Protein Alignment GABA-B-R1 and GLR3.4

DIOPT Version :10

• Sequence 1: NP_523569.3
• Gene: GABA-B-R1 / 34878
• FlyBaseID: FBgn0260446
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_172012.2
• Gene: GLR3.4 / 839268
• AraportID: AT1G05200
• Length: 959
• Species: Arabidopsis thaliana
• Alignment Length: 921
• Identity: 170/921 - (18%)
• Similarity: 305/921 - (33%)
• Gaps: 337/921 - (36%)

  Fly    29 RPDELHIGGIFP----IAGKGGWQGGQACMPAARLALDDVNKQPNLLPGFKLILHSNDSECEPGL 89
            ||..:::|.:|.    |        |:|..||.:.|:||||...::|.|.||.:...||.|...:
plant    57 RPSSVNVGALFTYDSFI--------GRAAKPAVKAAMDDVNADQSVLKGIKLNIIFQDSNCSGFI 113

  Fly    90 GASVMYNLLYNK------PQKLMLLAGCSTVCTTVAEAAKMWNLIVLCYGASSPALSDRKRFPTL 148
            |......|:.||      ||.       |.:...::..|...::.:|.:||:.|.||. .:||..
plant   114 GTMGALQLMENKVVAAIGPQS-------SGIAHMISYVANELHVPLLSFGATDPTLSS-LQFPYF 170

  Fly   149 FRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLENRCMEAGVEIV--------TR 205
            .||..:...........:...||      :|...:|:      ::.|...|:.::        :|
plant   171 LRTTQNDYFQMHAIADFLSYSGW------RQVIAIFV------DDECGRNGISVLGDVLAKKRSR 223

  Fly   206 QSFLSDPT---------DAVRNLRRQDARIIV---------GLFYVVAARRVLCEMYKQQLYGRA 252
            .|:.:..|         |.:.::...::|:.|         .:|.|..:..::...|
plant   224 ISYKAAITPGADSSSIRDLLVSVNLMESRVFVVHVNPDSGLNVFSVAKSLGMMASGY-------- 280

  Fly   253 HVWFFIGWYEDNWYEVNLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRL 317
             ||....|              :...::.|.     |:.::.:       ..:.|:.|  |||..
plant   281 -VWIATDW--------------LPTAMDSME-----HVDSDTM-------DLLQGVVA--FRHYT 316

  Fly   318 NQALIEEGYDI--NHDRYPEGYQE-APLAYDAVWSVALAF-------------NKTMERLTTGK- 365
            .::.::..:..  .:.|..:|:.. |..|||:||.||.|.             |......|.|.
plant   317 IESSVKRQFMARWKNLRPNDGFNSYAMYAYDSVWLVARALDVFFRENNNITFSNDPNLHKTNGST 381

  Fly   366 ---KSLRDFTYTDKEIADEIYAAMNSTQFLGVSGVVAFSSQGDRIALTQIEQMIDGKYEK-LGYY 426
               .:|..|...:|.:  :|...||.|   ||:|.:.|.|..:|:........::|...: :||:
plant   382 IQLSALSVFNEGEKFM--KIILGMNHT---GVTGPIQFDSDRNRVNPAYEVLNLEGTAPRTVGYW 441

  Fly   427 DTQLDNLSWLNTEQ------------------------------WI---GGK-----VPQDRTIV 453
            ... ..||.::.|.                              |:   .||     ||...:..
plant   442 SNH-SGLSVVHPETLYSRPPNTSTANQRLKGIIYPGEVTKPPRGWVFPNNGKPLRIGVPNRVSYT 505

  Fly   454 THVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFG--------- 509
            .:|.:..:.|.....|    ..:|.|...::             .:||..|.:|:|
plant   506 DYVSKDKNPPGVRGYC----IDVFEAAIELL-------------PYPVPRTYILYGDGKRNPSYD 553

  Fly   510 -----VI----------ICLIS-----------------VILLGIDGRFVSPEEYPKICQARAWL 542
                 |:          |.:::                 |::..:.....||..:.|......|.
plant   554 NLVNEVVADNFDVAVGDITIVTNRTRYVDFTQPFIESGLVVVAPVKEAKSSPWSFLKPFTIEMWA 618

  Fly   543 LSTGFTLAYGAMFSKVWRV-HRFTTKAKTDPKKKVEPWKLYTMVSGLLSIDLVILLSWQIFDPLQ 606
            ::.||.|..|||   ||.: |||..:.:..|:::                  :|.:.|..|..:
plant   619 VTGGFFLFVGAM---VWILEHRFNQEFRGPPRRQ------------------LITIFWFSFSTM- 661

  Fly   607 RYLETFPLEDPVSTTDDIKIRPELEHCESQRNSM-------WLGLVYGFKGLILVFGLFLAYETR 664
                                  ...|.|:..:|:       ||.:|      :::...:.|..|.
plant   662 ----------------------FFSHRENTVSSLGRFVLIIWLFVV------LIINSSYTASLTS 698

  Fly   665 SIKVKQINDSRYVGMSIYNVVVLCLITA--PVGMVIASQQDASFAFVALAVIFCCFLSMLLIFVP 727
            .:.::|:. ||..|:.       .|:|:  |:|:     ||.:||...|       ::.|.|.
plant   699 ILTIRQLT-SRIEGID-------SLVTSNEPIGV-----QDGTFARNYL-------INELNIL-- 741

  Fly   728 KVIEVIRHPKDKAESKYNPDSAISKEDEERY-------------QKLVTENEELQRLITQKEEKI 779
                              |...:..:|||:|             ..:|.|...::.|:|....|.
plant   742 ------------------PSRIVPLKDEEQYLSALQRGPNAGGVAAIVDELPYIEVLLTNSNCKF 788

  Fly   780 RVLRQRLVERG 790
            |.:.|.....|
plant   789 RTVGQEFTRTG 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_523569.3	PBP1_GABAb_receptor	34..443	CDD:380589	96/498 (19%)
		7tmC_GABA-B-R1	463..734	CDD:320418	54/321 (17%)
		TM helix 1	463..488	CDD:320418	4/24 (17%)
		TM helix 2	500..521	CDD:320418	8/61 (13%)
		TM helix 3	537..561	CDD:320418	9/23 (39%)
		TM helix 4	581..601	CDD:320418	2/19 (11%)
		TM helix 5	638..664	CDD:320418	5/32 (16%)
		TM helix 6	673..696	CDD:320418	6/24 (25%)
		TM helix 7	703..728	CDD:320418	6/24 (25%)
GLR3.4	NP_172012.2	PBP1_GABAb_receptor_plant	62..450	CDD:380645	94/458 (21%)
		Lig_chan-Glu_bd	507..591	CDD:463166	12/100 (12%)
		Lig_chan	613..867	CDD:459656	52/277 (19%)