Protein Alignment ck and nmy-3

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_501620.2
• Gene: nmy-3 / 177750
• WormBaseID: WBGene00012437
• Length: 1464
• Species: Caenorhabditis elegans
• Alignment Length: 1218
• Identity: 352/1218 - (28%)
• Similarity: 579/1218 - (47%)
• Gaps: 193/1218 - (15%)

  Fly    10 IWIEPASGREFDVAIGARVVSA--EGRR---IQVRDDDGDEVWLAPERRI---KAMHASSVQGVE 66
            ||||       |...|.|:|:.  ||..   :..||:.|    ...::||   |....|.....|
 Worm    33 IWIE-------DDLYGYRMVTVIDEGLSDLLVGFRDEQG----FFEKKRIEKTKCEVPSLNNYSE 86

  Fly    67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPH 131
            |:.:|...:.|.:|..|.|||..|:|:|:.|...|.:||::.:|||:.:..:||:.:  .:||||
 Worm    87 DLCTLTQPNAATVLNALKIRYTSNVIHTFCGLFCVVINPWRNIPIYSDEVKQLYQLQ--NDLPPH 149

  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEANPILEA 196
            ::::..||:..:.:..::|.|:|:|||||||||:||.|:.::.:.|..::.|...::.:..:|||
 Worm   150 VYSVAQNAFHGILKGGRNQSILITGESGAGKTENTKKIIDFILSSSVSNNTIGDCVVTSGVLLEA 214

  Fly   197 FGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAG-L 260
            .|||:|..|.|||||||:|.|.|..|..:.|||||.|||||||:|.|:..:||:|:||.:|:. .
 Worm   215 MGNARTTHNSNSSRFGKFIRIEFDENSKLIGAKIECYLLEKSRVVFQSDGDRNFHIFYQMLSNYF 279

  Fly   261 SADEKSRLDLGMAA-DYKYLTGGNSITCEGRDDA--AEFSDIRSAMKVLLFSDQEIWEIIKLLAA 322
            ....||.|.|.... :||||...:|:.    |||  |:.:| .:..::.|..:::|| |.::|:|
 Worm   280 DNPHKSFLKLSKKVNEYKYLRNDDSMI----DDAETAKMTD-EAFTRIGLSEEEKIW-IFQILSA 338

  Fly   323 LLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRD 387
            :|..|:||:...  ..||.:.:.....|:.:|.||.:....|:||||:.|:..|.:.:....:..
 Worm   339 VLWIGDIKFGER--SGLDVSFVESMQEVDNIAELLEMKSSKLVDALTQPTIKVHDKLIRKNQNLA 401

  Fly   388 QSVDVRDAFVKGIYGRMFVHIVRKINTA--IFKPRGTSR--NAIGVLDIFGFENFDQNSFEQFCI 448
            :::....|..|.:|.|:|..||::.|.|  :.....|.|  ..|.||||.|||..::||||||||
 Worm   402 KTLSSASAMAKILYERLFGWIVKRCNDAFSVDDTESTCRLSRFIAVLDIAGFEIIEKNSFEQFCI 466

  Fly   449 NYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDN-QDALDLIAIKQLNIMALIDEEARFPK 512
            ||.||.|||||...:|..||.:|..|.|.|..:.|.:: |..:|||. |.:.|::.::||...|.
 Worm   467 NYTNEKLQQFFNHFMFAKEQSDYLEEGIKWTQVNFANHLQPTIDLIE-KPMGILSFLEEECVVPN 530

  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKSDINTS----FGLNHFAGVVFYDTRGFLDKNRDTFSPDLLH 573
            |:::::|.||.....:..::.|.|.....|    |.:.|:||.|.|:..|:||||||.....:|.
 Worm   531 GSEKSLLEKLCSNLSNDSSFKKSKQTQKCSTIRHFYVQHYAGEVHYNIDGWLDKNRDNVETSVLD 595

  Fly   574 LVSQSTNKFLRQIFAQDIEMGAETRKRTPTLST---QFRKSLDALMKTLSSCQPFFIRCIKPNEL 635
            ::||||:..|:.:|........:||:.|.|.||   .::..|..|:.||:|....||||:..|..
 Worm   596 ILSQSTHPLLKLLFPPVPVNNLKTRRGTITNSTVSFLYKNQLQCLLDTLNSSSAHFIRCVVSNYE 660

  Fly   636 KKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSR 700
            |.|...|..|...||:.:|::|.|||.|.|||.|....||:|||..|:.....:.....:...:.
 Worm   661 KLPGKIDAPLVLAQLKCNGVLEGIRICREGYPSRLSHSEFIERYSLLMKNKEQSKGASEKEKCTL 725

  Fly   701 ICA-VVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIR------GWVYRRRFLR 758
            ||. ..:.|..|.:|.||:|.|......||.:|:..::..|:::|.:||      ..:.||:.|.
 Worm   726 ICQDAQVRKERYAVGKTKLFCKVGVISELETKRNNYISSFIILIQANIRYLNIQKDLIERRKKLE 790

  Fly   759 LRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHAR------ 817
               |.:|:|...:.:|:..::...|:.::....:.|:|. ..|...|....:.|:...:
 Worm   791 ---AVVTIQDNVRQFAELSQWPWYRIYHLTRGLIPRNRD-KERIEELENEKLKLEEEIQEMEIKN 851

  Fly   818 ----------GYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQEL 872
                      ..|:.||...|    :|:|..:..:....| .||..:.::|.:.::  ::|:.|.
 Worm   852 EEALKENLKLSMLLDREKSEK----VKVQKELEEVEKQGR-EKLLEKEREFRKTME--EMEQNEE 909

  Fly   873 LHRGNKHAREIAEQHYR-----DRLHELERREIQEQL---------ENRRRVEVNMNIINDAARK 923
            :.  |...|:..|||.:     |.|.|.||:  .|||         ||::..|......:..:..
 Worm   910 IF--NVLERKYNEQHKKVMKMNDVLREYERK--IEQLNMEKTDLENENQKLRETQNRQDSHYSNL 970

  Fly   924 QEEPVDDGKLVEAM---FDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIH--ISED 983
            ::|.::...|::.:   ...|.|.:::........||::.::  .|:...|::.|..:.  |||.
 Worm   971 EKEVMEKSSLIDELQNQIQKLSDENNEQRLTIAKLETALEDE--KARFARQNNTIGDMQKLISEL 1033

  Fly   984 EEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKY 1048
            .|.::.|                                  |.:|
 Worm  1034 NEKIARF----------------------------------DNIA-------------------- 1044

  Fly  1049 HTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKL 1113
              ::..::|..:.:....|......:||..:.|...:|.   ||::.|           ||||:.
 Worm  1045 --LNERNSTRKIEREKEKLNEELTTAKEIIQKQAKKIDE---LKEECR-----------KRKNEA 1093

  Fly  1114 GEDVRRRLQDDE--------YTADSYQSWLQ---------SRPTSNLE 1144
            .. :.|:|:|.|        ...||::..|:         .|..|.||
 Worm  1094 SR-LERKLEDKEAMMADCVKELKDSHKERLKEMEQKVEDVKRKNSKLE 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	243/660 (37%)
		MyTH4	<1138..1245	CDD:214535	4/7 (57%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
nmy-3	NP_501620.2	MYSc_class_II	97..747	CDD:276951	243/660 (37%)
		SMC_prok_B	848..>1463	CDD:274008	68/377 (18%)