DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(H) and Rbpjl

DIOPT Version :9

Sequence 1:	NP_001285948.1	Gene:	Su(H) / 34881	FlyBaseID:	FBgn0004837	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001102074.1	Gene:	Rbpjl / 362268	RGDID:	1304786	Length:	515	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	245/515 - (47%)
Similarity:	334/515 - (64%)	Gaps:	46/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VNPNGSPLDPHQQQQQQSQDMPHFGLPGPQPPSSQQQQQQLQVHHQQQQQQQQQQQQQQHQQQMQ 88
            :|| |...||         .:|    |||....|.....::::                  |...
  Rat     1 MNP-GETTDP---------SVP----PGPLTHLSLPDSSEVRL------------------QNDG 33

  Fly    89 MSLLPGPYRPHIEEKKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIYLFGSG 153
            .|||....|...|...:.|:.:...:::|.:..:.||||||||||||.||||||||||:||.|.|
  Rat    34 PSLLGSWTRSPPEHATILREGVRTCLQQRCEQTVWILHAKVAQKSYGTEKRFFCPPPCVYLAGPG 98

  Fly   154 WR-RRYEEMLQQGEGEQGAQLCAFIGI---GSSDQDMQQLDL----NGKQYCAAKTLFISDSDKR 210
            || :..::.:.| ..:.|..:|.::|:   ..|..:.|:|:.    :.:::..||||||||:|||
  Rat    99 WRVKPMQDQVHQ-SADTGPTVCGYMGLDGASGSAPETQKLNFEEQPDSREFGCAKTLFISDADKR 162

  Fly   211 KHFMLSVKMFYGNGHDIGVFNSKRIKVISKPSKKKQSLKNADLCIASGTNVALFNRLRSQTVSTR 275
            |||.|.:::....|.::|.|:|:.||||||||:|||||||.||||:||:.|:|||||||||||||
  Rat   163 KHFRLVLRLVQRGGRELGTFHSRLIKVISKPSQKKQSLKNTDLCISSGSKVSLFNRLRSQTVSTR 227

  Fly   276 YLHVENGHFHASSTQWGAFTIHLLDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRK 340
            ||.||:|.|.||:.||.|||:||.|.:.|:. :|..::|||.||:.|:|||:|||:.||.:||||
  Rat   228 YLSVEDGAFVASARQWAAFTLHLADGHCSQG-DFPPQEGYIRYGSLVQLVCTVTGITLPPMIIRK 291

  Fly   341 VDKQMALLEADDPVSQLHKCAF-YMKDTD---RMYLCLSQEKIIQFQATPCPKEPNKEMINDGAC 401
            |.||.|||:.|:|:|||||||| :..||.   ..|||||.||:::|||:.||||.|:.::||.:|
  Rat   292 VAKQCALLDVDEPISQLHKCAFQFPGDTPGGAGTYLCLSTEKVVRFQASLCPKEANRALLNDSSC 356

  Fly   402 WTIISTDKAEYQFYEGMGPVASPVTPVPIVNSLNLNGGGDVAMLELSGDNFTPHLQVWFGDVEAE 466
            ||||.|:..|:.|...:.....||||||.:::|.|:||||||.|||.|:||...|:|||||||||
  Rat   357 WTIIGTESVEFSFSTSLACTPEPVTPVPHISTLELSGGGDVATLELHGENFHAGLKVWFGDVEAE 421

  Fly   467 TMYRCTETLLCVVPEISQFRGEWLWVRQPTQVPISLVRNDGIIYATGLTFTYTPEPGPRP 526
            ||||...:|:||||:::.|..:|.|:|.|..||:||:|.|.:.|.:..:||||||...||
  Rat   422 TMYRSPRSLVCVVPDVAAFGSDWRWLRTPITVPVSLLRADALFYPSAFSFTYTPEYSTRP 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(H)	NP_001285948.1	LAG1-DNAbind	122..251	CDD:286370	68/136 (50%)
		BTD	253..402	CDD:286369	90/152 (59%)
		IPT_RBP-Jkappa	424..520	CDD:238581	54/95 (57%)
Rbpjl	NP_001102074.1	LAG1-DNAbind	67..203	CDD:286370	68/136 (50%)
		BTD	205..357	CDD:286369	90/152 (59%)
		IPT_RBP-Jkappa	379..475	CDD:238581	54/95 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344232
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3743
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323392at33208
OrthoFinder	1	1.000	-	-		FOG0002244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10665
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1483
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850