DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(H) and rbpjb

DIOPT Version :9

Sequence 1:	NP_001285948.1	Gene:	Su(H) / 34881	FlyBaseID:	FBgn0004837	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001077020.1	Gene:	rbpjb / 563306	ZFINID:	ZDB-GENE-070319-1	Length:	491	Species:	Danio rerio

Alignment Length:	475	Identity:	357/475 - (75%)
Similarity:	404/475 - (85%)	Gaps:	5/475 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LLPGPYRPHIEEKKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIYLFGSGWR 155
            ::.|.:....:.::|||:||..|::||.|..::|||||||||||||||||||||||:||.|.||:
Zfish     4 VVTGKFGERPQPQRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGCGWK 68

  Fly   156 RRYEEMLQQGEGEQGAQLCAFIGIGSSDQDMQQLDLNGKQYCAAKTLFISDSDKRKHFMLSVKMF 220
            ::.|:|.:.|..||.:|.|||||||:|:|:||||:|.||.||.||||:|||||||||||||||||
Zfish    69 KKREQMERDGCSEQESQPCAFIGIGNSEQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMF 133

  Fly   221 YGNGHDIGVFNSKRIKVISKPSKKKQSLKNADLCIASGTNVALFNRLRSQTVSTRYLHVENGHFH 285
            |||..|||||.||||||||||||||||||||||||||||.||||||||||||||||||||.|:||
Zfish   134 YGNSADIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFH 198

  Fly   286 ASSTQWGAFTIHLLDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQMALLEA 350
            |||.|||||.||||||.|||.|||.|||||||||.||||||||||||||||||||||||.|||:|
Zfish   199 ASSQQWGAFFIHLLDDEESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDA 263

  Fly   351 DDPVSQLHKCAFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMINDGACWTIISTDKAEYQFY 415
            |||||||||||||:|||:|||||||||:||||||||||||||||||||||.|||||||||||.||
Zfish   264 DDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFY 328

  Fly   416 EGMGPVASPVTPVPIVNSLNLNGGGDVAMLELSGDNFTPHLQVWFGDVEAETMYRCTETLLCVVP 480
            ||||||.:||||||:|.||.||||||||||||:|.||:|.|:||||||||||||||.|::|||||
Zfish   329 EGMGPVHTPVTPVPVVESLQLNGGGDVAMLELTGQNFSPTLRVWFGDVEAETMYRCGESMLCVVP 393

  Fly   481 EISQFRGEWLWVRQPTQVPISLVRNDGIIYATGLTFTYTPEPGPRPHCNTQAEDVMRARQNNNNN 545
            :||.||..|.|||||.|||::|||||||||:|.|||||||||||||||:. |..::|    ..:.
Zfish   394 DISAFREGWRWVRQPVQVPVTLVRNDGIIYSTTLTFTYTPEPGPRPHCSA-AGAILR----TGSA 453

  Fly   546 NITSISNNNNSNNAGSPAAG 565
            ::.|||.|:...|..:...|
Zfish   454 SLLSISGNSTGGNGETAPYG 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(H)	NP_001285948.1	LAG1-DNAbind	122..251	CDD:286370	99/128 (77%)
		BTD	253..402	CDD:286369	134/148 (91%)
		IPT_RBP-Jkappa	424..520	CDD:238581	74/95 (78%)
rbpjb	NP_001077020.1	LAG1-DNAbind	35..164	CDD:286370	99/128 (77%)
		BTD	166..315	CDD:286369	134/148 (91%)
		IPT_RBP-Jkappa	337..433	CDD:238581	74/95 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585298
Domainoid	1	1.000	281	1.000	Domainoid score	I1632
eggNOG	1	0.900	-	-		E1_KOG3743
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7511
Inparanoid	1	1.050	742	1.000	Inparanoid score	I572
OMA	1	1.010	-	-		QHG48640
OrthoDB	1	1.010	-	-		D323392at33208
OrthoFinder	1	1.000	-	-		FOG0002244
OrthoInspector	1	1.000	-	-		otm24919
orthoMCL	1	0.900	-	-		OOG6_104439
Panther	1	1.100	-	-	LDO	PTHR10665
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3206
SonicParanoid	1	1.000	-	-		X1483
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800