIRPVNIPRKE----KDF 1498

  Fly  1489 TGV--YVVDDQEQ----VLLELSFPEITAVS----------------------SQKTNKVFTQTF 1525
            .|:  |..:|:::    ::|||. |...||:                      .||...:.|.|.
Mouse  1499 QGMLEYKREDEQKLVKNLILELK-PRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTI 1562

  Fly  1526 -SLSTV---RGEEF 1535
             |:..|   ||::|
Mouse  1563 NSIKKVLKKRGDDF 1576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	291/700 (42%)
		MYSc_Myo7	77..721	CDD:276832	283/675 (42%)
		MyTH4	<1138..1245	CDD:214535	24/108 (22%)
		B41	1251..1467	CDD:214604	47/245 (19%)
		FERM_B-lobe	1355..1439	CDD:271216	19/90 (21%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	23/118 (19%)
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo5a	XP_006510890.1	COG5022	7..1448	CDD:227355	462/1564 (30%)
		MYSc_Myo5	83..751	CDD:276831	283/675 (42%)
		Myo5a_CBD	1506..1880	CDD:271262	16/72 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810