DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(H) and RBPJ

DIOPT Version :9

Sequence 1:	NP_001285948.1	Gene:	Su(H) / 34881	FlyBaseID:	FBgn0004837	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_016863659.1	Gene:	RBPJ / 3516	HGNCID:	5724	Length:	506	Species:	Homo sapiens

Alignment Length:	474	Identity:	365/474 - (77%)
Similarity:	408/474 - (86%)	Gaps:	10/474 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LLPGPYRPHIEE---KKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIYLFGS 152
            |.|...|...|.   |:|||:||..|::||.|..::|||||||||||||||||||||||:||.||
Human    20 LYPASLRKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS 84

  Fly   153 GWRRRYEEMLQQGEGEQGAQLCAFIGIGSSDQDMQQLDLNGKQYCAAKTLFISDSDKRKHFMLSV 217
            ||:::.|:|.:.|..||.:|.|||||||:|||:||||:|.||.||.||||:||||||||||||||
Human    85 GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSV 149

  Fly   218 KMFYGNGHDIGVFNSKRIKVISKPSKKKQSLKNADLCIASGTNVALFNRLRSQTVSTRYLHVENG 282
            ||||||..|||||.||||||||||||||||||||||||||||.||||||||||||||||||||.|
Human   150 KMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGG 214

  Fly   283 HFHASSTQWGAFTIHLLDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQMAL 347
            :|||||.|||||.||||||:|||.|||.|||||||||.||||||||||||||||||||||||.||
Human   215 NFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTAL 279

  Fly   348 LEADDPVSQLHKCAFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMINDGACWTIISTDKAEY 412
            |:||||||||||||||:|||:|||||||||:||||||||||||||||||||||.|||||||||||
Human   280 LDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEY 344

  Fly   413 QFYEGMGPVASPVTPVPIVNSLNLNGGGDVAMLELSGDNFTPHLQVWFGDVEAETMYRCTETLLC 477
            .||||||||.:||||||:|.||.||||||||||||:|.||||:|:||||||||||||||.|::||
Human   345 TFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLC 409

  Fly   478 VVPEISQFRGEWLWVRQPTQVPISLVRNDGIIYATGLTFTYTPEPGPRPHCNTQAEDVMRARQNN 542
            |||:||.||..|.|||||.|||::|||||||||:|.|||||||||||||||:. |..::||
Human   410 VVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSA-AGAILRA---- 469

  Fly   543 NNNNITSISNNNNSNNAGS 561
            |::.:.  .|.:|:|:.||
Human   470 NSSQVP--PNESNTNSEGS 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(H)	NP_001285948.1	LAG1-DNAbind	122..251	CDD:286370	101/128 (79%)
		BTD	253..402	CDD:286369	134/148 (91%)
		IPT_RBP-Jkappa	424..520	CDD:238581	75/95 (79%)
RBPJ	XP_016863659.1	LAG1-DNAbind	54..183	CDD:312691	101/128 (79%)
		BTD	185..334	CDD:312690	134/148 (91%)
		IPT_RBP-Jkappa	356..452	CDD:238581	75/95 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150742
Domainoid	1	1.000	282	1.000	Domainoid score	I1671
eggNOG	1	0.900	-	-		E1_KOG3743
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7511
Inparanoid	1	1.050	750	1.000	Inparanoid score	I574
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48640
OrthoDB	1	1.010	-	-		D323392at33208
OrthoFinder	1	1.000	-	-		FOG0002244
OrthoInspector	1	1.000	-	-		oto91275
orthoMCL	1	0.900	-	-		OOG6_104439
Panther	1	1.100	-	-	LDO	PTHR10665
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3206
SonicParanoid	1	1.000	-	-		X1483
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800