|
Fly 10 IWI-------EPASGREFDVAIGARVVSAE-GRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVE 66
:|: ||||.:| :|...|.|...| |::::|..|| |:.|:......||
Mouse 32 VWVPSSKNGFEPASLKE-EVGEEAIVELVENGKKVKVNKDD-----------IQKMNPPKFSKVE 84
Fly 67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPH 131
||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.:::||.:|..|:|||
Mouse 85 DMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPH 149
Fly 132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH------SWIEQQILEA 190
|:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..| ..:|:|:|:|
Mouse 150 IYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQA 214
Fly 191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255
||||||||||||::|||||||||:|.|:|..||.|.||.||.|||||||.:.|...||.:|:||.
Mouse 215 NPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYY 279
Fly 256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320
:|:|.....|:.|.|.....|::|:.|: :|..|:.|...|.:...||:::...:.|...:::::
Mouse 280 LLSGAGEHLKTDLLLEPYNKYRFLSNGH-VTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVI 343
Fly 321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385
:.:|..|||.:|.. .|.|...:|::...::|:.|||:.:......:....:....:.|....:
Mouse 344 SGVLQLGNIAFKKE--RNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQT 406
Fly 386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINY 450
::|:....:|..|..|.|||..:|.:||.|:.|.:....:.||:|||.|||.||.|||||.||||
Mouse 407 KEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINY 471
Fly 451 ANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLI--AIKQLNIMALIDEEARFPK 512
.||.|||.|...:|.||||||..|.|.|..|:| :|.|..:||| ......|:||:|||..|||
Mouse 472 TNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPK 536
Fly 513 GTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVS 576
.||::.:.|:.:..|:|..:.|||. .....|.:.|:||.|.|....:|.||.|..:.::..|:.
Mouse 537 ATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLH 601
Fly 577 QSTNKFLRQIFAQDIEM----------------GA-ETRK-RTPTLSTQFRKSLDALMKTLSSCQ 623
||::||:.::: :|::. || :||| ...|:...:::.|..||.||.:..
Mouse 602 QSSDKFVSELW-KDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTN 665
Fly 624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVP 687
|.|:|||.||..||....|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|
Mouse 666 PNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIP 730
Fly 688 PAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVY 752
.......||....|.|:.|..:.|::|.:|||.:......||:|||..:|..|:..|...||::.
Mouse 731 KGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLA 795
Fly 753 RRRFLRLR---AAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQA 814
|:.|.:.: .|...:||....|.:.:.::..|: :.:::.|:.| .|| ...::..:|
Mouse 796 RKAFAKRQQQLTAMKVLQRNCAAYLRLRNWQWWRL-FTKVKPLLNS------IRH-EDELLAKEA 852
Fly 815 HARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRY---RKLRLEHKQFAEV------------LQL 864
... .||.:: :..::.:..|..|:.. .||:|:.:..||. |..
Mouse 853 ELT--KVREKH-------LAAENRLTEMETMQSQLMAEKLQLQEQLQAETELCAEAEELRARLTA 908
Fly 865 RKLEEQELLHRGNKHAREIAEQHYRDRLHELERR-------EIQEQLENRRRVEVNMNIINDAAR 922
:|.|.:|:.| :..|| :.|:..|.:..:.|:: |::||||. .::||
Mouse 909 KKQELEEICH--DLEAR-VEEEEERCQYLQAEKKKMQQNIQELEEQLEE-----------EESAR 959
Fly 923 KQ---EEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISED- 983
:: |:...:.|| :.:.:|.| |.||
Mouse 960 QKLQLEKVTTEAKL---------------------------------KKLEEDQI-----IMEDQ 986
Fly 984 ------EEDLSEFKFQKFAATYF-QGNVNHQYAKKALKHPL----LPLHTQGDQLAAQALWITIL 1037
|:.|.|.:..:|..... :...:...||...||.. |....:.::...|.|..|..
Mouse 987 NCKLAKEKKLLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Fly 1038 RFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLK----QKPRSI 1098
:..|| :.|..|..:.:....|.|.....:.:|..:|.|..::.:|..| :|.|.:
Mouse 1052 KLEGD-------STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL 1109
Fly 1099 RHKLVSL-------------TLKRKNKLGEDVRRRLQDDEYTADS--YQSWLQSRPTSNLEKLHF 1148
..::..| ..|:|..|||::.....:.|.|.|| .|..|:|:....:
Mouse 1110 ETQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV----- 1169
Fly 1149 IIGHGILRAELRDEI---YCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIRE 1210
.||:..|.||. ..|| ..::..| |..|...|...:....::|.:
Mouse 1170 ----SILKKTLEDEAKTHEAQI------QEMRQKH-------SQAVEELADQLEQTKRVKATL-- 1215
Fly 1211 GPPGYAPYCEERLKRTFNN----------------GTRNQPPSWLELQATKSKKPIMLPITFMDG 1259
|:.|:|..| |........:|.|..: |.:.|.:|
Mouse 1216 ----------EKAKQTLENERGELANEVKALLQGKGDSEHKRKKVEAQLQE------LQVKFSEG 1264
Fly 1260 -NTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAK 1323
..:|.|||..|..:...:.::..:|..| .|.|.|......:...:...::..:
Mouse 1265 ERVRTELADKVTKLQVELDSVTGLLSQSD-----------SKSSKLTKDFSALESQLQDTQELLQ 1318
Fly 1324 EQGAQERNAPWRL--------FFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDL 1380
|:..|:.:...:| .||::: ...::...|| |:.:
Mouse 1319 EENRQKLSLSTKLKQMEDEKNSFREQL------EEEEEAKRNL------------------EKQI 1359
Fly 1381 AMIAAQQYFIEYSTDMSMERLFTLLPNFIPD--FCLSGVDKAIERWAALVLQAYKKSYYVKD-KI 1442
|.:.|| .|||..: :.| .||...::|..| || || :.
Mouse 1360 ATLHAQ------VTDMKKK---------MEDGVGCLETAEEAKRR-----LQ--------KDLEG 1396
Fly 1443 APLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFP 1507
...:::|.:.:|.| |.| |...:..:.:.:|::|...
Mouse 1397 LSQRLEEKVAAYDK--------------------LEK---------TKTRLQQELDDLLVDLDHQ 1432
Fly 1508 EITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAP 1572
..:..:.:|..|.|.|..: ||.|..:..||: ||.. ..:.|.|...||...||.
Mouse 1433 RQSVSNLEKKQKKFDQLLA------EEKTISAKYAEE-RDRA-----EAEAREKETKALSLARAL 1485
Fly 1573 SD-----------GTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLP 1626
.: ...|.:..: ||:..:|: .|:||.. :.:..|:.| :.|..:.
Mouse 1486 EEAMEQKAELERLNKQFRTEME-DLMSSKDD-VGKSVHE----LEKSKRALE------QQVEEMK 1538
Fly 1627 TLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLS 1691
|..:..:|.| :|....:|.:..|..|: |....:.|...
Mouse 1539 TQLEELEDEL------QATEDAKLRLEVNLQAM---------------------KAQFERDLQGR 1576
Fly 1692 SKRSEELWRYSRDPIKAPLLRKLQSKEEFAE----EACFAFAAILKYMGDLPSKRPRMGNEITDH 1752
.::|||. |..|:|:::..|...| :...|.||..|...|| .::..|
Mouse 1577 DEQSEEK--------KKQLVRQVREMEAELEDERKQRSMAMAARKKLEMDL--------KDLEAH 1625
Fly 1753 IFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRH 1817
| |..|:..||...:|..|...:..| ::||.....:|..
Mouse 1626 I-----------------------DTANKNREEAIKQLRKLQAQMKDC----MRELDDTRASREE 1663
Fly 1818 PISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAK---- 1878
.::| .:..::|....:.|:..:|. |:.::.|||
Mouse 1664 ILAQ---------AKENEKKLKSMEAEMIQLQE-------------------ELAAAERAKRQAQ 1700
Fly 1879 -------DFCNNISQRLSLRTSEGFSLFVKIA--DKVISVPEGDFFFDFVRHLTDWIKKARPIRD 1934
|...|.|.:.:|...|...|..:|| ::.:...:|: ...:.|.:|||....|
Mouse 1701 QERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN-----TELINDRLKKANLQID 1760
Fly 1935 GANPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREEAAKLAAL--VFRV 1997
..|.....: .:...|:.|| .|:| .:.::|..|||..: ..:.
Mouse 1761 QINTDLNLE---------RSHAQKNENA------RQQL-------ERQNKELKAKLQEMESAVKS 1803
Fly 1998 RFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKR 2032
::..:...|:|....|.|.:.::..:.|:.|:..|
Mouse 1804 KYKASIAALEAKIAQLEEQLDNETKERQAASKQVR 1838
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