DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myo1b

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_006495827.1	Gene:	Myo1b / 17912	MGIID:	107752	Length:	1138	Species:	Mus musculus

Alignment Length:	1069	Identity:	346/1069 - (32%)
Similarity:	556/1069 - (52%)	Gaps:	139/1069 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIK 118
            :|:....::.||.||:.|..|:|...:.||..|:..|.||||.||::::||||:.||||:.::::
Mouse     6 VKSSLLDNMIGVGDMVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVE 70

  Fly   119 LYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWI 183
            .|:.|...||.|||||:.|.||..::...:||||:|:|||||||||::||::.|:||:.||.:.:
Mouse    71 DYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEV 135

  Fly   184 EQ---QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNH 245
            .|   |:|::||:|||||||||:|||||||||||:||.|...|...|..|..|||||||:|.|..
Mouse   136 NQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPR 200

  Fly   246 SERNYHVFYCILAGLSADEKSRLDLGMAAD---YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLL 307
            .|||:||||.:|:|  |.|:....|.:..|   |.||: .:|....|.||||.|..:|:||:::.
Mouse   201 GERNFHVFYQLLSG--ASEELLYKLKLERDFSRYNYLS-LDSAKVNGVDDAANFRTVRNAMQIVG 262

  Fly   308 FSDQEIWEIIKLLAALLHCGNIKYK-ATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRR 371
            |.|.|...:::::||:|..|||::| .:.|:.||.::|.:...::.:..|..:....|..|.:.|
Mouse   263 FLDHEAEAVLEVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTSIDQVVLERAFSFR 327

  Fly   372 TLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFE 436
            |:.|..|.|.:||:..|:...|||..|.:|.|:|..:|.:||.:|.......:..:|||||:|||
Mouse   328 TVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFE 392

  Fly   437 NFD--QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLN 499
            .|:  .||||||.|||.||.|||.|::...|.|||||..|.|.|.||::.:|....|||......
Mouse   393 IFENADNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNG 457

  Fly   500 IMALIDEEARFP-KGTDQTMLAKLHKTHGSHKN----------YLKPKSDINTSFGLNHFAGVVF 553
            |:|::|||...| ..||:|.|.||::...:|::          :|...:..::.|.:.|:||.|.
Mouse   458 ILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVL 522

  Fly   554 YDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETR---KRTPTLSTQFRKSLDAL 615
            |...||:|||.|....||...:.::.:..::.:|.:    |...:   ||.||..:||:.|:..|
Mouse   523 YQVEGFVDKNNDLLYRDLSQAMWKAGHSLIKSLFPE----GNPAKVNLKRPPTAGSQFKASVATL 583

  Fly   616 MKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYR 680
            |:.|.:..|.:|||||||:.|...:|:..|.|.|:||.|::|.:|:|||||..|..:...:|||:
Mouse   584 MRNLQTKNPNYIRCIKPNDKKAAHIFNESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYK 648

  Fly   681 FLIPGVPPAHRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLF-LEQERDRVLTRKILIL 743
            .|.....|..:...::....:. .:.:...::..|.:|:|:::...|| ||..|.:.|.....::
Mouse   649 MLCKQTWPHWKGPARSGVEVLFNELEIPVEEHSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLI 713

  Fly   744 QRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHR 801
            |:..|||..|..||.::.:.:.:..:::.|||:|||:.::...:.:|:.||.       |.|.|:
Mouse   714 QKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQ 778

  Fly   802 FRHLRGHIVGLQAHARGYLVRREY---------GHKM------WAVIKIQSHVRRM--IAMRRYR 849
             :..:.....:.|:..|...|||.         .|.:      |...|.:..::|:  .|.|::.
Mouse   779 -KRCKEAATTIAAYWHGTQARRELRRLKDEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHA 842

  Fly   850 -----------KLRLEHKQFAEV--------LQLRKLEEQELLHRGNK----------------- 878
                       |:|.|:::|...        ..|:::.::.||...||
Mouse   843 VAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPYL 907

  Fly   879 -----HAREIAE-------QHYRDRLHELERREIQEQLE--------------------NRRRVE 911
                 | :|:..       :.|||:..:.::...:|:||                    ....:|
Mouse   908 FLDSTH-KELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLE 971

  Fly   912 VNMN----IINDAARKQ---EEPVD-----DGKLVEAMFDFLPDSSSDAPTPHGGRETSV-FNDL 963
            :|.|    .:.||..::   .|.|:     :||....:|....::...|....|..::.| ..|:
Mouse   972 INKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDV 1036

  Fly   964 PHAQNVNQDDIIAPIHISEDEEDLSEFKF 992
            ......:|:|....:|:.|..|..|:..|
Mouse  1037 TKVSMSSQNDGFFAVHLKEGSEAASKGDF 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	275/693 (40%)
		MYSc_Myo7	77..721	CDD:276832	264/667 (40%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo1b	XP_006495827.1	MYSc_Myo1	29..690	CDD:276829	264/667 (40%)
		IQ	751..773	CDD:197470	3/21 (14%)
		Myosin_TH1	943..1120	CDD:368706	23/123 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910