DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R1 and Gabbr2

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_113990.2	Gene:	Gabbr2 / 83633	RGDID:	619864	Length:	940	Species:	Rattus norvegicus

Alignment Length:	844	Identity:	285/844 - (33%)
Similarity:	454/844 - (53%)	Gaps:	56/844 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LCLIASPHLQGGVAGRP------DELHIGGIFPI---AGKGGWQGGQACMPAARLALDDVNKQPN 69
            |.|..:|...|...|.|      ..|.|.|:.|:   ..||..  |:..:||..||::.:..:..
  Rat    30 LLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSI--GRGVLPAVELAIEQIRNESL 92

  Fly    70 LLPGFKLILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAG-CSTVCTTVAEAAKMWNLIVLCYG 133
            |.|.| |.|...|:||:...|....|:.:...|..||:..| |.:|.:.:||:.:.|||:.|.:.
  Rat    93 LRPYF-LDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFA 156

  Fly   134 ASSPALSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLENRCMEA 198
            |::|.|:|:|::|..|||.||....||..:||:|.|.|.||..|.|..:.|.....||.......
  Rat   157 ATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGE 221

  Fly   199 GVEIVTRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRAHVWFFIGWYED 263
            .:||...:||.:||..:|:.|:..|.|||:|.|....|.:|.|..:::.::|..:.|...||||.
  Rat   222 DIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEP 286

  Fly   264 NWYE-VNLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRLNQALIEEGYD 327
            .|:| |:::|....|....:..|.||::..:....:.....||||.|.:::....|......|..
  Rat   287 AWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNSKRSGVGPS 351

  Fly   328 INHDRYPEGYQEAPLAYDAVWSVALAFNKTMERL--TTGKKSLRDFTYTDKEIADEIYAAMNSTQ 390
            ..|     ||     |||.:|.:|....:.||.|  ::..:.::||.|||..:...|..|||.|.
  Rat   352 KFH-----GY-----AYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETN 406

  Fly   391 FLGVSGVVAFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSWLN-TEQWIGGKVPQDRTIVT 454
            |.||:|.|.|.: |:|:...:..|..|.:..|:|.|:...|.|..:| |.::.|.:.|:|:||:.
  Rat   407 FFGVTGQVVFRN-GERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIIL 470

  Fly   455 HVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLISVIL 519
            ..||.:||||:..:..::..|:.:|.|.:.|||.|:::::|:.|.|..|.:::.|.::...|:.|
  Rat   471 EQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFL 535

  Fly   520 LGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPKKKVEPWKLYTM 584
            .|:||.|||.:.:..:|..|.|:|:.|:|.|:||||:|.||||......|. .||.::..||..:
  Rat   536 FGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKM-KKKIIKDQKLLVI 599

  Fly   585 VSGLLSIDLVILLSWQIFDPLQRYLETFPLE-DPVSTTDDIKIRPELEHCESQRNSMWLGLVYGF 648
            |.|:|.|||.||:.||..|||:|.:|.:.:| ||...  ||.|||.|||||:...::|||:||.:
  Rat   600 VGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGR--DISIRPLLEHCENTHMTIWLGIVYAY 662

  Fly   649 KGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDASFAFVALAV 713
            |||:::||.|||:|||::.:..:|||:|:|||:|||.::|:|.|.|..:...|.:..|..|||.:
  Rat   663 KGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVI 727

  Fly   714 IFCCFLSMLLIFVPKVIEVIRHP--------------KDKAESKYNPD-SAISKEDEERYQKLVT 763
            |||..:::.|:||||:|.:..:|              :.|.:||.:.. :::::....|.:.|.:
  Rat   728 IFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQS 792

  Fly   764 ENEELQRLITQKEEKIRVLRQRLVERGDAKGT--------ELNGATGVASAAVATTSQPASLIN 819
            ||..|:..||:.::.:..:..:|.:..: |.|        |||....:.:...:|....|.|.|
  Rat   793 ENHRLRMKITELDKDLEEVTMQLQDTPE-KTTYIKQNHYQELNDILSLGNFTESTDGGKAILKN 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	131/409 (32%)
		ANF_receptor	52..415	CDD:279440	118/366 (32%)
		7tm_3	476..730	CDD:278433	111/254 (44%)
Gabbr2	NP_113990.2	PBP1_GABAb_receptor	57..459	CDD:380589	133/415 (32%)
		7tmC_GABA-B-R2	479..748	CDD:320421	115/271 (42%)
		TM helix 1	480..504	CDD:320421	6/23 (26%)
		TM helix 2	516..537	CDD:320421	5/20 (25%)
		TM helix 3	553..575	CDD:320421	11/21 (52%)
		TM helix 4	598..614	CDD:320421	8/15 (53%)
		TM helix 5	652..675	CDD:320421	12/22 (55%)
		TM helix 6	688..710	CDD:320421	12/21 (57%)
		TM helix 7	717..742	CDD:320421	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..789		4/26 (15%)
		GBR2_CC	778..816	CDD:375881	7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49267
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830