DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myh11

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_006521906.1 Gene:Myh11 / 17880 MGIID:102643 Length:1979 Species:Mus musculus


Alignment Length:2263 Identity:557/2263 - (24%)
Similarity:914/2263 - (40%) Gaps:552/2263 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IWIEPASGREFDVAI-----GARVV---SAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVE 66
            :|: |:..:.|:.|.     |..||   ...|:::.|..||           |:.|:......||
Mouse    36 VWV-PSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDD-----------IQKMNPPKFSKVE 88

  Fly    67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPH 131
            ||..|..|:||.:|.||..||...|||||:|...|.||||:.||||:...:.:||.:|..|:|||
Mouse    89 DMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKYLPIYSEKIVDMYKGKKRHEMPPH 153

  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW-------------- 182
            |:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..|..              
Mouse   154 IYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITQGPSFAY 218

  Fly   183 --IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNH 245
              :|:|:|:|||||||||||||::|||||||||:|.|:|...|.|.||.||.|||||||.:.|..
Mouse   219 GELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAR 283

  Fly   246 SERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSD 310
            .||.:|:||.:|||.....||.|.|.....|.:|:.| .:......|...|.:...||.::.|::
Mouse   284 DERTFHIFYYLLAGAKEKMKSDLLLESFNSYTFLSNG-FVPIPAAQDDEMFQETLEAMSIMGFNE 347

  Fly   311 QEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA 375
            :|...|:|:::::|..|||.:|..  .|.|...:|::...::|..|:|:.:.....|:....:..
Mouse   348 EEQLAILKVVSSVLQLGNIVFKKE--RNTDQASMPDNTAAQKVCHLVGINVTDFTRAILTPRIKV 410

  Fly   376 HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQ 440
            ..:.|....:::|:....:|..|..|.|:|..|:.::|.|:.|......:.:|:|||.|||.|:.
Mouse   411 GRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFLGILDIAGFEIFEV 475

  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLN----I 500
            |||||.||||.||.|||.|...:|.||||||..|.|.|..|:| :|.|..::|  |::.|    :
Mouse   476 NSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIEL--IERPNNPPGV 538

  Fly   501 MALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGVVFYDTRGFLDKNR 564
            :||:|||..|||.||::.:.||....|:|..:.|||. ...|.|.:.|:||.|.|:...:|.||.
Mouse   539 LALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNM 603

  Fly   565 DTFSPDLLHLVSQSTNKFLRQIFAQDI-------EMGAETRKRTP-----------TLSTQFRKS 611
            |..:.::..|::.|::||:..:: :|:       :|...|....|           |:...:::.
Mouse   604 DPLNDNVTSLLNASSDKFVADLW-KDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQ 667

  Fly   612 LDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFV 676
            |..||.||.:..|.|:|||.||..|:....|..|...|||.:|::|.|||.|.|:|.|..|:||.
Mouse   668 LGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFR 732

  Fly   677 ERYRFLIP-GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKI 740
            :||..|.. .:|.......||....|.|:.|..:.|::|.:|:|.:......||:|||..:|..|
Mouse   733 QRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVI 797

  Fly   741 LILQRSIRGWVYRRRFLRLR---AAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRF 802
            :..|...||::.|:.|.:.:   .|...:||....|.:.:.::..|: :.:::.|::        
Mouse   798 MAFQAMCRGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL-FTKVKPLLQ-------- 853

  Fly   803 RHLRGHIVGLQAHARGYLVRREYGHKMWA----VIKIQSHVRRMIAMRRYRKLRLEHKQFAE--- 860
                             :.|:|  .:|.|    :.||:.  |:..|....::|..:|.|.||   
Mouse   854 -----------------VTRQE--EEMQAKEEEMQKIKE--RQQKAETELKELEQKHTQLAEEKT 897

  Fly   861 VLQLRKLEEQELLHRGNKHAREIA--EQHYRDRLHELERR-----------------------EI 900
            :||.:...|.||.....:....:|  :|...:.|||:|.|                       ::
Mouse   898 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962

  Fly   901 QEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFD----------FLPDSSSDAPTPHGGR 955
            :||||........:.:....|..:.:.::|..||  |.|          .|.:..||.       
Mouse   963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDDILV--MDDQNSKLSKERKLLEERVSDL------- 1018

  Fly   956 ETSVFNDLPHAQNVNQ-----DDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKH 1015
            .|::..:...|:|:.:     :.:|:.:.:...:|:.|..:.:|.              |:.|:.
Mouse  1019 TTNLAEEEEKAKNLTKLKSKHESMISELEVRLKKEEKSRQELEKL--------------KRKLEG 1069

  Fly  1016 PLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGR---------NF 1071
            .....|.|...|.||...:                  :|.......::.|.|.|         |.
Mouse  1070 DASDFHEQIADLQAQIAEL------------------KMQLAKKEEELQAALARLDEEIAQKNNA 1116

  Fly  1072 IRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQ 1136
            ::.....|..:..|..|.   ...|:.|:|    ..|:|..|||::.....:.|.|.||      
Mouse  1117 LKKIRELEGHISDLQEDL---DSERAARNK----AEKQKRDLGEELEALKTELEDTLDS------ 1168

  Fly  1137 SRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFV 1201
               |:..::         |||:...|:  .:.|:..:...:|..|:   :..:........|:..
Mouse  1169 ---TATQQE---------LRAKREQEV--TVLKKALDEETRSHEAQ---VQEMRQKHTQAVEELT 1216

  Fly  1202 NYLRAFIREGPPGYAPYCEERLKRTFNN------------GTRNQPPSWLELQATKSKKPIMLPI 1254
            ..|..|.|      |....::.|:|...            |...|     |::..|.|    |.:
Mouse  1217 EQLEQFKR------AKANLDKSKQTLEKENADLAGELRVLGQAKQ-----EVEHKKKK----LEV 1266

  Fly  1255 TFMDGNTKTLLADSATTARELCNQLSDKI------------SLKDQFGFSLYIALFDKVSSLGSG 1307
            ...|..:|....:.|..      :||||:            .|.:..|.::.:|  ..|:|||| 
Mouse  1267 QLQDLQSKCSDGERARA------ELSDKVHKLQNEVESVTGMLNEAEGKAIKLA--KDVASLGS- 1322

  Fly  1308 GDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEY 1372
                  .:...::..:|:..|:.|                      |:|.|  :|:         
Mouse  1323 ------QLQDTQELLQEETRQKLN----------------------VSTKL--RQL--------- 1348

  Fly  1373 RCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAAL--VLQAYKKS 1435
                 ||.......|...|.....::||..:.|     :..||...|.::.:|:.  |::..||.
Mouse  1349 -----EDERNSLQDQLDEEMEAKQNLERHVSTL-----NIQLSDSKKKLQDFASTIEVMEEGKKR 1403

  Fly  1436 YYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPK--NDVIIAVNWTGVYVVDDQE 1498
            ...:.:....:.:|...:|.|          .|..:|   .|.:  :|:::.        :|:|.
Mouse  1404 LQKEMEGLSQQYEEKAAAYDK----------LEKTKN---RLQQELDDLVVD--------LDNQR 1447

  Fly  1499 QVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYV 1563
            |::..|          :|..|.|.|..:      ||....|..|:: ||..     ..:.|.|..
Mouse  1448 QLVSNL----------EKKQKKFDQLLA------EEKNISSKYADE-RDRA-----EAEAREKET 1490

  Fly  1564 IALQDYRAPSDG----------TSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFP 1618
            .||...||..:.          ...|.....||:..:|:            :|:.....|:....
Mouse  1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD------------VGKNVHELEKSKRA 1543

  Fly  1619 AET-VYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKR 1682
            .|| :..:.|..:..:|.|      :|....:|.:..|..|:                     |.
Mouse  1544 LETQMEEMKTQLEELEDEL------QATEDAKLRLEVNMQAL---------------------KG 1581

  Fly  1683 TMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAE----EACFAFAAILKYMGDLPSKRP 1743
            ...:.|....:::||..|        .|.|:|...|...|    :...|.||..|..|||.....
Mouse  1582 QFERDLQARDEQNEEKRR--------QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

  Fly  1744 RMGNEITDHIFDGPLKHEILRDEIYCQLMK---QLTDNRNRMSEERG------------------ 1787
            :..:.|..            |:|...||.|   |:.|.:..:.:.|.                  
Mouse  1639 QADSAIKG------------REEAIKQLRKLQAQMKDFQRELDDARASRDEIFATSKENEKKAKS 1691

  Fly  1788 --WELMWLATGLFACSQG----------LLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPP 1840
              .:||.|...|.|..:.          |.:||...|..|.  ..||...||:..|...:.:...
Mouse  1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN--TLQDEKRRLEARIAQLEEELEE 1754

  Fly  1841 HQVEVEAIQ---HKTT----QIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSL 1898
            .|..:||:.   .|.|    |:.:::.....|.:..|   |.|.:....|...|..|:..|| ::
Mouse  1755 EQGNMEAMSDRVRKATLQAEQLSNELATERSTAQKNE---SARQQLERQNKELRSKLQEVEG-AV 1815

  Fly  1899 FVKIADKVISVPEGDFFFDFVRHLTDWI-KKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNA 1962
            ..|:...|.::...      :..|.:.: ::||.                |:..|.::..||:..
Mouse  1816 KAKLKSTVAALEAK------IAQLEEQVEQEARE----------------KQAATKSLKQKDKKL 1858

  Fly  1963 DLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRV--------RFGENKQELQAIPQMLREL--- 2016
            ..:....::..|:...|.:.:.:...|:..|..::        |...|:::||      |||   
Mouse  1859 KEVLLQVEDERKMAEQYKEQAEKGNTKVKQLKRQLEEAEEESQRINANRRKLQ------RELDEA 1917

  Fly  2017 ------IPSDIMKIQSTSEWKRSIVASY-------------NQDGGMTSEDAK 2050
                  :..::..::  |:.:|...||:             |.||.....||:
Mouse  1918 TESNEAMGREVNALK--SKLRRGNEASFVPSRRAGGRRVIENTDGSEEEMDAR 1968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 273/709 (39%)
MYSc_Myo7 77..721 CDD:276832 263/684 (38%)
MyTH4 <1138..1245 CDD:214535 18/118 (15%)
B41 1251..1467 CDD:214604 40/229 (17%)
FERM_B-lobe 1355..1439 CDD:271216 17/85 (20%)
FERM_C1_MyoVII 1461..1559 CDD:270019 18/99 (18%)
SH3 1560..1624 CDD:302595 13/74 (18%)
MyTH4 1701..1849 CDD:214535 39/184 (21%)
B41 1856..2068 CDD:214604 38/226 (17%)
FERM_M 1966..2068 CDD:278785 20/115 (17%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Myh11XP_006521906.1 Myosin_N 33..71 CDD:367160 8/35 (23%)
MYSc_class_II 99..778 CDD:276951 263/684 (38%)
Myosin_tail_1 855..1935 CDD:366712 248/1365 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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