DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R1 and LOC560647

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_021322611.1	Gene:	LOC560647 / 560647	-ID:	-	Length:	903	Species:	Danio rerio

Alignment Length:	790	Identity:	226/790 - (28%)
Similarity:	395/790 - (50%)	Gaps:	53/790 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VTFW-----IFLLCLIASPHLQGGVAGRPDELHIGGIFPIAGKGGWQGG--QACMPAARLALDDV 64
            :.||     ....||:.            .:|.:..|.|::|..| :|.  ...:||..|||..:
Zfish    11 IFFWELTRVPLCYCLVR------------QKLPVLWIMPLSGAPG-KGNITAEVLPAVELALQHL 62

  Fly    65 NKQPNLLPGFKLILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAG-CSTVCTTVAEAAKMWNLI 128
            ::|.:.|..::|..|..||||:........:..:::.|:.||:..| ||:|.:.:|::.:.|||:
Zfish    63 SEQTSNLANYELQFHLTDSECDNSKALKAFFETIFSGPKPLMIFGGACSSVTSVLAQSLESWNLV 127

  Fly   129 VLCYGASSPALSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLEN 193
            .|.:..:.|.|:|::|||..|||.||.:..|...::.::::|||||..|.|.|:.|.....||..
Zfish   128 QLSFAVTVPLLADKRRFPNFFRTVPSDSAVNVALVRFLRQYGWSRVGTLTQREQSFTEVQTDLNR 192

  Fly   194 RCMEAGVEIVTRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRAHVWFFI 258
            ...||.:::...:||...|.|.|:.|:..|.||::..|....|.:|.|.:|..::||:.:.|...
Zfish   193 HLEEANIQLAEAESFSEAPCDCVKKLKDNDVRIVIAHFDQSLAAKVFCCIYNVKMYGQKYQWILP 257

  Fly   259 GWYEDN-WYEVNLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRLNQALI 322
            .|.:.: |.::    :...||.|.:..|.||.::.:....:.::...|||.|.:|:....|:.
Zfish   258 EWVQSSRWTDI----DSTNCTSENILTAIEGSISADIESLSSSHIRGISGRTPQEYEKEYNER-- 316

  Fly   323 EEGYDINHDRYPEGYQEAPLAYDAVWSVALAFNKTMERLTTGKKSL--RDFTYTDKEIADEIYAA 385
            .:...:...:: .|:     |||..|.:|.|..:.||.:...::..  |:||.||:|:...|..|
Zfish   317 RQMKQLGGSKF-HGF-----AYDGTWVIAKALTRVMETVKYRERYSVHRNFTLTDQEVGQMILEA 375

  Fly   386 MNSTQFLGVSGVVAFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSWLNTEQWIGGKVPQDR 450
            |:...|.||:|.|.| .:|:|:|..:..|..|||...:..|....|.|.:::..::...|..:||
Zfish   376 MDKINFFGVTGHVMF-QKGERVANVKFAQYQDGKAVDIEKYSAITDELEFISPIRFHKDKPTKDR 439

  Fly   451 TIVTHVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLI 515
            |.|....:.:|:.|:..:..::..|||.|...::|::.::....|..|.|:.|::::.|.::...
Zfish   440 THVYPHRKRISILLYAIVSFLTFLGIFTACIFLVFSLKHRSHWAISMSRPLMNSLIILGAVLSYS 504

  Fly   516 SVILLGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPKKKVEPWK 580
            |:..:|:||.:||...:...|..:...||.|.|.|:||||:|:|::|.|......| ||..:.:.
Zfish   505 SIFFMGLDGSYVSDRVFEVSCTVQISCLSIGCTTAFGAMFAKIWQIHLFFKNHSID-KKNTKNYG 568

  Fly   581 LYTMVSGLLSIDLVILLSWQIFDPLQRYLETFPLEDPVSTTDDIKIRPELEHCESQRNSMWLGLV 645
            ...:|..|..|||.:|:|.|:.||.:|.::.:.:: |.....|..|:|..|.||:.....|:...
Zfish   569 PNLLVILLFLIDLSLLISLQVLDPFRRTVKEYRIQ-PHPHGQDFFIQPFSERCENTHGLFWMAAF 632

  Fly   646 YGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDASFAFVA 710
            |.:||.:|:...|||:.||.:.:..:||||.:..|::..|.:.||.....|....:.:..|..|.
Zfish   633 YIYKGTLLLSTCFLAWSTRHMNIPAVNDSRSIRFSVFVSVPVILIGTCASMFWQHRPNVQFCIVT 697

  Fly   711 LAVIFCCFLSMLLIFVPKVIEVIRHPKDKAESKYNPDSAISKEDEERYQKLVTENEELQRLITQK 775
            |.::.||..::.::||||:| :||         ..||.|..    .|...|...:.||::...|.
Zfish   698 LVIVTCCCCTLCMVFVPKII-IIR---------MGPDPAFL----SRRFHLKQWHSELEKETEQN 748

  Fly   776 EEKIRVLRQR 785
            ::|..:|.||
Zfish   749 KDKRCMLEQR 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	120/408 (29%)
		ANF_receptor	52..415	CDD:279440	108/366 (30%)
		7tm_3	476..730	CDD:278433	78/253 (31%)
LOC560647	XP_021322611.1	PBP1_GABAb_receptor	35..407	CDD:107361	114/385 (30%)
		7tm_GPCRs	453..720	CDD:333717	81/269 (30%)
		TM helix 1	453..477	CDD:320095	6/23 (26%)
		TM helix 2	489..510	CDD:320095	4/20 (20%)
		TM helix 3	526..548	CDD:320095	10/21 (48%)
		TM helix 4	571..587	CDD:320095	6/15 (40%)
		TM helix 5	625..648	CDD:320095	7/22 (32%)
		TM helix 6	658..683	CDD:320095	8/24 (33%)
		TM helix 7	690..715	CDD:320095	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920