Protein Alignment ck and myo9a

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_002934596.2
• Gene: myo9a / 100216086
• XenbaseID: XB-GENE-492474
• Length: 2613
• Species: Xenopus tropicalis
• Alignment Length: 2514
• Identity: 577/2514 - (22%)
• Similarity: 927/2514 - (36%)
• Gaps: 849/2514 - (33%)

  Fly    22 VAIGARVVSAEGRRIQVRDDDGD--------EVWL--APERR--IKAMHASSVQG--VEDMISLG 72
            :|:.|| .|.|..|..:|:.:.|        :.||  ..|||  ::.......||  .||:..|.
 Frog    94 LALEAR-GSGEDYRFLLREKNMDGSIHYGSLQSWLRVTEERRHMVERGFLPQQQGPECEDLCGLP 157

  Fly    73 DLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGD 137
            ||.|..:|..|..|:::..||||.|:|||||||::.||||....:|:|..|::|:..|||:|:.|
 Frog   158 DLSERALLETLRTRFRQEKIYTYVGTILVAVNPFRFLPIYNPKYVKMYDNRRLGDREPHIYAVAD 222

  Fly   138 NAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNA 200
            .||..|.|.:::||||||||:|:|||:||..::.:|.|:|  |..|.:||.||.|.|:|||||||
 Frog   223 AAYHAMLRRQRNQCIVISGETGSGKTQSTNFLIHHLTALSQKGYASGVEQIILGAGPVLEAFGNA 287

  Fly   201 KTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEK 265
            ||.:|:|||||||:|.:::...|.:.||.:|:|||||||:|.|...||||||||.:|||.|.:||
 Frog   288 KTYQNNNSSRFGKFIQVNYHETGTVRGAYVEKYLLEKSRLVYQEQQERNYHVFYYLLAGASEEEK 352

  Fly   266 SRLDLGMAADYKYLT------------------GGNSITCEGRDDAAEFSDIRSAMKVLLFSDQE 312
            :...|.....|.||.                  ..:|:..||.|...:|..::.||:::.|....
 Frog   353 AEFHLEHPESYHYLNQRTRKPQRQVWGESYGEDETDSLGGEGEDLRHDFERLQLAMEMVGFMPAT 417

  Fly   313 IWEIIKLLAALLHCGNIKYKATVV--DNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA 375
            ..:|:.||:|:||.|||:||....  :::|.:. ||.:|:  |:.||.:..:.|:|||..|....
 Frog   418 RRQIVSLLSAILHLGNIQYKRKTYRDESIDISN-PETLNI--VSELLKVREEMLLDALITRKTVT 479

  Fly   376 HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFK------PRGTSRNAIGVLDIFG 434
            .||.::......:::.|||:..|.:|..:|..||.:||.|:..      ..|:...:||||||||
 Frog   480 VGEKLILPYRLPEAITVRDSLAKSLYSALFDWIVFRINHALLNINSKAIDEGSQTLSIGVLDIFG 544

  Fly   435 FENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLN 499
            ||::..|||||||||||||.||.:|.||:|:||||.|..|.|:|.:|.:.||...::||:.|...
 Frog   545 FEDYGTNSFEQFCINYANERLQHYFNQHLFQLEQELYRSEGISWSNITYSDNGGCINLISKKPTG 609

  Fly   500 IMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNR 564
            ::.|:|||:.||:.|.||:|.|. |.|.....|::..:.:..:|.::|:||.|.|..:.|.:||.
 Frog   610 LLQLLDEESNFPQATHQTLLEKF-KRHNERNPYIEFPAVMEPAFIIHHYAGKVKYGVKDFREKNT 673

  Fly   565 DTFSPDLLHLVSQSTNKFLR----------------QIFAQDIE--------------------- 592
            |...||::.|:..|.|.|:|                :.|.:.:|
 Frog   674 DHMRPDIVALLRSSRNAFIRGMISISPVGAFRWALLRAFFRAVEAFKQSGKSSSKKTGSGPLCTP 738

  Fly   593 --------------------------------------------------MGAET---------- 597
                                                              .||.|
 Frog   739 GPPGSAHKGISSFSFLQHPVHQRSLQILQRCQTDQYNIPRRTPRTPLSDLQGANTIQDRSPKEMS 803

  Fly   598 ----------------------------------------------------------------- 597
                                                                             
 Frog   804 WTSRRQNRLSSSNSYLEGGGIFISSSSSNQNNSTDSKLLERAHGILMRNKSTKNKPALPKHLLDV 868

  Fly   598 ------------------------RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKP 638
                                    :|:.|::|.||:.||:.||:||...:|:|::||:.|..|.|
 Frog   869 KSLKHLSNLTLHDRITKSLLHHHKKKKPPSISAQFQTSLNKLMETLGQAEPYFVKCIRSNAEKVP 933

  Fly   639 MMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRIC 702
            |.||..|..|||||:||:||:|||::||..::.|::||.::..|:| .:.|.|    |:......
 Frog   934 MRFDDALVLRQLRYTGMLETVRIRQSGYSCKYPFQDFVTQFSVLLPKDISPVH----QSIKEFFW 994

  Fly   703 AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQ 767
            .:......||:|.|.||||:.....|.:...:.:.::|::|||.||..:.|:|||..|.|.||:|
 Frog   995 RIGHSPDQYQVGRTMVFLKEQERQCLMEMLHQTVLQRIILLQRWIRARLQRKRFLLFRDAVITIQ 1059

  Fly   768 RFWKGYAQR------------------------KRYRNMRVGYMRLQ---ALIRSRVLSHRFRHL 805
            |.|:.|.:|                        .|.|..|:.:::.:   .:|::....|..:..
 Frog  1060 RCWRHYKRRWIGEEPPVPHTLIPCEAACIIQSWWRCRRTRLRFLKTKNSVLVIQNCWREHNLKKQ 1124

  Fly   806 RGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQ 870
            |. .|.:|:..|....:..|..|:..:|.:|:..|..:|..|:..| ::.|..:.|.:|.:.::.
 Frog  1125 RA-AVSIQSWWRASYQKSLYQRKLKCIIVLQAASRGYLARCRFHSL-MDQKSNSFVHELSQGDKG 1187

  Fly   871 ELLHRGNKHAREI-------------------------------AEQHYRDRLHELE----RREI 900
            ....|...|..::                               .|.|.|:|...||    |...
 Frog  1188 SEPIRLTAHTPDMNCTHLQDSASFELPGQQLLDSSCSADLNTIPVEVHIRERPKSLENPNQRTVF 1252

  Fly   901 QEQLENRRRVEVN--------MNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRET 957
            :.:.|:||..|:.        :.:.:......||....|::::.:.| .|:|.|
 Frog  1253 RAKRESRRLRELEQAQFSLELLKVRSGGISPSEERRWSGEVLDKLVD-TPESDS----------- 1305

  Fly   958 SVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHT 1022
            |||:                :.:...||:|                       ::.|.|  |.|.
 Frog  1306 SVFS----------------LELINPEENL-----------------------QSPKDP--PTHP 1329

  Fly  1023 QGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRN------------FIRSK 1075
            ...::                               :.|..|.||..|            ...||
 Frog  1330 SASEI-------------------------------IPSSPTDTLASNATEACQDFPICDMAASK 1363

  Fly  1076 EFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDD-EYTADSYQSWLQSRP 1139
            .:..:.|..::|.              .|.||:.:.....|....|.:: .||.:...:.....|
 Frog  1364 TYDPSILSRIEPP--------------YSATLEPQCTPSNDHGSHLSNEHHYTPEKLPTCGSLSP 1414

  Fly  1140 TSNLEKLHFIIG---HGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFV 1201
            |.::....|:.|   |..:.:      |.....|:::.|:..| :.|.|:.::       :|:..
 Frog  1415 THSVPHSKFLPGSPNHDSVNS------YFTNHTQVSSRPVNVS-SNGPIISNV-------TEENA 1465

  Fly  1202 NYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLA 1266
            ::      ...|..|....:     .:..:..|.|...|:..:...|. .||:.......:.||:
 Frog  1466 SF------HHTPSAASIAVD-----ISQSSWRQKPQGFEISESAPAKS-SLPVFNRTHTREPLLS 1518

  Fly  1267 DSATTARELCNQLSDKISLKDQFGFSLYIALFDKV--SSLGSGGDHVMDAISQCEQYAKEQGAQE 1329
            .|..|                     .|:...:.|  ..|...|:...:::.|..|...|:..|:
 Frog  1519 SSLPT---------------------FYLPQQETVRTQKLTETGEIPTESVLQRLQKLNEEKEQQ 1562

  Fly  1330 RNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYST 1394
                     :|::                  ||........:.|.:|:|    :..|:...|
 Frog  1563 ---------QKQL------------------QQEKERQMMEQIRQEKQE----LERQRRIQE--- 1593

  Fly  1395 DMSMERLFTLLPNFIPDFCLSGVDKAI-ERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYK 1458
                    |..|..||    .|..|.| :|..:|::|:.::      |..|.|
 Frog  1594 --------TQEPEKIP----LGTSKRISDRPQSLLIQSSQQ------KSPPTK------------ 1628

  Fly  1459 WPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQ 1523
             |.:..:.........|.:.:||..|:
 Frog  1629 -PTVEIKGLSIGGKCDPQVSQNDRPIS-------------------------------------- 1654

  Fly  1524 TFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAP---SDGTSFLSFF--K 1583
                .||.|::...:.|..|                     |....:.|   :.|.|.: ||  |
 Frog  1655 ----KTVGGQDPPCRDPVGE---------------------ARDTGKRPWLHTTGNSTI-FFNPK 1693

  Fly  1584 GDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQ----------DILAL 1638
            |::                       .:.|.|             |.|||          |....
 Frog  1694 GNI-----------------------SNPEIG-------------SSPPQRCARDPIKRLDATEP 1722

  Fly  1639 FNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSR 1703
            ..:.||.|.|:..||        |.|...:...||.......:......|.|.:..:||..|.|:
 Frog  1723 SAVTEAPHRRKARMA--------RTRSDIMTRGALGGADSEEESDDQGELNLPTNAAEEAGRLSQ 1779

  Fly  1704 ----------------DPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDH 1752
                            |  ||..|.|..|:.|.       |..::.:.......||:.| :|.
 Frog  1780 ACHSDSEMMLQRVQGGD--KASRLHKAVSQGEM-------FRFLISHNTSESDTRPQKG-KIR-- 1832

  Fly  1753 IFDGPLK--------HEILRDEIYCQLMKQLTDNRNRMSEERGWEL---MWLATGLFACSQGLLK 1806
             |.|.||        .|||..::.       ...::.||.....::   :||.......|:|..|
 Frog  1833 -FWGKLKASEKLTTPSEILEMDVD-------PSGKDCMSSILSSDVDSGLWLVPHSPDLSRGREK 1889

  Fly  1807 ELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAF-- 1869
            |            ::|...::|   |....|.....:|....||:..||..........||..
 Frog  1890 E------------NKDPSPKVQ---RRRSLKISSAGLEPVQWQHEHAQIICSASDLKCMDEFLQK 1939

  Fly  1870 ---EVDSSTRAKD-------------FCNNISQ--RLSLRTSEGFS--------LFVKIADKVIS 1908
               ::||....||             |..||..  ..||...||.|        ||.:|.||.:.
 Frog  1940 KIGDLDSEDGKKDSLVDVLFKRALKEFRQNIFSLYSTSLMGEEGKSIRYRDLGALFEQILDKTMK 2004

  Fly  1909 VPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFF------MKKLWTNTVPGK--------- 1958
                      .:|...|.:.  |:|...|   |::||.      .|.|  |..|||
 Frog  2005 ----------QQHPRSWSES--PLRVWIN---TFKVFLDEFVTEYKPL--NYTPGKIQKTERKKR 2052

  Fly  1959 -DRNADLIFHYHQELPKLLR----------------------------GYHK---------CSRE 1985
             .:::|::..::..:.|:.:                            ..||         |:::
 Frog  2053 RKKDSDIVEEHNGHIFKITQYNIPTYCEYCSSLIWIMDRAAVCKLCRYACHKKCCSLINVACNKK 2117

  Fly  1986 EAAKLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAK 2050
            ..::|:...|.|.......|.:.:|.:|.:||                   ||.:..|:.:|.
 Frog  2118 NDSELSTRQFGVDLSRLTNEERLVPVLLEKLI-------------------SYIEMHGLYTEG-- 2161

  Fly  2051 VAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLI 2094
                  :||.|...:...|::|:.:.:...:.|...|.|.::.:
 Frog  2162 ------IYRKPGSTNKIRELRQSLDTDIENVNLDDYNIHVIASV 2199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	280/858 (33%)
		MyTH4	<1138..1245	CDD:214535	17/109 (16%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	15/99 (15%)
		B41	1251..1467	CDD:214604	36/218 (17%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	9/97 (9%)
		SH3	1560..1624	CDD:473055	10/68 (15%)
		MyTH4	1701..1849	CDD:214535	33/174 (19%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	30/130 (23%)
		B41	1856..2068	CDD:214604	53/292 (18%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	5/31 (16%)
myo9a	XP_002934596.2	Ubl1_cv_Nsp3_N-like	17..112	CDD:475130	7/18 (39%)
		MYSc_Myo9	162..1013	CDD:276836	280/858 (33%)
		IQ	1145..1167	CDD:197470	6/21 (29%)
		C1_Myosin-IXa	2061..2118	CDD:410433	4/56 (7%)
		RhoGAP	2127..2312	CDD:470621	19/100 (19%)
		APG6_N	<2393..>2438	CDD:465452