DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myh4

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_034985.2	Gene:	Myh4 / 17884	MGIID:	1339713	Length:	1939	Species:	Mus musculus

Alignment Length:	2242	Identity:	549/2242 - (24%)
Similarity:	914/2242 - (40%)	Gaps:	570/2242 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67
            |..:.||..            :.|.|.|.||.::..:.:.|..|.:..: ::.:|:......:||
Mouse    27 AQNKPFDAKSSVFVVDAKESYVKATVQSREGGKVTAKTEGGATVTVKDD-QVFSMNPPKYDKIED 90

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132
            |..:..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
Mouse    91 MAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHI 155

  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI------------SGK-HSWIE 184
            |:|.||||..|...|::|.|:|:||||||||.:||.::||.|.|            ||| ...:|
Mouse   156 FSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEATSGKMQGTLE 220

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            .||:.|||:|||||||||:||||||||||:|.|||.|.|.:..|.||.|||||||:..|..:||:
Mouse   221 DQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLKAERS 285

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAA------DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308
            ||:||.|:    :::|..| :.|..      |:.|::.| .||....||..|.....:|:.:|.|
Mouse   286 YHIFYQIM----SNKKPEL-IEMLLITTNPYDFAYVSQG-EITVPSIDDQEELMATDTAVDILGF 344

  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTR 370
            |..|...|.||..|::|.||:|:|....:..   |.||:     .::.|.|..|....|:.||..
Mouse   345 SADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-----ADKAAYLTSLNSADLLKALCY 404

  Fly   371 RTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIF 433
            ..:....|.|....:..|..:...|..|.:|.:||:.:|.:||..:  .:||   :..||||||.
Mouse   405 PRVKVGNEYVTKGQTVQQVYNSVGALAKSMYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIA 466

  Fly   434 GFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQ 497
            |||.||.|:.||.|||:.||.|||||..|:|.||||||..|.|:|:.|:| :|....::||. |.
Mouse   467 GFEIFDFNTLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIE-KP 530

  Fly   498 LNIMALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRG 558
            :.|.::::||..|||.||.:...||::.| |...|:.||   |......|.|.|:||.|.|:..|
Mouse   531 MGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKAEAHFSLVHYAGTVDYNIIG 595

  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIF----AQDIEMGAETR------KRTPTLSTQFRKSLD 613
            :||||:|..:..::.|..:|..|.|..:|    |.:.|.|...:      ....|:|..||::|:
Mouse   596 WLDKNKDPLNETVVGLYQKSGLKTLAFLFSGGQAAEAEGGGGKKGGKKKGSSFQTVSALFRENLN 660

  Fly   614 ALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVER 678
            .||..|.|..|.|:||:.|||.|.|...:..|...|||.:|::|.|||.|.|:|.|..:.:|.:|
Mouse   661 KLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQR 725

  Fly   679 YRFL-IPGVPPAHRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKIL 741
            |:.| ...:|.....|.:.|:.::. ::.:..:.|:.||||||.|......||:.||..|.:.|.
Mouse   726 YKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLIT 790

  Fly   742 ILQRSIRGWVYRRRFLRL---RAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFR 803
            ..|...||::.|..|.::   |.:...:|...:.:...|.:..|:: |.:::.|::|........
Mouse   791 RTQAVCRGYLMRVEFKKMMERRESIFCIQYNVRAFMNVKHWPWMKL-YFKIKPLLKSAETEKEMA 854

  Fly   804 HLRGHIVGLQAH-ARGYLVRREYGHKMWAVIKIQSHVRRMI---------AMRR-----YRKLRL 853
            :::......:.. |:....|:|...||.|:::.::.::..:         |..|     ..|::|
Mouse   855 NMKEDFEKAKEDLAKSEAKRKELEEKMVALMQEKNDLQLQVQAEADGLADAEERCDQLIKTKIQL 919

  Fly   854 EHK-----QFAE---------VLQLRKLEEQ--ELLH------------RGNKHAREIAEQHYRD 890
            |.|     :.||         ..:.||||::  ||..            ...|||.|...::..:
Mouse   920 EAKIKELTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 984

  Fly   891 RLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLP 942
            .:..|         |::.:||    .|::.:..|..:|.:..|..|.|:.|||   :|...:
Mouse   985 EMAGLDENIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDD---LEGSLE--- 1043

  Fly   943 DSSSDAPTPHGGRETSVFNDLPHAQNVNQDDI----IAPIHISEDEEDLSE-FKFQKFAATYFQG 1002
                        :|..:..||..|:...:.|:    .:.:.|..|::.|.| .|.::|..:..|.
Mouse  1044 ------------QEKKLRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSNLQS 1096

  Fly  1003 NVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTTSVMS 1061
            .:..:.|     :|.:|.....:....:::.|: |......:...|:........:|::...  .
Mouse  1097 KIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG--G 1159

  Fly  1062 KVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGEDVRRRL 1121
            ..:|.:..|..|..|||:   |..|      .:..:::|:..:..|::|:     :|||.:
Mouse  1160 ATSAQIEMNKKREAEFQK---MRRD------LEEATLQHEATAAALRKKHADSVAELGEQI---- 1211

  Fly  1122 QDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWIL 1186
                   |:.|     |....|||         .::||:.||     ..|.:|....|.|:|.:
Mouse  1212 -------DNLQ-----RVKQKLEK---------EKSELKMEI-----DDLASNMETVSKAKGNL- 1249

  Fly  1187 LSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIM 1251
                       ||....|...:.|     ....||..:|..|           ||...|::
Mouse  1250 -----------EKMCRTLEDQLSE-----VKTKEEEQQRLIN-----------ELSTQKAR---- 1283

  Fly  1252 LPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAIS 1316
                            ..|.:.|...||.:|.::               ||.|..|.......|.
Mouse  1284 ----------------LHTESGEFSRQLDEKDAM---------------VSQLSRGKQAFTQQIE 1317

  Fly  1317 QCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLA 1381
            :.::..:|: ::.:||                              :...::...:.||
Mouse  1318 ELKRQLEEE-SKAKNA------------------------------LAHALQSARHDCD------ 1345

  Fly  1382 MIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAAL----VLQAYKKSYYVKDKI 1442
             :..:||..|......::|            .:|..:..:.:|...    .:|..::....|.|:
Mouse  1346 -LLREQYEEEQEAKAELQR------------AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397

  Fly  1443 AP-LKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNL-----------------PKNDVIIAVNWT 1489
            |. |:..|:.|.....|...| .:..:..:|...:|                 .:|...:...|.
Mouse  1398 AQRLQDAEEHVEAVNSKCASL-EKTKQRLQNEVEDLMIDVERSNAACAALDKKQRNFDKVLAEWK 1461

  Fly  1490 GVYVVDDQEQVLLELSFPEITAVSSQ--KTNKVFTQTF-SLSTVRGEEFTFQSPNAEDIRDLVVY 1551
            ..|   ::.|..||.|..|..::|::  |....:.::. .|.|::.|....|    ::|.||...
Mouse  1462 QKY---EETQAELEASQKESRSLSTELFKVKNAYEESLDQLETLKRENKNLQ----QEISDLTEQ 1519

  Fly  1552 FLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGD 1616
            ..:|    .|::..|:..:...|                                     ||:.:
Mouse  1520 IAEG----GKHIHELEKIKKQID-------------------------------------QEKSE 1543

  Fly  1617 FPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPK 1681
            ..|                    ::|||                         |.:|:|
Mouse  1544 LQA--------------------SLEEA-------------------------EASLEH------ 1557

  Fly  1682 RTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILK--YMGDLPSKRPR 1744
             ...|.|.:..:.::         :|:.:.||:..|:|..::        ||  ::..:.|.:..
Mouse  1558 -EEGKILRIQLELNQ---------VKSEIDRKIAEKDEEIDQ--------LKRNHLRVVESMQST 1604

  Fly  1745 MGNEITDHIFDGPLKHEILR---------DEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFAC 1800
            :..||..       :::.||         :|:..||     ::.||.:.|        |......
Mouse  1605 LDAEIRS-------RNDALRIKKKMEGDLNEMEIQL-----NHANRQAAE--------AIRNLRN 1649

  Fly  1801 SQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDT 1865
            :||:||:..|.|.....  .||.   |::.:...:|:....|.|:|.::....|          |
Mouse  1650 TQGMLKDTQLHLDDALR--GQDD---LKEQLAMVERRANLMQAEIEELRASLEQ----------T 1699

  Fly  1866 DEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSLF--VKIADKVISVPEGDFFFDFVRHLTDWIKK 1928
            :.:..|     |:....:.|:|:.|..::..||.  .|..:..||..:|:        :.|.:::
Mouse  1700 ERSRRV-----AEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE--------MEDIVQE 1751

  Fly  1929 ARPIRDGANPQFTYQVFF----------------MKKLWTNTVPGKDRNADLIFHYHQELPKL-L 1976
            ||...:.|....|.....                |||....||  ||     :.|...|..:| |
Mouse  1752 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV--KD-----LQHRLDEAEQLAL 1809

  Fly  1977 RGYHKCSREEAAKLAALVFRVRFGEN------KQELQAI------PQMLRELI------PSDIMK 2023
            :|    .:::..||.|   |||..||      |:.::|:      .:.::||.      ..::::
Mouse  1810 KG----GKKQIQKLEA---RVRELENEVENEQKRNIEAVKGLRKHERRVKELTYQTEEDRKNVLR 1867

  Fly  2024 IQSTSEWKRSIVASYNQDGGMTSEDAKVAFLK 2055
            :|...:..::.|.:|.:......|.:.|...|
Mouse  1868 LQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAK 1899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	281/709 (40%)
		MYSc_Myo7	77..721	CDD:276832	272/684 (40%)
		MyTH4	<1138..1245	CDD:214535	23/106 (22%)
		B41	1251..1467	CDD:214604	30/220 (14%)
		FERM_B-lobe	1355..1439	CDD:271216	9/87 (10%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	21/117 (18%)
		SH3	1560..1624	CDD:302595	6/63 (10%)
		MyTH4	1701..1849	CDD:214535	32/158 (20%)
		B41	1856..2068	CDD:214604	47/237 (20%)
		FERM_M	1966..2068	CDD:278785	23/109 (21%)
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myh4	NP_034985.2	Myosin_N	35..73	CDD:308391	7/37 (19%)
		MYSc_Myh4	100..770	CDD:276879	272/684 (40%)
		Actin-binding. /evidence=ECO:0000250	659..681		10/21 (48%)
		Actin-binding. /evidence=ECO:0000250	761..775		7/13 (54%)
		SMC_N	850..1927	CDD:330553	241/1402 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1128..1147		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1172		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1276..1299		7/42 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000