DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and myo1d

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_002935562.1	Gene:	myo1d / 100497691	XenbaseID:	XB-GENE-5877220	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	979	Identity:	347/979 - (35%)
Similarity:	509/979 - (51%)	Gaps:	116/979 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGEL 128
            |..|.:.:..:.....:.||.:|:::..|||:.|.::|:||||:.||||..|.|:.||.|::.|.
Frog    10 GKADFVLMDSVTLPEFMENLKLRFEKGRIYTFIGEVVVSVNPYKNLPIYGRDTIEQYKGRELYER 74

  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS-----GKHSWIEQQIL 188
            |||:|:|.|.||..|||..:|.||||||||||||||::|.|:||:|||:     .:...::..:|
Frog    75 PPHLFSIADAAYKAMKRRCKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLL 139

  Fly   189 EANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVF 253
            ::|.:|||||||||.|||||||||||:||:|...|...|..|..|||||||::.|...|||:|.|
Frog   140 KSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHISNYLLEKSRVIVQQLGERNFHSF 204

  Fly   254 YCILAGLSADEKSRLDLGMAAD---YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWE 315
            |.::.|  |.|::...|.:..|   |.| |...:......:|..:|.|:..||||:.|..:||..
Frog   205 YQMILG--APEQTLRSLHLQKDISLYAY-TRSLAQLKSSNNDTGDFKDVAEAMKVIGFKPEEIQT 266

  Fly   316 IIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETV 380
            :.|:|||:||.||:|:   |:|. |.|.|.....:..||.|||...:.:..||..||: |.|..|
Frog   267 VYKILAAILHLGNLKF---VLDG-DTTLIENGKVISVVADLLGTRSEQVEKALLFRTV-ATGRDV 326

  Fly   381 VSTLSRDQSVDV-RDAFVKGIYGRMFVHIVRKINTAI-FKPRGTS----RNAIGVLDIFGFENFD 439
            :.....::..:. ||||.|.||.|:|..||.:||..| .|.:..:    ...||||||:|||.||
Frog   327 IDKQHTEKEANYGRDAFAKAIYERLFCWIVNRINDVIDVKQQDAALHGKNTVIGVLDIYGFEIFD 391

  Fly   440 QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALI 504
            .||||||||||.||.|||.|:|.:...||.||..|.|.|:||::.|||..:||:..:...|:||:
Frog   392 NNSFEQFCINYCNEKLQQLFIQLVLTQEQAEYQREGIPWKHIDYFDNQIIVDLVEQQHRGIIALL 456

  Fly   505 DEEA-RFPKGTDQTMLAKLHKTHGSHKNYLKPK-------SDINTSFGLNHFAGVVFYDTRGFLD 561
            |:.. ...|.||...|..|.|..|.|.:|...|       .:.|..|.:.|:||.|.|...||:|
Frog   457 DDACMNVGKVTDNMFLEALDKQLGKHAHYSSRKVCATDKALEYNRDFRIRHYAGDVVYSVVGFID 521

  Fly   562 KNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFF 626
            ||:||...|...|:..|:|..|:.::.:......|..||..|.:|.|:.|:.||:..|:|.:|::
Frog   522 KNKDTLFQDFKRLMFNSSNAVLKAMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYY 586

  Fly   627 IRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHR 691
            :|||||||.|.|.:||...|..|:.|.|::|.:|:||||:..|..:.:|:.||:.:.....|.|.
Frog   587 VRCIKPNEKKSPALFDEVRCKHQVEYLGLLENVRVRRAGFAYRQVYEKFLHRYKLISSLTWPNHS 651

  Fly   692 TDC-QAATSRI---CAVVLGKSDYQLGHTKVFLKDAHDL-FLEQERDRVLTRKILILQRSIRGWV 751
            ... :.|..|.   |.:   ..|...|.||:|::....| |||:.|..:|.|.||.||:..||.:
Frog   652 LPSDRIAVERFMVDCGL---NHDAAYGKTKIFIRTPRTLFFLEERRSEMLIRIILFLQKLWRGTL 713

  Fly   752 YRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSR-------------VLSHRFR 803
            .|||..|:| |.:|:.|:::.|..:...|.:   ..|...:..||             || .||:
Frog   714 ARRRCKRIR-AGLTILRYYRRYKVKSYLREV---MHRFNGVKNSRDYGKHVKWPTPPKVL-RRFQ 773

  Fly   804 HLRGHIVGLQAHARGYLVRR--------EYGHKMWAVIKIQSHVRRMIAMRR-----YRKLRLEH 855
            ....||..   ..|||.:.|        :...|:.|...::.| |..:.::|     |..|..|:
Frog   774 EALQHIYN---RWRGYQIIRSLPPAEIPKVRAKVAAFENLKGH-RVDMGLQRCWEGSYLALNQEN 834

  Fly   856 KQFAEVLQLRKLEEQELLHRGNKHAREIAEQHYR--DRLHELERREIQEQLENRRRVEVNMNIIN 918
            .:.:::...|..|    |.|.:|..:.:...|.|  :|.:::|.|.|               .|.
Frog   835 GRDSDLFVSRSSE----LQRKDKFMQALFSCHVRKVNRFNKVEDRAI---------------FIT 880

  Fly   919 DAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISED 983
            |   :....:|.||..:.|                 ..|.::|....:....:|.::  :..::|
Frog   881 D---RHLYKMDPGKAYKVM-----------------TSTPLYNVSGISVTSGKDQLV--VFHTKD 923

  Fly   984 EEDL 987
            .:||
Frog   924 NKDL 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	284/695 (41%)
		MYSc_Myo7	77..721	CDD:276832	278/669 (42%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
myo1d	XP_002935562.1	MYSc_Myo1	24..682	CDD:276829	278/668 (42%)
myo1d	XP_002935562.1	Myosin_TH1	803..1004	CDD:368706	31/167 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000