Protein Alignment ck and Myh2

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_001034634.2
• Gene: Myh2 / 17882
• MGIID: 1339710
• Length: 1942
• Species: Mus musculus
• Alignment Length: 2246
• Identity: 545/2246 - (24%)
• Similarity: 909/2246 - (40%)
• Gaps: 575/2246 - (25%)

  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67
            |..|.||..            :...:.|.:..::.|:.:.|..: ...|.:|..|:......:||
Mouse    27 AQNRPFDAKTSVFVAEPKESFVKGTIQSKDAGKVTVKTEAGATL-TVKEDQIFPMNPPKYDKIED 90

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132
            |..:..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
Mouse    91 MAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHI 155

  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI------------SGK-HSWIE 184
            |:|.||||..|...|::|.|:|:||||||||.:||.::||.|.|            ||| ...:|
Mouse   156 FSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEATSGKMQGTLE 220

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            .||:.|||:|||||||||:||||||||||:|.|||...|.:..|.||.|||||||:..|..:||:
Mouse   221 DQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERS 285

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAA------DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308
            ||:||.|    ::::|..| :.|..      ||.:::.| .|:....||..|.....||:.:|.|
Mouse   286 YHIFYQI----TSNKKPEL-IEMLLITTNPYDYPFVSQG-EISVASIDDQEELMATDSAIDILGF 344

  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTR 370
            ::.|...|.||..|::|.||:|:|....:..   |.||:     .::.|.|.||....|:.||..
Mouse   345 TNDEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-----ADKAAYLQGLNSADLLKALCY 404

  Fly   371 RTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIF 433
            ..:....|.|....:.:|..:...|..|.:|.:||:.:|.:||..:  .:||   :..||||||.
Mouse   405 PRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIA 466

  Fly   434 GFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQ 497
            |||.||.||.||.|||:.||.|||||..|:|.||||||..|.|.|..|:| :|....::||. |.
Mouse   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KP 530

  Fly   498 LNIMALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRG 558
            :.|.::::||..|||.||.:...||::.| |...|:.||   |......|.|.|:||.|.|:..|
Mouse   531 MGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAHFSLIHYAGTVDYNITG 595

  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIF--AQDIEMGAET--------RKR---TPTLSTQFRK 610
            :||||:|..:..::.|..:|:.|.|..:|  ||..|..|.:        :|:   ..|:|..||:
Mouse   596 WLDKNKDPLNETVVGLYQKSSVKTLAYLFSGAQTAEAEASSGGAAKKGAKKKGSSFQTVSALFRE 660

  Fly   611 SLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREF 675
            :|:.||..|.|..|.|:|||.|||.|.|...:..|...|||.:|::|.|||.|.|:|.|..:.:|
Mouse   661 NLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 725

  Fly   676 VERYRFL-IPGVPPAHRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTR 738
            .:||:.| ...:|.....|.:.|:.::. ::.:..:.|:.||||||.|......||:.||..|.:
Mouse   726 KQRYKVLNASAIPEGQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQ 790

  Fly   739 KILILQRSIRGWVYR---RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS----- 795
            .|...|...||::.|   ::.:..|.:...:|...:.:...|.:..|:: :.:::.|::|
Mouse   791 LITRTQAMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKL-FFKIKPLLKSAETEK 854

  Fly   796 --RVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMI---------AMRR-- 847
              ..:...|:..:..:      |:....|:|...||.:::|.::.::..:         |..|
Mouse   855 EMATMKEEFQKTKDDL------AKSEAKRKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCD 913

  Fly   848 ---YRKLRLEHK-----QFAE---------VLQLRKLEEQ--ELLH------------RGNKHAR 881
               ..|::||.|     :.||         ..:.||||::  ||..            ...|||.
Mouse   914 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 978

  Fly   882 EIAEQHYRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKL 933
            |...::..:.:..|         |::.:||    .|::.:..|..:|.:..|..|.|:.|||
Mouse   979 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD--- 1040

  Fly   934 VEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDI-IAP---IHISEDEEDLSE-FKFQ 993
            :|...:               :|..:..||..|:...:.|: :|.   :.|..:::.|.| .|.:
Mouse  1041 LEGSLE---------------QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDERLKKK 1090

  Fly   994 KFAATYFQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMD 1052
            :|..:..|..:..:.|     :|.:|.....:....:::.|: |......:...|:........:
Mouse  1091 EFEMSNLQSKIEDEQAIGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1155

  Fly  1053 RMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----K 1112
            |::...  ...:|.:..|..|..|||:   |..|      .:..:::|:..:.||::|:     :
Mouse  1156 RLEEAG--GATSAQIEMNKKREAEFQK---MRRD------LEEATLQHEATAATLRKKHADSVAE 1209

  Fly  1113 LGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLK 1177
            |||.:           |:.|     |....|||         .::|::.||     ..|.:|...
Mouse  1210 LGEQI-----------DNLQ-----RVKQKLEK---------EKSEMKMEI-----DDLASNVET 1244

  Fly  1178 SSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQ 1242
            .|.|:|.:                                   |::.||..:          ::.
Mouse  1245 VSKAKGNL-----------------------------------EKMCRTLED----------QVS 1264

  Fly  1243 ATKSKKP----IMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSS 1303
            ..|||:.    ::..:|...|..:       |.:.|...||.:|.:|               ||.
Mouse  1265 ELKSKEEEQQRLINDLTTQRGRLQ-------TESGEFSRQLDEKEAL---------------VSQ 1307

  Fly  1304 LGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVK 1368
            |..|.......|.:.::..:|: .:.:||                              :...::
Mouse  1308 LSRGKQAFTQQIEELKRQLEEE-VKAKNA------------------------------LAHALQ 1341

  Fly  1369 FGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAAL----VL 1429
            ...:.||       :..:||..|..:...::|            .||..:..:.:|...    .:
Mouse  1342 SSRHDCD-------LLREQYEEEQESKAELQR------------ALSKANSEVAQWRTKYETDAI 1387

  Fly  1430 QAYKKSYYVKDKIAP-LKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNL---------------- 1477
            |..::....|.|:|. |:..|:.|.....|...| .:..:..:|...:|
Mouse  1388 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASL-EKTKQRLQNEVEDLMLDVERTNAACAALDK 1451

  Fly  1478 -PKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQ--KTNKVFTQTF-SLSTVRGEEFTFQ 1538
             .:|...|...|...|   ::....||.|..|..::.::  |....:.::. .|.|::.|....|
Mouse  1452 KQRNFDKILAEWKQKY---EETHAELEASQKEARSLGTELFKMKNAYEESLDQLETLKRENKNLQ 1513

  Fly  1539 SPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGW 1603
                ::|.||.....:|.|:                             |.|.|...:.|
Mouse  1514 ----QEISDLTEQIAEGGKR-----------------------------IHELEKIKKQV----- 1540

  Fly  1604 CIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTL 1668
                   .||:.:..|.                    :|||
Mouse  1541 -------EQEKCELQAA--------------------LEEA------------------------ 1554

  Fly  1669 MEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILK 1733
             |.:|:|       ...|.|.:..:.::         :|:.:.||:..|:|..::.......:::
Mouse  1555 -EASLEH-------EEGKILRIQLELNQ---------VKSEIDRKIAEKDEEIDQLKRNHIRVVE 1602

  Fly  1734 YMGDLPSKRPRMGNEITDHI-----FDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWL 1793
            .|........|..|   |.|     .:|.|      :|:..||     ::.|||:.|
Mouse  1603 SMQSTLDAEIRSRN---DAIRIKKKMEGDL------NEMEIQL-----NHSNRMAAE-------- 1645

  Fly  1794 ATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHG----QRKYPPHQVEVEAIQHKTTQ 1854
            |...:..:||:||:..|.|         |...|.|:.::..    :|:....|.|:|.::....|
Mouse  1646 ALRNYRNTQGILKDTQLHL---------DDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1701

  Fly  1855 IFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSLF--VKIADKVISVPEGDFFFD 1917
                      |:.:.::     |:....:.|:|:.|..::..||.  .|..:..||..:|:
Mouse  1702 ----------TERSRKI-----AEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE---- 1747

  Fly  1918 FVRHLTDWIKKARPIRDGANPQFTYQVFF----------------MKKLWTNTVPGKDRNADLIF 1966
                :.|.:::||...:.|....|.....                |||....||      .||..
Mouse  1748 ----MEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV------KDLQL 1802

  Fly  1967 HYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAI------PQMLRELI------PS 2019
            ...:.....|:|..|..::..|::..|...|. .|.|:..:|:      .:.::||.      ..
Mouse  1803 RLDEAEQLALKGGKKQIQKLEARVRELEGEVE-SEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1866

  Fly  2020 DIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFLK 2055
            :|:::|...:..::.|.||.:......|.:.....|
Mouse  1867 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLSK 1902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	275/687 (40%)
		MyTH4	<1138..1245	CDD:214535	15/106 (14%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	16/101 (16%)
		B41	1251..1467	CDD:214604	34/220 (15%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	21/117 (18%)
		SH3	1560..1624	CDD:473055	7/63 (11%)
		MyTH4	1701..1849	CDD:214535	33/156 (21%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	20/114 (18%)
		B41	1856..2068	CDD:214604	41/230 (18%)
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myh2	NP_001034634.2	Myosin_N	33..77	CDD:460670	5/44 (11%)
		Motor_domain	100..773	CDD:473979	275/687 (40%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	662..684		11/21 (52%)
		Myosin_tail_1	853..1930	CDD:460256	237/1403 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1130..1175		6/46 (13%)