DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R1 and gabbr2

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001137515.1	Gene:	gabbr2 / 560267	ZFINID:	ZDB-GENE-060503-620	Length:	935	Species:	Danio rerio

Alignment Length:	758	Identity:	260/758 - (34%)
Similarity:	423/758 - (55%)	Gaps:	41/758 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QACMPAARLALDDVNKQPNLLPGFKLILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAG-CSTV 114
            |...||.:||:..:.:....  .|.||....|:||:...|....::.:...|:.||:..| |.:|
Zfish    73 QGIEPAVQLAIQHIRESRQY--SFSLITKIYDTECDNAKGLRAFFDAICYGPKHLMIFGGVCPSV 135

  Fly   115 CTTVAEAAKMWNLIVLCYGASSPALSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQ 179
            .:.:||:.:.|||:.|.:.|::|.|:|||::|..|||.||....||..:|.:..:.||||..|.|
Zfish   136 TSIIAESLEGWNLVQLSFAATTPVLADRKKYPNFFRTVPSDNAVNPAVVKFLNFYNWSRVGTLTQ 200

  Fly   180 AEEVFISTVEDLENRCMEAGVEIVTRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMY 244
            ..:.|.....||.|...:|.::|...:||.:||...|:.|:..|.|||:|.|....|.:|.|..|
Zfish   201 DVQRFSEVRNDLTNELEKADIQIADTESFSNDPCVNVKKLKDNDVRIIIGQFDENLAAKVFCCAY 265

  Fly   245 KQQLYGRAHVWFFIGWYEDNWYEVNLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMT 309
            ...:||..:.|...|||:.||:|   :|....||..::..|.||:::.:....:......|||.|
Zfish   266 NLNMYGSKYQWIIPGWYQGNWWE---QANSTNCTTRKLLTAMEGYISVDFEPLSAKQIKGISGRT 327

  Fly   310 AEEFRHRLNQALIEEGYDIN--HDRYPEGYQEAPLAYDAVWSVALAFNKTMERLTTGKK--SLRD 370
            .:|:....|:...::|.:.:  |     |:     |||.:|.:|....:.||.|...::  ...:
Zfish   328 PQEYEREYNRERDQKGVETSKFH-----GF-----AYDGIWVIAKTLTRVMELLRHKERHDMYHN 382

  Fly   371 FTYTDKEIADEIYAAMNSTQFLGVSGVVAFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSW 435
            ||..|:|:...:...||.|.|.||:|.|.|.: |:|:...:..|..:|:..|:|.|:...|.|..
Zfish   383 FTVDDREVGKMVLDVMNETNFFGVTGQVMFRN-GERMGTIKFTQFQEGQEVKVGEYNAIADVLDL 446

  Fly   436 L-NTEQWIGGKVPQDRTIVTHVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSH 499
            : ||.::.|.:.|:|||.|....|.:::||:..:.||:..|:.:..|.:.|||.|::.|:|:.|.
Zfish   447 INNTIRFQGVEPPKDRTFVRLQRRQINVPLYSILSTITILGMLMGGAFLFFNIKNRNHRLIKMSS 511

  Fly   500 PVCNTIMLFGVIICLISVILLGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRF 564
            |..|.:::.|.::...|:.|.|:||.|||.:|:..:|..|.|:|..|:|.|:||||:|.||||..
Zfish   512 PYMNNLIILGGMLSYASIFLFGLDGSFVSDKEFETLCTVRTWILIVGYTTAFGAMFAKTWRVHAI 576

  Fly   565 TTKAKTDPKKKVEPWKLYTMVSGLLSIDLVILLSWQIFDPLQRYLETFPLE-DPVSTTDDIKIRP 628
            ....|. .||.::..||:.:|.|:|.|||.||:.|||.|||:|.:|.:.|| ||...  ||.|||
Zfish   577 FKNVKM-KKKIIKDQKLFIIVGGMLLIDLCILICWQIVDPLKRTVEEYSLEADPQGR--DIAIRP 638

  Fly   629 ELEHCESQRNSMWLGLVYGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAP 693
            .|||||:...::|||:||.:|||:::||.|||:|||::.:..:|||:|:|||:|||.::|:|.|.
Zfish   639 FLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAA 703

  Fly   694 VGMVIASQQDASFAFVALAVIFCCFLSMLLIFVPKVIEVIRHP--------------KDKAESKY 744
            |..:...|.:..|..|||.:|||..:::.|:||||.:.:..:|              :.|.:||.
Zfish   704 VSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKFVTMRTNPDAATQNRRLKFTQNQKKEDSKT 768

  Fly   745 NPD-SAISKEDEERYQKLVTENEELQRLITQKEEKIRVLRQRL 786
            :.. :::::.:..|...|.::|..|:..||:.::::..:..:|
Zfish   769 STSVTSVNQANTSRLDGLQSDNHRLRMKITELDKELEEVTMQL 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	121/391 (31%)
		ANF_receptor	52..415	CDD:279440	113/367 (31%)
		7tm_3	476..730	CDD:278433	114/254 (45%)
gabbr2	NP_001137515.1	PBP1_GABAb_receptor	58..440	CDD:107361	119/382 (31%)
		ANF_receptor	76..419	CDD:279440	113/358 (32%)
		7tm_3	488..739	CDD:278433	113/253 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49267
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830