DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(H) and rbpja

DIOPT Version :9

Sequence 1:	NP_001285948.1	Gene:	Su(H) / 34881	FlyBaseID:	FBgn0004837	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_942579.2	Gene:	rbpja / 386772	ZFINID:	ZDB-GENE-031117-1	Length:	496	Species:	Danio rerio

Alignment Length:	485	Identity:	363/485 - (74%)
Similarity:	414/485 - (85%)	Gaps:	22/485 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LPGPYRPHIEEKKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIYLFGSGWRR 156
            ||.|       |:|||:||..|::||.|..::|||||||||||||||||||||||:||.|.||::
Zfish    12 LPQP-------KRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGCGWKK 69

  Fly   157 RYEEMLQQGEGEQGAQLCAFIGIGSSDQDMQQLDLNGKQYCAAKTLFISDSDKRKHFMLSVKMFY 221
            :.|:|.::|..||.:|.|||||||:|:|:||||:|.||.:|.||||:||||||||||||||||||
Zfish    70 KKEQMEREGCSEQESQPCAFIGIGNSEQEMQQLNLEGKNFCTAKTLYISDSDKRKHFMLSVKMFY 134

  Fly   222 GNGHDIGVFNSKRIKVISKPSKKKQSLKNADLCIASGTNVALFNRLRSQTVSTRYLHVENGHFHA 286
            ||..|||||.||||||||||||||||||||||||||||.||||||||||||||||||||.|:|||
Zfish   135 GNSADIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHA 199

  Fly   287 SSTQWGAFTIHLLDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQMALLEAD 351
            ||.|||||.||||||:|||.|||.|||||||||.||||||||||||||||||||||||.||::||
Zfish   200 SSQQWGAFYIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALMDAD 264

  Fly   352 DPVSQLHKCAFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMINDGACWTIISTDKAEYQFYE 416
            ||||||||||||:|||:|||||||||:||||||||||||.|||||||||.|||||||||||.|||
Zfish   265 DPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKETNKEMINDGASWTIISTDKAEYTFYE 329

  Fly   417 GMGPVASPVTPVPIVNSLNLNGGGDVAMLELSGDNFTPHLQVWFGDVEAETMYRCTETLLCVVPE 481
            |||||.|||||||:|.||.||||||||||||:|.||||:|:||||||||:|||||.|::|||||:
Zfish   330 GMGPVPSPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEADTMYRCGESVLCVVPD 394

  Fly   482 ISQFRGEWLWVRQPTQVPISLVRNDGIIYATGLTFTYTPEPGPRPHCNTQAEDVMRARQNNNNNN 546
            ||.||..|.|||||.|||::|||||||||:|.|||||||||||||||:. |..::||    |:|:
Zfish   395 ISAFREGWRWVRQPVQVPVTLVRNDGIIYSTALTFTYTPEPGPRPHCSA-AGAILRA----NSNS 454

  Fly   547 ITSISNNNNSNN----------AGSPAAGG 566
            .||.|:::::::          ||..|:||
Zfish   455 STSPSSSSSASSLLLQSAVDSQAGYGASGG 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(H)	NP_001285948.1	LAG1-DNAbind	122..251	CDD:286370	98/128 (77%)
		BTD	253..402	CDD:286369	132/148 (89%)
		IPT_RBP-Jkappa	424..520	CDD:238581	74/95 (78%)
rbpja	NP_942579.2	LAG1-DNAbind	35..164	CDD:286370	98/128 (77%)
		BTD	166..315	CDD:286369	132/148 (89%)
		IPT_RBP-Jkappa	345..433	CDD:238581	67/87 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585297
Domainoid	1	1.000	281	1.000	Domainoid score	I1632
eggNOG	1	0.900	-	-		E1_KOG3743
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	742	1.000	Inparanoid score	I572
OMA	1	1.010	-	-		QHG48640
OrthoDB	1	1.010	-	-		D323392at33208
OrthoFinder	1	1.000	-	-		FOG0002244
OrthoInspector	1	1.000	-	-		otm24919
orthoMCL	1	0.900	-	-		OOG6_104439
Panther	1	1.100	-	-	O	PTHR10665
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3206
SonicParanoid	1	1.000	-	-		X1483
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300