DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myo9a

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_599162.2 Gene:Myo9a / 171296 RGDID:621395 Length:2626 Species:Rattus norvegicus


Alignment Length:2605 Identity:601/2605 - (23%)
Similarity:998/2605 - (38%) Gaps:830/2605 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 VSAEGRRIQVRDDDGD--------EVWL-APERRIKAMHASSV-----QGVEDMISLGDLHEAGI 79
            :|.|..|..:|:.:.|        :.|| ..|.|.:.|....:     :..:|:.||.||:|..:
  Rat    98 LSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTL 162

  Fly    80 LRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMK 144
            |.||..|:|...||||.||||:|:||::.||||....:|:|...::|:|.|||:|:.|.||..|.
  Rat   163 LENLRNRFKHEKIYTYVGSILIAINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAML 227

  Fly   145 RYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDN 207
            :.:::||||||||||:|||:||..::.:|.|:|  |..|.:||.||.|.|:|||||||||..|:|
  Rat   228 QRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNN 292

  Fly   208 SSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGM 272
            ||||||:|.:::...|.:.||.:|:|||||||:|.|.|:||||||||.:|||.|.:|:....|..
  Rat   293 SSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEEERLAFHLKQ 357

  Fly   273 AADYKYLTGGNSIT------------------C---EGRDDAAEFSDIRSAMKVLLFSDQEIWEI 316
            ..:|.:|   |.||                  |   ||.|...:|..::.||:::.|..:...:|
  Rat   358 PEEYHFL---NQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQI 419

  Fly   317 IKLLAALLHCGNIKYKATVV--DNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            ..||:|:||.|||.||....  |::|... ||.:.:  |:.||.:..:.|.:||..|.....||.
  Rat   420 FSLLSAILHLGNISYKKKTYRDDSIDICN-PEVLPI--VSELLEVKEEMLFEALVTRKTVTVGEK 481

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN----AIGVLDIFGFENFDQ 440
            ::......::|.||::..|.:|..:|..||.:||.|:...:...::    :||||||||||:::.
  Rat   482 LILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEKDTKTLSIGVLDIFGFEDYEN 546

  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALID 505
            |||||||||:|||.||.:|.|||||||||||..|.|:|.:|:::||...::||:.|...::.|:|
  Rat   547 NSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLD 611

  Fly   506 EEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPD 570
            ||:.||:.|:||:|.|....| ...:|::..:.:..:|.:.|:||.|.|..:.|.:||.|...||
  Rat   612 EESNFPQATNQTLLDKFKHQH-EENSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPD 675

  Fly   571 LLHLVSQSTNKF-----------------LRQIFAQ----------------------------- 589
            ::.|:..|.|.|                 ||..|..                             
  Rat   676 IVALLRSSRNAFVSGMTGIDPVAVFRWAVLRAFFRAVVAFREAGKRHIQRKSGHDDTTPCTILKS 740

  Fly   590 --------------------------------------------------------DIEMGAET- 597
                                                                    ||.....| 
  Rat   741 MDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNTLNEKNQHDTFDIAWNVRTG 805

  Fly   598 ----------------------------------------------------------------- 597
                                                                             
  Rat   806 IRQSRLPTNNTSLLDKDGIFANSASSKLLERAHGILTRNKNFRSKPVLPKHLLEVNSLKHLTRLT 870

  Fly   598 --------------RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCR 648
                          :|:.|::|.||:.||..||:||...:|:|::||:.|..|.|:.|...|..|
  Rat   871 LQDRITKSLLHLHKKKKPPSISAQFQVSLSKLMETLDQAEPYFVKCIRSNAEKLPLRFSDALVLR 935

  Fly   649 QLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVVLGKSDYQL 713
            ||||:||:||:|||::||..::.|::||..:..|:|......:.:.|....:|   .:...:||:
  Rat   936 QLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPQHIIPSKFNIQDFFRKI---NINPDNYQV 997

  Fly   714 GHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKR 778
            |.|.||||:.....|:....:.:.|:|::|||..|..:.|::||.||.|::.:||||:.|..:|:
  Rat   998 GKTMVFLKEHERQHLQDLLHQEVLRRIILLQRWFRVLLSRQQFLHLRQASVIIQRFWRNYLNQKQ 1062

  Fly   779 YRNM-------------------------RVGYMRLQALIRSRVLSHRFRHL--RGHIVG--LQA 814
            .||.                         |..|:.|:|  .:.::..|:|.|  |.|...  :|:
  Rat  1063 VRNAAVEKDAFIMASAASLLQASWRAHLERQRYLELRA--AAVIIQQRWRELCRRRHRAATCIQS 1125

  Fly   815 HARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKL--------RLEH---------------- 855
            ..|||...::|..:...:|.:||..|...|.:||:.|        :|||                
  Rat  1126 RWRGYRQSKKYKEQRNKIILLQSIYRGFRARQRYKALKEERLKETKLEHGLAQIKTCGPLEIQGS 1190

  Fly   856 -------KQFAEVLQLRKLEEQELLHRGNKHAREIA---------EQHYRDR------------- 891
                   :.||.  :::.:||.:.:...|:.:||.:         :|..|.|             
  Rat  1191 DPSEWEDRSFAN--RVKAIEECKSVIESNRISRESSMDFSKESPDKQQERGRSQSGTDLQGDVIV 1253

  Fly   892 ------LHELERREI-QEQLENRRRVEVNMNIINDAARKQE-----EPVDDGK-LVEAMFDFL-- 941
                  |.:|.:::: :.:.|:||..|:...|.:....|..     .|.::.: ..|.|.:.|  
  Rat  1254 RQRPKSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGMSPSEERRWSTELMPEGLQS 1318

  Fly   942 PDSSSDAPTPHGGRE--TSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKF--------- 995
            |..:.|:.:..|..|  |...|.....:::..||  ..:.||..    |.|...||         
  Rat  1319 PQGTPDSESSQGSLELLTCDENQKSKPESLILDD--GELKISSP----STFTNPKFDSQNNALSA 1377

  Fly   996 ---AATYFQG--------NVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYH 1049
               .::.|.|        ::.:..|::.|.:...|: |...||....:..::..|.....:....
  Rat  1378 SSETSSTFSGKGASSDSEHLKNGTAEEKLVYSSQPI-TCKSQLRDSFVSSSLPTFFYIPHQEPLK 1441

  Fly  1050 TMDRMDTT---------SVMSKVTATLGRNFIRSKEFQEAQLMG----LDPDAFLKQKPRSIRHK 1101
            |..::||:         ....|.|.||..|    :|.::.|..|    |:||:..     ::..|
  Rat  1442 TSSQLDTSIQRNKLPERETTLKTTLTLDIN----REARKCQFSGQVTPLNPDSSC-----TVLKK 1497

  Fly  1102 LVSLTLKRKNK-----------LGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGIL 1155
            |..|.::::.:           :.|.:|::....|....::::..|||..::|....|.      
  Rat  1498 LEKLNIEKEKRQKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEQSRTEASLLAPSFY------ 1556

  Fly  1156 RAELRDEIYCQICKQLTNNPLK------------------SSHARGWILLSLCVGCFAPSEKFVN 1202
              :.|.::.......:.|.|.|                  |.|             ..|.::.|.
  Rat  1557 --QSRQKVERPSSLHIQNTPSKGEAGVLGSPSALATKDSPSIH-------------LPPKDRPVT 1606

  Fly  1203 YLRAFIREGPPGYAPYCEER----LKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKT 1263
            ..  |.|:|.|     |:.|    |.:|...||::                          :...
  Rat  1607 LF--FERKGSP-----CQSRTVKELTKTERMGTQH--------------------------DAAC 1638

  Fly  1264 LLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSG-------GDHVMDAISQCEQY 1321
            .|:::..|.||         ..|....:|   ...|..|..||.       .|:|   |:.....
  Rat  1639 RLSNNRNTERE---------HFKSTHSYS---HRSDDPSREGSSRPIFFTPKDNV---ITPLVHS 1688

  Fly  1322 AKEQGAQERNAPWRLFF----RKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAM 1382
            ...|..::....|:...    ::|:..|.|:.......|...:  :.||. |.:...|.|||   
  Rat  1689 GNPQVHKQDEPAWKSKLAGPGQREVARPAHKKKARMARTRSDF--LTRGT-FADGEGDTEED--- 1747

  Fly  1383 IAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKI 1447
                    :|  |..:|.|.:|             |:|..                 .::.|:  
  Rat  1748 --------DY--DDIIEPLLSL-------------DQASH-----------------SELGPV-- 1770

  Fly  1448 KEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAV 1512
              ..:..|.:....:.|:.:.:                        ||:|.::...:|..|||.:
  Rat  1771 --SSLGQASHSDSEMTSQRFSS------------------------VDEQARLHKAMSQGEITKL 1809

  Fly  1513 SS-QKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGT 1576
            :. ||::.:                       |||          .:|:|               
  Rat  1810 AGRQKSSDL-----------------------DIR----------PQRAK--------------- 1826

  Fly  1577 SFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALF-- 1639
              :.|                     |..|:      :|:  .:|..|.|.   |..::.:||  
  Rat  1827 --MRF---------------------WAKGK------QGE--KKTTRVKPA---PQSEVSSLFAG 1857

  Fly  1640 -NIEEAH-HGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEEL-WRY 1701
             ::...| ....|:.......:.| :.|.:..:...::....||....:.:.:||...:.: |:.
  Rat  1858 SDVTPVHPFSDELTQYHPTPPLSP-ELPGSCRKEFKENKEPSPKAKRKRGVKISSVALDSMHWQN 1921

  Fly  1702 SRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDE 1766
            ....|.|. ...|:|.:||          :||.|.||.::..:. :.:.|.:|...||.  .|..
  Rat  1922 DSVQIIAS-ANDLKSMDEF----------LLKKMNDLDNEDSKK-DTLVDVVFKKALKE--FRQN 1972

  Fly  1767 IYCQ--------------------LMKQLTDNRNRMSEERGWE----LMWLATGLFACSQGLLKE 1807
            |:..                    |.:|:.:...|. |:|.|.    .:|:.|     .:..|.|
  Rat  1973 IFSSYSSALAMDDGKSIRYKDLYALFEQILEKTMRF-EQRDWNESPVRVWVNT-----FKVFLDE 2031

  Fly  1808 LLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVE------VEAIQH---------------- 1850
            .:...:|     ...:..::.||.|..:||.....||      .:|.|:                
  Rat  2032 YMNEFKT-----LDSTAPKVLKTERKKRRKKETDLVEEHNGHMFKATQYSIPTYCEYCSSLIWIM 2091

  Fly  1851 -------------------KTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGF 1896
                               |||....|.|.|:.:...|.|:               ||..|||..
  Rat  2092 DRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVE---------------LSRLTSEDR 2141

  Fly  1897 SLFVKIADKVISVPE-GDFFFDFVRHLTDWIKKARPIRDGA------------NPQFTYQVFFMK 1948
            ::.: :.:|:|:..| ...:.:.:...:....|.:.:|.|.            |......||   
  Rat  2142 AVPL-VVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIASVF--- 2202

  Fly  1949 KLWTNTVPGKDRNADLIFHYH---------QELPKLLRGYH----KCSREEAAKLAALVF---RV 1997
            |.|...:|    |..:.|..:         ||..:.:||.:    :.||...:.|..|:|   |:
  Rat  2203 KQWLRDLP----NPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLSTLERLIFHLVRI 2263

  Fly  1998 RFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPT 2062
            ...|:...:.|  ..|..:....|::...|::..:|:     ||...|:...::..::.:.::..
  Rat  2264 ALQEDTNRMSA--NALAIVFAPCILRCPDTTDPLQSV-----QDISKTTTCVELIVVEQMNKYKA 2321

  Fly  2063 FGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNWS-SGNTYFHMTIGN 2126
                  .:|..:...:.|...    |..:|||....|.:|:...|..|:..| ||.       |.
  Rat  2322 ------RLKDISSLEFAENKA----KTRLSLIRRSMKPVLIAVRFMSITRSSVSGK-------GR 2369

  Fly  2127 LVRGS 2131
            |.|||
  Rat  2370 LHRGS 2374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 288/879 (33%)
MYSc_Myo7 77..721 CDD:276832 279/854 (33%)
MyTH4 <1138..1245 CDD:214535 21/128 (16%)
B41 1251..1467 CDD:214604 36/226 (16%)
FERM_B-lobe 1355..1439 CDD:271216 15/83 (18%)
FERM_C1_MyoVII 1461..1559 CDD:270019 13/98 (13%)
SH3 1560..1624 CDD:302595 6/63 (10%)
MyTH4 1701..1849 CDD:214535 36/177 (20%)
B41 1856..2068 CDD:214604 43/240 (18%)
FERM_M 1966..2068 CDD:278785 20/117 (17%)
FERM_C2_MyoVII 2064..2159 CDD:270020 18/69 (26%)
Myo9aNP_599162.2 Actin-binding. /evidence=ECO:0000250 908..919 4/10 (40%)
Neck or regulatory domain. /evidence=ECO:0000250 1022..1163 41/142 (29%)
Tail. /evidence=ECO:0000250 1164..2589 261/1527 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1221..1276 8/54 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1397 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1562..1602 6/52 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1618..1673 15/92 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1689..1726 5/36 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1765..1784 2/22 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1872..1907 4/35 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2365..2385 7/17 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2449..2527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2552..2614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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