DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myh3

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_001093105.1 Gene:Myh3 / 17883 MGIID:1339709 Length:1940 Species:Mus musculus


Alignment Length:2232 Identity:542/2232 - (24%)
Similarity:899/2232 - (40%) Gaps:550/2232 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYK 88
            :..::.|::..::.|..:|...:.:.|| .:.||:......:|||..|..|:|..:|.||..||.
Mouse    48 VKGKIKSSQDGKVTVETEDSRTLVVKPE-DVYAMNPPKFDKIEDMAMLTHLNEPAVLYNLKDRYT 111

  Fly    89 ENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIV 153
            ..:||||:|...|.||||:.||:|..:.:..|:.:|..|.|||||:|.||||..|...|::|.|:
Mouse   112 SWMIYTYSGLFCVTVNPYKWLPVYNPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSIL 176

  Fly   154 ISGESGAGKTESTKLILQYLAAI-----------SGKHSWIEQQILEANPILEAFGNAKTIRNDN 207
            |:||||||||.:||.::||.|.|           |.....:|.||:.|||:|||||||||:||||
Mouse   177 ITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDN 241

  Fly   208 SSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGM 272
            ||||||:|.|||...|.:..|.||.|||||||:..|..:||:||:||.|   ||..:...::|.:
Mouse   242 SSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQI---LSNKKPELIELLL 303

  Fly   273 AA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKA 333
            ..    ||.:::.| .|.....|||.|.....||:.:|.|:.:|...:.||..|::|.||:|:|.
Mouse   304 ITTNPYDYPFISQG-EILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQ 367

  Fly   334 TVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDA 395
            ...:..   |.||:     .::.|.|:||....|:.||....:....|.|....:.||.....:|
Mouse   368 KQREEQAEPDGTEV-----ADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNA 427

  Fly   396 FVKGIYGRMFVHIVRKINTAIFK--PRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQF 458
            ..|.:|.::|:.:|.:||..:..  ||   ::.||||||.|||.|:.||.||.|||:.||.||||
Mouse   428 LSKSVYEKLFLWMVTRINQQLDTKLPR---QHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489

  Fly   459 FVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKL 522
            |..|:|.||||||..|.|.|..|:| :|....::||. |.:.|.::::||..|||.||.:...||
Mouse   490 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKL 553

  Fly   523 HKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFL 583
            :..| |...|:.||   |......|.|.|:||.|.|...|:|:||:|..:..::.|..:|:|:.|
Mouse   554 YDQHLGKSNNFQKPKVVKGKAEAHFSLVHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLL 618

  Fly   584 RQIFAQDIEMGAETRKRT---------PTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPM 639
            ..::|......|:..|:.         .|:|..||::|:.||..|.:..|.|:|||.|||.|.|.
Mouse   619 AHLYATFATTDADGGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPG 683

  Fly   640 MFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFL-IPGVPPAHRTDCQAATSRICA 703
            ..:..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.| ...:|.....|.:.|..::.|
Mouse   684 AMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLA 748

  Fly   704 VV-LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRL---RAAAI 764
            .: :..:.|:.||||||.|......||:.||..|.:.|...|...||::.|..|.::   |.:..
Mouse   749 SIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRTQAVCRGFLMRVEFQKMMQRRESIF 813

  Fly   765 TVQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHRFRHLRGHIVGLQAHARGYLVR 822
            .:|...:.:...|.:..|:: :.:::.|::|       ..:...|:..:..:      |:....|
Mouse   814 CIQYNIRAFMNVKHWPWMKL-FFKIKPLLKSAETEKEMATMKEEFQKTKDEL------AKSEAKR 871

  Fly   823 REYGHKMWAVI--------KIQSHVRRMI-AMRR-----YRKLRLEHK-----QFAE-------- 860
            :|...|:..::        ::|:....:: |..|     ..|.:||.|     :.||        
Mouse   872 KELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAE 936

  Fly   861 -VLQLRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRLHEL---------ERREIQ 901
             ..:.||||::  ||..            ...|||.|...::..:.|..|         |::.:|
Mouse   937 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELAGLDETIAKLTREKKALQ 1001

  Fly   902 E----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFND 962
            |    .|::.:..|..:|.::....|.|:.|||   :|:..:               :|..:..|
Mouse  1002 EAHQQTLDDLQAEEDKVNSLSKLKSKLEQQVDD---LESSLE---------------QEKKLRVD 1048

  Fly   963 LPHAQNVNQDDI-IAP---IHISEDEEDLSE-FKFQKFAATYFQGNV-NHQYAKKALKHPLLPLH 1021
            |...:...:.|: :|.   :.:..|::.|.| .|.:.|..:..|..| :.|.....|:..:..|.
Mouse  1049 LERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLSLQLQKKIKELQ 1113

  Fly  1022 TQGDQL-----AAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQ 1081
            .:.::|     |.:|......:...|.........:|::....::.....|.:.       :||:
Mouse  1114 ARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKK-------REAE 1171

  Fly  1082 LMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGED------VRRRLQDD----EYTADSY 1131
            .:.|..|.    :..:::|:....||::|:     :|.|.      |:::|:.:    :...|..
Mouse  1172 FLKLRRDL----EEATLQHEATVATLRKKHADSAAELAEQIDNLQRVKQKLEKEKSEFKLEIDDL 1232

  Fly  1132 QSWLQ--SRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCF 1194
            .|.::  |:..:||||                     ||:.|.:   :.|.|||           
Mouse  1233 SSSVESVSKSKANLEK---------------------ICRTLED---QLSEARG----------- 1262

  Fly  1195 APSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDG 1259
                                    ..|.::|:.:           ||...||:            
Mouse  1263 ------------------------KNEEMQRSLS-----------ELTTQKSR------------ 1280

  Fly  1260 NTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKE 1324
                    ..|.|.||..||.:|.|:..|...|                   ..|.:|..:..|.
Mouse  1281 --------LQTEAGELSRQLEEKESIVSQLSRS-------------------KQAFTQQIEELKR 1318

  Fly  1325 QGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYF 1389
            |..:|..|.                           ..:...::...:.||       :..:||.
Mouse  1319 QLEEENKAK---------------------------NALAHALQSSRHDCD-------LLREQYE 1349

  Fly  1390 IEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSY 1454
            .|......::|            .||..:..:.:|         ::.|..|.|...:..|:    
Mouse  1350 EEQEGKAELQR------------ALSKANSEVAQW---------RTKYETDAIQRTEELEE---- 1389

  Fly  1455 AKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVN-------WTGVYVVDDQEQVLLELSFPEITAV 1512
            ||.|   |..|..::          .:.:.|||       .|...:..:.|.:::::......|.
Mouse  1390 AKKK---LAQRLQDS----------EEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAA 1441

  Fly  1513 SSQKTNKVFTQTFSLSTVRGEEFTFQSPNA-EDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGT 1576
            :..|..:.|.:..:....:.||...:...| ::.|.|..   :..|.::.|..||..        
Mouse  1442 ALDKKQRNFDKVLAEWKTKCEESQAELEAALKESRSLST---ELFKLKNAYEEALDQ-------- 1495

  Fly  1577 SFLSFFKGDLIILEDE--SCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALF 1639
              |...|.:...||.|  ...|.:..||..|...::|:::.:.....:.:.              
Mouse  1496 --LETVKRENKNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMA-------------- 1544

  Fly  1640 NIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRD 1704
             :|||                         |.||:|       ..:|.|.:..:.::        
Mouse  1545 -LEEA-------------------------EAALEH-------EEAKILRIQLELTQ-------- 1568

  Fly  1705 PIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRD--EI 1767
             :|:.:.||:..|:|..|:....:...::.|........|..||..      .||.::..|  ||
Mouse  1569 -VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAI------RLKKKMEGDLNEI 1626

  Fly  1768 YCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLR----------------TRR 1816
            ..||     .:.||.:.|....|..:        ||.||:..|.|.                .||
Mouse  1627 EIQL-----SHANRQAAETIKHLRSV--------QGQLKDTQLHLDDALRGQEDLKEQLAIVERR 1678

  Fly  1817 HPISQDSMHRLQKTIRHGQRKYPPHQVE-------VEAIQHKTTQIFHKVYFPDDTDEAFEVDSS 1874
            ..:.|..:..|:.|:...:|.....:.|       |:.:..:.|.:.|       |.:..|.|.:
Mouse  1679 ANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIH-------TKKKLETDLT 1736

  Fly  1875 ---TRAKDFCNNISQRLSLRTSEGFSLFVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGA 1936
               :..:|.|.:      .|.:|      :.|.|.|               ||....|..::  .
Mouse  1737 QLQSEVEDACRD------ARNAE------EKAKKAI---------------TDAAMMAEELK--K 1772

  Fly  1937 NPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKL-LRGYHKCSREEAAKLAALVFRVRFG 2000
            ....:..:..|||....||  ||     :.|...|..:| |:|..|..::...::..|.|.:. |
Mouse  1773 EQDTSAHLERMKKNLEQTV--KD-----LQHRLDEAEQLALKGGKKQIQKLETRIRELEFELE-G 1829

  Fly  2001 ENKQELQAI------PQMLRELI------PSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVAF 2053
            |.|:..:::      .:.::||.      ..:::::|...:..:..|.||.:......|.|....
Mouse  1830 EQKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL 1894

  Fly  2054 LKIVYRWPTFGSAFFEVKQTTE 2075
            .|       |..|..|:::..|
Mouse  1895 TK-------FRKAQHELEEAEE 1909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 278/704 (39%)
MYSc_Myo7 77..721 CDD:276832 269/679 (40%)
MyTH4 <1138..1245 CDD:214535 15/106 (14%)
B41 1251..1467 CDD:214604 34/215 (16%)
FERM_B-lobe 1355..1439 CDD:271216 10/83 (12%)
FERM_C1_MyoVII 1461..1559 CDD:270019 16/105 (15%)
SH3 1560..1624 CDD:302595 13/65 (20%)
MyTH4 1701..1849 CDD:214535 35/172 (20%)
B41 1856..2068 CDD:214604 43/227 (19%)
FERM_M 1966..2068 CDD:278785 22/114 (19%)
FERM_C2_MyoVII 2064..2159 CDD:270020 3/12 (25%)
Myh3NP_001093105.1 Myosin_N 35..73 CDD:367160 3/24 (13%)
MYSc_Myh3 100..767 CDD:276878 269/679 (40%)
Actin-binding. /evidence=ECO:0000250 656..678 10/21 (48%)
Actin-binding. /evidence=ECO:0000250 758..772 7/13 (54%)
Myosin_tail_1 847..1924 CDD:366712 242/1418 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1260..1289 12/94 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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