Protein Alignment GABA-B-R1 and gabbr2

DIOPT Version :9

• Sequence 1: NP_001246033.1
• Gene: GABA-B-R1 / 34878
• FlyBaseID: FBgn0260446
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_001016007.2
• Gene: gabbr2 / 548761
• XenbaseID: XB-GENE-5815161
• Length: 962
• Species: Xenopus tropicalis
• Alignment Length: 777
• Identity: 266/777 - (34%)
• Similarity: 436/777 - (56%)
• Gaps: 43/777 - (5%)

  Fly    33 LHIGGIFPI---AGKGGWQGGQACMPAARLALDDVNKQPNLLPGFKLILHSNDSECEPGLGASVM 94
            |.|.|:.|:   ..||..  |:..:||.:||:|.: :..:||..:.|.|...|:.|:...|....
 Frog    81 LSIMGLMPLNETVAKGNI--GRGVLPAVQLAIDQI-RNISLLHPYFLDLKLYDTACDNAQGLKAF 142

  Fly    95 YNLLYNKPQKLMLLAG-CSTVCTTVAEAAKMWNLIVLCYGASSPALSDRKRFPTLFRTHPSATVH 158
            |:.:...|..||:..| |.:|.:.:||:.|.|||:.|.:.|::|.|:|:|::|..|||.||....
 Frog   143 YDAIKYGPNHLMVFGGVCPSVTSIIAESLKGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAV 207

  Fly   159 NPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLENRCMEAGVEIVTRQSFLSDPTDAVRNLRRQD 223
            ||..:|.:|.|.|.||..|.|..:.|.....||.....::.::|...:||.:||..:|:.|:..|
 Frog   208 NPAIVKFLKHFKWKRVGTLTQDIQRFSEVRNDLTGELEDSAIQIADTESFSNDPCSSVKKLKGND 272

  Fly   224 ARIIVGLFYVVAARRVLCEMYKQQLYGRAHVWFFIGWYEDNWYEVNLKAEGITCTVEQMRIAAEG 288
            .|||:|.|....|.:|.|..:.:.:||..:.|...|||:..|::   :|...||:.:.:..|.||
 Frog   273 VRIIIGQFDEHMAAKVFCCAFDEDMYGSKYQWIIPGWYQALWWQ---QANTSTCSTKNLLTAMEG 334

  Fly   289 HLTTEALMWNQNNQTTISGMTAEEFRHRLNQALIEEGYDINHDRYPEGYQEAPLAYDAVWSVALA 353
            ::..:....:.....||||.|.:::....|    |:...:...:: .||     |||.:|.:|..
 Frog   335 YIGVDFEPLSTKQIKTISGRTPQQYEKEYN----EKRAGVEPSKF-HGY-----AYDGIWVIAKT 389

  Fly   354 FNKTMERLTTGK--KSLRDFTYTDKEIADEIYAAMNSTQFLGVSGVVAFSSQGDRIALTQIEQMI 416
            .::.:|.|.:.|  :.::||.|||.::......|||.|.|.||:|.|.|.: |:|:...:..|..
 Frog   390 LHRALEYLYSSKQRQRIQDFNYTDHKLGKIFLDAMNETNFFGVTGQVVFRN-GERMGTIKFTQFQ 453

  Fly   417 DGKYEKLGYYDTQLDNLSWLN-TEQWIGGKVPQDRTIVTHVLRTVSLPLFVCMCTISSCGIFVAF 480
            |||..|:|.|:...|:|..:| |.::.|.:.|:|:|.:....|.:.|||:..:.|::..|:.:|.
 Frog   454 DGKEVKVGEYNAVADSLELINDTIRFQGVEPPKDQTFIREERRQIYLPLYSILSTLTIIGMIMAS 518

  Fly   481 ALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLISVILLGIDGRFVSPEEYPKICQARAWLLST 545
            ..:.|||.|:::::|:.|.|..|.:::.|.::...|:.|.|:||.|||...:..:|..|.|:|:.
 Frog   519 TFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSANTFETLCTVRTWILTV 583

  Fly   546 GFTLAYGAMFSKVWRVHRFTTKAKTDPKKKVEPWKLYTMVSGLLSIDLVILLSWQIFDPLQRYLE 610
            |:|.|:||||:|.||||......|. .||.::..||..:|.|:|.|||.||:.|||.|||:|.:|
 Frog   584 GYTTAFGAMFAKTWRVHAIFKNVKM-KKKIIKDQKLLVIVGGMLLIDLCILICWQIVDPLKRTVE 647

  Fly   611 TFPLE-DPVSTTDDIKIRPELEHCESQRNSMWLGLVYGFKGLILVFGLFLAYETRSIKVKQINDS 674
            .:.|| ||...  ||.|||.|||||:...::|||:||.:|||:::||.|||:|||::.:..:|||
 Frog   648 EYNLEPDPAGR--DIAIRPFLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDS 710

  Fly   675 RYVGMSIYNVVVLCLITAPVGMVIASQQDASFAFVALAVIFCCFLSMLLIFVPKVIEV------- 732
            :|:|||:|||.::|:|.|.|..:...|.:..|..|||.:|||..:::.|:||||:|.:
 Frog   711 KYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAA 775

  Fly   733 -------IRHPKDKAESKYNPD-SAISKEDEERYQKLVTENEELQRLITQKEEKIRVLRQRL 786
                   ..|.:.|.:||.:.. :::::....|.:.|.:||..|:..||:.::.:..:..:|
 Frog   776 TQNRRFQFTHNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQL 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	128/408 (31%)
		ANF_receptor	52..415	CDD:279440	113/365 (31%)
		7tm_3	476..730	CDD:278433	112/254 (44%)
gabbr2	NP_001016007.2	PBP1_GABAb_receptor	83..481	CDD:380589	130/414 (31%)
		7tmC_GABA-B-R2	501..770	CDD:320421	117/271 (43%)
		TM helix 1	501..526	CDD:320421	7/24 (29%)
		TM helix 2	538..559	CDD:320421	5/20 (25%)
		TM helix 3	575..599	CDD:320421	12/23 (52%)
		TM helix 4	618..638	CDD:320421	10/19 (53%)
		TM helix 5	674..700	CDD:320421	14/25 (56%)
		TM helix 6	709..732	CDD:320421	13/22 (59%)
		TM helix 7	739..764	CDD:320421	10/24 (42%)
		GBR2_CC	800..838	CDD:375881	8/38 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49267
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930