DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myh6

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_006518740.1	Gene:	Myh6 / 17888	MGIID:	97255	Length:	1939	Species:	Mus musculus

Alignment Length:	2082	Identity:	540/2082 - (25%)
Similarity:	890/2082 - (42%)	Gaps:	400/2082 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67
            |..|.||:.            :.|:|||.||.::....::|..|.: .|.::...:......:||
Mouse    26 AQTRPFDIRTECFVPDDKEEYVKAKVVSREGGKVTAETENGKTVTI-KEDQVMQQNPPKFDKIED 89

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132
            |..|..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
Mouse    90 MAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHI 154

  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHS----------WIEQ 185
            |:|.||||.:|...|::|.|:|:||||||||.:||.::||.|:|:  |..|          .:|.
Mouse   155 FSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANKGTLED 219

  Fly   186 QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNY 250
            ||::|||.|||||||||:||||||||||:|.|||.|.|.:..|.||.|||||||::.|..:||||
Mouse   220 QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNY 284

  Fly   251 HVFYCILAGLSADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQ 311
            |:||.|   ||..:...||:.:..    ||.:::.| .::....||:.|.....||..||.|:.:
Mouse   285 HIFYQI---LSNKKPELLDMLLVTNNPYDYAFVSQG-EVSVASIDDSEELLATDSAFDVLSFTAE 345

  Fly   312 EIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373
            |...:.||..|::|.||:|:|....:..   |.||     :.::.|.|:||....|:..|....:
Mouse   346 EKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTE-----DADKSAYLMGLNSADLLKGLCHPRV 405

  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENF 438
            ....|.|....|..|......|..|.:|.:||..:|.:|| |..:.:...:..||||||.|||.|
Mouse   406 KVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRIN-ATLETKQPRQYFIGVLDIAGFEIF 469

  Fly   439 DQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMA 502
            |.|||||.|||:.||.|||||..|:|.||||||..|.|.|:.|:| :|.|..:|||. |.:.||:
Mouse   470 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIE-KPMGIMS 533

  Fly   503 LIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKN 563
            :::||..|||.:|.|..|||:..| |...|:.||   |......|.|.|:||.|.|:..|:|:||
Mouse   534 ILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGTVDYNIMGWLEKN 598

  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQ-------DIEMGAETRKR---TPTLSTQFRKSLDALMKT 618
            :|..:..::.|..:|:.|.:..:|:.       |...|...:|:   ..|:|...|::|:.||..
Mouse   599 KDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENLNKLMTN 663

  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683
            |.:..|.|:|||.|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.
Mouse   664 LKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 728

  Fly   684 P-GVPPAHRTDCQAATSRICAVVLGKSD-----YQLGHTKVFLKDAHDLFLEQERDRVLTRKILI 742
            | .:|.....|.:....::    ||..|     |:.||||||.|......||:.||..|:|.|..
Mouse   729 PAAIPEGQFIDSRKGAEKL----LGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITR 789

  Fly   743 LQRSIRGWVYRRRFLRL---RAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRH 804
            :|...||.:.|..|.::   |.|.:.:|...:.:...|.:..|:: |.:::.|::|........:
Mouse   790 IQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKL-YFKIKPLLKSAETEKEMAN 853

  Fly   805 LR---GHIVGL--QAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRR--------------YRK 850
            ::   |.:...  ::.||    |:|...||.::::.::.::..:...:              ..|
Mouse   854 MKEEFGRVKDALEKSEAR----RKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNK 914

  Fly   851 LRLEH--KQFAEVLQ------------LRKLEEQ--ELLH------------RGNKHAREIAEQH 887
            ::||.  |:..|.|:            .||||::  ||..            ...|||.|...::
Mouse   915 IQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 979

  Fly   888 YRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFD 939
            ..:.:..|         |::.:||    .|::.:..|..:|.:..:..|.|:.|||   :|...:
Mouse   980 LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDD---LEGSLE 1041

  Fly   940 FLPDSSSDAPTPHGGRETSVFNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFA 996
                           :|..|..||..|:       .:.|:.|   :.:..|:..|.| .|.::|.
Mouse  1042 ---------------QEKKVRMDLERAKRKLEGDLKLTQESI---MDLENDKLQLEEKLKKKEFD 1088

  Fly   997 ATYFQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMD 1055
            .:.....:..:.|     :|.||.....:....::|.|: .....:.:...|:........:|::
Mouse  1089 ISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1153

  Fly  1056 TTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGE 1115
            .....:.|...:.:.  |..|||:   |..|      .:..:::|:..:..|::|:     :|||
Mouse  1154 EAGGATSVQIEMNKK--REAEFQK---MRRD------LEEATLQHEATAAALRKKHADSVAELGE 1207

  Fly  1116 DV---RRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLK 1177
            .:   :|..|..|.....::..|.. .|||:|:        |::|:...|   ::.:.|
Mouse  1208 QIDNLQRVKQKLEKEKSEFKLELDD-VTSNMEQ--------IIKAKANLE---KVSRTL------ 1254

  Fly  1178 SSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNG---TRNQPPSWL 1239
                                |...|..|..:.|.......:..:|.|....||   .:.:....|
Mouse  1255 --------------------EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299

  Fly  1240 ELQATKSKKPIMLPITFM------DGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALF 1298
            ..|.|:.|......:..:      :|..|..||.:..::|..|:      .|::|:
Mouse  1300 ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCD------LLREQY--------- 1349

  Fly  1299 DKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQV 1363
                      :..|:|.::.::...:  |....|.||..:..:......|           .::.
Mouse  1350 ----------EEEMEAKAELQRVLSK--ANSEVAQWRTKYETDAIQRTEE-----------LEEA 1391

  Fly  1364 VRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALV 1428
            .:  |..:...|.||.:..:.|:        ..|:|:....|.|.|.|..   ||......||..
Mouse  1392 KK--KLAQRLQDAEEAVEAVNAK--------CSSLEKTKHRLQNEIEDLM---VDVERSNAAAAA 1443

  Fly  1429 LQAYKKSYYVKDKI-APLKIK-----EDIVSYAKYKWPLLFSRF------------YEAYRNSGP 1475
            |...::::   ||| |..|.|     .::.|..|....|....|            .|.::....
Mouse  1444 LDKKQRNF---DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1505

  Fly  1476 NLPK--NDVIIAVNWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTV 1530
            ||.:  :|:...:...|..|.:        :.|::.|:.:..|..|....:..|:.......:.:
Mouse  1506 NLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI 1570

  Fly  1531 RGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQ-----DYRAPSDGTSFLSFFKGDLIILE 1590
            :.|   .:...||...::.    ...:...:.|.:||     :.|:.::........:|||..:|
Mouse  1571 KAE---IERKLAEKDEEME----QAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1628

  Fly  1591 DE--------SCGESVLNNGWCIGR-----CDRSQERGDFPAETVYVLP----TLSKPPQDILAL 1638
            .:        |..:..|.|.....:     .|.:....|...|.:.::.    .|....:::.|:
Mouse  1629 IQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAV 1693

  Fly  1639 FNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSR 1703
              :|:....|:|:...   .:|..:|...|  ::.:...:..|:.|...||......||
Mouse  1694 --VEQTERSRKLAEQE---LIETSERVQLL--HSQNTSLINQKKKMESDLTQLQTEVEE------ 1745

  Fly  1704 DPIKAPLLRKLQSKEEFAEEA---CFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRD 1765
                  .:::.::.||.|::|   ....|..||...|..:...||...:...|.|  |:|.:...
Mouse  1746 ------AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD--LQHRLDEA 1802

  Fly  1766 EIYC------QLMK-----QLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPI 1819
            |...      ||.|     :..:|.....::|..|.:   .|: ..|:..:|||     |.:...
Mouse  1803 EQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV---KGM-RKSERRIKEL-----TYQTEE 1858

  Fly  1820 SQDSMHRLQKTIRHGQRKYPPHQVEV-EAIQHKTTQI--FHKVYFP-DDTDEAFEVDSS----TR 1876
            .:.::.|||..:...|.|...::.:. ||.:...|.:  |.||... |:.:|..::..|    .|
Mouse  1859 DKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1923

  Fly  1877 AK 1878
            ||
Mouse  1924 AK 1925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	289/708 (41%)
		MYSc_Myo7	77..721	CDD:276832	279/683 (41%)
		MyTH4	<1138..1245	CDD:214535	18/109 (17%)
		B41	1251..1467	CDD:214604	41/239 (17%)
		FERM_B-lobe	1355..1439	CDD:271216	16/83 (19%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	16/119 (13%)
		SH3	1560..1624	CDD:302595	14/81 (17%)
		MyTH4	1701..1849	CDD:214535	34/162 (21%)
		B41	1856..2068	CDD:214604	9/28 (32%)
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myh6	XP_006518740.1	Myosin_N	34..72	CDD:367160	8/38 (21%)
		MYSc_class_II	99..768	CDD:276951	279/683 (41%)
		Myosin_tail_1	848..1925	CDD:366712	218/1241 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910