DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myo10

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_062345.2 Gene:Myo10 / 17909 MGIID:107716 Length:2062 Species:Mus musculus


Alignment Length:2369 Identity:631/2369 - (26%)
Similarity:1029/2369 - (43%) Gaps:551/2369 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 GDYIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPE-----RRIKAMHASSVQGVE 66
            |..:|:. .:|:.|...:.:   .|||  :.|...|..:|:...:     :::.|||....:||:
Mouse     8 GARVWLR-ENGQHFPSTVNS---CAEG--VVVFQTDYGQVFTYKQSTITNQKVTAMHPLHEEGVD 66

  Fly    67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQ-ILPIYTGDQIKLYKERKIGELPP 130
            ||.||.:||...|:.||..|||.|.||||.|||:.:||||| |..:|....::.|....:|||||
Mouse    67 DMASLAELHGGSIMYNLFQRYKRNQIYTYIGSIIASVNPYQPIAGLYERATMEEYSRCHLGELPP 131

  Fly   131 HIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS---------GKHSWIEQQ 186
            |||||.:..|..:.:...:||::|||||||||||||||||::|:.||         .|.|.:||.
Mouse   132 HIFAIANECYRCLWKRHDNQCVLISGESGAGKTESTKLILKFLSVISQQTLDLGLQEKTSSVEQA 196

  Fly   187 ILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYH 251
            ||:::||:||||||||:.|:|||||||::.::....|.|:|.:|..|||||:|:|.||..|||||
Mouse   197 ILQSSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQQGNIQGGRIVDYLLEKNRVVRQNPGERNYH 261

  Fly   252 VFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEI 316
            :||.:||||...|:....|.:..:|.||........:...|...|..:.:||:|:.||.:|:.|:
Mouse   262 IFYALLAGLDQGEREEFYLSLPENYHYLNQSGCTEDKTISDQESFRQVITAMEVMQFSKEEVREV 326

  Fly   317 IKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVV 381
            ::|||.:||.|||::...     ...:||....:.|.|.||||....|.||||:|::...||.::
Mouse   327 LRLLAGILHLGNIEFITA-----GGAQIPFKTALGRSADLLGLDPTQLTDALTQRSMILRGEEIL 386

  Fly   382 STLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI-----FKPRGTSRNAIGVLDIFGFENFDQN 441
            :.||..|:||.||:....:|.|.|..:::|||:.|     ||       :||:|||||||||:.|
Mouse   387 TPLSVQQAVDSRDSLAMALYARCFEWVIKKINSRIKGKDDFK-------SIGILDIFGFENFEVN 444

  Fly   442 SFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDE 506
            .||||.||||||.||::|.:|||.|||.||:.|.:.|:.|:::||.:.||||. |:|.::|||:|
Mouse   445 HFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIE-KKLGLLALINE 508

  Fly   507 EARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDL 571
            |:.||:.||.|:|.|||..|.::..|:||:..:| :||:.|:||.|.||.||.|:||||||..||
Mouse   509 ESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVN-NFGVKHYAGEVQYDVRGILEKNRDTFRDDL 572

  Fly   572 LHLVSQSTNKFLRQIFA-------QD-IEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIR 628
            |:|:.:|...|:..:|.       || ::.|::.|:  ||:|:||:.||.:||.||||..|||:|
Mouse   573 LNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRR--PTVSSQFKDSLHSLMATLSSSNPFFVR 635

  Fly   629 CIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTD 693
            |||||..|.|..||:.:...|||||||:||:|||:|||.:|..|::|.:||:.|:..:  |...|
Mouse   636 CIKPNTQKMPDQFDQVVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNL--ALPDD 698

  Fly   694 CQAATSRICAVVL-----GKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYR 753
            .:..    |.|:|     ..|::|||.|||||:::.:..||:.|:..:.|..::::..|.|::.|
Mouse   699 IRGK----CTVLLQVYDASNSEWQLGKTKVFLRESLEQKLEKRREEEIDRAAMVIRAHILGYLAR 759

  Fly   754 RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARG 818
            :::.::....:|:|:.::.:..||                       :|.||:...:..|...||
Mouse   760 KQYRKVLCGVVTIQKNYRAFLARK-----------------------KFLHLKKAAIVFQKQLRG 801

  Fly   819 YLVRREYGHKMWAVIKIQSHVRR-------------------MIAMRRYRKLRLEHKQFAEVLQ- 863
            .|.||.|...:....:::...||                   ...:|.:::.....:|..|.|| 
Mouse   802 QLARRVYRQLLAEKRELEEKKRREEEKKREEEERERERAQREADLLRAHQEAETRRQQELEALQK 866

  Fly   864 -------LRKLEEQELLHRGNKHAREI--AEQHYRDRLHELERREIQ---------EQL--ENRR 908
                   .|:||:|    |.||...||  .|:...|.....||:|:.         :||  |..|
Mouse   867 SQREADLTRELEKQ----RENKQVEEILRLEKEIEDLQRMKERQELSLTEASLQKLQQLRDEELR 927

  Fly   909 RVE-------------VNMNIINDAARKQEEPVDDGKLV--EAMFDFLPDSSSDAPT-----PHG 953
            |:|             :|.:.|::..|..|..:..|..:  |.:.:....:|.:.|.     |:.
Mouse   928 RLEDEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEISGEELSELAESASGEKPNFNFSQPYP 992

  Fly   954 GRE---------TSVFNDLPH-AQNVNQDDIIAPIHISED--EEDLSEFKFQKFAATYFQGNVNH 1006
            ..|         ...|.|.|: :::.:.|...:.|..|:|  |||    .:..:.......:.:.
Mouse   993 AEEEVDEGFEADDDAFKDSPNPSEHGHSDQRTSGIRTSDDSSEED----PYMNYTVVPTSPSADS 1053

  Fly  1007 QYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEP--KY-HTMDRMDTTSVMSKVTATLG 1068
            .....|.......||......:...:    .:..||:|.|  .| :..|..:..::.|..:.|..
Mouse  1054 TVLLAASMQDSASLHNSSSGESTYCM----PQNNGDLPSPDGDYDYDQDDYEDGAITSGSSVTFS 1114

  Fly  1069 RNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLG------EDVRRRLQDDEYT 1127
            .::  ..::        .||         .|:.:.:.     |..|      |..:...:|.|..
Mouse  1115 NSY--GSQW--------SPD---------YRYSVGTY-----NSSGAYRFSSEGAQSSFEDSEED 1155

  Fly  1128 ADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQL--------TNNPLKSSHARGW 1184
            .|       ||..:: ::|.:          .||.:|.  |..|        ....|.:|..|.|
Mouse  1156 FD-------SRFDTD-DELSY----------RRDSVYS--CVTLPYFHSFLYMKGGLMNSWKRRW 1200

  Fly  1185 ILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTF----NNGT-----RNQPPSWLE 1240
                    |....|.|: :.|:            .:|.||:.:    ..|:     ||....|..
Mouse  1201 --------CVLKDETFL-WFRS------------KQEALKQGWLHKKGGGSSTLSRRNWKKRWFV 1244

  Fly  1241 LQATKSKKPIMLPITFMDGNTKTLLADS--ATTARELCNQLSDKISLKDQFGFSLYIALFDKVSS 1303
            |:.:|        :.:.:.:::..|..:  ..||:|:.:..|      .:.|..:.:|       
Mouse  1245 LRQSK--------LMYFENDSEEKLKGTVEVRTAKEIIDNTS------KENGIDIILA------- 1288

  Fly  1304 LGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPT-------HDQVATNLIYQ 1361
                 |.....|::..:.|.:         |     ..:.:..|..|       ||:.|..   |
Mouse  1289 -----DRTFHLIAESPEDASQ---------W-----FSVLSQVHSSTDQEIREMHDEQANP---Q 1331

  Fly  1362 QVVRGVKFG--EYRC-----DKEEDLAMIAAQQYF-IEYSTDMSMERLFTLLPNFIPDFCLSGVD 1418
            ..|..:..|  :..|     |:.....:|.|.:.. ....|...|....|||.....|..:.|.:
Mouse  1332 NAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITLLQRSKGDTRVEGQE 1396

  Fly  1419 KAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVI 1483
            ..:..|       ..|......|::.||:|:        :|.:|.....:.|::|..|..|...:
Mouse  1397 FIVRGW-------LHKEVKNSPKMSSLKLKK--------RWFVLTHNSLDYYKSSEKNALKLGTL 1446

  Fly  1484 IAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDL 1548
            :..:...  ||...|::..|..:..:|....:...:::|:.                        
Mouse  1447 VLNSLCS--VVPPDEKIFKETGYWNVTVYGRKHCYRLYTKL------------------------ 1485

  Fly  1549 VVYFLDGLKKRSKYVIALQ---DYRAPSDGTSFLSFFKGDLIILED--ESCGESVLNNGWCIGRC 1608
                   |.:.:::..|:|   |.:||.|..:        ..:::|  |:|..|.:        .
Mouse  1486 -------LNEATRWSSAIQNVTDTKAPIDTPT--------QQLIQDIKENCLNSDV--------V 1527

  Fly  1609 DRSQERGDFPAETVYVL--PTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEY 1671
            ::..:|......|.:.|  |.|..|..||             .|::..:.|..       ||.:.
Mouse  1528 EQIYKRNPILRYTHHPLHSPLLPLPYGDI-------------NLNLLKDKGYT-------TLQDE 1572

  Fly  1672 ALDHFR-LPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYM 1735
            |:..|. |....:||                  |||  |:::                 .||:..
Mouse  1573 AIKIFNSLQQLESMS------------------DPI--PIIQ-----------------GILQTG 1600

  Fly  1736 GDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQL--TDNRNRMSEERGWELMWLATGLF 1798
            .||   ||                   ||||:||||:||.  ..:...:.....|:::...:..|
Mouse  1601 HDL---RP-------------------LRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSCTF 1643

  Fly  1799 ACSQGLLKELLLFLRTRRHPISQDSMHR--------LQKTIRHGQRKYPPHQVEVEAIQHKTTQI 1855
            ..|:|:||.|...|:..|.......|.:        |:||   ..|::.|.:.|:||:.|: .::
Mouse  1644 LPSRGILKYLKFHLKRIREQFPGTEMEKYALFIYESLKKT---KCREFVPSRDEIEALIHR-QEM 1704

  Fly  1856 FHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEG-FSLFVKIADKVISVPEGDFFFDFV 1919
            ...||..........::|.|.|.:....:.:.|::..|.. |:||........::.......|. 
Mouse  1705 TSTVYCHGGGSCKITINSHTTAGEVVEKLIRGLAMEDSRNMFALFEYNGQVDKAIESRTIVADV- 1768

  Fly  1920 RHLTDWIKKARPIRDGANP-QFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCS 1983
              |..:.|.|.....|..| :|.::::..  |.|:::| || :.:..|.:.|....::.|:|...
Mouse  1769 --LAKFEKLAATSEAGDAPWKFYFKLYCF--LDTDSMP-KD-SVEFAFMFEQAHEAVIHGHHPAP 1827

  Fly  1984 REEAAKLAALVFRVRFGE--------------NKQELQA-IPQMLRELIPSDIMKIQSTS----- 2028
            .|....||||..:...|:              :.|.|:| |.|..:...|.:.::.:.||     
Mouse  1828 EESLQVLAALRLQYLQGDYTPHTSIPPLEEVYSVQRLRARISQSTKTFTPYERLEKRRTSFLEGT 1892

  Fly  2029 ----------------------EW--------KRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTF 2063
                                  .|        :.||:..:.:..||..|.|...::.::..||.:
Mouse  1893 LRRSFRTGSVVRQKAEEEQMLDMWIKEEVCSARTSIIDKWKKLQGMNQEQAMAKYMALIKEWPGY 1957

  Fly  2064 GSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNWSS--GNTYFHMTIGN 2126
            ||..|:| :..|..:|:.|.:.::...||:........|....:..|.::.:  .|||     ..
Mouse  1958 GSTLFDV-ECKEGGFPQELWLGVSADAVSVYKRGEGKPLEVFQYEHILSFGAPLANTY-----KI 2016

  Fly  2127 LVRGSKLLCETSLGYKMDDLLTSYISLML 2155
            :|...:||.|||....:..|:.:|||:::
Mouse  2017 VVDERELLFETSEVVDVAKLMKAYISMIV 2045

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 319/696 (46%)
MYSc_Myo7 77..721 CDD:276832 308/671 (46%)
MyTH4 <1138..1245 CDD:214535 23/123 (19%)
B41 1251..1467 CDD:214604 38/232 (16%)
FERM_B-lobe 1355..1439 CDD:271216 17/91 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 12/97 (12%)
SH3 1560..1624 CDD:302595 12/68 (18%)
MyTH4 1701..1849 CDD:214535 38/157 (24%)
B41 1856..2068 CDD:214604 51/263 (19%)
FERM_M 1966..2068 CDD:278785 29/151 (19%)
FERM_C2_MyoVII 2064..2159 CDD:270020 24/94 (26%)
Myo10NP_062345.2 MYSc 58..739 CDD:214580 320/702 (46%)
MYSc_Myo10 77..727 CDD:276840 308/671 (46%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 619..641 15/21 (71%)
IQ 741..763 CDD:197470 4/21 (19%)
ARGLU 796..939 CDD:291991 34/146 (23%)
SAH. /evidence=ECO:0000250|UniProtKB:P79114, ECO:0000305|PubMed:16030012 815..907 20/95 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..844 2/21 (10%)
SPEC <843..957 CDD:295325 28/117 (24%)
Mediates antiparallel dimerization. /evidence=ECO:0000250 882..932 15/49 (31%)
MYO10_CC 882..932 CDD:293340 15/49 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 963..1047 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1062..1089 5/30 (17%)
PH-like 1185..>1227 CDD:302622 11/62 (18%)
PH2_MyoX 1219..1320 CDD:270108 20/140 (14%)
PH 1219..1314 CDD:278594 18/134 (13%)
PH3_MyoX-like 1385..1510 CDD:270109 27/172 (16%)
PH 1400..1499 CDD:278594 21/146 (14%)
MyTH4 1553..1699 CDD:214535 49/227 (22%)
UBQ 1705..>1750 CDD:294102 9/44 (20%)
B41 1708..1962 CDD:214604 51/260 (20%)
FERM_M 1803..1962 CDD:278785 31/159 (19%)
FERM_C_MyoX 1958..2046 CDD:270023 24/94 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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