DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myh2

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_001034634.2 Gene:Myh2 / 17882 MGIID:1339710 Length:1942 Species:Mus musculus


Alignment Length:2246 Identity:545/2246 - (24%)
Similarity:909/2246 - (40%) Gaps:575/2246 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67
            |..|.||..            :...:.|.:..::.|:.:.|..: ...|.:|..|:......:||
Mouse    27 AQNRPFDAKTSVFVAEPKESFVKGTIQSKDAGKVTVKTEAGATL-TVKEDQIFPMNPPKYDKIED 90

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132
            |..:..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
Mouse    91 MAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHI 155

  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI------------SGK-HSWIE 184
            |:|.||||..|...|::|.|:|:||||||||.:||.::||.|.|            ||| ...:|
Mouse   156 FSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEATSGKMQGTLE 220

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            .||:.|||:|||||||||:||||||||||:|.|||...|.:..|.||.|||||||:..|..:||:
Mouse   221 DQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERS 285

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAA------DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308
            ||:||.|    ::::|..| :.|..      ||.:::.| .|:....||..|.....||:.:|.|
Mouse   286 YHIFYQI----TSNKKPEL-IEMLLITTNPYDYPFVSQG-EISVASIDDQEELMATDSAIDILGF 344

  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTR 370
            ::.|...|.||..|::|.||:|:|....:..   |.||:     .::.|.|.||....|:.||..
Mouse   345 TNDEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-----ADKAAYLQGLNSADLLKALCY 404

  Fly   371 RTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIF 433
            ..:....|.|....:.:|..:...|..|.:|.:||:.:|.:||..:  .:||   :..||||||.
Mouse   405 PRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIA 466

  Fly   434 GFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQ 497
            |||.||.||.||.|||:.||.|||||..|:|.||||||..|.|.|..|:| :|....::||. |.
Mouse   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KP 530

  Fly   498 LNIMALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRG 558
            :.|.::::||..|||.||.:...||::.| |...|:.||   |......|.|.|:||.|.|:..|
Mouse   531 MGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAHFSLIHYAGTVDYNITG 595

  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIF--AQDIEMGAET--------RKR---TPTLSTQFRK 610
            :||||:|..:..::.|..:|:.|.|..:|  ||..|..|.:        :|:   ..|:|..||:
Mouse   596 WLDKNKDPLNETVVGLYQKSSVKTLAYLFSGAQTAEAEASSGGAAKKGAKKKGSSFQTVSALFRE 660

  Fly   611 SLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREF 675
            :|:.||..|.|..|.|:|||.|||.|.|...:..|...|||.:|::|.|||.|.|:|.|..:.:|
Mouse   661 NLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 725

  Fly   676 VERYRFL-IPGVPPAHRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTR 738
            .:||:.| ...:|.....|.:.|:.::. ::.:..:.|:.||||||.|......||:.||..|.:
Mouse   726 KQRYKVLNASAIPEGQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQ 790

  Fly   739 KILILQRSIRGWVYR---RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS----- 795
            .|...|...||::.|   ::.:..|.:...:|...:.:...|.:..|:: :.:::.|::|     
Mouse   791 LITRTQAMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKL-FFKIKPLLKSAETEK 854

  Fly   796 --RVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMI---------AMRR-- 847
              ..:...|:..:..:      |:....|:|...||.:::|.::.::..:         |..|  
Mouse   855 EMATMKEEFQKTKDDL------AKSEAKRKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCD 913

  Fly   848 ---YRKLRLEHK-----QFAE---------VLQLRKLEEQ--ELLH------------RGNKHAR 881
               ..|::||.|     :.||         ..:.||||::  ||..            ...|||.
Mouse   914 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 978

  Fly   882 EIAEQHYRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKL 933
            |...::..:.:..|         |::.:||    .|::.:..|..:|.:..|..|.|:.|||   
Mouse   979 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD--- 1040

  Fly   934 VEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDI-IAP---IHISEDEEDLSE-FKFQ 993
            :|...:               :|..:..||..|:...:.|: :|.   :.|..:::.|.| .|.:
Mouse  1041 LEGSLE---------------QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDERLKKK 1090

  Fly   994 KFAATYFQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMD 1052
            :|..:..|..:..:.|     :|.:|.....:....:::.|: |......:...|:........:
Mouse  1091 EFEMSNLQSKIEDEQAIGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1155

  Fly  1053 RMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----K 1112
            |::...  ...:|.:..|..|..|||:   |..|      .:..:::|:..:.||::|:     :
Mouse  1156 RLEEAG--GATSAQIEMNKKREAEFQK---MRRD------LEEATLQHEATAATLRKKHADSVAE 1209

  Fly  1113 LGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLK 1177
            |||.:           |:.|     |....|||         .::|::.||     ..|.:|...
Mouse  1210 LGEQI-----------DNLQ-----RVKQKLEK---------EKSEMKMEI-----DDLASNVET 1244

  Fly  1178 SSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQ 1242
            .|.|:|.:                                   |::.||..:          ::.
Mouse  1245 VSKAKGNL-----------------------------------EKMCRTLED----------QVS 1264

  Fly  1243 ATKSKKP----IMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSS 1303
            ..|||:.    ::..:|...|..:       |.:.|...||.:|.:|               ||.
Mouse  1265 ELKSKEEEQQRLINDLTTQRGRLQ-------TESGEFSRQLDEKEAL---------------VSQ 1307

  Fly  1304 LGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVK 1368
            |..|.......|.:.::..:|: .:.:||                              :...::
Mouse  1308 LSRGKQAFTQQIEELKRQLEEE-VKAKNA------------------------------LAHALQ 1341

  Fly  1369 FGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAAL----VL 1429
            ...:.||       :..:||..|..:...::|            .||..:..:.:|...    .:
Mouse  1342 SSRHDCD-------LLREQYEEEQESKAELQR------------ALSKANSEVAQWRTKYETDAI 1387

  Fly  1430 QAYKKSYYVKDKIAP-LKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNL---------------- 1477
            |..::....|.|:|. |:..|:.|.....|...| .:..:..:|...:|                
Mouse  1388 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASL-EKTKQRLQNEVEDLMLDVERTNAACAALDK 1451

  Fly  1478 -PKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQ--KTNKVFTQTF-SLSTVRGEEFTFQ 1538
             .:|...|...|...|   ::....||.|..|..::.::  |....:.::. .|.|::.|....|
Mouse  1452 KQRNFDKILAEWKQKY---EETHAELEASQKEARSLGTELFKMKNAYEESLDQLETLKRENKNLQ 1513

  Fly  1539 SPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGW 1603
                ::|.||.....:|.|:                             |.|.|...:.|     
Mouse  1514 ----QEISDLTEQIAEGGKR-----------------------------IHELEKIKKQV----- 1540

  Fly  1604 CIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTL 1668
                   .||:.:..|.                    :|||                        
Mouse  1541 -------EQEKCELQAA--------------------LEEA------------------------ 1554

  Fly  1669 MEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILK 1733
             |.:|:|       ...|.|.:..:.::         :|:.:.||:..|:|..::.......:::
Mouse  1555 -EASLEH-------EEGKILRIQLELNQ---------VKSEIDRKIAEKDEEIDQLKRNHIRVVE 1602

  Fly  1734 YMGDLPSKRPRMGNEITDHI-----FDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWL 1793
            .|........|..|   |.|     .:|.|      :|:..||     ::.|||:.|        
Mouse  1603 SMQSTLDAEIRSRN---DAIRIKKKMEGDL------NEMEIQL-----NHSNRMAAE-------- 1645

  Fly  1794 ATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHG----QRKYPPHQVEVEAIQHKTTQ 1854
            |...:..:||:||:..|.|         |...|.|:.::..    :|:....|.|:|.::....|
Mouse  1646 ALRNYRNTQGILKDTQLHL---------DDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1701

  Fly  1855 IFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSLF--VKIADKVISVPEGDFFFD 1917
                      |:.:.::     |:....:.|:|:.|..::..||.  .|..:..||..:|:    
Mouse  1702 ----------TERSRKI-----AEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE---- 1747

  Fly  1918 FVRHLTDWIKKARPIRDGANPQFTYQVFF----------------MKKLWTNTVPGKDRNADLIF 1966
                :.|.:::||...:.|....|.....                |||....||      .||..
Mouse  1748 ----MEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV------KDLQL 1802

  Fly  1967 HYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAI------PQMLRELI------PS 2019
            ...:.....|:|..|..::..|::..|...|. .|.|:..:|:      .:.::||.      ..
Mouse  1803 RLDEAEQLALKGGKKQIQKLEARVRELEGEVE-SEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1866

  Fly  2020 DIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFLK 2055
            :|:::|...:..::.|.||.:......|.:.....|
Mouse  1867 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLSK 1902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 284/712 (40%)
MYSc_Myo7 77..721 CDD:276832 275/687 (40%)
MyTH4 <1138..1245 CDD:214535 15/106 (14%)
B41 1251..1467 CDD:214604 34/220 (15%)
FERM_B-lobe 1355..1439 CDD:271216 10/87 (11%)
FERM_C1_MyoVII 1461..1559 CDD:270019 21/117 (18%)
SH3 1560..1624 CDD:302595 7/63 (11%)
MyTH4 1701..1849 CDD:214535 33/156 (21%)
B41 1856..2068 CDD:214604 41/230 (18%)
FERM_M 1966..2068 CDD:278785 18/102 (18%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Myh2NP_001034634.2 Myosin_N 36..73 CDD:280832 3/37 (8%)
Myosin_head 88..773 CDD:278492 281/699 (40%)
Motor_domain 100..773 CDD:277568 275/687 (40%)
Myosin_tail_1 853..1930 CDD:279860 237/1403 (17%)
RILP-like 968..1101 CDD:304877 30/150 (20%)
MIT_CorA-like <1302..>1414 CDD:294313 25/176 (14%)
DUF342 <1673..1770 CDD:302792 21/119 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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