Protein Alignment ck and myo-1

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_492053.1
• Gene: myo-1 / 172471
• WormBaseID: WBGene00002348
• Length: 1938
• Species: Caenorhabditis elegans
• Alignment Length: 2265
• Identity: 571/2265 - (25%)
• Similarity: 896/2265 - (39%)
• Gaps: 601/2265 - (26%)

  Fly    10 IWIEPAS-----------GREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQ 63
            :||..|.           |.:.|..|    |:|.|:.:.::.|...||           :....:
 Worm    35 VWIPDAEEGYIEGVIKGPGPKADTVI----VTAGGKDVTLKKDIVQEV-----------NPPKFE 84

  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGEL 128
            ..|||.:|..|::|.:|.||..||...|||||:|...|.:|||:.|||||....:::..::..|:
 Worm    85 KTEDMSNLTFLNDASVLWNLRSRYAAMLIYTYSGLFCVVINPYKRLPIYTDSVARMFMGKRRTEM 149

  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISG----------KHSWI 183
            |||:||:.|.||.:|.:..::|.::|:|||||||||:||.::.|.|.:..          |...:
 Worm   150 PPHLFAVSDQAYRYMLQDHENQSMLITGESGAGKTENTKKVICYFATVGASQKAALKEGEKEVTL 214

  Fly   184 EQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSER 248
            |.||::.||:|||||||||:||:|||||||:|.|||:.:|.:....||.|||||||::.|...||
 Worm   215 EDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGTLASCDIEHYLLEKSRVIRQAPGER 279

  Fly   249 NYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEI 313
            .||:||.|.:......:..|.|.......:......:..:|.||..||.....|..||.||..|.
 Worm   280 CYHIFYQIYSDFKPQLRDELLLNHPISNYWFVAQAELLIDGIDDTEEFQLTDEAFDVLKFSPTEK 344

  Fly   314 WEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGE 378
            .:..:|::|.:|.||:|:|....:  :..|.......||...:.|:.:...:.||....:....|
 Worm   345 MDCYRLMSAHMHMGNMKFKQRPRE--EQAEPDGQDEAERACNMYGIDVDQFLKALVSPRVKVGTE 407

  Fly   379 TVVSTLSRDQSVD----VRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN-AIGVLDIFGFENF 438
            .|    |:.|:||    ...|..||:|.|:|..:|:|.|..: ..:|..|: .||||||.|||.|
 Worm   408 WV----SKGQNVDQVHWAIGAMAKGLYARVFHWLVKKCNLTL-DQKGIDRDYFIGVLDIAGFEIF 467

  Fly   439 DQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMA 502
            |.|||||..||:.||.|||||..|:|.||||||..|.|.|..|:| :|.|..::||. |.|.|::
 Worm   468 DFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELIE-KPLGIIS 531

  Fly   503 LIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKPK----SDINTSFGLNHFAGVVFYDTRGFLDK 562
            ::|||...||.||.|:..||...| |.|.|:.|||    ......|.:.|:||.|.|:...:|:|
 Worm   532 MLDEECIVPKATDMTLAQKLTDQHLGKHPNFEKPKPPKGKQGEAHFAMRHYAGTVRYNVLNWLEK 596

  Fly   563 NRDTFSPDLLHLVSQS-TNKFLRQIFAQDIEMGAETRKRTP--------------TLSTQFRKSL 612
            |:|..:..::.::..| .|..|.:|: ||.....|......              |:|..:|:||
 Worm   597 NKDPLNDTVVSVMKASKKNDLLVEIW-QDYTTQEEAAAAAKAGGGRKGGKSGSFMTVSMMYRESL 660

  Fly   613 DALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVE 677
            :.||..|....|.|||||.|||.|:..|.|..|...||..:|::|.|||.|.|:|.|....:||:
 Worm   661 NKLMTMLHKTHPHFIRCIIPNEKKQSGMIDAALVLNQLTCNGVLEGIRICRKGFPNRTQHPDFVQ 725

  Fly   678 RYRFLIPGVPPAHRTD----CQAATSRICAVV----LGKSDYQLGHTKVFLKDAHDLFLEQERDR 734
            ||..|  ....|..:|    |..|.  :.|::    |....:::||||||.|......:|..||.
 Worm   726 RYAIL--AAKEAKSSDDMKTCAGAI--LQALINQKQLNDEQFRIGHTKVFFKAGVVAHIEDLRDD 786

  Fly   735 VLTRKI--------------------------LILQRSIRGWVYRRRFLRLRAAAITVQRFWKGY 773
            .|.:.|                          :||||:||.|              .|.|.|..:
 Worm   787 KLNQIITGFQSAIRWYTATADAGARRKQLNSYIILQRNIRSW--------------CVLRTWDWF 837

  Fly   774 AQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSH 838
                    :..|.:|.|  ::...::.....:......|:|.|:                |.:|
 Worm   838 --------LLFGKLRPQ--LKCGKMAEEMIKMAEEQKVLEAEAK----------------KAES- 875

  Fly   839 VRRMIAMRRYRKLRLEHKQFAEVLQLRK-----LEEQELLHRGNKHAREIAE--QHYRDRLHELE 896
             .|......|.||..|..:..|.|:|.:     :||:  |.|.|...:|:.:  ....|||.|.|
 Worm   876 -ARKSQEEAYAKLSAERSKLLEALELTQGGSAAIEEK--LTRLNSARQEVEKSLNDANDRLSEHE 937

  Fly   897 ---------RREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPH 952
                     ||:.|:::||              .:|..|.| ||.|.:::.:
 Worm   938 EKNADLEKQRRKAQQEVEN--------------LKKSIEAV-DGNLAKSLEE------------- 974

  Fly   953 GGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPL 1017
                        .|...||      ||..:||.:..:...         |.:|.:  ||.|:...
 Worm   975 ------------KAAKENQ------IHSLQDEMNSQDETI---------GKINKE--KKLLEENN 1010

  Fly  1018 LPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQL 1082
            ..|  ..|..|.:|......|..|.:.:    |:|.|:......|   .:.....:||...|.:|
 Worm  1011 RQL--VDDLQAEEAKQAQANRLRGKLEQ----TLDEMEEAVEREK---RIRAETEKSKRKVEGEL 1066

  Fly  1083 MG------------LDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWL 1135
            .|            |:.||.||:|...|            :.||.    |::|::..|:.    |
 Worm  1067 KGAQETIDELSAIKLETDASLKKKEADI------------HALGV----RIEDEQALANR----L 1111

  Fly  1136 QSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKF 1200
            ..:...|.:::          .|:.||:     :....:..|:..||            |..::.
 Worm  1112 TRQSKENAQRI----------IEIEDEL-----EHERQSRSKADRAR------------AELQRE 1149

  Fly  1201 VNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITF-MDGNTKTL 1264
            ::.|               .|||         ::....||:|...:||.....|.| .|.:.|.:
 Worm  1150 LDEL---------------NERL---------DEQNKQLEIQQDNNKKKDSEIIKFRRDLDEKNM 1190

  Fly  1265 L-ADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSL-----------GSGGDHVMDAISQ 1317
            . .|.....|...|   |:||           ||.:.:.:|           |.....:.|..:|
 Worm  1191 ANEDQMAMIRRKNN---DQIS-----------ALTNTLDALQKSKAKIEKEKGVLQKELDDINAQ 1241

  Fly  1318 CEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVV--RGVKFGEYRCDK---E 1377
            .:|..|.:..|||.|.     :.||          |||.   .||.|  :..:.|||...|   .
 Worm  1242 VDQETKSRVEQERLAK-----QYEI----------QVAE---LQQKVDEQSRQIGEYTSTKGRLS 1288

  Fly  1378 EDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKI 1442
            .|.:.:|.|           :|.|         :..|:.:::|...:::.:::|.|.:
 Worm  1289 NDNSDLARQ-----------VEEL---------EIHLATINRAKTAFSSQLVEAKKAA------- 1326

  Fly  1443 APLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLP------------KNDV---IIAVN----- 1487
                  ||.:...:        .|:.|.:|....|.            |:|:   :..:|
 Worm  1327 ------EDELHERQ--------EFHAACKNLEHELDQCHELLEEQINGKDDIQRQLSRINSEISQ 1377

  Fly  1488 WTGVY----VVDDQEQVLLELSFPEITAVS------SQKTNKVFTQTFSLSTVRGEEFTFQSPNA 1542
            |...|    :|..:|  |.||...::..|.      |...|||    .||...:|:...    ..
 Worm  1378 WKARYEGEGLVGSEE--LEELKRKQMNRVMDLQEALSAAQNKV----ISLEKAKGKLLA----ET 1432

  Fly  1543 EDIRD------LVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNN 1601
            ||.|.      .|:..|:  ||:..:...:.|::.           |.|.|..|.::......|.
 Worm  1433 EDARSDVDRHLTVIASLE--KKQRAFDKIVDDWKR-----------KVDDIQKEIDATTRDSRNT 1484

  Fly  1602 GWCIGRCDRSQERGDFPAETVYVL----PTLSKPPQDILALF-----NIEEAHHG-RRLSMASNG 1656
            ...:.:...|.   |..:|.:..|    ...|:..:||....     ..:|.|.. |||.
 Worm  1485 STEVFKLRSSM---DNLSEQIETLRRENKIFSQEIRDINEQITQGGRTYQEVHKSVRRLE----- 1541

  Fly  1657 GAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFA 1721
               :.:|.    :::|||......:...||.|.|..:..:         |::.:.:::|.|||..
 Worm  1542 ---QEKDE----LQHALDEAEAALEAEESKVLRLQIEVQQ---------IRSEIEKRIQEKEEEF 1590

  Fly  1722 E-------EACFAFAAIL----KYMGDLPSKRPRMGNEIT------DHI----FDGPLKHEILRD 1765
            |       .|..:..|.|    |...:|...:.::..:|.      ||.    .|.....:.|.|
 Worm  1591 ENTRKNHQRALESIQASLETEAKSKAELARAKKKLETDINQLEIALDHANKANVDAQKNLKKLFD 1655

  Fly  1766 EIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKT 1830
            ::. :|..|:.|.:.|..|.|.   .:||..         |.|.:.|..     |:|..||::.:
 Worm  1656 QVK-ELQGQVDDEQRRREEIRE---NYLAAE---------KRLAIALSE-----SEDLAHRIEAS 1702

  Fly  1831 IRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTD--------EAFEVDSSTRAKDFCNNISQR 1887
            .:|.:      |:|:|..:.|::          :|:        .|.:.......:...|.:.:.
 Worm  1703 DKHKK------QLEIEQAELKSS----------NTELIGNNAALSAMKRKVENEVQIARNELDEY 1751

  Fly  1888 LS-LRTSEGFSLFV-----KIADKVISVPEGDFFFDFVRHLTDWIKK--ARPIRDGANPQFTYQV 1944
            |: |:.||..:...     ::|::|....|.....|..|...:...|  ...|.|.......:..
 Worm  1752 LNELKASEERARKAAADADRLAEEVRQEQEHAVHVDRQRKSLELNAKELQAKIDDAERAMIQFGA 1816

  Fly  1945 FFMKKLWTNTVPGKDRNADLIFHYHQEL---PKLLRGYHKCSREEAAKLAALVFRV--------R 1998
            ..:.|:       :||...|....|.|.   .:.::||.|..|    :...|.|:|        |
 Worm  1817 KALAKV-------EDRVRSLEAELHSEQRRHQESIKGYTKQER----RARELQFQVEEDKKAFDR 1870

  Fly  1999 FGENKQEL-QAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVA 2052
            ..||.::| |.|....|::..::.:..|:.|::::..:|..|.:     |.|:||
 Worm  1871 LQENVEKLQQKIRVQKRQIEEAEEVATQNLSKFRQIQLALENAE-----ERAEVA 1920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	263/687 (38%)
		MyTH4	<1138..1245	CDD:214535	15/106 (14%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	24/110 (22%)
		B41	1251..1467	CDD:214604	45/233 (19%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	28/133 (21%)
		SH3	1560..1624	CDD:473055	9/63 (14%)
		MyTH4	1701..1849	CDD:214535	36/168 (21%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	16/112 (14%)
		B41	1856..2068	CDD:214604	43/225 (19%)
		FERM_C2_MyoVII	2064..2159	CDD:270020
myo-1	NP_492053.1	Myosin_N	30..73	CDD:460670	9/41 (22%)
		MYSc_class_II	98..773	CDD:276951	263/687 (38%)
		Myosin_tail_1	854..1919	CDD:460256	270/1391 (19%)