Protein Alignment ck and Myo9a

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_063120884.1
• Gene: Myo9a / 171296
• RGDID: 621395
• Length: 2627
• Species: Rattus norvegicus
• Alignment Length: 2615
• Identity: 602/2615 - (23%)
• Similarity: 1002/2615 - (38%)
• Gaps: 849/2615 - (32%)

  Fly    29 VSAEGRRIQVRDDDGD--------EVWL-APERRIKAMHASSV-----QGVEDMISLGDLHEAGI 79
            :|.|..|..:|:.:.|        :.|| ..|.|.:.|....:     :..:|:.||.||:|..:
  Rat    98 LSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTL 162

  Fly    80 LRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMK 144
            |.||..|:|...||||.||||:|:||::.||||....:|:|...::|:|.|||:|:.|.||..|.
  Rat   163 LENLRNRFKHEKIYTYVGSILIAINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAML 227

  Fly   145 RYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDN 207
            :.:::||||||||||:|||:||..::.:|.|:|  |..|.:||.||.|.|:|||||||||..|:|
  Rat   228 QRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNN 292

  Fly   208 SSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGM 272
            ||||||:|.:::...|.:.||.:|:|||||||:|.|.|:||||||||.:|||.|.:|:....|..
  Rat   293 SSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEEERLAFHLKQ 357

  Fly   273 AADYKYLTGGNSIT------------------C---EGRDDAAEFSDIRSAMKVLLFSDQEIWEI 316
            ..:|.:|   |.||                  |   ||.|...:|..::.||:::.|..:...:|
  Rat   358 PEEYHFL---NQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQI 419

  Fly   317 IKLLAALLHCGNIKYKATVV--DNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            ..||:|:||.|||.||....  |::|... ||.:.:  |:.||.:..:.|.:||..|.....||.
  Rat   420 FSLLSAILHLGNISYKKKTYRDDSIDICN-PEVLPI--VSELLEVKEEMLFEALVTRKTVTVGEK 481

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN----AIGVLDIFGFENFDQ 440
            ::......::|.||::..|.:|..:|..||.:||.|:...:...::    :||||||||||:::.
  Rat   482 LILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEKDTKTLSIGVLDIFGFEDYEN 546

  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALID 505
            |||||||||:|||.||.:|.|||||||||||..|.|:|.:|:::||...::||:.|...::.|:|
  Rat   547 NSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLD 611

  Fly   506 EEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPD 570
            ||:.||:.|:||:|.|....| ...:|::..:.:..:|.:.|:||.|.|..:.|.:||.|...||
  Rat   612 EESNFPQATNQTLLDKFKHQH-EENSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPD 675

  Fly   571 LLHLVSQSTNKF-----------------LRQIFAQ----------------------------- 589
            ::.|:..|.|.|                 ||..|..
  Rat   676 IVALLRSSRNAFVSGMTGIDPVAVFRWAVLRAFFRAVVAFREAGKRHIQRKSGHDDTTPCTILKS 740

  Fly   590 --------------------------------------------------------DIEMGAET- 597
                                                                    ||.....|
  Rat   741 MDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNTLNEKNQHDTFDIAWNVRTG 805

  Fly   598 ----------------------------------------------------------------- 597
                                                                             
  Rat   806 IRQSRLPTNNTSLLDKDGIFANSASSKLLERAHGILTRNKNFRSKPVLPKHLLEVNSLKHLTRLT 870

  Fly   598 --------------RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCR 648
                          :|:.|::|.||:.||..||:||...:|:|::||:.|..|.|:.|...|..|
  Rat   871 LQDRITKSLLHLHKKKKPPSISAQFQVSLSKLMETLDQAEPYFVKCIRSNAEKLPLRFSDALVLR 935

  Fly   649 QLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVVLGKSDYQL 713
            ||||:||:||:|||::||..::.|::||..:..|:|......:.:.|....:|   .:...:||:
  Rat   936 QLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPQHIIPSKFNIQDFFRKI---NINPDNYQV 997

  Fly   714 GHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKR 778
            |.|.||||:.....|:....:.:.|:|::|||..|..:.|::||.||.|::.:||||:.|..:|:
  Rat   998 GKTMVFLKEHERQHLQDLLHQEVLRRIILLQRWFRVLLSRQQFLHLRQASVIIQRFWRNYLNQKQ 1062

  Fly   779 YRNM-------------------------RVGYMRLQALIRSRVLSHRFRHL--RGHIVG--LQA 814
            .||.                         |..|:.|:|  .:.::..|:|.|  |.|...  :|:
  Rat  1063 VRNAAVEKDAFIMASAASLLQASWRAHLERQRYLELRA--AAVIIQQRWRELCRRRHRAATCIQS 1125

  Fly   815 HARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKL--------RLEH---------------- 855
            ..|||...::|..:...:|.:||..|...|.:||:.|        :|||
  Rat  1126 RWRGYRQSKKYKEQRNKIILLQSIYRGFRARQRYKALKEERLKETKLEHGLAQIKTCGPLEIQGS 1190

  Fly   856 -------KQFAEVLQLRKLEEQELLHRGNKHAREIA---------EQHYRDR------------- 891
                   :.||.  :::.:||.:.:...|:.:||.:         :|..|.|
  Rat  1191 DPSEWEDRSFAN--RVKAIEECKSVIESNRISRESSMDFSKESPDKQQERGRSQSGTDLQGDVIV 1253

  Fly   892 ------LHELERREI-QEQLENRRRVEVNMNIINDAARKQE-----EPVDDGK-LVEAMFDFL-- 941
                  |.:|.:::: :.:.|:||..|:...|.:....|..     .|.::.: ..|.|.:.|
  Rat  1254 RQRPKSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGMSPSEERRWSTELMPEGLQS 1318

  Fly   942 PDSSSDAPTPHGGRE--TSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKF--------- 995
            |..:.|:.:..|..|  |...|.....:::..||  ..:.||..    |.|...||
  Rat  1319 PQGTPDSESSQGSLELLTCDENQKSKPESLILDD--GELKISSP----STFTNPKFDSQNNALSA 1377

  Fly   996 ---AATYFQG--------NVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYH 1049
               .::.|.|        ::.:..|::.|.:...|: |...||....:..::..|.....:....
  Rat  1378 SSETSSTFSGKGASSDSEHLKNGTAEEKLVYSSQPI-TCKSQLRDSFVSSSLPTFFYIPHQEPLK 1441

  Fly  1050 TMDRMDTT---------SVMSKVTATLGRNFIRSKEFQEAQLMG----LDPDAFLKQKPRSIRHK 1101
            |..::||:         ....|.|.||..|    :|.::.|..|    |:||:..     ::..|
  Rat  1442 TSSQLDTSIQRNKLPERETTLKTTLTLDIN----REARKCQFSGQVTPLNPDSSC-----TVLKK 1497

  Fly  1102 LVSLTLKRKNK-----------LGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGIL 1155
            |..|.::::.:           :.|.:|::....|....::::..|||..::|....|.
  Rat  1498 LEKLNIEKEKRQKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEQSRTEASLLAPSFY------ 1556

  Fly  1156 RAELRDEIYCQICKQLTNNPLK------------------SSHARGWILLSLCVGCFAPSEKFVN 1202
              :.|.::.......:.|.|.|                  |.|             ..|.::.|.
  Rat  1557 --QSRQKVERPSSLHIQNTPSKGEAGVLGSPSALATKDSPSIH-------------LPPKDRPVT 1606

  Fly  1203 YLRAFIREGPPGYAPYCEER----LKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKT 1263
            ..  |.|:|.|     |:.|    |.:|...||::                          :...
  Rat  1607 LF--FERKGSP-----CQSRTVKELTKTERMGTQH--------------------------DAAC 1638

  Fly  1264 LLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSG-------GDHVMDAISQCEQY 1321
            .|:::..|.||         ..|....:|   ...|..|..||.       .|:|   |:.....
  Rat  1639 RLSNNRNTERE---------HFKSTHSYS---HRSDDPSREGSSRPIFFTPKDNV---ITPLVHS 1688

  Fly  1322 AKEQGAQERNAPWRLFF-----RKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLA 1381
            ...|..::....|:...     |:::..|.|:.......|...:  :.||. |.:...|.|||
  Rat  1689 GNPQVHKQDEPAWKSKLAGPGQREQVARPAHKKKARMARTRSDF--LTRGT-FADGEGDTEED-- 1748

  Fly  1382 MIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLK 1446
                     :|  |..:|.|.:|             |:|..                 .::.|:
  Rat  1749 ---------DY--DDIIEPLLSL-------------DQASH-----------------SELGPV- 1771

  Fly  1447 IKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITA 1511
               ..:..|.:....:.|:.:.:                        ||:|.::...:|..|||.
  Rat  1772 ---SSLGQASHSDSEMTSQRFSS------------------------VDEQARLHKAMSQGEITK 1809

  Fly  1512 VSS-QKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDG 1575
            ::. ||::.:                       |||          .:|:|
  Rat  1810 LAGRQKSSDL-----------------------DIR----------PQRAK-------------- 1827

  Fly  1576 TSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALF- 1639
               :.|                     |..|:      :|:  .:|..|.|.   |..::.:||
  Rat  1828 ---MRF---------------------WAKGK------QGE--KKTTRVKPA---PQSEVSSLFA 1857

  Fly  1640 --NIEEAH-HGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEEL-WR 1700
              ::...| ....|:.......:.| :.|.:..:...::....||....:.:.:||...:.: |:
  Rat  1858 GSDVTPVHPFSDELTQYHPTPPLSP-ELPGSCRKEFKENKEPSPKAKRKRGVKISSVALDSMHWQ 1921

  Fly  1701 YSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKH----- 1760
            .....|.|. ...|:|.:||          :||.|.||.::..:. :.:.|.:|...||.
  Rat  1922 NDSVQIIAS-ANDLKSMDEF----------LLKKMNDLDNEDSKK-DTLVDVVFKKALKEFRQNI 1974

  Fly  1761 --------------EILRDEIYCQLMKQLTDNRNRMSEERGWE----LMWLATGLFACSQGLLKE 1807
                          .|...::|. |.:|:.:...|. |:|.|.    .:|:.|     .:..|.|
  Rat  1975 FSSYSSALAMDDGKSIRYKDLYA-LFEQILEKTMRF-EQRDWNESPVRVWVNT-----FKVFLDE 2032

  Fly  1808 LLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVE------VEAIQH---------------- 1850
            .:...:|     ...:..::.||.|..:||.....||      .:|.|:
  Rat  2033 YMNEFKT-----LDSTAPKVLKTERKKRRKKETDLVEEHNGHMFKATQYSIPTYCEYCSSLIWIM 2092

  Fly  1851 -------------------KTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGF 1896
                               |||....|.|.|:.:...|.|:               ||..|||..
  Rat  2093 DRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVE---------------LSRLTSEDR 2142

  Fly  1897 SLFVKIADKVISVPE--GDFFFDFVRH--LTDWIKKARP-------------------------- 1931
            ::.: :.:|:|:..|  |.:.....|.  .|:.||:.|.
  Rat  2143 AVPL-VVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQW 2206

  Fly  1932 IRDGANPQFTYQVF--FMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYH----KCSREEAAKL 1990
            :||..||..|::::  |::.:..                 ||..:.:||.:    :.||...:.|
  Rat  2207 LRDLPNPLMTFELYEEFLRAMGL-----------------QERKETIRGVYSVIDQLSRTHLSTL 2254

  Fly  1991 AALVF---RVRFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVA 2052
            ..|:|   |:...|:...:.|  ..|..:....|::...|::..:|:     ||...|:...::.
  Rat  2255 ERLIFHLVRIALQEDTNRMSA--NALAIVFAPCILRCPDTTDPLQSV-----QDISKTTTCVELI 2312

  Fly  2053 FLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNWS-SG 2116
            .::.:.::..      .:|..:...:.|...    |..:|||....|.:|:...|..|:..| ||
  Rat  2313 VVEQMNKYKA------RLKDISSLEFAENKA----KTRLSLIRRSMKPVLIAVRFMSITRSSVSG 2367

  Fly  2117 NTYFHMTIGNLVRGS 2131
            .       |.|.|||
  Rat  2368 K-------GRLHRGS 2375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	279/854 (33%)
		MyTH4	<1138..1245	CDD:214535	21/128 (16%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	17/109 (16%)
		B41	1251..1467	CDD:214604	36/227 (16%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	13/98 (13%)
		SH3	1560..1624	CDD:473055	6/63 (10%)
		MyTH4	1701..1849	CDD:214535	36/176 (20%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	25/128 (20%)
		B41	1856..2068	CDD:214604	44/250 (18%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	18/69 (26%)
Myo9a	XP_063120884.1	None