DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R1 and Shbg

DIOPT Version :9

Sequence 1:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_006246648.1	Gene:	Shbg / 24775	RGDID:	3671	Length:	445	Species:	Rattus norvegicus

Alignment Length:	214	Identity:	43/214 - (20%)
Similarity:	72/214 - (33%)	Gaps:	97/214 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSDGAVTFWI---FLLCLIASPHLQGGVAGRPD---ELHIGGI--------FPIA-------GK 44
            |..| ::..|:   .:|||   ..:...:|..|.   .:.:||:        ||:.       .:
  Rat   179 MNGD-SLLLWVDGKEMLCL---RQVSASLADHPQLSMRIALGGLLLPTSKLRFPLVPALDGCIRR 239

  Fly    45 GGWQGGQACM-PAARLALD--DVNKQPNL--------------LP-------------GFKLI-- 77
            ..|.|.||.: .:||.:|.  ||:.||.|              :|             ||||:
  Rat   240 DIWLGHQAQLSTSARTSLGNCDVDLQPGLFFPPGTHAEFSLQDIPQPHTDPWTFSLELGFKLVDG 304

  Fly    78 -----------------LHSND------SECEPGLGASV-----------MYNLLYNKPQKLMLL 108
                             ||..|      ||.||.|...:           ::.:..::..|:.:|
  Rat   305 AGRLLTLGTGTNSSWLTLHLQDQTVVLSSEAEPKLALPLAVGLPLQLKLDVFKVALSQGPKMEVL 369

  Fly   109 AGCSTVCTTVAEAAKMWNL 127
            :      |::...|.:|.|
  Rat   370 S------TSLLRLASLWRL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	35/175 (20%)
		ANF_receptor	52..415	CDD:279440	28/142 (20%)
		7tm_3	476..730	CDD:278433
Shbg	XP_006246648.1	Laminin_G_1	118..248	CDD:278483	15/72 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900