DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myh8

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_036012291.1	Gene:	Myh8 / 17885	MGIID:	1339712	Length:	1966	Species:	Mus musculus

Alignment Length:	2089	Identity:	534/2089 - (25%)
Similarity:	878/2089 - (42%)	Gaps:	437/2089 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLI 92
            :.|.:|.::.|:.:.|..: ...|.::..|:......:|||..:..|||.|:|.||..||...:|
Mouse    54 IQSKDGGKVTVKTESGATL-TVKEDQVFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYAAWMI 117

  Fly    93 YTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGE 157
            |||:|...|.||||:.||:|..:.:..|:.:|..|.|||||:|.||||..|...|::|.|:|:||
Mouse   118 YTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 182

  Fly   158 SGAGKTESTKLILQYLAAI----------SGK-HSWIEQQILEANPILEAFGNAKTIRNDNSSRF 211
            ||||||.:||.::||.|.|          ||| ...:|.||:.|||:|||||||||:||||||||
Mouse   183 SGAGKTVNTKRVIQYFATIAVTGDKKKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRF 247

  Fly   212 GKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAA-- 274
            ||:|.|||...|.:..|.||.|||||||:..|..:||:||:||.|    ::::|..| :.|..
Mouse   248 GKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQI----TSNKKPEL-IEMLLIT 307

  Fly   275 ----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATV 335
                ||.:::.| .||....||..|.....||:.:|.||.:|...|.||..|::|.||:|:|...
Mouse   308 TNPYDYAFVSQG-EITVPSIDDQEELMATDSAIDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQ 371

  Fly   336 VDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFV 397
            .:..   |.||:     .::.|.|..|....|:.||....:....|.|....:..|..:...|..
Mouse   372 REEQAEPDGTEV-----ADKAAYLQCLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALA 431

  Fly   398 KGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFV 460
            |.:|.:||:.:|.:||..:  .:||   :..||||||.|||.||.||.||.|||:.||.|||||.
Mouse   432 KAVYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFN 493

  Fly   461 QHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHK 524
            .|:|.||||||..|.|.|..|:| :|....::||. |.|.|.::::||..|||.||.:...||:.
Mouse   494 HHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYD 557

  Fly   525 TH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQ 585
            .| |...|:.||   |......|.|.|:||.|.|:..|:||||:|..:..::.|..:|..|.|..
Mouse   558 QHLGKSNNFQKPKPTKGKAEAHFSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLAS 622

  Fly   586 IF----AQDIEMGAE--TRKR---TPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMF 641
            :|    :.:.:.||:  .:|:   ..|:|..||::|:.||..|.|..|.|:|||.|||.|.|...
Mouse   623 LFSTYASAEADGGAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAM 687

  Fly   642 DRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFL-IPGVPPAHRTDCQAATSRIC-AV 704
            :..|...|||.:|::|.|||.|.|:|.|..:.:|.:||:.| ...:|.....|.:.|:.::. ::
Mouse   688 EHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFIDSKKASEKLLGSI 752

  Fly   705 VLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWV----YRRRFLRLRAAAIT 765
            .:..:.|:.||||||.|......||:.||..|.:.|...|...||::    |::..|| |.:...
Mouse   753 DIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGYLMRVEYQKMLLR-RESIFC 816

  Fly   766 VQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHRFRHLRGHIVGLQAHARGYLVRR 823
            :|...:.:...|.:..|:: :.:::.|::|       ..:...|:..:..:      |:....|:
Mouse   817 IQYNVRAFMNVKHWPWMKL-FFKIKPLLKSAETEKEMATMKEEFQKTKDEL------AKSEAKRK 874

  Fly   824 EYGHKMWAVIKIQSHVRRMI---------AMRR-----YRKLRLEHK-----QFAE--------- 860
            |...||..::|.::.::..:         |..|     ..|::||.|     :.||
Mouse   875 ELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEDEEEINAEL 939

  Fly   861 VLQLRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRLHEL---------ERREIQE 902
            ..:.||||::  ||..            ...|||.|...::..:.:..|         |::.:||
Mouse   940 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDENIAKLTKEKKALQE 1004

  Fly   903 ----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDL 963
                .|::.:..|..:|.:..|..|.|:.|||   :|...:               :|..:..||
Mouse  1005 AHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDD---LEGSLE---------------QEKKLRMDL 1051

  Fly   964 PHAQNVNQDDI----IAPIHISEDEEDLSE-FKFQKFAATYFQGNVNHQYAKK-ALKHPLLPLHT 1022
            ..|:...:.|:    .:.:.|..|::.|.| .|.::|..:.....:..:.|.: .|:..:..|..
Mouse  1052 ERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEISNLISKIEDEQAVEIQLQKKIKELQA 1116

  Fly  1023 QGDQL-----AAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQL 1082
            :.::|     |.:|......:...|:........:|::...  ...:|.:..|..|..|||:
Mouse  1117 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG--GATSAQVEMNKKRETEFQK--- 1176

  Fly  1083 MGLDPDAFLKQ--KPRSIRHKLVSLTLKRKN-----KLGEDVRRRLQDDEYTADSYQSWLQSRPT 1140
                    |::  :..:::|:..:..|::|:     :|||.:           |:.|     |..
Mouse  1177 --------LRRDLEEATLQHEATAAALRKKHADSVAELGEQI-----------DNLQ-----RVK 1217

  Fly  1141 SNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLR 1205
            ..|||         .::||:.||     ..|::|....:.|:|.:            ||....|.
Mouse  1218 QKLEK---------EKSELKMEI-----DDLSSNAEAIAKAKGNL------------EKMCRTLE 1256

  Fly  1206 AFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSAT 1270
            ..:.|     ....||..:|..|..|..:  :.|:.:|.:..:.:         :.|..|....:
Mouse  1257 DQVSE-----LKSKEEEQQRLINELTAQR--ARLQTEAGEYSRQL---------DEKDALVSQLS 1305

  Fly  1271 TAR--------ELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQ-- 1325
            .::        ||..||.::...|:....:|            ....|..|.:.  |||.:||
Mouse  1306 RSKQASTQQIEELKRQLEEETKAKNALAHAL------------QSSRHDCDLLR--EQYEEEQEG 1356

  Fly  1326 ---------GAQERNAPWRLFFRKEIFAPWH--EPTHDQVATNLIYQQVVRGVKFGEYRC----- 1374
                     .|....|.||..:..:......  |....::|..|  |.....|:....:|
Mouse  1357 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QAAEEHVEAVNAKCASLEK 1419

  Fly  1375 ------DKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERW-------AA 1426
                  ::.||| ||..::      |:.:...|.....||         ||.:..|       .|
Mouse  1420 TKQRLQNEVEDL-MIDVER------TNAACAALDKKQRNF---------DKVLSEWRQKYEETQA 1468

  Fly  1427 LVLQAYKKSYYVKDKIAPLKIK---EDIVSYAKYKWPLLFSRFYEAYRNSGPNLPK--NDVIIAV 1486
            .:....|:|..:..::  .|:|   |:.:.:            .|..|....||.:  :|:...:
Mouse  1469 ELESCQKESRTLSTEL--FKVKNAYEESLDH------------LETLRRENKNLQQEISDLTEQI 1519

  Fly  1487 NWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAE 1543
            ...|.::.:        :||:..::.:..|..|....:..|:......|:.|:.|.....:...|
Mouse  1520 AEGGKHIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDE 1584

  Fly  1544 DIRDLVVYFLDGLKKRSKYVIALQ------DYRAPSDGTSFLSFFKGDLIILE------DESCGE 1596
            :|        |.||:....|:...      :.|:.:|........:|||..:|      :....|
Mouse  1585 EI--------DQLKRNHVRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAE 1641

  Fly  1597 SVLNNGWCIG-------RCD---RSQERGDFPAETVYV---LPTLSKPPQDILALFNIEEAHHGR 1648
            |:.|.....|       ..|   |.||  |...:...|   ...|....:::.|  .:|:....|
Mouse  1642 SLRNYRNTQGILKDTQLHLDDALRGQE--DLKEQLAIVERRANLLQAEIEELRA--TLEQTERSR 1702

  Fly  1649 RLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRD--------- 1704
            :::......|.|.....||.....::     .|:.:...::......||:.:.||:
Mouse  1703 KIAEQELLDASERVQLLHTQNTSLIN-----TKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAI 1762

  Fly  1705 ------------PIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGP 1757
                        |:.....|.....:.||.:|.. .|..||...|..:...||...:...:.|
Mouse  1763 TDVSTTHITLPTPVLPATTRAYFCLDLFASQAAM-MAEELKKEQDTSAHLERMKKNMEQTVKD-- 1824

  Fly  1758 LKHEILRDEIYCQL-----MKQLTDNRNRMSE---------ERGWELMWLATGLFACSQGL---- 1804
            |:|.:...|   ||     .||:.....|:.|         :|..|.:          :||
Mouse  1825 LQHRLDEAE---QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAV----------KGLRKHE 1876

  Fly  1805 --LKELLLFLRTRRHPI--SQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDT 1865
              :|||.......|..:  .||.:.:||..::..:|:....:.:..|...|..::.|::   ::.
Mouse  1877 RRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLAKFRKLQHEL---EEA 1938

  Fly  1866 DEAFEVDSS 1874
            :|..::..|
Mouse  1939 EERADIAES 1947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	285/706 (40%)
		MYSc_Myo7	77..721	CDD:276832	276/681 (41%)
		MyTH4	<1138..1245	CDD:214535	23/106 (22%)
		B41	1251..1467	CDD:214604	43/257 (17%)
		FERM_B-lobe	1355..1439	CDD:271216	20/101 (20%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	19/107 (18%)
		SH3	1560..1624	CDD:302595	16/85 (19%)
		MyTH4	1701..1849	CDD:214535	37/190 (19%)
		B41	1856..2068	CDD:214604	3/19 (16%)
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myh8	XP_036012291.1	Myosin_N	37..75	CDD:397036	4/21 (19%)
		Motor_domain	102..769	CDD:419868	276/681 (41%)
		Myosin_tail_1	849..1955	CDD:396244	227/1276 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910