DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myo15

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_034992.2 Gene:Myo15 / 17910 MGIID:1261811 Length:3511 Species:Mus musculus


Alignment Length:2587 Identity:660/2587 - (25%)
Similarity:1033/2587 - (39%) Gaps:750/2587 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 PERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTG 114
            |..|.:..|..  .|||||..|.||.|..:|.||..|::.||||||.|||||:||||::..||..
Mouse  1195 PSMRSREQHRE--DGVEDMTQLEDLQETTVLANLKTRFERNLIYTYIGSILVSVNPYRMFAIYGP 1257

  Fly   115 DQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGK 179
            :|::.|..|.:||.|||:|||.:.|:|.|...:|:||::||||||:||||:|||||:.|||::.:
Mouse  1258 EQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLILRCLAAMNQR 1322

  Fly   180 HSWIEQ-QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQ 243
            ...::| :||||.|:|||||||||:||||||||||:::| |...|||.||...||||||||||.|
Mouse  1323 RDVMQQIKILEATPLLEAFGNAKTVRNDNSSRFGKFVEI-FLEGGVICGAITSQYLLEKSRIVFQ 1386

  Fly   244 NHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308
            ..:|||||:||.:||||.|..:....|..|..|.||..|.:....|:.||.:|..:.:||:||.|
Mouse  1387 AKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGF 1451

  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373
            :.::...|.::||::||.||:.::....|..:...:.....::.||.||.:..:.|..|:|.:..
Mouse  1452 TSEDQDSIFRILASILHLGNVYFEKHETDAQEVASVVSAREIQAVAELLQVSPEGLQKAITFKVT 1516

  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENF 438
            ....|.:.:.|:.:.:||.|||..|.:|..:|..::.::|..:...:.|.  :|.:|||:|||:.
Mouse  1517 ETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPKQDTL--SIAILDIYGFEDL 1579

  Fly   439 DQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMAL 503
            ..|||||.||||||||||..|.:.:|:.|||||..|.::|:.|.|.|||..::||::|...|:.:
Mouse  1580 SFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQPCINLISLKPYGILRI 1644

  Fly   504 IDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFS 568
            :|::..||:.||.|.|.|.|..||::..|.|||..: ..|.:.|:||.|.|....|||||.|...
Mouse  1645 LDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPL-PEFTIKHYAGKVTYQVHKFLDKNHDQVR 1708

  Fly   569 PDLLHLVSQSTNKFLRQIFAQDIEMGAETR----------KRTPTLSTQFRKSLDALMKTLSSCQ 623
            .|:|.|...|..:.:..:|:......|..|          .:..|::.:|::||..|::.:..|.
Mouse  1709 QDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYKAHTVAAKFQQSLLDLVEKMERCN 1773

  Fly   624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP---G 685
            |.|:||:|||..|:|.:|:..:...||||||::||:|||:.|:|:|..|:.|::|||.|:.   .
Mouse  1774 PLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVALKLN 1838

  Fly   686 VPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGW 750
            | ||....|.:..||:|.|.  ...|::|.:|:|||:.....||..|:||..|..|.|||.:||:
Mouse  1839 V-PADGDMCVSLLSRLCTVT--PDMYRVGISKLFLKEHLHQLLESMRERVQNRAALTLQRYLRGF 1900

  Fly   751 VYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAH 815
            ..:|                                              .||.||..|:.||:.
Mouse  1901 FIQR----------------------------------------------HFRSLRRKIILLQSR 1919

  Fly   816 ARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHA 880
            |||:|.|:.|.....:::|.:|.|...:..|||.|||.|.::.|:...||   |||         
Mouse  1920 ARGFLARQRYQQMRQSLLKFRSLVHTYVNRRRYLKLRAEQRRRAQEAWLR---EQE--------- 1972

  Fly   881 REIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSS 945
                         ||.:||:         |.|         |..|.|.:...|::|        :
Mouse  1973 -------------ELSKREV---------VPV---------RHLEVPAEVAGLLQA--------A 1998

  Fly   946 SDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAK 1010
            :......|.|...|  ..|..|  .:..:..|:       |::.:...||...:|: ..:.....
Mouse  1999 AGLKLSSGPRVAVV--RAPRLQ--AEPCVTLPL-------DINNYPMAKFIRCHFK-EPSFGMLT 2051

  Fly  1011 KALKHPL--LPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIR 1073
            ..||.||  ||:....:.::...|   ||||.||   |..|....|                   
Mouse  2052 VPLKMPLTRLPVEHHAEAISVFKL---ILRFMGD---PHLHGTQEM------------------- 2091

  Fly  1074 SKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSR 1138
                    ::|                                                      
Mouse  2092 --------ILG------------------------------------------------------ 2094

  Fly  1139 PTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNY 1203
                    ::|:..|::...|||||..|:..|:..||...:..|||:||:.|:..||||.....:
Mouse  2095 --------NYIVHQGLVEPALRDEILAQLANQVWRNPNAYNSKRGWLLLAACLSGFAPSPHLDKF 2151

  Fly  1204 LRAFIRE-GPPGYAPYCEERLKRTFNNG-TRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLA 1266
            |..|:.: |..|:...|:.||.:...:| .|..||:.||..|.:.|..:.|.::..:|:..:...
Mouse  2152 LLKFVSDYGQNGFQAVCQHRLLQAMGSGAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCPV 2216

  Fly  1267 DSATTARELCNQLSDKISLKDQF-GFSLYIA-------------LFDKVSSL------------- 1304
            .:.:|...:...:.....|.|.: |:::.:.             :.|.||.|             
Mouse  2217 HTWSTGEAVAGDILKHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYF 2281

  Fly  1305 --GSGG-----------------------------DHVM---DAISQCEQYAKEQGAQERNAPWR 1335
              |:.|                             |||.   |....|..  ||.|........|
Mouse  2282 IVGAEGPLAGRGDTRGVFGNCWDSDEDTPTRPQPQDHVAKMPDLDGYCSH--KEDGTNGETEAQR 2344

  Fly  1336 LFFRKEIFAPWHEPT-------------HDQV----------ATNLIYQQVVRGVKFGEYRCDKE 1377
            ....::......|.|             .|.|          .|.:.|:....|...|......|
Mouse  2345 WTSNRQAVDSIGESTVPPRELDGYLDSLFDPVLACGDADLEKPTAIAYRMKGGGQPGGGGGSTSE 2409

  Fly  1378 E----------------DLAMIAAQQYFIE-----YSTDMSMERLF-----------------TL 1404
            :                |.:.:|.||.||.     .:.:|:::.|.                 .|
Mouse  2410 DTSRRPPEPKLKPIPGLDASTLALQQAFIHRQAVLLAREMTLQALALQQQPLSATSRPQLPERPL 2474

  Fly  1405 LPNFIP--------------------DFCLSGVDKA-------------IERWAA---------- 1426
            .|...|                    .:....|.||             .:.|.|          
Mouse  2475 APEARPKTVVGTGPPAKPVLVRPTPQSWAPGSVAKAPKIPSKPVAVPILAQDWTAPESISASPEL 2539

  Fly  1427 -------------------LVLQAYKKS------------------------------------- 1435
                               .:::.||:.                                     
Mouse  2540 VRYSTLNSEHFPQPTQQIRSIIKQYKQPPWAGHPEARRTDGGKVFRRPPDPHEEALMILKGQKTQ 2604

  Fly  1436 ----------------------------------------------------------------- 1435
                                                                             
Mouse  2605 LAVVPGTQVSREAVAMVKPVTSAPRPCMGPTPVQPSRSLEPPEDPVQTQLHRLVNPNFYGYQDIP 2669

  Fly  1436 ---------YYVKDKI--------------------APLKIKED--------------------- 1450
                     :|.||..                    |.|:|.||                     
Mouse  2670 WRIFLRKEVFYPKDNYSHPVQLDLLFRQILHDTFSEACLRISEDERLQMKALFAQNQLDTQRPLV 2734

  Fly  1451 -------IVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGV----YVVDDQE-----Q 1499
                   .:|.|:..|.:.|||.:.|..:.|..:.    |:||:.||:    .|...:|     :
Mouse  2735 TESVKRAAISMARDSWEIYFSRLFPAMGSVGTGVQ----ILAVSHTGIKLLQMVKGSKEASRRLR 2795

  Fly  1500 VLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVI 1564
            ||...||.:|..|:....|.:   .|:||   .|:....|..|:.::.||..|:..|||.|.||:
Mouse  2796 VLCAYSFADILFVTMPSQNML---EFNLS---NEKLILFSARAQQVKTLVDTFILELKKDSDYVV 2854

  Fly  1565 ALQDYRAPSDGTSFLSFFKGDLIILED-------ESCGESVLNN--------------GWCIGRC 1608
            |::::.  |:....|||.|||:|.|:.       .|.|..|...              ||..|..
Mouse  2855 AVRNFL--SEDPELLSFHKGDIIHLQSLEPTRVGYSAGCVVRKKLVYLEELRRRGPDFGWRFGAV 2917

  Fly  1609 DRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMAS---------------NGGA 1658
              ....|.||:|.|.  |..:   .|.|.|  ..|...||..::|:               .|..
Mouse  2918 --HGRVGRFPSELVQ--PAAA---PDFLQL--PAEPGRGRAAAVAAAVASAAAAQEVGRRREGPP 2973

  Fly  1659 VEPRDR----------PHTLMEYALDHFRLPPKRTMSKTLTLSSKRS------EELWRYSRDPIK 1707
            |..|..          |.|::|:|..:|| .|:|.....|.|.||..      |::..:::.||:
Mouse  2974 VRARSADSGEDSIALPPSTMLEFAQKYFR-DPRRRPRDGLKLKSKEDRESKTLEDVLCFTKVPIQ 3037

  Fly  1708 APLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLK----HEILRDEIY 1768
            ..|:.  .|.....:.|...|.|::::|||.|.|    |....| :....||    ||::|||.|
Mouse  3038 ESLIE--LSDSNLNKMAVDMFVAVMRFMGDAPLK----GQSELD-VLCTLLKLCGDHEVMRDECY 3095

  Fly  1769 CQLMKQLTDNRNRMSE--ERGWELMWLATGLFACSQGLLKELLLFLR----TRRHP---ISQDSM 1824
            ||::||:|||.:...:  :|||.|:::....::||:.....|:.||:    |...|   |::...
Mouse  3096 CQIVKQITDNSSPKQDSCQRGWRLLYIMAAYYSCSEVFYPYLIRFLQHVSWTPGLPFQGIAKACE 3160

  Fly  1825 HRLQKTIRHGQRKYPPHQVEVEAI---QHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQ 1886
            ..||||:|.|.|...|..:|:.|:   :....|:|   ..|...:...::.:.|.|.|....:..
Mouse  3161 QNLQKTLRFGGRLEFPSNMELRAMLAGRSSKRQLF---LLPGGLERHLKIKTCTVALDVIEGLCT 3222

  Fly  1887 RLSLRTSEGFSLFVKIADKVISVPEGDFFFDFV--------------RHLTDWIKKARPIRDGAN 1937
            .::|...|.|                |.:..||              .::.|...:...:..|  
Mouse  3223 EMALTRPEAF----------------DEYVIFVVTNRGQHVCPLSCRAYILDVASEMEQVDGG-- 3269

  Fly  1938 PQFTYQVFFMKKLWTNTVPGKDRNADLI-FHYHQELPKLLRGYHKC---------SREEAAKLAA 1992
                |.::|.:.||..  |.|..|...: .||:|.||..|:|....         ..::.:|||:
Mouse  3270 ----YTLWFRRVLWDQ--PLKFENELYVTMHYNQVLPDYLKGLFSSVPARQPTEQQLQQVSKLAS 3328

  Fly  1993 LVFRVR---FGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFL 2054
            |..|.:   :..:.:|:|       |.||:.:....:...|...:.....|...::...|:..||
Mouse  3329 LQHRAKDHFYLPSVREVQ-------EYIPAQLYHTTAGDTWLNLVSQHRQQTQALSPHQARAQFL 3386

  Fly  2055 KIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRI-SNW----- 2113
            .::..:|.|||:||.::..:....|...::|:|.:|::.:...|.:::|..|...| |.|     
Mouse  3387 GLLSAFPLFGSSFFFIQSCSNVLVPAPCILAVNHNGLNFLSTKTHELIVKIPLKEIQSTWTQQPT 3451

  Fly  2114 -SSGNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLMLTNMNKNRTI 2164
             :|...|..:::|::.....:..:...|.::..::..::..||:...:..|:
Mouse  3452 ANSSYPYVEISLGDVAAQRTMQLQLEQGLELCRVVAVHVESMLSAREERLTL 3503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 288/682 (42%)
MYSc_Myo7 77..721 CDD:276832 275/657 (42%)
MyTH4 <1138..1245 CDD:214535 35/108 (32%)
B41 1251..1467 CDD:214604 62/558 (11%)
FERM_B-lobe 1355..1439 CDD:271216 24/294 (8%)
FERM_C1_MyoVII 1461..1559 CDD:270019 30/106 (28%)
SH3 1560..1624 CDD:302595 24/84 (29%)
MyTH4 1701..1849 CDD:214535 51/163 (31%)
B41 1856..2068 CDD:214604 46/238 (19%)
FERM_M 1966..2068 CDD:278785 26/113 (23%)
FERM_C2_MyoVII 2064..2159 CDD:270020 20/101 (20%)
Myo15NP_034992.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..690
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..1030
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1135
MYSc 1201..1883 CDD:214580 289/690 (42%)
MYSc_Myo15 1220..1871 CDD:276838 275/657 (42%)
Actin-binding. /evidence=ECO:0000255 1776..1783 4/6 (67%)
FliJ 1870..1960 CDD:280262 38/135 (28%)
Neck or regulatory domain 1872..2013 56/239 (23%)
Tail 2014..3511 315/1660 (19%)
MyTH4 2049..2195 CDD:214535 52/240 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2330..2359 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2392..2425 4/32 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2460..2509 4/48 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2565..2584 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2629..2648 0/18 (0%)
SH3 2852..2931 CDD:302595 23/84 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2964..2984 3/19 (16%)
MyTH4 3031..3185 CDD:214535 51/160 (32%)
B41 3195..3400 CDD:214604 46/238 (19%)
FERM_B-lobe 3290..3390 CDD:271216 22/106 (21%)
FERM_C_MyoXV 3396..3497 CDD:270022 20/100 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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