Protein Alignment ck and hum-8

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_001294574.1
• Gene: hum-8 / 176872
• WormBaseID: WBGene00002041
• Length: 1279
• Species: Caenorhabditis elegans
• Alignment Length: 1080
• Identity: 336/1080 - (31%)
• Similarity: 530/1080 - (49%)
• Gaps: 166/1080 - (15%)

  Fly     7 GDYIWIEPASGREFDVAIGARVV--SAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMI 69
            |..:||..|:    |....||::  ||.|..:::.|:.||.|....| .:.|....|.:.|||..
 Worm    76 GRTVWITDAT----DGFRAARIIDLSATGFTLRLLDNTGDTVTRVFE-DVLACEDDSRRHVEDNC 135

  Fly    70 SLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILP-IYTGDQIKLYKERKIGELPPHIF 133
            .|..|:||.:|.|:.:||:...||:|..:||:::||||.:. .|:..:||.|:.:.:|:..||||
 Worm   136 QLMHLNEATLLNNIRLRYQNGKIYSYVANILISINPYQTIDGFYSLQKIKEYRGKSLGQKEPHIF 200

  Fly   134 AIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW------IEQQILEANP 192
            ||.|.:|..|.|:|:.|.|::|||||||||||.|.:|:||.     .:|      |::::||.||
 Worm   201 AIADKSYREMIRHRKSQSIIVSGESGAGKTESQKAVLRYLC-----ENWGSGAGEIQKRLLETNP 260

  Fly   193 ILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCIL 257
            ||||||||||:||:|||||||::.|||:..|.:.|..:..||||.|||..|...|||||:||.::
 Worm   261 ILEAFGNAKTLRNNNSSRFGKFVQIHFADTGNVAGGYVSHYLLETSRICRQAAGERNYHIFYQLI 325

  Fly   258 AGLSADEKSRLDLGMAADYKYL------------TGGNSITCEGR------------DDAAEFSD 298
            ||.|.:....|.||....:.||            :|..|...:.|            ||.::|..
 Worm   326 AGSSPELFKFLALGQPNQFNYLKRGFIGFFTHPSSGTTSKIPKNRLSDPKFTQDSMVDDFSDFQR 390

  Fly   299 IRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEI--PEHINVERVAGLLGLPI 361
            :..|:|:...|:|||..|...:||:||.||::::.::.|:....::  ....::.:.|.||||..
 Worm   391 LEYALKLTGLSEQEIHFIWTTIAAILHLGNVEFEESLDDSRGGCKVFNGSEQDLIQAARLLGLET 455

  Fly   362 QPLIDALTRRTL-----FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRG 421
            ..|...|..|.:     .|.|..:...|...::...|||..|.||.::|..:|.:||.:|  |..
 Worm   456 MELKMGLCARIMQTTKGGARGTLIRVPLKPHEACSGRDALSKAIYSKLFDWLVSRINDSI--PFE 518

  Fly   422 TSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDN 486
            .|.|.:||||:.|||.:.:|||||||||:.||.||.||.|.|.:.|||.|..|.:|.:.|||:||
 Worm   519 KSTNFVGVLDVAGFEFYAKNSFEQFCINFCNEKLQNFFNQRILREEQELYEKEGLNVRKIEFIDN 583

  Fly   487 QDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSH-------KNYLKPKSDINTSFG 544
            ||.::|..:|...:..|:||||:||....::...:.|:.:..|       |:.:|...::....|
 Worm   584 QDCIELFELKGNGLFDLLDEEAKFPTSNYKSFTKRAHEENRKHFRLDTPRKSKVKSHRELRDDEG 648

  Fly   545 L--NHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLS-- 605
            |  .|:||.|.|:|:.|::||.|.....|..|:.|||.:.|..:|.   .....|:.:...||
 Worm   649 LLIRHYAGSVCYETKHFVEKNDDLLHNSLQILIEQSTIRLLVSLFG---STAYPTKSKLKALSVG 710

  Fly   606 TQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRH 670
            .:|:..|..|:..|.|....|:||||||....|..||......||:.:||...:::.:.|:|.|.
 Worm   711 AKFKNQLSTLLIKLESTGTHFVRCIKPNNQMIPFEFDGSAILSQLQCAGMTSVLKLMQDGFPSRT 775

  Fly   671 GFREFVERYRFLIPGVPPAHRTD----CQAATSRIC---AVVLGKSDYQLGHTKVFLKDA----H 724
            ||.:....|:..:|  |...:.|    |:      |   |:.|.:.|:|.|.||||.:..    .
 Worm   776 GFGDLYACYQKKLP--PKLSKLDPRMFCK------CLFRALGLDQHDFQFGLTKVFFRAGKFAEF 832

  Fly   725 DLFLEQERDRVLTRKILILQRSIRGWVYRRRF----------------LRLRAAAIT-VQRFWKG 772
            |..::|:.:.:.:     |.:.:..|:...|:                :..|:|.:| :|...:|
 Worm   833 DQMMKQDPETMTS-----LIQKVNEWLVGARWKQSQYAVWSVIKLKNKIAWRSAQVTRLQSIARG 892

  Fly   773 YAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYG-----HKMWAV 832
            |..|:|:......|.:..||:::.      :.:...:..|..|:|.......:.     .|:.:.
 Worm   893 YLTRQRFSRQIALYRKSVALLKNS------KEIEKILFRLNEHSRAKYTSSAHSTIRDLEKLVSH 951

  Fly   833 IKI---------------QSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHARE 882
            ||:               :.:|:|:.:|....|.:.:..:.||:.:.|:..|:       |...|
 Worm   952 IKLTTSANDHFEKAENAYEHYVKRVDSMIADLKKQQKSDELAEIERKRRESEE-------KERLE 1009

  Fly   883 IAEQHYRDRLHELERREIQEQLENRRRVEVNMNI--INDAARKQE--------EPVD-------- 929
            |..:...:|..|: :|:::||.:|.::...|..|  |:.||.:.|        |.:|
 Worm  1010 IEAKKEAERQREI-KRKLEEQQQNAQKEHENYLISEIHKAAEETEKKRQNEEKEKLDKMVSNRLA 1073

  Fly   930 --DG-KLVEAMFDFLPDSSS----DAPTPHGGRETSVFND 962
              || .|:.:..:..|.|.|    |.....||...:...|
 Worm  1074 EADGVALISSKMEIEPSSGSATFRDGKYDVGGCSFAYLRD 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	256/699 (37%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
hum-8	NP_001294574.1	MYSc_Myo6	143..825	CDD:276833	256/699 (37%)
		CBD_MYO6-like	836..987	CDD:409646	25/161 (16%)
		tolA_full	983..>1076	CDD:274303	22/100 (22%)
		MyUb_Myo6	1099..1139	CDD:439319	3/15 (20%)
		Myosin-VI_CBD	1180..1276	CDD:465157