Protein Alignment GABA-B-R1 and GLR3.5

DIOPT Version :10

• Sequence 1: NP_523569.3
• Gene: GABA-B-R1 / 34878
• FlyBaseID: FBgn0260446
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_001324013.1
• Gene: GLR3.5 / 817800
• AraportID: AT2G32390
• Length: 953
• Species: Arabidopsis thaliana
• Alignment Length: 944
• Identity: 178/944 - (18%)
• Similarity: 312/944 - (33%)
• Gaps: 321/944 - (34%)

  Fly     7 VTFWIFLLCLIA---SPHLQGGVAGR------------PDELHIGGIFPIAGKGGWQG--GQACM 54
            |:....|||:.|   .| :||  |||            |..:::|.:|.      :..  |:|..
plant    10 VSMGFMLLCISALWVLP-IQG--AGRESFSRNSSSSSLPSSVNVGALFT------YDSFIGRAAK 65

  Fly    55 PAARLALDDVNKQPNLLPGFKLILHSNDSECEPGLGASVMYNLLYNK------PQKLMLLAGCST 113
            .|...|::|:|...::|.|.||.:...|:.|...:|......|:.||      ||.       |.
plant    66 LAFVAAIEDINADQSILRGTKLNIVFQDTNCSGFVGTMGALQLMENKVVAAIGPQS-------SG 123

  Fly   114 VCTTVAEAAKMWNLIVLCYGASSPALSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQ 178
            :...::..|...::..|.:.|:.|.||. .::|...||..:...........:..|.|..|..:.
plant   124 IGHIISHVANELHVPFLSFAATDPTLSS-LQYPYFLRTTQNDYFQMNAITDFVSYFRWREVVAIF 187

  Fly   179 QAEEVFISTVEDLENRCMEAGVEIVTRQSF-----LSDPTDAVRNLRRQDARIIV-------GLF 231
            ..:|...:.:..|.:...:...:|..:.:|     .|..:|.:.::...::||.|       ||.
plant   188 VDDEYGRNGISVLGDALAKKRAKISYKAAFPPGADNSSISDLLASVNLMESRIFVVHVNPDSGLN 252

  Fly   232 YVVAARRVLCEMYKQQLYGRAHVWFFIGWY---EDNWYEVNLKAEGITCTVEQMRIAAEGHLTTE 293
            ....|:.:       .:.|..:||....|.   .|:...::.:|..:...|...|     |.|.|
plant   253 IFSVAKSL-------GMMGSGYVWITTDWLLTALDSMEPLDPRALDLLQGVVAFR-----HYTPE 305

  Fly   294 ALMWNQNNQTTISGMTAEEFRHRLNQALIEEGYDINHDRYPEGYQEAPL-AYDAVWSVALAFNKT 357
            :     :|:        .:|:.|......:|..     :..:|:....| |||:||.||.|.:..
plant   306 S-----DNK--------RQFKGRWKNLRFKESL-----KSDDGFNSYALYAYDSVWLVARALDVF 352

  Fly   358 MERLTT----GKKSLRD-----------FTYTDKEIADEIYAAMNSTQFLGVSGVVAFSSQGDRI 407
            ..:..|    ...|||:           ..:.:.|...::...||.|   |::|.:.|:|:.:|
plant   353 FSQGNTVTFSNDPSLRNTNDSGIKLSKLHIFNEGERFLQVILEMNYT---GLTGQIEFNSEKNR- 413

  Fly   408 ALTQIEQMIDGKYE----------KLGYY------------------------DTQLDNLSWLN- 437
                    |:..|:          ::||:                        |.:|:.:.|..
plant   414 --------INPAYDILNIKSTGPLRVGYWSNHTGFSVAPPETLYSKPSNTSAKDQRLNEIIWPGE 470

  Fly   438 ----TEQWI---GGK-----VPQDRTIVTHVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNK 490
                ...|:   .||     || :|....:.......||.|           ..|.:.||
plant   471 VIKPPRGWVFPENGKPLKIGVP-NRVSYKNYASKDKNPLGV-----------KGFCIDIF----- 518

  Fly   491 HRRVIQ-SSHPVCNTIMLFG----------VI--------------ICLIS-------------- 516
             ...|| ..:||..|.:|:|          :|              :.:|:
plant   519 -EAAIQLLPYPVPRTYILYGDGKKNPSYDNLISEVAANIFDVAVGDVTIITNRTKFVDFTQPFIE 582

  Fly   517 ---VILLGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRV-HRFTTKAKTDPKKKVE 577
               |::..:.|...||..:.|......|.::....|..||:   :|.: |||..:.:..|:::
plant   583 SGLVVVAPVKGAKSSPWSFLKPFTIEMWAVTGALFLFVGAV---IWILEHRFNEEFRGPPRRQ-- 642

  Fly   578 PWKLYTMVSGLLSIDLVILLSWQIFDPL---QRYLETFPLEDPVSTTDDIKIRPELEHCESQRNS 639
                            :|.:.|..|..:   .|       |:.|||.....:            .
plant   643 ----------------IITVFWFSFSTMFFSHR-------ENTVSTLGRFVL------------L 672

  Fly   640 MWLGLVYGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDA 704
            :||.:|      :::...:.|..|..:.|:|:. ||..||.     .|.....|:|:     ||.
plant   673 VWLFVV------LIINSSYTASLTSILTVQQLT-SRIEGMD-----TLIASNEPIGV-----QDG 720

  Fly   705 SFAFVALAVIFCCFLSMLLIFVPKVIEVIRHPKDKAESKYNPDSAISKEDEERY----------- 758
            :||:..|.                           .|....|...|..:|||.|
plant   721 TFAWKFLV---------------------------NELNIAPSRIIPLKDEEEYLSALQRGPRGG 758

  Fly   759 --QKLVTENEELQRLITQKEEKIRVLRQRLVERG 790
              ..:|.|...::.|::....|.|.:.|.....|
plant   759 GVAAIVDELPYIKALLSNSNCKFRTVGQEFTRTG 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_523569.3	PBP1_GABAb_receptor	34..443	CDD:380589	91/489 (19%)
		7tmC_GABA-B-R1	463..734	CDD:320418	56/316 (18%)
		TM helix 1	463..488	CDD:320418	6/24 (25%)
		TM helix 2	500..521	CDD:320418	8/61 (13%)
		TM helix 3	537..561	CDD:320418	5/23 (22%)
		TM helix 4	581..601	CDD:320418	2/19 (11%)
		TM helix 5	638..664	CDD:320418	4/25 (16%)
		TM helix 6	673..696	CDD:320418	6/22 (27%)
		TM helix 7	703..728	CDD:320418	4/24 (17%)
GLR3.5	NP_001324013.1	PBP1_GABAb_receptor_plant	49..444	CDD:380645	87/450 (19%)
		GluR_Plant	485..828	CDD:270404	74/410 (18%)